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Protein

Thiol:disulfide interchange protein DsbC

Gene

dsbC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.

GO - Biological processi

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-3075-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbC
Gene namesi
Name:dsbC
Ordered Locus Names:STM3043
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003427422 – 237Thiol:disulfide interchange protein DsbCAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 122Redox-activeSequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55890
PRIDEiP55890

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3043

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Beta strandi39 – 42Combined sources4
Beta strandi48 – 53Combined sources6
Beta strandi56 – 61Combined sources6
Beta strandi66 – 70Combined sources5
Beta strandi72 – 74Combined sources3
Beta strandi76 – 79Combined sources4
Helixi83 – 93Combined sources11
Helixi94 – 98Combined sources5
Beta strandi99 – 102Combined sources4
Beta strandi108 – 115Combined sources8
Helixi120 – 127Combined sources8
Helixi129 – 134Combined sources6
Beta strandi137 – 143Combined sources7
Beta strandi149 – 151Combined sources3
Helixi152 – 161Combined sources10
Beta strandi163 – 165Combined sources3
Helixi166 – 175Combined sources10
Helixi188 – 198Combined sources11
Beta strandi202 – 207Combined sources6
Helixi220 – 232Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5QX-ray1.96A/B23-237[»]
4ILFX-ray2.00A/B23-237[»]
ProteinModelPortaliP55890
SMRiP55890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4105T95 Bacteria
COG1651 LUCA
HOGENOMiHOG000222077
KOiK03981
OMAiQMIVYKA
PhylomeDBiP55890

Family and domain databases

CDDicd03020 DsbA_DsbC_DsbG, 1 hit
Gene3Di3.10.450.70, 1 hit
InterProiView protein in InterPro
IPR033954 DiS-bond_Isoase_DsbC/G
IPR018950 DiS-bond_isomerase_DsbC/G_N
IPR009094 DiS-bond_isomerase_DsbC/G_N_sf
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
PfamiView protein in Pfam
PF10411 DsbC_N, 1 hit
PF13098 Thioredoxin_2, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54423 SSF54423, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRFMMFTL LAAVFSGVAH ADDAAIRQSL AKLGVQSTEI QASPVAGMKT
60 70 80 90 100
VLTHSGVLYV TDDGKHIIQG PMYDVSGAHP VNVTNKLLMS QLNALEKEMI
110 120 130 140 150
VYKAPDEKHV ITVFTDITCG YCHKLHEEMK DYNALGITVR YLAFPRQGLE
160 170 180 190 200
SQAEQDMKSI WCAKDKNKAF DDAMAGKGVK PASCDVNIAD HYALGVQLGV
210 220 230
SGTPAIVLSN GYVVPGYQGP KEMKAFLDEH QKQTSGK
Length:237
Mass (Da):25,836
Last modified:December 19, 2001 - v2
Checksum:i61F958FC1FE2ECC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44P → A in AAC45775 (PubMed:9370270).Curated1
Sequence conflicti93N → K in AAC45775 (PubMed:9370270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL21918.1
U92524 Genomic DNA Translation: AAC45775.1
RefSeqiNP_461959.1, NC_003197.2
WP_000745625.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21918; AAL21918; STM3043
GeneIDi1254566
KEGGistm:STM3043
PATRICifig|99287.12.peg.3223

Similar proteinsi

Entry informationi

Entry nameiDSBC_SALTY
AccessioniPrimary (citable) accession number: P55890
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: April 25, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health