P55890 (DSBC_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbC

Gene names

Name:	dsbC
Ordered Locus Names:	STM3043

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.
Subunit structure	Homodimer By similarity.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 237	216	Thiol:disulfide interchange protein DsbC		PRO_0000034274
Amino acid modifications
	Disulfide bond	119 ↔ 122		Redox-active Potential
Experimental info
	Sequence conflict	44	1	P → A in AAC45775. Ref.2
	Sequence conflict	93	1	N → K in AAC45775. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P55890 [UniParc]. Last modified December 19, 2001. Version 2. Checksum: 61F958FC1FE2ECC0	FASTA	237	25,836
	10 20 30 40 50 60 MKKRFMMFTL LAAVFSGVAH ADDAAIRQSL AKLGVQSTEI QASPVAGMKT VLTHSGVLYV 70 80 90 100 110 120 TDDGKHIIQG PMYDVSGAHP VNVTNKLLMS QLNALEKEMI VYKAPDEKHV ITVFTDITCG 130 140 150 160 170 180 YCHKLHEEMK DYNALGITVR YLAFPRQGLE SQAEQDMKSI WCAKDKNKAF DDAMAGKGVK 190 200 210 220 230 PASCDVNIAD HYALGVQLGV SGTPAIVLSN GYVVPGYQGP KEMKAFLDEH QKQTSGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[2]	"Salmonella typhimurium specifies a circular chromosome dimer resolution system which is homologous to the Xer site-specific recombination system of Escherichia coli." Hayes F., Lubetzki S.A., Sherratt D.J. Gene 198:105-110(1997) [PubMed: 9370270] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-174. Strain: LT2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL21918.1. U92524 Genomic DNA. Translation: AAC45775.1.
RefSeq	NP_461959.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P55890.
SMR	P55890. Positions 22-237.
ModBase	Search...
Proteomic databases
PRIDE	P55890.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1254566.
GenomeReviews	Gene locus STM3043 in contig AE006468_GR.
KEGG	stm:STM3043.
NMPDR	fig|99287.1.peg.2936.
PATRIC	32384829. VBISalEnt20916_3223.
Phylogenomic databases
HOGENOM	HBG469935.
OMA	GLYEVKL.
ProtClustDB	PRK10877.
Enzyme and pathway databases
BioCyc	STYP99287:STM3043-MONOMER.
Family and domain databases
InterPro	IPR018950. DiS-bond_isomerase_DsbC/G_N. IPR009094. DiS-bond_isomerase_DsbC_N. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03981.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
SUPFAM	SSF54423. Disulfide_bond_isomerase_N. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_SALTY

Accession

Primary (citable) accession number: P55890

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 19, 2001
Last modified:	January 25, 2012
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program