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P55850 (DSC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Desmocollin-3
Gene names
Name:Dsc3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length895 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential. Cell junction › desmosome By similarity.

Tissue specificity

First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At E15.5, highly expressed in general body epidermis and at E16.5, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells. Ref.1 Ref.2

Domain

Calcium may be bound by the cadherin-like repeats Potential.

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3A (identifier: P55850-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3B (identifier: P55850-2)

The sequence of this isoform differs from the canonical sequence as follows:
     831-838: KLHVCNQN → DSIRGHTG
     839-895: Missing.
Note: Contains a phosphoserine at position 832.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Propeptide32 – 135104 Potential
PRO_0000003877
Chain136 – 895760Desmocollin-3
PRO_0000003878

Regions

Topological domain136 – 695560Extracellular Potential
Transmembrane696 – 71621Helical; Potential
Topological domain717 – 895179Cytoplasmic Potential
Domain136 – 243108Cadherin 1
Domain244 – 355112Cadherin 2
Domain356 – 472117Cadherin 3
Domain473 – 580108Cadherin 4
Domain581 – 691111Cadherin 5

Amino acid modifications

Modified residue8581Phosphoserine Ref.4
Modified residue8621Phosphoserine Ref.4
Modified residue8671Phosphoserine Ref.4
Glycosylation1661N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential
Glycosylation6301N-linked (GlcNAc...) (high mannose) Ref.3

Natural variations

Alternative sequence831 – 8388KLHVCNQN → DSIRGHTG in isoform 3B.
VSP_000665
Alternative sequence839 – 89557Missing in isoform 3B.
VSP_000666

Experimental info

Sequence conflict7151V → I in CAA03996. Ref.2
Sequence conflict750 – 76718WIHHP…LLWYN → NGFTTHTANNSSQGFCGTM in CAA03996. Ref.2
Sequence conflict8401N → D in CAA03996. Ref.2
Sequence conflict873 – 8742EG → IK in CAA03996. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 3A [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: D561E67C57232270

FASTA895100,654
        10         20         30         40         50         60 
MVVPEFRSPQ CRALCTKLLL TLWVFSFVGE ACKKVTFHVP STLEVDKIIG RVSLKECLSS 

        70         80         90        100        110        120 
ADGIMPSDPD FRVLDDGSVY PTRAVVLSDE KRSFTIQLSD SKMQTQKEIP VILEHKKKVL 

       130        140        150        160        170        180 
KKRHTKETVL RRSKRRWAPI PCSMQENSLG PFPLFLQQVQ SDAAQNYTVF YSISGRGADQ 

       190        200        210        220        230        240 
EPLNWFFIER DTGNLYCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IKIEDENDNY 

       250        260        270        280        290        300 
PLFTEAIYAF EVPEGSRLGT VVGTVCATDK DEPDTMHTRL KYSILEQTPP SPGLFSVHPD 

       310        320        330        340        350        360 
TGVITTVSHY MDREVVDKYK LIMKVQDMNG QFFGLISTST CIITVQDSND NAPTFRQNTY 

       370        380        390        400        410        420 
ETAVEENTYN VEILRIPVDD KDMINTANWK ANFTILKGNE NGWFKITTDP VTNEGVLCVV 

       430        440        450        460        470        480 
KPLDYEENRQ VTLETGVNNE APFIKDVANR IPTMNRAMVT VHVKDQNEGP ECKPPEQYVR 

       490        500        510        520        530        540 
IKENSAVGSK INGYKAYDPE TKNSNGLRYK KLQDPKDWVS IEEVSGLLTI SKTLDREIIA 

       550        560        570        580        590        600 
PRNDMYNITV MAIDQEGKSC TGTLAVNIED VNDNAPEIIQ DYIVICKPKM GYTDISAVDP 

       610        620        630        640        650        660 
DEPIHGPPFQ FNLANTSPEV NRIWTINQVN DTAARLSYQK TADVQIYNVP VTVKDRAGQS 

       670        680        690        700        710        720 
ATKILRVNLC DCTHPSQCPL RSRSAGITLG KWAYLAILLG IALLFSVLLT LVCGVVTARK 

       730        740        750        760        770        780 
GKHFPEDLAH ENLIISNTEA PGDDRVCSAW IHHPHCQQLQ PRLLWYNGSG MRNGGQETIE 

       790        800        810        820        830        840 
MMKGHQTLDS CRVAGHHHTL DSGRGGHMDT DNCRYTYSEW HSFTQPRLGE KLHVCNQNEN 

       850        860        870        880        890 
HIPSQDYVLT YNYEGRGSPA GSVGCCSEKQ EEEGLDFLNN LEPKFLTLAK TCTKR

« Hide

Isoform 3B [UniParc].

Checksum: FBAF0BD509C8B237
Show »

FASTA83894,177

References

« Hide 'large scale' references
[1]"Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development."
Chidgey M.A.J., Yue K.K.M., Gould S., Byrne C., Garrod D.R.
Dev. Dyn. 210:315-327(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse."
King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S.
Differentiation 62:83-96(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-874, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[3]"High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-630, MASS SPECTROMETRY.
Tissue: Epidermis.
[4]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-858; SER-862 AND SER-867, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 (ISOFORM 2), MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y11169 mRNA. Translation: CAA72045.1.
AJ000329 mRNA. Translation: CAA03996.1.
IPIIPI00113853.
IPI00876127.
RefSeqNP_031908.3. NM_007882.3.
UniGeneMm.89935.

3D structure databases

ProteinModelPortalP55850.
SMRP55850. Positions 137-670.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4996857.

PTM databases

PhosphoSiteP55850.

Proteomic databases

PaxDbP55850.
PRIDEP55850.

Protocols and materials databases

DNASU13507.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID13507.
KEGGmmu:13507.

Organism-specific databases

CTD1825.
MGIMGI:1194993. Dsc3.

Phylogenomic databases

eggNOGNOG304955.
HOGENOMHOG000231253.
HOVERGENHBG102801.
KOK07602.
OrthoDBEOG4TB49Z.

Gene expression databases

CleanExMM_DSC3.
GenevestigatorP55850.
GermOnlineENSMUSG00000059898. Mus musculus.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERPTHR24025. PTHR24025. 1 hit.
PfamPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01820. DESMOCOLLIN.
SMARTSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMSSF49313. Cadherin. 6 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284050.
SOURCESearch...

Entry information

Entry nameDSC3_MOUSE
AccessionPrimary (citable) accession number: P55850
Secondary accession number(s): O55110, O55122
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: May 29, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents