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P55850

- DSC3_MOUSE

UniProt

P55850 - DSC3_MOUSE

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Protein
Desmocollin-3
Gene
Dsc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. in utero embryonic development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Desmocollin-3
Gene namesi
Name:Dsc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1194993. Dsc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini136 – 695560Extracellular Reviewed prediction
Add
BLAST
Transmembranei696 – 71621Helical; Reviewed prediction
Add
BLAST
Topological domaini717 – 895179Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. desmosome Source: MGI
  3. extracellular region Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed prediction
Add
BLAST
Propeptidei32 – 135104 Reviewed prediction
PRO_0000003877Add
BLAST
Chaini136 – 895760Desmocollin-3
PRO_0000003878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi547 – 5471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi630 – 6301N-linked (GlcNAc...) (high mannose)1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP55850.
PRIDEiP55850.

PTM databases

PhosphoSiteiP55850.

Expressioni

Tissue specificityi

First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At E15.5, highly expressed in general body epidermis and at E16.5, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells.2 Publications

Gene expression databases

CleanExiMM_DSC3.
GenevestigatoriP55850.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996857.

Structurei

3D structure databases

ProteinModelPortaliP55850.
SMRiP55850. Positions 137-670.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 243108Cadherin 1
Add
BLAST
Domaini244 – 355112Cadherin 2
Add
BLAST
Domaini356 – 472117Cadherin 3
Add
BLAST
Domaini473 – 580108Cadherin 4
Add
BLAST
Domaini581 – 691111Cadherin 5
Add
BLAST

Domaini

Calcium may be bound by the cadherin-like repeats Reviewed prediction.
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG304955.
HOGENOMiHOG000231253.
HOVERGENiHBG102801.
KOiK07602.
PhylomeDBiP55850.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 3A (identifier: P55850-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVVPEFRSPQ CRALCTKLLL TLWVFSFVGE ACKKVTFHVP STLEVDKIIG    50
RVSLKECLSS ADGIMPSDPD FRVLDDGSVY PTRAVVLSDE KRSFTIQLSD 100
SKMQTQKEIP VILEHKKKVL KKRHTKETVL RRSKRRWAPI PCSMQENSLG 150
PFPLFLQQVQ SDAAQNYTVF YSISGRGADQ EPLNWFFIER DTGNLYCTRP 200
VDREEYDVFD LIAYASTADG YSADLPLPLP IKIEDENDNY PLFTEAIYAF 250
EVPEGSRLGT VVGTVCATDK DEPDTMHTRL KYSILEQTPP SPGLFSVHPD 300
TGVITTVSHY MDREVVDKYK LIMKVQDMNG QFFGLISTST CIITVQDSND 350
NAPTFRQNTY ETAVEENTYN VEILRIPVDD KDMINTANWK ANFTILKGNE 400
NGWFKITTDP VTNEGVLCVV KPLDYEENRQ VTLETGVNNE APFIKDVANR 450
IPTMNRAMVT VHVKDQNEGP ECKPPEQYVR IKENSAVGSK INGYKAYDPE 500
TKNSNGLRYK KLQDPKDWVS IEEVSGLLTI SKTLDREIIA PRNDMYNITV 550
MAIDQEGKSC TGTLAVNIED VNDNAPEIIQ DYIVICKPKM GYTDISAVDP 600
DEPIHGPPFQ FNLANTSPEV NRIWTINQVN DTAARLSYQK TADVQIYNVP 650
VTVKDRAGQS ATKILRVNLC DCTHPSQCPL RSRSAGITLG KWAYLAILLG 700
IALLFSVLLT LVCGVVTARK GKHFPEDLAH ENLIISNTEA PGDDRVCSAW 750
IHHPHCQQLQ PRLLWYNGSG MRNGGQETIE MMKGHQTLDS CRVAGHHHTL 800
DSGRGGHMDT DNCRYTYSEW HSFTQPRLGE KLHVCNQNEN HIPSQDYVLT 850
YNYEGRGSPA GSVGCCSEKQ EEEGLDFLNN LEPKFLTLAK TCTKR 895
Length:895
Mass (Da):100,654
Last modified:June 1, 2001 - v2
Checksum:iD561E67C57232270
GO
Isoform 3B (identifier: P55850-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     831-838: KLHVCNQN → DSIRGHTG
     839-895: Missing.

Note: Contains a phosphoserine at position 832.

Show »
Length:838
Mass (Da):94,177
Checksum:iFBAF0BD509C8B237
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei831 – 8388KLHVCNQN → DSIRGHTG in isoform 3B.
VSP_000665
Alternative sequencei839 – 89557Missing in isoform 3B.
VSP_000666Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti715 – 7151V → I in CAA03996. 1 Publication
Sequence conflicti750 – 76718WIHHP…LLWYN → NGFTTHTANNSSQGFCGTM in CAA03996. 1 Publication
Add
BLAST
Sequence conflicti840 – 8401N → D in CAA03996. 1 Publication
Sequence conflicti873 – 8742EG → IK in CAA03996. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11169 mRNA. Translation: CAA72045.1.
AJ000329 mRNA. Translation: CAA03996.1.
RefSeqiNP_031908.3. NM_007882.3.
UniGeneiMm.89935.

Genome annotation databases

GeneIDi13507.
KEGGimmu:13507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11169 mRNA. Translation: CAA72045.1 .
AJ000329 mRNA. Translation: CAA03996.1 .
RefSeqi NP_031908.3. NM_007882.3.
UniGenei Mm.89935.

3D structure databases

ProteinModelPortali P55850.
SMRi P55850. Positions 137-670.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996857.

PTM databases

PhosphoSitei P55850.

Proteomic databases

PaxDbi P55850.
PRIDEi P55850.

Protocols and materials databases

DNASUi 13507.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13507.
KEGGi mmu:13507.

Organism-specific databases

CTDi 1825.
MGIi MGI:1194993. Dsc3.

Phylogenomic databases

eggNOGi NOG304955.
HOGENOMi HOG000231253.
HOVERGENi HBG102801.
KOi K07602.
PhylomeDBi P55850.

Miscellaneous databases

NextBioi 284050.
PROi P55850.
SOURCEi Search...

Gene expression databases

CleanExi MM_DSC3.
Genevestigatori P55850.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development."
    Chidgey M.A.J., Yue K.K.M., Gould S., Byrne C., Garrod D.R.
    Dev. Dyn. 210:315-327(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
    King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
    Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-874, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  3. "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
    Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
    Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-630.
    Tissue: Epidermis.

Entry informationi

Entry nameiDSC3_MOUSE
AccessioniPrimary (citable) accession number: P55850
Secondary accession number(s): O55110, O55122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi