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P55851

- UCP2_HUMAN

UniProt

P55851 - UCP2_HUMAN

Protein

Mitochondrial uncoupling protein 2

Gene

UCP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular metabolic process Source: Reactome
    3. cellular response to amino acid starvation Source: Ensembl
    4. cellular response to glucose stimulus Source: Ensembl
    5. cellular response to insulin stimulus Source: Ensembl
    6. female pregnancy Source: Ensembl
    7. liver regeneration Source: Ensembl
    8. mitochondrial transport Source: Ensembl
    9. negative regulation of apoptotic process Source: Ensembl
    10. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    11. positive regulation of cell death Source: Ensembl
    12. proton transport Source: Reactome
    13. respiratory electron transport chain Source: Reactome
    14. response to fatty acid Source: Ensembl
    15. response to hypoxia Source: Ensembl
    16. response to superoxide Source: Ensembl
    17. small molecule metabolic process Source: Reactome
    18. transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_6196. The proton buffering model.
    REACT_6258. The fatty acid cycling model.

    Protein family/group databases

    TCDBi2.A.29.3.4. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial uncoupling protein 2
    Short name:
    UCP 2
    Alternative name(s):
    Solute carrier family 25 member 8
    UCPH
    Gene namesi
    Name:UCP2
    Synonyms:SLC25A8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12518. UCP2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi607447. phenotype.
    Orphaneti276556. Hyperinsulinism due to UCP2 deficiency.
    PharmGKBiPA37165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Mitochondrial uncoupling protein 2PRO_0000090664Add
    BLAST

    Proteomic databases

    PaxDbiP55851.
    PRIDEiP55851.

    PTM databases

    PhosphoSiteiP55851.

    Expressioni

    Tissue specificityi

    Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

    Gene expression databases

    ArrayExpressiP55851.
    BgeeiP55851.
    CleanExiHS_UCP2.
    GenevestigatoriP55851.

    Organism-specific databases

    HPAiCAB025583.

    Interactioni

    Subunit structurei

    Acts as a dimer forming a proton channel.By similarity

    Protein-protein interaction databases

    BioGridi113198. 5 interactions.
    IntActiP55851. 1 interaction.
    STRINGi9606.ENSP00000312029.

    Structurei

    3D structure databases

    ProteinModelPortaliP55851.
    SMRiP55851. Positions 14-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial matrixSequence Analysis
    Topological domaini33 – 7745Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11919Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini137 – 18044Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21417Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini235 – 26834Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 13617Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 19717Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23420Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29123Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10696Solcar 1Add
    BLAST
    Repeati114 – 20390Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni276 – 29823Purine nucleotide bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300436.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiP55851.
    KOiK15103.
    OMAiSPNIARN.
    OrthoDBiEOG793B7Z.
    PhylomeDBiP55851.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP    50
    VRATASAQYR GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY 100
    DSVKQFYTKG SEHASIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA 150
    GGGRRYQSTV NAYKTIAREE GFRGLWKGTS PNVARNAIVN CAELVTYDLI 200
    KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY 250
    SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 300
    ACTSREAPF 309
    Length:309
    Mass (Da):33,229
    Last modified:November 1, 1997 - v1
    Checksum:i2E1741391621E3D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2191T → I in AAB48411. (PubMed:9054939)Curated

    Polymorphismi

    Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIMi:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551A → V.4 Publications
    Corresponds to variant rs660339 [ dbSNP | Ensembl ].
    VAR_016129
    Natural varianti76 – 761R → Q.1 Publication
    Corresponds to variant rs45541732 [ dbSNP | Ensembl ].
    VAR_023998
    Natural varianti154 – 1541R → Q.1 Publication
    Corresponds to variant rs45486692 [ dbSNP | Ensembl ].
    VAR_023999
    Natural varianti268 – 2681A → G.1 Publication
    Corresponds to variant rs45490393 [ dbSNP | Ensembl ].
    VAR_024000
    Natural varianti282 – 2821S → C.1 Publication
    Corresponds to variant rs45596837 [ dbSNP | Ensembl ].
    VAR_024001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82819 mRNA. Translation: AAC51336.1.
    U76367 mRNA. Translation: AAB48411.1.
    U94592 mRNA. Translation: AAB53091.1.
    AJ223477, AJ223478, AJ223479 Genomic DNA. Translation: CAA11402.1.
    AF019409 Genomic DNA. Translation: AAC39690.1.
    AF096289 Genomic DNA. Translation: AAD21151.1.
    AK222540 mRNA. Translation: BAD96260.1.
    AK222557 mRNA. Translation: BAD96277.1.
    DQ087219 Genomic DNA. Translation: AAY68217.1.
    BC011737 mRNA. Translation: AAH11737.1.
    CCDSiCCDS8228.1.
    RefSeqiNP_003346.2. NM_003355.2.
    UniGeneiHs.80658.

