P55867 (CAS1B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Caspase-1-B
Short name=CASP-1-B
EC=3.4.22.36

Alternative name(s):
Interleukin-1 beta convertase homolog B
Short name=xICE-B

Gene names

Name:	casp1-b
Synonyms:	casp1b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase C14A family. Contains 1 CARD domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
PTM	Zymogen
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – ?		Potential		PRO_0000004539
	Chain	? – 382		Caspase-1-B		PRO_0000004540
Regions
	Domain	22 – 88	67	CARD
Sites
	Active site	216	1	By similarity
	Active site	270	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55867 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 81D2FB7BF3C2230F	FASTA	382	43,389
	10 20 30 40 50 60 MTAQLNKVRK AIINGCNPAM ISDLLDDLQD KHVLKDYEVE HINKKNNTSR DRCRDMIDSV 70 80 90 100 110 120 KKKGEYSSNI LLESLVKNHK TLAESLGLHE HAPSPIQEHN EDTIKDKEIN SVIPCSAEEF 130 140 150 160 170 180 KNIYDSHGDK IYEVREREGR KRLALIICNE TFQSMSERRG AKLDLEGMNK LLNELGYQVQ 190 200 210 220 230 240 QHTNLTKAEM VKAMKEFAAR EEHADSDSTF IVLMSHGDKP GVCGTDSKKT ENGQYGVTNL 250 260 270 280 290 300 LQVDEIFSTF NNVNCSRLWD KPKVIIIQAC RGENQGGELV RDDVAPAPLE DDAVHHVQTE 310 320 330 340 350 360 TDSICFYSST PDTASWRNPT KGSVFIIRLI EKMNELAHCQ PLGDIFLEVQ SSFKDKSPNQ 370 380 YSQMPTQERS TMTKKFYLFP GY

References

[1]	"Cloning of the Xenopus homologue of ICE." Nakajima K. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89785 mRNA. Translation: BAA14019.1.
RefSeq	NP_001079341.1. NM_001085872.1.
UniGene	Xl.138.
3D structure databases
ProteinModelPortal	P55867.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	378669.
KEGG	xla:378669.
Organism-specific databases
CTD	378669.
Xenbase	XB-GENE-6077552. casp1.
Phylogenomic databases
HOVERGEN	HBG076981.
KO	K01370.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR001315. CARD. IPR017350. Caspase_IL-1_beta. IPR011029. DEATH-like_dom. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
PANTHER	PTHR10454. PTHR10454. 1 hit.
Pfam	PF00619. CARD. 1 hit. PF00656. Peptidase_C14. 1 hit. [Graphical view]
PIRSF	PIRSF038001. Caspase_ICE. 1 hit.
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00114. CARD. 1 hit. SM00115. CASc. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50209. CARD. 1 hit. PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAS1B_XENLA

Accession

Primary (citable) accession number: P55867

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	March 6, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program