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Protein

Thiol:disulfide interchange protein DsbC

Gene

dsbC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3063-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbC
Gene namesi
Name:dsbC
Ordered Locus Names:STM3043
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 237216Thiol:disulfide interchange protein DsbCPRO_0000034274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 122Redox-activeSequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55890.
PRIDEiP55890.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3043.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 3210Combined sources
Beta strandi39 – 424Combined sources
Beta strandi48 – 536Combined sources
Beta strandi56 – 616Combined sources
Beta strandi66 – 705Combined sources
Beta strandi72 – 743Combined sources
Beta strandi76 – 794Combined sources
Helixi83 – 9311Combined sources
Helixi94 – 985Combined sources
Beta strandi99 – 1024Combined sources
Beta strandi108 – 1158Combined sources
Helixi120 – 1278Combined sources
Helixi129 – 1346Combined sources
Beta strandi137 – 1437Combined sources
Beta strandi149 – 1513Combined sources
Helixi152 – 16110Combined sources
Beta strandi163 – 1653Combined sources
Helixi166 – 17510Combined sources
Helixi188 – 19811Combined sources
Beta strandi202 – 2076Combined sources
Helixi220 – 23213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5QX-ray1.96A/B23-237[»]
4ILFX-ray2.00A/B23-237[»]
ProteinModelPortaliP55890.
SMRiP55890. Positions 22-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4105T95. Bacteria.
COG1651. LUCA.
HOGENOMiHOG000222077.
KOiK03981.
OMAiVWCAKDP.
OrthoDBiEOG632D3W.
PhylomeDBiP55890.

Family and domain databases

Gene3Di3.10.450.70. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR018950. DiS-bond_isomerase_DsbC/G_N.
IPR009094. DiS-bond_isomerase_DsbC_N.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF10411. DsbC_N. 1 hit.
PF13098. Thioredoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54423. SSF54423. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRFMMFTL LAAVFSGVAH ADDAAIRQSL AKLGVQSTEI QASPVAGMKT
60 70 80 90 100
VLTHSGVLYV TDDGKHIIQG PMYDVSGAHP VNVTNKLLMS QLNALEKEMI
110 120 130 140 150
VYKAPDEKHV ITVFTDITCG YCHKLHEEMK DYNALGITVR YLAFPRQGLE
160 170 180 190 200
SQAEQDMKSI WCAKDKNKAF DDAMAGKGVK PASCDVNIAD HYALGVQLGV
210 220 230
SGTPAIVLSN GYVVPGYQGP KEMKAFLDEH QKQTSGK
Length:237
Mass (Da):25,836
Last modified:December 19, 2001 - v2
Checksum:i61F958FC1FE2ECC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441P → A in AAC45775 (PubMed:9370270).Curated
Sequence conflicti93 – 931N → K in AAC45775 (PubMed:9370270).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21918.1.
U92524 Genomic DNA. Translation: AAC45775.1.
RefSeqiNP_461959.1. NC_003197.1.
WP_000745625.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21918; AAL21918; STM3043.
GeneIDi1254566.
KEGGistm:STM3043.
PATRICi32384829. VBISalEnt20916_3223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21918.1.
U92524 Genomic DNA. Translation: AAC45775.1.
RefSeqiNP_461959.1. NC_003197.1.
WP_000745625.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5QX-ray1.96A/B23-237[»]
4ILFX-ray2.00A/B23-237[»]
ProteinModelPortaliP55890.
SMRiP55890. Positions 22-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3043.

Proteomic databases

PaxDbiP55890.
PRIDEiP55890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21918; AAL21918; STM3043.
GeneIDi1254566.
KEGGistm:STM3043.
PATRICi32384829. VBISalEnt20916_3223.

Phylogenomic databases

eggNOGiENOG4105T95. Bacteria.
COG1651. LUCA.
HOGENOMiHOG000222077.
KOiK03981.
OMAiVWCAKDP.
OrthoDBiEOG632D3W.
PhylomeDBiP55890.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3063-MONOMER.

Family and domain databases

Gene3Di3.10.450.70. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR018950. DiS-bond_isomerase_DsbC/G_N.
IPR009094. DiS-bond_isomerase_DsbC_N.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF10411. DsbC_N. 1 hit.
PF13098. Thioredoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54423. SSF54423. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  2. "Salmonella typhimurium specifies a circular chromosome dimer resolution system which is homologous to the Xer site-specific recombination system of Escherichia coli."
    Hayes F., Lubetzki S.A., Sherratt D.J.
    Gene 198:105-110(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-174.
    Strain: LT2.

Entry informationi

Entry nameiDSBC_SALTY
AccessioniPrimary (citable) accession number: P55890
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: November 11, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.