    Genome annotation databases

    EnsembliENST00000310473; ENSP00000312029; ENSG00000175567.
    GeneIDi7351.
    KEGGihsa:7351.
    UCSCiuc001oup.1. human.

    Polymorphism databases

    DMDMi2497981.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82819 mRNA. Translation: AAC51336.1 .
    U76367 mRNA. Translation: AAB48411.1 .
    U94592 mRNA. Translation: AAB53091.1 .
    AJ223477 , AJ223478 , AJ223479 Genomic DNA. Translation: CAA11402.1 .
    AF019409 Genomic DNA. Translation: AAC39690.1 .
    AF096289 Genomic DNA. Translation: AAD21151.1 .
    AK222540 mRNA. Translation: BAD96260.1 .
    AK222557 mRNA. Translation: BAD96277.1 .
    DQ087219 Genomic DNA. Translation: AAY68217.1 .
    BC011737 mRNA. Translation: AAH11737.1 .
    CCDSi CCDS8228.1.
    RefSeqi NP_003346.2. NM_003355.2.
    UniGenei Hs.80658.

    3D structure databases

    ProteinModelPortali P55851.
    SMRi P55851. Positions 14-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113198. 5 interactions.
    IntActi P55851. 1 interaction.
    STRINGi 9606.ENSP00000312029.

    Protein family/group databases

    TCDBi 2.A.29.3.4. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei P55851.

    Polymorphism databases

    DMDMi 2497981.

    Proteomic databases

    PaxDbi P55851.
    PRIDEi P55851.

    Protocols and materials databases

    DNASUi 7351.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310473 ; ENSP00000312029 ; ENSG00000175567 .
    GeneIDi 7351.
    KEGGi hsa:7351.
    UCSCi uc001oup.1. human.

    Organism-specific databases

    CTDi 7351.
    GeneCardsi GC11M073685.
    GeneReviewsi UCP2.
    H-InvDB HIX0095887.
    HGNCi HGNC:12518. UCP2.
    HPAi CAB025583.
    MIMi 601693. gene.
    607447. phenotype.
    neXtProti NX_P55851.
    Orphaneti 276556. Hyperinsulinism due to UCP2 deficiency.
    PharmGKBi PA37165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300436.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi P55851.
    KOi K15103.
    OMAi SPNIARN.
    OrthoDBi EOG793B7Z.
    PhylomeDBi P55851.
    TreeFami TF323211.

    Enzyme and pathway databases

    Reactomei REACT_6196. The proton buffering model.
    REACT_6258. The fatty acid cycling model.

    Miscellaneous databases

    ChiTaRSi UCP2. human.
    GeneWikii UCP2.
    GenomeRNAii 7351.
    NextBioi 28778.
    PROi P55851.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55851.
    Bgeei P55851.
    CleanExi HS_UCP2.
    Genevestigatori P55851.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression."
      Boss O., Samec S., Paoloni-Giacobino A., Dulloo A., Seydoux J., Rossier C., Muzzin P., Giacobino J.-P.
      FEBS Lett. 408:39-42(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung and Skeletal muscle.
    3. "Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis."
      Gimeno R.E., Dembski M., Weng X., Deng N., Shyjan A.W., Gimeno C.J., Iris F., Ellis S.J., Woolf E.A., Tartaglia L.A.
      Diabetes 46:900-906(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-55.
      Tissue: Spleen.
    4. Klannemark M., Orho M., Groop L.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-55.
    5. "Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects."
      Argyropoulos G., Brown A.M., Peterson R., Likes C.E., Watson D.K., Garvey W.T.
      Diabetes 47:685-687(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene."
      Pecqueur C., Cassard-Doulcier A.M., Raimbault S., Miroux B., Fleury C., Gelly C., Bouillaud F., Ricquier D.
      Biochem. Biophys. Res. Commun. 255:40-46(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-55.
      Tissue: Adipose tissue.
    8. NIEHS SNPs program
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-55; GLN-76; GLN-154; GLY-268 AND CYS-282.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell.
    10. "A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans."
      Esterbauer H., Schneitler C., Oberkofler H., Ebenbichler C., Paulweber B., Sandhofer F., Ladurner G., Hell E., Strosberg A.D., Patsch J.R., Krempler F., Patsch W.
      Nat. Genet. 28:178-183(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN BMIQ4 AND SUSCEPTIBILITY TO OBESITY.

    Entry informationi

    Entry nameiUCP2_HUMAN
    AccessioniPrimary (citable) accession number: P55851
    Secondary accession number(s): Q4PJH8, Q53HM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3