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Protein

Caspase-1-B

Gene

casp1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei216By similarity1
Active sitei270By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1-B (EC:3.4.22.36)
Short name:
CASP-1-B
Alternative name(s):
Interleukin-1 beta convertase homolog B
Short name:
xICE-B
Gene namesi
Name:casp1-b
Synonyms:casp1b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6077552. casp1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004540? – 382Caspase-1-B
PropeptideiPRO_00000045391 – ?Sequence analysis

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliP55867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 88CARDPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

HOVERGENiHBG076981.
KOiK01370.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQLNKVRK AIINGCNPAM ISDLLDDLQD KHVLKDYEVE HINKKNNTSR
60 70 80 90 100
DRCRDMIDSV KKKGEYSSNI LLESLVKNHK TLAESLGLHE HAPSPIQEHN
110 120 130 140 150
EDTIKDKEIN SVIPCSAEEF KNIYDSHGDK IYEVREREGR KRLALIICNE
160 170 180 190 200
TFQSMSERRG AKLDLEGMNK LLNELGYQVQ QHTNLTKAEM VKAMKEFAAR
210 220 230 240 250
EEHADSDSTF IVLMSHGDKP GVCGTDSKKT ENGQYGVTNL LQVDEIFSTF
260 270 280 290 300
NNVNCSRLWD KPKVIIIQAC RGENQGGELV RDDVAPAPLE DDAVHHVQTE
310 320 330 340 350
TDSICFYSST PDTASWRNPT KGSVFIIRLI EKMNELAHCQ PLGDIFLEVQ
360 370 380
SSFKDKSPNQ YSQMPTQERS TMTKKFYLFP GY
Length:382
Mass (Da):43,389
Last modified:November 1, 1997 - v1
Checksum:i81D2FB7BF3C2230F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89785 mRNA. Translation: BAA14019.1.
RefSeqiNP_001079341.1. NM_001085872.1.
UniGeneiXl.138.

Genome annotation databases

GeneIDi378669.
KEGGixla:378669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89785 mRNA. Translation: BAA14019.1.
RefSeqiNP_001079341.1. NM_001085872.1.
UniGeneiXl.138.

3D structure databases

ProteinModelPortaliP55867.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378669.
KEGGixla:378669.

Organism-specific databases

CTDi378669.
XenbaseiXB-GENE-6077552. casp1.

Phylogenomic databases

HOVERGENiHBG076981.
KOiK01370.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAS1B_XENLA
AccessioniPrimary (citable) accession number: P55867
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 15, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.