ID   GLI3_CHICK              Reviewed;         663 AA.
AC   P55879;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Zinc finger protein GLI3;
DE   Flags: Fragment;
GN   Name=GLI3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97105842; PubMed=8948590; DOI=10.1006/dbio.1996.0300;
RA   Marigo V., Johnson R.L., Vortkamp A., Tabin C.J.;
RT   "Sonic hedgehog differentially regulates expression of GLI and GLI3
RT   during limb development.";
RL   Dev. Biol. 180:273-283(1996).
CC   -!- FUNCTION: Implicated in the transduction of Shh signal (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains at least 5 C2H2-type zinc fingers.
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DR   EMBL; U60763; AAB51660.1; -; mRNA.
DR   IPI; IPI00596211; -.
DR   UniGene; Gga.4969; -.
DR   HSSP; P08151; 2GLI.
DR   Ensembl; ENSGALG00000011630; Gallus gallus.
DR   HOVERGEN; P55879; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   ProDom; PD000003; Znf_C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN        <1   >663       Zinc finger protein GLI3.
FT                                /FTId=PRO_0000047205.
FT   ZN_FING     234    259       C2H2-type.
FT   ZN_FING     267    294       C2H2-type.
FT   ZN_FING     300    324       C2H2-type.
FT   ZN_FING     330    355       C2H2-type.
FT   ZN_FING     361    386       C2H2-type.
FT   NON_TER       1      1
FT   NON_TER     663    663
SQ   SEQUENCE   663 AA;  73107 MW;  46E32C33FF6BD4FF CRC64;
     LMAGHPNYGD ILMQSGGAAG TAHLHEYLSP VDVSRFSSPR VTPRLSRKRA LSISPLSDAS
     IDLQTMIRTS PNSLVAYINN SRSSSAASGS YGHLSAGTIS PAFSFPHPIN PVTYQQILTQ
     QRGLSSAFGH TPPLIQPSPT FPPRQHMAVI SVNPPPAQIS SNSNCISDSS QSKQSSESAV
     SSTVNPVINK RTKVKTEVEG LPQYPQPRQE HLTDLKEDLD KDECKQEPEV IYETNCHWEG
     CTKEYDTQEQ LVHHINNDHI HGEKKEFVCR WQDCTREQKP FKAQYMLVVH MRRHTGEKPH
     KCTFEGCSKA YSRLENLKTH LRSHTGEKPY VCEHEGCNKA FSNASDRAKH QNRTHSNEKP
     YVCKIPGCTK RYTDPSSLRK HVKTVHGPDA HVTKKQRNDV HPRPPPLKEN GDNEASAKQS
     SKVSEESPEA NSTTRSMEDC LQVKTIKTEN SVMCQSSPGG QSSCSSEPSP LGSTNNNDSG
     VEMNMHGGGS LGDLTGWMTR LPVVDSTVSS GNLTVSLQLR KHMTTMQRLE QLKKEKLKTV
     KDSCSWVNPA PQGRNTKLPP ISGNGSILEN SGGSSRTLPN PRIMELSVNE VTMLNQINER
     RDSTTSTISS AYTVSRRSSG ISPYFSSRRS SEASQLGHRP NNTSSADSYD PISTGGREFD
     IKL
//