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P55878 (GLI1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein GLI1
Short name=GLI
Gene names
Name:GLI1
Synonyms:GLI
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length556 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation By similarity.

Subcellular location

Nucleus. Cytoplasm By similarity.

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DiseaseProto-oncogene
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtranscription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›556›556Zinc finger protein GLI1
PRO_0000047199

Regions

Zinc finger247 – 27226C2H2-type 1
Zinc finger280 – 30728C2H2-type 2
Zinc finger313 – 33725C2H2-type 3
Zinc finger343 – 36826C2H2-type 4
Zinc finger374 – 39926C2H2-type 5

Experimental info

Non-terminal residue5561

Sequences

Sequence LengthMass (Da)Tools
P55878 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 722D2AA5A1CA4D98

FASTA55660,216
        10         20         30         40         50         60 
MFNPVTPQAR PYAEHCCPRP LHGASAGTPG LQGLDFPVCH QPNLASSHHG YGLVPGTEHP 

        70         80         90        100        110        120 
GGAADGSRFS TPRGAGKLGK KRALSISPLS DSSVDLQTVI RTSPNSLVAF INSRCASAGG 

       130        140        150        160        170        180 
SYGHLSISTI SPSLGYQNPP GQQKGQGQLF SHTPPLPPCS SHETLSSRPG LLHPTPARGT 

       190        200        210        220        230        240 
IKHCQQLKLE RSLSSPLTAK YPEEKSEGDI SSPASTGTQD PLLGMLSVRD DLEKEDGKPE 

       250        260        270        280        290        300 
SETIYETNCY WDGCAKEFDT QEQLVHHINN EHIHGEKKEF VCHWAACSRE QRPFKAQYML 

       310        320        330        340        350        360 
VVHMRRHTGE KPHKCTFEGC NKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR 

       370        380        390        400        410        420 
AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKHR GSVVPGHALP 

       430        440        450        460        470        480 
ASAAPQDMKQ EKNTNGPAEI RKDDGKLLVP DLVSKPQPSP GGQSSCSSDR SPLGSTTNND 

       490        500        510        520        530        540 
SGVEMTGNTG GSYEDLVHAG GCGARGSHGH LGADGLQKLE NLRIDKLKQM RKPSTKGLNL 

       550 
PAIPEPVCRR CVRVCV

« Hide

References

[1]"Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development."
Marigo V., Johnson R.L., Vortkamp A., Tabin C.J.
Dev. Biol. 180:273-283(1996) [PubMed: 8948590] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U60762 mRNA. Translation: AAB51659.1.
IPIIPI00579758.
UniGeneGga.614.

3D structure databases

ProteinModelPortalP55878.
SMRP55878. Positions 246-400.
ModBaseSearch...

Protein-protein interaction databases

STRINGP55878.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGveNOG07205.
GeneTreeENSGT00600000084058.
HOVERGENHBG082955.
InParanoidP55878.
OrthoDBEOG4T1HKP.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
PfamPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLI1_CHICK
AccessionPrimary (citable) accession number: P55878
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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