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P55865

- CAS1A_XENLA

UniProt

P55865 - CAS1A_XENLA

Protein

Caspase-1-A

Gene

casp1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei218 – 2181By similarity
    Active sitei274 – 2741By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: InterPro
    2. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-1-A (EC:3.4.22.36)
    Short name:
    CASP-1-A
    Alternative name(s):
    Interleukin-1 beta convertase homolog A
    Short name:
    xICE-A
    Gene namesi
    Name:casp1-a
    Synonyms:casp1a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252623. casp1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 386Caspase-1-APRO_0000004538
    Propeptidei1 – ?Sequence AnalysisPRO_0000004537

    Keywords - PTMi

    Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP55865.
    SMRiP55865. Positions 304-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 8867CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG076981.
    KOiK01370.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55865-1 [UniParc]FASTAAdd to Basket

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    MTAQLNKVRR AIIDGCNPAM ISDLLDDLRE KNVLVDSEVE HIKESNNTNR    50
    DRCRAMIDSV KKKGDDPSNI LLESLVKNHK TLAKSLGLHE PPMAPVPIQE 100
    HNADTIKNKD IKGVIPCSAE EFKKIQDTQG DKIYDVRKRE GRKGLALIIC 150
    NEKFENLNER HGAKVDLDGM TKLLNELGYQ VHPHTNLTKT EMVKVMKEFA 200
    AQEEHADSDS TFIVLMSHGD RQGVCGTDSK KTEKEKGQYE VTNLLEIDEI 250
    FSTFNNVNCS KLRNKPKVII IQACRGENKG GLLVRDDVAS PPLEDDGLHF 300
    VQREADFICF CSSTPDTVSW RDPTKGSVFI THLIEKMNEY AHCQPLGDIF 350
    LEVQSLFKDK CPNSRSQMPT QERCTLTKKF YLFPGY 386
    Length:386
    Mass (Da):43,663
    Last modified:November 1, 1997 - v1
    Checksum:i927C71FC9FED79E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89783 mRNA. Translation: BAA14017.1.
    BC129548 mRNA. Translation: AAI29549.1.
    RefSeqiNP_001081223.1. NM_001087754.1.
    UniGeneiXl.126.

    Genome annotation databases

    GeneIDi397719.
    KEGGixla:397719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89783 mRNA. Translation: BAA14017.1 .
    BC129548 mRNA. Translation: AAI29549.1 .
    RefSeqi NP_001081223.1. NM_001087754.1.
    UniGenei Xl.126.

    3D structure databases

    ProteinModelPortali P55865.
    SMRi P55865. Positions 304-386.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397719.
    KEGGi xla:397719.

    Organism-specific databases

    CTDi 397719.
    Xenbasei XB-GENE-6252623. casp1.

    Phylogenomic databases

    HOVERGENi HBG076981.
    KOi K01370.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail."
      Yaoita Y., Nakajima K.
      J. Biol. Chem. 272:5122-5127(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCAS1A_XENLA
    AccessioniPrimary (citable) accession number: P55865
    Secondary accession number(s): A2VD67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3