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P55865 (CAS1A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase-1-A

Short name=CASP-1-A
EC=3.4.22.36
Alternative name(s):
Interleukin-1 beta convertase homolog A
Short name=xICE-A
Gene names
Name:casp1-a
Synonyms:casp1a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase C14A family.

Contains 1 CARD domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Thiol protease
   PTMZymogen
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: InterPro

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of apoptotic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – ? PotentialPRO_0000004537
Chain? – 386Caspase-1-APRO_0000004538

Regions

Domain22 – 8867CARD

Sites

Active site2181 By similarity
Active site2741 By similarity

Sequences

Sequence LengthMass (Da)Tools
P55865 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 927C71FC9FED79E6

FASTA38643,663
        10         20         30         40         50         60 
MTAQLNKVRR AIIDGCNPAM ISDLLDDLRE KNVLVDSEVE HIKESNNTNR DRCRAMIDSV 

        70         80         90        100        110        120 
KKKGDDPSNI LLESLVKNHK TLAKSLGLHE PPMAPVPIQE HNADTIKNKD IKGVIPCSAE 

       130        140        150        160        170        180 
EFKKIQDTQG DKIYDVRKRE GRKGLALIIC NEKFENLNER HGAKVDLDGM TKLLNELGYQ 

       190        200        210        220        230        240 
VHPHTNLTKT EMVKVMKEFA AQEEHADSDS TFIVLMSHGD RQGVCGTDSK KTEKEKGQYE 

       250        260        270        280        290        300 
VTNLLEIDEI FSTFNNVNCS KLRNKPKVII IQACRGENKG GLLVRDDVAS PPLEDDGLHF 

       310        320        330        340        350        360 
VQREADFICF CSSTPDTVSW RDPTKGSVFI THLIEKMNEY AHCQPLGDIF LEVQSLFKDK 

       370        380 
CPNSRSQMPT QERCTLTKKF YLFPGY 

« Hide

References

« Hide 'large scale' references
[1]"Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail."
Yaoita Y., Nakajima K.
J. Biol. Chem. 272:5122-5127(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89783 mRNA. Translation: BAA14017.1.
BC129548 mRNA. Translation: AAI29549.1.
RefSeqNP_001081223.1. NM_001087754.1.
UniGeneXl.126.

3D structure databases

ProteinModelPortalP55865.
SMRP55865. Positions 304-386.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397719.
KEGGxla:397719.

Organism-specific databases

CTD397719.
XenbaseXB-GENE-6252623. casp1.

Phylogenomic databases

HOVERGENHBG076981.
KOK01370.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR001315. CARD.
IPR017350. Caspase_IL-1_beta.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFPIRSF038001. Caspase_ICE. 1 hit.
PRINTSPR00376. IL1BCENZYME.
SMARTSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAS1A_XENLA
AccessionPrimary (citable) accession number: P55865
Secondary accession number(s): A2VD67
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries