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Protein

Mitochondrial uncoupling protein 2

Gene

UCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175567-MONOMER.
ReactomeiR-HSA-167826. The fatty acid cycling model.
R-HSA-167827. The proton buffering model.

Protein family/group databases

TCDBi2.A.29.3.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
UCPH
Gene namesi
Name:UCP2
Synonyms:SLC25A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12518. UCP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7351.
MalaCardsiUCP2.
MIMi607447. phenotype.
OpenTargetsiENSG00000175567.
Orphaneti276556. Hyperinsulinism due to UCP2 deficiency.
PharmGKBiPA37165.

Polymorphism and mutation databases

BioMutaiUCP2.
DMDMi2497981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906641 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiP55851.
PRIDEiP55851.

PTM databases

iPTMnetiP55851.
PhosphoSitePlusiP55851.

Expressioni

Tissue specificityi

Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Gene expression databases

BgeeiENSG00000175567.
CleanExiHS_UCP2.
ExpressionAtlasiP55851. baseline and differential.
GenevisibleiP55851. HS.

Organism-specific databases

HPAiCAB025583.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-2842077,EBI-10172290

Protein-protein interaction databases

BioGridi113198. 20 interactors.
IntActiP55851. 2 interactors.
STRINGi9606.ENSP00000312029.

Structurei

3D structure databases

ProteinModelPortaliP55851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP55851.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP55851.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP
60 70 80 90 100
VRATASAQYR GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHASIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV NAYKTIAREE GFRGLWKGTS PNVARNAIVN CAELVTYDLI
210 220 230 240 250
KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

ACTSREAPF
Length:309
Mass (Da):33,229
Last modified:November 1, 1997 - v1
Checksum:i2E1741391621E3D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219T → I in AAB48411 (PubMed:9054939).Curated1

Polymorphismi

Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIMi:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01612955A → V.4 PublicationsCorresponds to variant rs660339dbSNPEnsembl.1
Natural variantiVAR_02399876R → Q.1 PublicationCorresponds to variant rs45541732dbSNPEnsembl.1
Natural variantiVAR_023999154R → Q.1 PublicationCorresponds to variant rs45486692dbSNPEnsembl.1
Natural variantiVAR_024000268A → G.1 PublicationCorresponds to variant rs45490393dbSNPEnsembl.1
Natural variantiVAR_024001282S → C.1 PublicationCorresponds to variant rs45596837dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82819 mRNA. Translation: AAC51336.1.
U76367 mRNA. Translation: AAB48411.1.
U94592 mRNA. Translation: AAB53091.1.
AJ223477, AJ223478, AJ223479 Genomic DNA. Translation: CAA11402.1.
AF019409 Genomic DNA. Translation: AAC39690.1.
AF096289 Genomic DNA. Translation: AAD21151.1.
AK222540 mRNA. Translation: BAD96260.1.
AK222557 mRNA. Translation: BAD96277.1.
DQ087219 Genomic DNA. Translation: AAY68217.1.
BC011737 mRNA. Translation: AAH11737.1.
CCDSiCCDS8228.1.
RefSeqiNP_003346.2. NM_003355.2.
UniGeneiHs.80658.

Genome annotation databases

EnsembliENST00000310473; ENSP00000312029; ENSG00000175567.
GeneIDi7351.
KEGGihsa:7351.
UCSCiuc001oup.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82819 mRNA. Translation: AAC51336.1.
U76367 mRNA. Translation: AAB48411.1.
U94592 mRNA. Translation: AAB53091.1.
AJ223477, AJ223478, AJ223479 Genomic DNA. Translation: CAA11402.1.
AF019409 Genomic DNA. Translation: AAC39690.1.
AF096289 Genomic DNA. Translation: AAD21151.1.
AK222540 mRNA. Translation: BAD96260.1.
AK222557 mRNA. Translation: BAD96277.1.
DQ087219 Genomic DNA. Translation: AAY68217.1.
BC011737 mRNA. Translation: AAH11737.1.
CCDSiCCDS8228.1.
RefSeqiNP_003346.2. NM_003355.2.
UniGeneiHs.80658.

3D structure databases

ProteinModelPortaliP55851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113198. 20 interactors.
IntActiP55851. 2 interactors.
STRINGi9606.ENSP00000312029.

Protein family/group databases

TCDBi2.A.29.3.4. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP55851.
PhosphoSitePlusiP55851.

Polymorphism and mutation databases

BioMutaiUCP2.
DMDMi2497981.

Proteomic databases

PaxDbiP55851.
PRIDEiP55851.

Protocols and materials databases

DNASUi7351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310473; ENSP00000312029; ENSG00000175567.
GeneIDi7351.
KEGGihsa:7351.
UCSCiuc001oup.2. human.

Organism-specific databases

CTDi7351.
DisGeNETi7351.
GeneCardsiUCP2.
GeneReviewsiUCP2.
H-InvDBHIX0095887.
HGNCiHGNC:12518. UCP2.
HPAiCAB025583.
MalaCardsiUCP2.
MIMi601693. gene.
607447. phenotype.
neXtProtiNX_P55851.
OpenTargetsiENSG00000175567.
Orphaneti276556. Hyperinsulinism due to UCP2 deficiency.
PharmGKBiPA37165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP55851.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP55851.
TreeFamiTF323211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175567-MONOMER.
ReactomeiR-HSA-167826. The fatty acid cycling model.
R-HSA-167827. The proton buffering model.

Miscellaneous databases

ChiTaRSiUCP2. human.
GeneWikiiUCP2.
GenomeRNAii7351.
PROiP55851.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175567.
CleanExiHS_UCP2.
ExpressionAtlasiP55851. baseline and differential.
GenevisibleiP55851. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP2_HUMAN
AccessioniPrimary (citable) accession number: P55851
Secondary accession number(s): Q4PJH8, Q53HM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.