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P55867

- CAS1B_XENLA

UniProt

P55867 - CAS1B_XENLA

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Protein

Caspase-1-B

Gene

casp1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei216 – 2161By similarity
Active sitei270 – 2701By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: InterPro
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1-B (EC:3.4.22.36)
Short name:
CASP-1-B
Alternative name(s):
Interleukin-1 beta convertase homolog B
Short name:
xICE-B
Gene namesi
Name:casp1-b
Synonyms:casp1b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6077552. casp1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 382Caspase-1-BPRO_0000004540
Propeptidei1 – ?Sequence AnalysisPRO_0000004539

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliP55867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8867CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG076981.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55867-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAQLNKVRK AIINGCNPAM ISDLLDDLQD KHVLKDYEVE HINKKNNTSR
60 70 80 90 100
DRCRDMIDSV KKKGEYSSNI LLESLVKNHK TLAESLGLHE HAPSPIQEHN
110 120 130 140 150
EDTIKDKEIN SVIPCSAEEF KNIYDSHGDK IYEVREREGR KRLALIICNE
160 170 180 190 200
TFQSMSERRG AKLDLEGMNK LLNELGYQVQ QHTNLTKAEM VKAMKEFAAR
210 220 230 240 250
EEHADSDSTF IVLMSHGDKP GVCGTDSKKT ENGQYGVTNL LQVDEIFSTF
260 270 280 290 300
NNVNCSRLWD KPKVIIIQAC RGENQGGELV RDDVAPAPLE DDAVHHVQTE
310 320 330 340 350
TDSICFYSST PDTASWRNPT KGSVFIIRLI EKMNELAHCQ PLGDIFLEVQ
360 370 380
SSFKDKSPNQ YSQMPTQERS TMTKKFYLFP GY
Length:382
Mass (Da):43,389
Last modified:November 1, 1997 - v1
Checksum:i81D2FB7BF3C2230F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89785 mRNA. Translation: BAA14019.1.
RefSeqiNP_001079341.1. NM_001085872.1.
UniGeneiXl.138.

Genome annotation databases

GeneIDi378669.
KEGGixla:378669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89785 mRNA. Translation: BAA14019.1 .
RefSeqi NP_001079341.1. NM_001085872.1.
UniGenei Xl.138.

3D structure databases

ProteinModelPortali P55867.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 378669.
KEGGi xla:378669.

Organism-specific databases

CTDi 378669.
Xenbasei XB-GENE-6077552. casp1.

Phylogenomic databases

HOVERGENi HBG076981.
KOi K01370.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the Xenopus homologue of ICE."
    Nakajima K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCAS1B_XENLA
AccessioniPrimary (citable) accession number: P55867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3