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P55867 (CAS1B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase-1-B

Short name=CASP-1-B
EC=3.4.22.36
Alternative name(s):
Interleukin-1 beta convertase homolog B
Short name=xICE-B
Gene names
Name:casp1-b
Synonyms:casp1b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase C14A family.

Contains 1 CARD domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Thiol protease
   PTMZymogen
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: InterPro

regulation of apoptotic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – ? PotentialPRO_0000004539
Chain? – 382Caspase-1-BPRO_0000004540

Regions

Domain22 – 8867CARD

Sites

Active site2161 By similarity
Active site2701 By similarity

Sequences

Sequence LengthMass (Da)Tools
P55867 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 81D2FB7BF3C2230F

FASTA38243,389
        10         20         30         40         50         60 
MTAQLNKVRK AIINGCNPAM ISDLLDDLQD KHVLKDYEVE HINKKNNTSR DRCRDMIDSV 

        70         80         90        100        110        120 
KKKGEYSSNI LLESLVKNHK TLAESLGLHE HAPSPIQEHN EDTIKDKEIN SVIPCSAEEF 

       130        140        150        160        170        180 
KNIYDSHGDK IYEVREREGR KRLALIICNE TFQSMSERRG AKLDLEGMNK LLNELGYQVQ 

       190        200        210        220        230        240 
QHTNLTKAEM VKAMKEFAAR EEHADSDSTF IVLMSHGDKP GVCGTDSKKT ENGQYGVTNL 

       250        260        270        280        290        300 
LQVDEIFSTF NNVNCSRLWD KPKVIIIQAC RGENQGGELV RDDVAPAPLE DDAVHHVQTE 

       310        320        330        340        350        360 
TDSICFYSST PDTASWRNPT KGSVFIIRLI EKMNELAHCQ PLGDIFLEVQ SSFKDKSPNQ 

       370        380 
YSQMPTQERS TMTKKFYLFP GY 

« Hide

References

[1]"Cloning of the Xenopus homologue of ICE."
Nakajima K.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89785 mRNA. Translation: BAA14019.1.
RefSeqNP_001079341.1. NM_001085872.1.
UniGeneXl.138.

3D structure databases

ProteinModelPortalP55867.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID378669.
KEGGxla:378669.

Organism-specific databases

CTD378669.
XenbaseXB-GENE-6077552. casp1.

Phylogenomic databases

HOVERGENHBG076981.
KOK01370.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFPIRSF038001. Caspase_ICE. 1 hit.
PRINTSPR00376. IL1BCENZYME.
SMARTSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAS1B_XENLA
AccessionPrimary (citable) accession number: P55867
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries