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P55865

- CAS1A_XENLA

UniProt

P55865 - CAS1A_XENLA

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Protein

Caspase-1-A

Gene

casp1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181By similarity
Active sitei274 – 2741By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: InterPro
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-1-A (EC:3.4.22.36)
Short name:
CASP-1-A
Alternative name(s):
Interleukin-1 beta convertase homolog A
Short name:
xICE-A
Gene namesi
Name:casp1-a
Synonyms:casp1a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252623. casp1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 386Caspase-1-APRO_0000004538
Propeptidei1 – ?Sequence AnalysisPRO_0000004537

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliP55865.
SMRiP55865. Positions 304-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8867CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG076981.
KOiK01370.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55865-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAQLNKVRR AIIDGCNPAM ISDLLDDLRE KNVLVDSEVE HIKESNNTNR
60 70 80 90 100
DRCRAMIDSV KKKGDDPSNI LLESLVKNHK TLAKSLGLHE PPMAPVPIQE
110 120 130 140 150
HNADTIKNKD IKGVIPCSAE EFKKIQDTQG DKIYDVRKRE GRKGLALIIC
160 170 180 190 200
NEKFENLNER HGAKVDLDGM TKLLNELGYQ VHPHTNLTKT EMVKVMKEFA
210 220 230 240 250
AQEEHADSDS TFIVLMSHGD RQGVCGTDSK KTEKEKGQYE VTNLLEIDEI
260 270 280 290 300
FSTFNNVNCS KLRNKPKVII IQACRGENKG GLLVRDDVAS PPLEDDGLHF
310 320 330 340 350
VQREADFICF CSSTPDTVSW RDPTKGSVFI THLIEKMNEY AHCQPLGDIF
360 370 380
LEVQSLFKDK CPNSRSQMPT QERCTLTKKF YLFPGY
Length:386
Mass (Da):43,663
Last modified:November 1, 1997 - v1
Checksum:i927C71FC9FED79E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89783 mRNA. Translation: BAA14017.1.
BC129548 mRNA. Translation: AAI29549.1.
RefSeqiNP_001081223.1. NM_001087754.1.
UniGeneiXl.126.

Genome annotation databases

GeneIDi397719.
KEGGixla:397719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89783 mRNA. Translation: BAA14017.1 .
BC129548 mRNA. Translation: AAI29549.1 .
RefSeqi NP_001081223.1. NM_001087754.1.
UniGenei Xl.126.

3D structure databases

ProteinModelPortali P55865.
SMRi P55865. Positions 304-386.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397719.
KEGGi xla:397719.

Organism-specific databases

CTDi 397719.
Xenbasei XB-GENE-6252623. casp1.

Phylogenomic databases

HOVERGENi HBG076981.
KOi K01370.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail."
    Yaoita Y., Nakajima K.
    J. Biol. Chem. 272:5122-5127(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiCAS1A_XENLA
AccessioniPrimary (citable) accession number: P55865
Secondary accession number(s): A2VD67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3