ID   GAST_HORSE              Reviewed;         107 AA.
AC   P55885;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=Gastrin;
DE   Contains:
DE     RecName: Full=Big gastrin;
DE     AltName: Full=Gastrin-34;
DE              Short=G34;
DE   Contains:
DE     RecName: Full=Gastrin;
DE   Flags: Precursor;
GN   Name=GAST; Synonyms=GAS;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 62-95, AMIDATION AT
RP   PHE-95, PYROGLUTAMATE FORMATION AT GLN-62 AND GLN-79, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Gastric mucosa;
RX   MEDLINE=98380242; PubMed=9716385;
RX   DOI=10.1046/j.1432-1327.1998.2550432.x;
RA   Johnsen A.H., Sandin A., Rourke I.J., Bundgaard J.R., Nilsson G.,
RA   Rehfeld J.F.;
RT   "Unique progastrin processing in equine G-cells suggests marginal
RT   tyrosyl sulfotransferase activity.";
RL   Eur. J. Biochem. 255:432-438(1998).
CC   -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and
CC       secrete hydrochloric acid and the pancreas to secrete its
CC       digestive enzymes. It also stimulates smooth muscle contraction
CC       and increases blood circulation and water secretion in the stomach
CC       and intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Neither gastrin is sulfated.
CC   -!- MASS SPECTROMETRY: Mass=1928; Method=MALDI; Range=63-78;
CC       Source=PubMed:9716385;
CC   -!- MASS SPECTROMETRY: Mass=3814; Method=MALDI; Range=62-95;
CC       Source=PubMed:9716385;
CC   -!- MASS SPECTROMETRY: Mass=3703; Method=MALDI; Range=63-95;
CC       Source=PubMed:9716385;
CC   -!- MASS SPECTROMETRY: Mass=2039; Method=MALDI; Range=80-95;
CC       Source=PubMed:9716385;
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
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DR   EMBL; Y09440; CAA70590.1; -; mRNA.
DR   RefSeq; NP_001075979.1; -.
DR   UniGene; Eca.13044; -.
DR   Ensembl; ENSECAG00000012504; Equus caballus.
DR   GeneID; 100034214; -.
DR   KEGG; ecb:100034214; -.
DR   HOVERGEN; P55885; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001651; Gastrin.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   Pfam; PF00918; Gastrin; 1.
DR   SMART; SM00029; GASTRIN; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Phosphoprotein;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL        1     21
FT   PROPEP       22     61
FT                                /FTId=PRO_0000010629.
FT   PEPTIDE      62     95       Big gastrin.
FT                                /FTId=PRO_0000010630.
FT   PEPTIDE      79     95       Gastrin.
FT                                /FTId=PRO_0000010631.
FT   PROPEP       99    107
FT                                /FTId=PRO_0000010632.
FT   MOD_RES      62     62       Pyrrolidone carboxylic acid.
FT   MOD_RES      79     79       Pyrrolidone carboxylic acid.
FT   MOD_RES      95     95       Phenylalanine amide.
FT   MOD_RES      99     99       Phosphoserine (By similarity).
SQ   SEQUENCE   107 AA;  11884 MW;  104166CAAE5C234F CRC64;
     MRRLCVYVLI FALALAAFSE ASWKPCSQLQ DAPSGPGANK GLYPHWPDQL DRLGPASHHR
     RQLGLQGSPH LVADLSKKQG PWLEKEEAAY GWMDFGRRSA EEGDQSP
//