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Protein

Thiol:disulfide interchange protein DsbC

Gene

dsbC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbC
Gene namesi
Name:dsbC
Ordered Locus Names:STM3043
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003427422 – 237Thiol:disulfide interchange protein DsbCAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 122Redox-activeSequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55890.
PRIDEiP55890.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3043.

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 32Combined sources10
Beta strandi39 – 42Combined sources4
Beta strandi48 – 53Combined sources6
Beta strandi56 – 61Combined sources6
Beta strandi66 – 70Combined sources5
Beta strandi72 – 74Combined sources3
Beta strandi76 – 79Combined sources4
Helixi83 – 93Combined sources11
Helixi94 – 98Combined sources5
Beta strandi99 – 102Combined sources4
Beta strandi108 – 115Combined sources8
Helixi120 – 127Combined sources8
Helixi129 – 134Combined sources6
Beta strandi137 – 143Combined sources7
Beta strandi149 – 151Combined sources3
Helixi152 – 161Combined sources10
Beta strandi163 – 165Combined sources3
Helixi166 – 175Combined sources10
Helixi188 – 198Combined sources11
Beta strandi202 – 207Combined sources6
Helixi220 – 232Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5QX-ray1.96A/B23-237[»]
4ILFX-ray2.00A/B23-237[»]
ProteinModelPortaliP55890.
SMRiP55890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4105T95. Bacteria.
COG1651. LUCA.
HOGENOMiHOG000222077.
KOiK03981.
OMAiVWCAKDP.
PhylomeDBiP55890.

Family and domain databases

CDDicd03020. DsbA_DsbC_DsbG. 1 hit.
Gene3Di3.10.450.70. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR033954. DiS-bond_Isoase_DsbC/G.
IPR018950. DiS-bond_isomerase_DsbC/G_N.
IPR009094. DiS-bond_isomerase_DsbC_N.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF10411. DsbC_N. 1 hit.
PF13098. Thioredoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54423. SSF54423. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRFMMFTL LAAVFSGVAH ADDAAIRQSL AKLGVQSTEI QASPVAGMKT
60 70 80 90 100
VLTHSGVLYV TDDGKHIIQG PMYDVSGAHP VNVTNKLLMS QLNALEKEMI
110 120 130 140 150
VYKAPDEKHV ITVFTDITCG YCHKLHEEMK DYNALGITVR YLAFPRQGLE
160 170 180 190 200
SQAEQDMKSI WCAKDKNKAF DDAMAGKGVK PASCDVNIAD HYALGVQLGV
210 220 230
SGTPAIVLSN GYVVPGYQGP KEMKAFLDEH QKQTSGK
Length:237
Mass (Da):25,836
Last modified:December 19, 2001 - v2
Checksum:i61F958FC1FE2ECC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44P → A in AAC45775 (PubMed:9370270).Curated1
Sequence conflicti93N → K in AAC45775 (PubMed:9370270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21918.1.
U92524 Genomic DNA. Translation: AAC45775.1.
RefSeqiNP_461959.1. NC_003197.1.
WP_000745625.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21918; AAL21918; STM3043.
GeneIDi1254566.
KEGGistm:STM3043.
PATRICi32384829. VBISalEnt20916_3223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL21918.1.
U92524 Genomic DNA. Translation: AAC45775.1.
RefSeqiNP_461959.1. NC_003197.1.
WP_000745625.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I5QX-ray1.96A/B23-237[»]
4ILFX-ray2.00A/B23-237[»]
ProteinModelPortaliP55890.
SMRiP55890.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3043.

Proteomic databases

PaxDbiP55890.
PRIDEiP55890.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21918; AAL21918; STM3043.
GeneIDi1254566.
KEGGistm:STM3043.
PATRICi32384829. VBISalEnt20916_3223.

Phylogenomic databases

eggNOGiENOG4105T95. Bacteria.
COG1651. LUCA.
HOGENOMiHOG000222077.
KOiK03981.
OMAiVWCAKDP.
PhylomeDBiP55890.

Family and domain databases

CDDicd03020. DsbA_DsbC_DsbG. 1 hit.
Gene3Di3.10.450.70. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR033954. DiS-bond_Isoase_DsbC/G.
IPR018950. DiS-bond_isomerase_DsbC/G_N.
IPR009094. DiS-bond_isomerase_DsbC_N.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
PfamiPF10411. DsbC_N. 1 hit.
PF13098. Thioredoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54423. SSF54423. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSBC_SALTY
AccessioniPrimary (citable) accession number: P55890
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 19, 2001
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.