Reviewed, UniProtKB/Swiss-Prot P55865 (CAS1A_XENLA)

Names and origin

Protein names

Recommended name:
    Caspase-1-A
      Short name=CASP-1-A
    EC=3.4.22.36
Alternative name(s):
    Interleukin-1 beta convertase homolog A
      Short name=xICE-A

Gene names

Name:	casp1-A
Synonyms:	casp1a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase C14A family. Contains 1 CARD domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
PTM	Zymogen
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – ?		Potential		PRO_0000004537
	Chain	? – 386		Caspase-1-A		PRO_0000004538
Regions
	Domain	22 – 88	67	CARD
Sites
	Active site	218	1	By similarity
	Active site	274	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55865-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 927C71FC9FED79E6	FASTA	386	43,663
	10 20 30 40 50 60 MTAQLNKVRR AIIDGCNPAM ISDLLDDLRE KNVLVDSEVE HIKESNNTNR DRCRAMIDSV 70 80 90 100 110 120 KKKGDDPSNI LLESLVKNHK TLAKSLGLHE PPMAPVPIQE HNADTIKNKD IKGVIPCSAE 130 140 150 160 170 180 EFKKIQDTQG DKIYDVRKRE GRKGLALIIC NEKFENLNER HGAKVDLDGM TKLLNELGYQ 190 200 210 220 230 240 VHPHTNLTKT EMVKVMKEFA AQEEHADSDS TFIVLMSHGD RQGVCGTDSK KTEKEKGQYE 250 260 270 280 290 300 VTNLLEIDEI FSTFNNVNCS KLRNKPKVII IQACRGENKG GLLVRDDVAS PPLEDDGLHF 310 320 330 340 350 360 VQREADFICF CSSTPDTVSW RDPTKGSVFI THLIEKMNEY AHCQPLGDIF LEVQSLFKDK 370 380 CPNSRSQMPT QERCTLTKKF YLFPGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail." Yaoita Y., Nakajima K. J. Biol. Chem. 272:5122-5127(1997) [PubMed: 9030578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89783 mRNA. Translation: BAA14017.1. BC129548 mRNA. Translation: AAI29549.1.
RefSeq	NP_001081223.1.
UniGene	Xl.126
3D structure databases
SMR	P55865. Positions 3-89, 114-386.
ModBase	Search...
Genome annotation databases
GeneID	397719.
KEGG	xla:397719.
Organism-specific databases
CTD	397719.
Phylogenomic databases
HOVERGEN	P55865.
Enzyme and pathway databases
BRENDA	3.4.22.36. 648.
Family and domain databases
InterPro	IPR001315. CARD. IPR017350. Caspase_IL-1_beta. IPR011029. DEATH-like. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
PANTHER	PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF00619. CARD. 1 hit. PF00656. Peptidase_C14. 1 hit. [Graphical view]
PIRSF	PIRSF038001. Caspase_ICE. 1 hit.
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00114. CARD. 1 hit. SM00115. CASc. 1 hit. [Graphical view]
PROSITE	PS50209. CARD. 1 hit. PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAS1A_XENLA

Accession

Primary (citable) accession number: P55865
Secondary accession number(s): A2VD67

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 19, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project