Reviewed, UniProtKB/Swiss-Prot P55881 (THIL_SALTY)

Names and origin

Protein names

Recommended name:
    Thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	STM0419

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Thiamine-monophosphate kinase		PRO_0000096198

Sequences

	Sequence		Length	Mass (Da)
	P55881-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: BF60DEB90C42B7CC	FASTA	325	34,986
	10 20 30 40 50 60 MACGEFSLIA RYFDRVRSSR LDVETGIGDD CALLNIPEKQ TLAISTDTLV AGNHFLPDID 70 80 90 100 110 120 PADLAYKALA VNLSDLAAMG ADPAWLTLAL TLPEVDEPWL EAFSDSLFAL LNYYDMQLIG 130 140 150 160 170 180 GDTTRGPLSM TLGIHGYIPA GRALKRSGAK PGDWIYVTGT PGDSAAGLAV LQNRLQVSEE 190 200 210 220 230 240 TDAHYLIQRH LRPTPRILHG QALRDIASAA IDLSDGLISD LGHIVKASGC GARVDVDALP 250 260 270 280 290 300 KSDAMMRHVD DGQALRWALS GGEDYELCFT VPELNRGALD VAIGQLGVPF TCIGQMSADI 310 320 EGLNFVRDGM PVTFDWKGYD HFATP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Webb E.A., Downs D.M. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U74758 Genomic DNA. Translation: AAB37319.1. AE006468 Genomic DNA. Translation: AAL19373.1.
PIR	T47117.
RefSeq	NP_459414.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P55881.
Genome annotation databases
GeneID	1251938.
GenomeReviews	Gene locus STM0419 in contig AE006468_GR.
KEGG	stm:STM0419.
NMPDR	fig|99287.1.peg.404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P55881.
OMA	MGAEPAW.
Enzyme and pathway databases
BioCyc	STYP99287:STM0419-MON.
BRENDA	2.7.4.16. 2.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_SALTY

Accession

Primary (citable) accession number: P55881

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)