ID   SUMO_CAEEL              Reviewed;          91 AA.
AC   P55853;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Small ubiquitin-related modifier;
DE            Short=SUMO;
DE   AltName: Full=Ubiquitin-like protein SMT3;
DE   Flags: Precursor;
GN   Name=smo-1; Synonyms=smt3, sumo; ORFNames=K12C11.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97237059; PubMed=9119407; DOI=10.1006/geno.1996.4556;
RA   Lapenta V., Chiurazzi P., van der Spek P.J., Pizzuti A., Hanaoka F.,
RA   Brahe C.;
RT   "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to
RT   chromosome 21qter and defines a novel gene family.";
RL   Genomics 40:362-367(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   MEDLINE=97318858; PubMed=9175795; DOI=10.1006/bbrc.1997.6709;
RA   Choudhury B.K., Li S.S.;
RT   "Identification and characterization of the SMT3 cDNA and gene from
RT   nematode Caenorhabditis elegans.";
RL   Biochem. Biophys. Res. Commun. 234:788-791(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [4]
RP   FUNCTION.
RX   PubMed=11806825;
RA   Jones D., Crowe E., Stevens T.A., Candido E.P.M.;
RT   "Functional and phylogenetic analysis of the ubiquitylation system in
RT   Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-
RT   activating enzymes, and ubiquitin-like proteins.";
RL   Genome Biol. 3:RESEARCH0002.1-RESEARCH0002.15(2002).
RN   [5]
RP   FUNCTION.
RX   PubMed=15466489; DOI=10.1101/gad.1227104;
RA   Broday L., Kolotuev I., Didier C., Bhoumik A., Gupta B.P.,
RA   Sternberg P.W., Podbilewicz B., Ronai Z.;
RT   "The small ubiquitin-like modifier (SUMO) is required for gonadal and
RT   uterine-vulval morphogenesis in Caenorhabditis elegans.";
RL   Genes Dev. 18:2380-2391(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=15107848; DOI=10.1038/ng1336;
RA   Zhang H., Smolen G.A., Palmer R., Christoforou A., van den Heuvel S.,
RA   Haber D.A.;
RT   "SUMO modification is required for in vivo Hox gene regulation by the
RT   Caenorhabditis elegans Polycomb group protein SOP-2.";
RL   Nat. Genet. 36:507-511(2004).
RN   [7]
RP   FUNCTION.
RX   PubMed=15689373; DOI=10.1242/dev.01664;
RA   Leight E.R., Glossip D., Kornfeld K.;
RT   "Sumoylation of LIN-1 promotes transcriptional repression and
RT   inhibition of vulval cell fates.";
RL   Development 132:1047-1056(2005).
RN   [8]
RP   FUNCTION.
RX   PubMed=15990876; DOI=10.1038/sj.emboj.7600726;
RA   Poulin G., Dong Y., Fraser A.G., Hopper N.A., Ahringer J.;
RT   "Chromatin regulation and sumoylation in the inhibition of Ras-induced
RT   vulval development in Caenorhabditis elegans.";
RL   EMBO J. 24:2613-2623(2005).
RN   [9]
RP   FUNCTION.
RX   PubMed=16701625; DOI=10.1016/j.ydbio.2006.04.001;
RA   Roy Chowdhuri S., Crum T., Woollard A., Aslam S., Okkema P.G.;
RT   "The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are
RT   required for ABa-derived pharyngeal muscle in C. elegans.";
RL   Dev. Biol. 295:664-677(2006).
CC   -!- FUNCTION: Ubiquitin-like protein which can be covalently attached
CC       to target lysines as a monomer. Does not seem to be involved in
CC       protein degradation and may function as an antagonist of ubiquitin
CC       in the degradation process. Plays a role in a number of cellular
CC       processes such as nuclear transport, DNA replication and repair,
CC       mitosis and signal transduction. Covalent attachment to its
CC       substrates requires prior activation by the E1 complex aos-1-uba-2
CC       and linkage to the E2 enzyme ubc-9, and can be promoted by an E3
CC       ligase such as gei-17. Required for embryonic development,
CC       fertility, vulval morphogenesis and inhibition of vulval cell
CC       fates.
CC   -!- SUBUNIT: Covalently attached to a number of proteins such as tbx-
CC       2, lin-1, lin-11 and sop-2.
CC   -!- INTERACTION:
CC       O62195:-; NbExp=1; IntAct=EBI-313647, EBI-315940;
CC       P90740:-; NbExp=1; IntAct=EBI-313647, EBI-313626;
CC       Q23158:atn-1; NbExp=1; IntAct=EBI-313647, EBI-314014;
CC       Q22799:dlc-1; NbExp=1; IntAct=EBI-313647, EBI-328324;
CC       O16299:figl-1; NbExp=1; IntAct=EBI-313647, EBI-320880;
CC       Q94420:mel-26; NbExp=1; IntAct=EBI-313647, EBI-320790;
CC       Q19905:sqv-4; NbExp=1; IntAct=EBI-313647, EBI-320696;
CC   -!- PTM: Cleavage of precursor form by ulp-1 is necessary for function
CC       (Probable).
CC   -!- SIMILARITY: Belongs to the ubiquitin family. SUMO subfamily.
CC   -!- SIMILARITY: Contains 1 ubiquitin-like domain.
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DR   EMBL; X99600; CAA67914.1; -; mRNA.
DR   EMBL; U94830; AAB67608.1; -; Genomic_DNA.
DR   EMBL; AF043701; AAK18969.1; -; Genomic_DNA.
DR   PIR; JC5582; JC5582.
DR   RefSeq; NP_490842.1; -.
DR   UniGene; Cel.18381; -.
DR   HSSP; Q93068; 1A5R.
DR   DIP; DIP:25461N; -.
DR   IntAct; P55853; 18.
DR   Ensembl; K12C11.2; Caenorhabditis elegans.
DR   GeneID; 266820; -.
DR   KEGG; cel:K12C11.2; -.
DR   NMPDR; fig|6239.3.peg.221; -.
DR   WormBase; WBGene00004888; smo-1.
DR   WormPep; K12C11.2; CE18056.
DR   OMA; P55853; DNAEYIK.
DR   NextBio; 953156; -.
DR   ArrayExpress; P55853; -.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0010171; P:body morphogenesis; IMP:WormBase.
DR   GO; GO:0040002; P:collagen and cuticulin-based cuticle develo...; IMP:WormBase.
DR   GO; GO:0009792; P:embryonic development ending in birth or eg...; IMP:WormBase.
DR   GO; GO:0001703; P:gastrulation with mouth forming first; IMP:WormBase.
DR   GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   GO; GO:0040027; P:negative regulation of vulval development; IMP:WormBase.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Isopeptide bond;
KW   Ubl conjugation pathway.
FT   CHAIN         1     91       Small ubiquitin-related modifier.
FT                                /FTId=PRO_0000114890.
FT   PROPEP       91     91       By similarity.
FT                                /FTId=PRO_0000271227.
FT   DOMAIN       13     91       Ubiquitin-like.
FT   CROSSLNK     90     90       Glycyl lysine isopeptide (Gly-Lys)
FT                                (interchain with K-? in acceptor
FT                                proteins) (By similarity).
SQ   SEQUENCE   91 AA;  10222 MW;  0894E99B6F7B37F5 CRC64;
     MADDAAQAGD NAEYIKIKVV GQDSNEVHFR VKYGTSMAKL KKSYADRTGV AVNSLRFLFD
     GRRINDDDTP KTLEMEDDDV IEVYQEQLGG F
//