P55879 (GLI2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein GLI2

Gene names

Name:

GLI2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	663 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a transcriptional activator or repressor. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Implicated in the transduction of Shh signal By similarity.
Subcellular location	Nucleus. Cytoplasm By similarity.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains at least 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›663	›663	Zinc finger protein GLI2		PRO_0000047205
Regions
	Zinc finger	234 – 259	26	C2H2-type
	Zinc finger	267 – 294	28	C2H2-type
	Zinc finger	300 – 324	25	C2H2-type
	Zinc finger	330 – 355	26	C2H2-type
	Zinc finger	361 – 386	26	C2H2-type
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	663	1

Sequences

	Sequence		Length	Mass (Da)
	P55879 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 46E32C33FF6BD4FF	FASTA	663	73,107
	10 20 30 40 50 60 LMAGHPNYGD ILMQSGGAAG TAHLHEYLSP VDVSRFSSPR VTPRLSRKRA LSISPLSDAS 70 80 90 100 110 120 IDLQTMIRTS PNSLVAYINN SRSSSAASGS YGHLSAGTIS PAFSFPHPIN PVTYQQILTQ 130 140 150 160 170 180 QRGLSSAFGH TPPLIQPSPT FPPRQHMAVI SVNPPPAQIS SNSNCISDSS QSKQSSESAV 190 200 210 220 230 240 SSTVNPVINK RTKVKTEVEG LPQYPQPRQE HLTDLKEDLD KDECKQEPEV IYETNCHWEG 250 260 270 280 290 300 CTKEYDTQEQ LVHHINNDHI HGEKKEFVCR WQDCTREQKP FKAQYMLVVH MRRHTGEKPH 310 320 330 340 350 360 KCTFEGCSKA YSRLENLKTH LRSHTGEKPY VCEHEGCNKA FSNASDRAKH QNRTHSNEKP 370 380 390 400 410 420 YVCKIPGCTK RYTDPSSLRK HVKTVHGPDA HVTKKQRNDV HPRPPPLKEN GDNEASAKQS 430 440 450 460 470 480 SKVSEESPEA NSTTRSMEDC LQVKTIKTEN SVMCQSSPGG QSSCSSEPSP LGSTNNNDSG 490 500 510 520 530 540 VEMNMHGGGS LGDLTGWMTR LPVVDSTVSS GNLTVSLQLR KHMTTMQRLE QLKKEKLKTV 550 560 570 580 590 600 KDSCSWVNPA PQGRNTKLPP ISGNGSILEN SGGSSRTLPN PRIMELSVNE VTMLNQINER 610 620 630 640 650 660 RDSTTSTISS AYTVSRRSSG ISPYFSSRRS SEASQLGHRP NNTSSADSYD PISTGGREFD IKL

References

[1]	"Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development." Marigo V., Johnson R.L., Vortkamp A., Tabin C.J. Dev. Biol. 180:273-283(1996) [PubMed: 8948590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U60763 mRNA. Translation: AAB51660.1.
IPI	IPI00596211.
UniGene	Gga.4969.
3D structure databases
ProteinModelPortal	P55879.
SMR	P55879. Positions 233-387.
ModBase	Search...
Protein-protein interaction databases
STRING	P55879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	veNOG04705.
GeneTree	ENSGT00600000084058.
HOVERGEN	HBG080668.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLI2_CHICK

Accession

Primary (citable) accession number: P55879

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program