ID   GLI1_CHICK              Reviewed;         556 AA.
AC   P55878;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-NOV-2011, entry version 73.
DE   RecName: Full=Zinc finger protein GLI1;
DE            Short=GLI;
DE   Flags: Fragment;
GN   Name=GLI1; Synonyms=GLI;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97105842; PubMed=8948590; DOI=10.1006/dbio.1996.0300;
RA   Marigo V., Johnson R.L., Vortkamp A., Tabin C.J.;
RT   "Sonic hedgehog differentially regulates expression of GLI and GLI3
RT   during limb development.";
RL   Dev. Biol. 180:273-283(1996).
CC   -!- FUNCTION: May act as a transcriptional activator. May regulate the
CC       transcription of specific genes during normal development. May
CC       play a role in craniofacial development and digital development,
CC       as well as development of the central nervous system and
CC       gastrointestinal tract. Mediates SHH signaling and thus cell
CC       proliferation and differentiation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
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DR   EMBL; U60762; AAB51659.1; -; mRNA.
DR   IPI; IPI00579758; -.
DR   UniGene; Gga.614; -.
DR   ProteinModelPortal; P55878; -.
DR   SMR; P55878; 246-400.
DR   STRING; P55878; -.
DR   eggNOG; veNOG07205; -.
DR   GeneTree; ENSGT00600000084058; -.
DR   HOVERGEN; HBG082955; -.
DR   InParanoid; P55878; -.
DR   OrthoDB; EOG4T1HKP; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Activator; Complete proteome; Cytoplasm; Developmental protein;
KW   Differentiation; DNA-binding; Metal-binding; Nucleus; Proto-oncogene;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1   >556       Zinc finger protein GLI1.
FT                                /FTId=PRO_0000047199.
FT   ZN_FING     247    272       C2H2-type 1.
FT   ZN_FING     280    307       C2H2-type 2.
FT   ZN_FING     313    337       C2H2-type 3.
FT   ZN_FING     343    368       C2H2-type 4.
FT   ZN_FING     374    399       C2H2-type 5.
FT   NON_TER     556    556
SQ   SEQUENCE   556 AA;  60216 MW;  722D2AA5A1CA4D98 CRC64;
     MFNPVTPQAR PYAEHCCPRP LHGASAGTPG LQGLDFPVCH QPNLASSHHG YGLVPGTEHP
     GGAADGSRFS TPRGAGKLGK KRALSISPLS DSSVDLQTVI RTSPNSLVAF INSRCASAGG
     SYGHLSISTI SPSLGYQNPP GQQKGQGQLF SHTPPLPPCS SHETLSSRPG LLHPTPARGT
     IKHCQQLKLE RSLSSPLTAK YPEEKSEGDI SSPASTGTQD PLLGMLSVRD DLEKEDGKPE
     SETIYETNCY WDGCAKEFDT QEQLVHHINN EHIHGEKKEF VCHWAACSRE QRPFKAQYML
     VVHMRRHTGE KPHKCTFEGC NKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR
     AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKHR GSVVPGHALP
     ASAAPQDMKQ EKNTNGPAEI RKDDGKLLVP DLVSKPQPSP GGQSSCSSDR SPLGSTTNND
     SGVEMTGNTG GSYEDLVHAG GCGARGSHGH LGADGLQKLE NLRIDKLKQM RKPSTKGLNL
     PAIPEPVCRR CVRVCV
//