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P55850

- DSC3_MOUSE

UniProt

P55850 - DSC3_MOUSE

Protein

Desmocollin-3

Gene

Dsc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. in utero embryonic development Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmocollin-3
    Gene namesi
    Name:Dsc3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1194993. Dsc3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. desmosome Source: MGI
    3. extracellular region Source: MGI
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Propeptidei32 – 135104Sequence AnalysisPRO_0000003877Add
    BLAST
    Chaini136 – 895760Desmocollin-3PRO_0000003878Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi630 – 6301N-linked (GlcNAc...) (high mannose)1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP55850.
    PRIDEiP55850.

    PTM databases

    PhosphoSiteiP55850.

    Expressioni

    Tissue specificityi

    First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At E15.5, highly expressed in general body epidermis and at E16.5, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells.2 Publications

    Gene expression databases

    CleanExiMM_DSC3.
    GenevestigatoriP55850.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996857.

    Structurei

    3D structure databases

    ProteinModelPortaliP55850.
    SMRiP55850. Positions 137-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini136 – 695560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini717 – 895179CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei696 – 71621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 243108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 355112Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini356 – 472117Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini473 – 580108Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 691111Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Calcium may be bound by the cadherin-like repeats.Curated
    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG304955.
    HOGENOMiHOG000231253.
    HOVERGENiHBG102801.
    KOiK07602.
    PhylomeDBiP55850.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01820. DESMOCOLLIN.
    SMARTiSM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 3A (identifier: P55850-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVPEFRSPQ CRALCTKLLL TLWVFSFVGE ACKKVTFHVP STLEVDKIIG    50
    RVSLKECLSS ADGIMPSDPD FRVLDDGSVY PTRAVVLSDE KRSFTIQLSD 100
    SKMQTQKEIP VILEHKKKVL KKRHTKETVL RRSKRRWAPI PCSMQENSLG 150
    PFPLFLQQVQ SDAAQNYTVF YSISGRGADQ EPLNWFFIER DTGNLYCTRP 200
    VDREEYDVFD LIAYASTADG YSADLPLPLP IKIEDENDNY PLFTEAIYAF 250
    EVPEGSRLGT VVGTVCATDK DEPDTMHTRL KYSILEQTPP SPGLFSVHPD 300
    TGVITTVSHY MDREVVDKYK LIMKVQDMNG QFFGLISTST CIITVQDSND 350
    NAPTFRQNTY ETAVEENTYN VEILRIPVDD KDMINTANWK ANFTILKGNE 400
    NGWFKITTDP VTNEGVLCVV KPLDYEENRQ VTLETGVNNE APFIKDVANR 450
    IPTMNRAMVT VHVKDQNEGP ECKPPEQYVR IKENSAVGSK INGYKAYDPE 500
    TKNSNGLRYK KLQDPKDWVS IEEVSGLLTI SKTLDREIIA PRNDMYNITV 550
    MAIDQEGKSC TGTLAVNIED VNDNAPEIIQ DYIVICKPKM GYTDISAVDP 600
    DEPIHGPPFQ FNLANTSPEV NRIWTINQVN DTAARLSYQK TADVQIYNVP 650
    VTVKDRAGQS ATKILRVNLC DCTHPSQCPL RSRSAGITLG KWAYLAILLG 700
    IALLFSVLLT LVCGVVTARK GKHFPEDLAH ENLIISNTEA PGDDRVCSAW 750
    IHHPHCQQLQ PRLLWYNGSG MRNGGQETIE MMKGHQTLDS CRVAGHHHTL 800
    DSGRGGHMDT DNCRYTYSEW HSFTQPRLGE KLHVCNQNEN HIPSQDYVLT 850
    YNYEGRGSPA GSVGCCSEKQ EEEGLDFLNN LEPKFLTLAK TCTKR 895
    Length:895
    Mass (Da):100,654
    Last modified:June 1, 2001 - v2
    Checksum:iD561E67C57232270
    GO
    Isoform 3B (identifier: P55850-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         831-838: KLHVCNQN → DSIRGHTG
         839-895: Missing.

    Note: Contains a phosphoserine at position 832.

    Show »
    Length:838
    Mass (Da):94,177
    Checksum:iFBAF0BD509C8B237
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti715 – 7151V → I in CAA03996. (PubMed:9404003)Curated
    Sequence conflicti750 – 76718WIHHP…LLWYN → NGFTTHTANNSSQGFCGTM in CAA03996. (PubMed:9404003)CuratedAdd
    BLAST
    Sequence conflicti840 – 8401N → D in CAA03996. (PubMed:9404003)Curated
    Sequence conflicti873 – 8742EG → IK in CAA03996. (PubMed:9404003)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei831 – 8388KLHVCNQN → DSIRGHTG in isoform 3B. CuratedVSP_000665
    Alternative sequencei839 – 89557Missing in isoform 3B. CuratedVSP_000666Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11169 mRNA. Translation: CAA72045.1.
    AJ000329 mRNA. Translation: CAA03996.1.
    RefSeqiNP_031908.3. NM_007882.3.
    UniGeneiMm.89935.

    Genome annotation databases

    GeneIDi13507.
    KEGGimmu:13507.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11169 mRNA. Translation: CAA72045.1 .
    AJ000329 mRNA. Translation: CAA03996.1 .
    RefSeqi NP_031908.3. NM_007882.3.
    UniGenei Mm.89935.

    3D structure databases

    ProteinModelPortali P55850.
    SMRi P55850. Positions 137-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996857.

    PTM databases

    PhosphoSitei P55850.

    Proteomic databases

    PaxDbi P55850.
    PRIDEi P55850.

    Protocols and materials databases

    DNASUi 13507.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 13507.
    KEGGi mmu:13507.

    Organism-specific databases

    CTDi 1825.
    MGIi MGI:1194993. Dsc3.

    Phylogenomic databases

    eggNOGi NOG304955.
    HOGENOMi HOG000231253.
    HOVERGENi HBG102801.
    KOi K07602.
    PhylomeDBi P55850.

    Miscellaneous databases

    NextBioi 284050.
    PROi P55850.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DSC3.
    Genevestigatori P55850.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01820. DESMOCOLLIN.
    SMARTi SM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development."
      Chidgey M.A.J., Yue K.K.M., Gould S., Byrne C., Garrod D.R.
      Dev. Dyn. 210:315-327(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
      King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
      Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-874, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    3. "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
      Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
      Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-630.
      Tissue: Epidermis.

    Entry informationi

    Entry nameiDSC3_MOUSE
    AccessioniPrimary (citable) accession number: P55850
    Secondary accession number(s): O55110, O55122
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3