Reviewed, UniProtKB/Swiss-Prot P55878 (GLI1_CHICK)

Names and origin

Protein names

Recommended name:
    Zinc finger protein GLI1
      Short name=GLI

Gene names

Name:	GLI1
Synonyms:	GLI

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	556 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›556	›556	Zinc finger protein GLI1		PRO_0000047199
Regions
	Zinc finger	247 – 272	26	C2H2-type 1
	Zinc finger	280 – 307	28	C2H2-type 2
	Zinc finger	313 – 337	25	C2H2-type 3
	Zinc finger	343 – 368	26	C2H2-type 4
	Zinc finger	374 – 399	26	C2H2-type 5
Experimental info
	Non-terminal residue	556	1

Sequences

	Sequence		Length	Mass (Da)
	P55878-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 722D2AA5A1CA4D98	FASTA	556	60,216
	10 20 30 40 50 60 MFNPVTPQAR PYAEHCCPRP LHGASAGTPG LQGLDFPVCH QPNLASSHHG YGLVPGTEHP 70 80 90 100 110 120 GGAADGSRFS TPRGAGKLGK KRALSISPLS DSSVDLQTVI RTSPNSLVAF INSRCASAGG 130 140 150 160 170 180 SYGHLSISTI SPSLGYQNPP GQQKGQGQLF SHTPPLPPCS SHETLSSRPG LLHPTPARGT 190 200 210 220 230 240 IKHCQQLKLE RSLSSPLTAK YPEEKSEGDI SSPASTGTQD PLLGMLSVRD DLEKEDGKPE 250 260 270 280 290 300 SETIYETNCY WDGCAKEFDT QEQLVHHINN EHIHGEKKEF VCHWAACSRE QRPFKAQYML 310 320 330 340 350 360 VVHMRRHTGE KPHKCTFEGC NKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR 370 380 390 400 410 420 AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKHR GSVVPGHALP 430 440 450 460 470 480 ASAAPQDMKQ EKNTNGPAEI RKDDGKLLVP DLVSKPQPSP GGQSSCSSDR SPLGSTTNND 490 500 510 520 530 540 SGVEMTGNTG GSYEDLVHAG GCGARGSHGH LGADGLQKLE NLRIDKLKQM RKPSTKGLNL 550 PAIPEPVCRR CVRVCV

References

[1]	"Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development." Marigo V., Johnson R.L., Vortkamp A., Tabin C.J. Dev. Biol. 180:273-283(1996) [PubMed: 8948590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U60762 mRNA. Translation: AAB51659.1.
IPI	IPI00579758.
UniGene	Gga.614
3D structure databases
SMR	P55878. Positions 246-400.
ModBase	Search...
Protein-protein interaction databases
STRING	P55878.
Genome annotation databases
Ensembl	ENSGALT00000023592; ENSGALP00000023546; ENSGALG00000014639; Gallus gallus. [Genome view]
Phylogenomic databases
eggNOG	veNOG07205.
HOVERGEN	P55878.
InParanoid	P55878.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLI1_CHICK

Accession

Primary (citable) accession number: P55878

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 19, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)