Reviewed,
UniProtKB/Swiss-Prot P55850 (DSC3_MOUSE)
Last modified
June 16, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Desmocollin-3 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 895 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein Potential. Cell junction › desmosome By similarity. |
| Tissue specificity | First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At E15.5, highly expressed in general body epidermis and at E16.5, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells. Ref.1 Ref.2 |
| Domain | Calcium may be bound by the cadherin-like repeats Potential. |
| Sequence similarities | Contains 5 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell junction Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | homophilic cell adhesion Inferred from electronic annotation. Source: InterPro in utero embryonic developmentInferred from mutant phenotype. Source: MGI |
| Cellular component | cytoplasm Inferred from direct assay. Source: MGI desmosomeInferred from direct assay. Source: MGI extracellular regionInferred from direct assay. Source: MGI integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 3A (identifier: P55850-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 3B (identifier: P55850-2) The sequence of this isoform differs from the canonical sequence as follows: 831-838: KLHVCNQN → DSIRGHTG 839-895: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 31 | 31 | Potential | ||||||
| Propeptide | 32 – 135 | 104 | Potential | PRO_0000003877 | |||||
| Chain | 136 – 895 | 760 | Desmocollin-3 | PRO_0000003878 | |||||
Regions | |||||||||
| Topological domain | 136 – 695 | 560 | Extracellular Potential | ||||||
| Transmembrane | 696 – 716 | 21 | Potential | ||||||
| Topological domain | 717 – 895 | 179 | Cytoplasmic Potential | ||||||
| Domain | 136 – 243 | 108 | Cadherin 1 | ||||||
| Domain | 244 – 355 | 112 | Cadherin 2 | ||||||
| Domain | 356 – 472 | 117 | Cadherin 3 | ||||||
| Domain | 473 – 580 | 108 | Cadherin 4 | ||||||
| Domain | 581 – 691 | 111 | Cadherin 5 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 817 | 1 | Phosphotyrosine By similarity | ||||||
| Glycosylation | 166 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 392 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 547 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 630 | 1 | N-linked (GlcNAc...) (high mannose) Ref.3 | ||||||
Natural variations | |||||||||
| Alternative sequence | 831 – 838 | 8 | KLHVCNQN → DSIRGHTG in isoform 3B. | VSP_000665 | |||||
| Alternative sequence | 839 – 895 | 57 | Missing in isoform 3B. | VSP_000666 | |||||
Experimental info | |||||||||
| Sequence conflict | 715 | 1 | V → I in CAA03996. Ref.2 | ||||||
| Sequence conflict | 750 – 767 | 18 | WIHHP…LLWYN → NGFTTHTANNSSQGFCGTM in CAA03996. Ref.2 | ||||||
| Sequence conflict | 840 | 1 | N → D in CAA03996. Ref.2 | ||||||
| Sequence conflict | 873 – 874 | 2 | EG → IK Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development." Chidgey M.A.J., Yue K.K.M., Gould S., Byrne C., Garrod D.R. Dev. Dyn. 210:315-327(1997) [PubMed: 9389456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse." King I.A., Angst B.D., Hunt D.M., Kruger M., Arnemann J., Buxton R.S. Differentiation 62:83-96(1997) [PubMed: 9404003] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-874, ALTERNATIVE SPLICING, TISSUE SPECIFICITY. |
| [3] | "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis." Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S. Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed: 16170054] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-630, MASS SPECTROMETRY. Tissue: Epidermis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y11169 mRNA. Translation: CAA72045.1. AJ000329 mRNA. Translation: CAA03996.1. | |
| IPI | IPI00113853. IPI00876127. |
| RefSeq | NP_031908.3. |
| UniGene | Mm.89935 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NCJ based on UniProtKB P15116. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P55850. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000059898. Mus musculus. [Contig view] |
| GeneID | 13507. |
| KEGG | mmu:13507. |
Organism-specific databases | |
| MGI | MGI:1194993. Dsc3. |
Phylogenomic databases | |
| HOGENOM | P55850. |
| HOVERGEN | P55850. |
Gene expression databases | |
| ArrayExpress | P55850. |
| Bgee | P55850. |
| CleanEx | MM_DSC3. |
| GermOnline | ENSMUSG00000059898. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR000233. Cadherin_C_term. IPR014868. Cadherin_pro. IPR009122. Desmo_cadherin. IPR009124. Desmocollin. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 4 hits. |
| Pfam | PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. PF08758. Cadherin_pro. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01820. DESMOCOLLIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| PROSITE | PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 284050. |
| SOURCE | Search... |
Entry information
| Entry name | DSC3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P55850 Secondary accession number(s): O55110, O55122 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


