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Protein

Desmocollin-1

Gene

Dsc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Desmocollin-1
Gene namesi
Name:Dsc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109173. Dsc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini135 – 691557ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71423HelicalSequence analysisAdd
BLAST
Topological domaini715 – 886172CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • desmosome Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Propeptidei30 – 134105Sequence analysisPRO_0000003865Add
BLAST
Chaini135 – 886752Desmocollin-1PRO_0000003866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Modified residuei385 – 3851PhosphothreonineBy similarity
Glycosylationi546 – 5461N-linked (GlcNAc...) (high mannose)1 Publication
Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence analysis
Modified residuei849 – 8491PhosphoserineBy similarity
Modified residuei853 – 8531PhosphoserineBy similarity
Modified residuei858 – 8581PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP55849.
PaxDbiP55849.
PeptideAtlasiP55849.
PRIDEiP55849.

PTM databases

iPTMnetiP55849.
PhosphoSiteiP55849.
UniCarbKBiP55849.

Expressioni

Gene expression databases

CleanExiMM_DSC1.

Interactioni

Subunit structurei

Binds to JUP/plakoglobin.By similarity

Protein-protein interaction databases

BioGridi199318. 1 interaction.
STRINGi10090.ENSMUSP00000042303.

Structurei

3D structure databases

ProteinModelPortaliP55849.
SMRiP55849. Positions 136-665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 242108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 354112Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini355 – 471117Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 575104Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini576 – 682107Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Calcium may be bound by the cadherin-like repeats.Curated

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231253.
HOVERGENiHBG102801.
InParanoidiP55849.
KOiK07600.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1A (identifier: P55849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVACAAPGS TFSKQLLFFL LVLVLFCDAC QKVSLHVPSH LKAETPVGKV
60 70 80 90 100
NLEECLKSPS LILSSDPAFR ILEDGTIYTT HDLLLSSEKR GFSILLSDGQ
110 120 130 140 150
GQEQKKLEVV LSAREKKVFR KRHTKEPVHN RSKRRWAPIP CSLMENSLGP
160 170 180 190 200
FPQHIQQIQS DAAQNYTIFY SISGPGVDKE PYNLFYIEKD TGDIYCTRSI
210 220 230 240 250
DREQYDQFLV YGYATTADGY APDYPLPLLF KVEDDNDNAP YFETKLTVFS
260 270 280 290 300
VPENCRSGTS VGQVTAIDKD EPGTLHTRLK YKILQQIPDQ PKHFSIHPDT
310 320 330 340 350
GVITTTTPLL DREKCDTYKL VMEVRDMGGQ PFGLFTTGTI TISLEDENDN
360 370 380 390 400
SPYFTQTSYT TEVEENRIDV EILRMVVHDQ DLPNTPHSKA VYTILKGNEN
410 420 430 440 450
GNFKITTDPN TNEGVLCVVK PLNYEVSRQV TLQIGVLNEA QFTNAANAQP
460 470 480 490 500
PTMCTTTVTV KIKDRDEGPE CQPPVKVIQS KDGLPAGQEL LGYKAVDPET
510 520 530 540 550
SSGEGLRYEM VGDEDNWFEI NKITGDLRTV KVLDRESKFV KNNQYNISVV
560 570 580 590 600
ATDTAGRSCT GTLVVLLEDF NDHPPQIDKE VTICQQEKDF AVLEPIDLDG
610 620 630 640 650
PDNGPPFQFL LDNSSSKLWT LESQDGKRAI LRQRHNLNYN YYSVPIQIQD
660 670 680 690 700
RHGFSAKHVL SVRVCDCTTP TECRMAVKEE RDAKPNIILG KWAILAMVLG
710 720 730 740 750
SALLLCILFT CFCVTTTKRT VKKCFPDDVA QQNLIVSNTE GPGEEVTEAN
760 770 780 790 800
IRLPTQTANI CDTSMSVGTL GGQGIKTQQS FEMVKGGHTL ESHKGGVLGA
810 820 830 840 850
AEPGRYAYTD WQTFTQPRLG EKVYLCGQAE EHKHCEDYVR PYNYEGKGSM
860 870 880
AGSVGCCSDR QEEEGLEFLD QLEPKFRTLA KTCVKK
Length:886
Mass (Da):98,938
Last modified:July 27, 2011 - v2
Checksum:iC06C012644BCC59A
GO
Isoform 1B (identifier: P55849-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-832: KVYLCGQAEEH → ESIRGHTLIKN
     840-886: Missing.

Show »
Length:839
Mass (Da):93,647
Checksum:iA15D4622251446D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771V → D in CAA66628 (PubMed:8823356).Curated
Sequence conflicti177 – 1771V → D in CAA66629 (PubMed:8823356).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei822 – 83211KVYLCGQAEEH → ESIRGHTLIKN in isoform 1B. 1 PublicationVSP_000653Add
BLAST
Alternative sequencei840 – 88647Missing in isoform 1B. 1 PublicationVSP_000654Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97986 mRNA. Translation: CAA66628.1.
X97986 mRNA. Translation: CAA66629.1.
AC132314 Genomic DNA. No translation available.
RefSeqiNP_001278733.1. NM_001291804.1. [P55849-1]
UniGeneiMm.33740.
Mm.482847.

Genome annotation databases

GeneIDi13505.
KEGGimmu:13505.
UCSCiuc008eeh.3. mouse. [P55849-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97986 mRNA. Translation: CAA66628.1.
X97986 mRNA. Translation: CAA66629.1.
AC132314 Genomic DNA. No translation available.
RefSeqiNP_001278733.1. NM_001291804.1. [P55849-1]
UniGeneiMm.33740.
Mm.482847.

3D structure databases

ProteinModelPortaliP55849.
SMRiP55849. Positions 136-665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199318. 1 interaction.
STRINGi10090.ENSMUSP00000042303.

PTM databases

iPTMnetiP55849.
PhosphoSiteiP55849.
UniCarbKBiP55849.

Proteomic databases

MaxQBiP55849.
PaxDbiP55849.
PeptideAtlasiP55849.
PRIDEiP55849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13505.
KEGGimmu:13505.
UCSCiuc008eeh.3. mouse. [P55849-1]

Organism-specific databases

CTDi1823.
MGIiMGI:109173. Dsc1.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231253.
HOVERGENiHBG102801.
InParanoidiP55849.
KOiK07600.

Miscellaneous databases

PROiP55849.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DSC1.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the 'skin-type' desmosomal cadherin DSC1 is closely linked to the keratinization of epithelial tissues during mouse development."
    King I.A., O'Brien T.J., Buxton R.S.
    J. Invest. Dermatol. 107:531-538(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
    Strain: C57BL/6J.
    Tissue: Skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis."
    Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S.
    Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546.
    Tissue: Epidermis.

Entry informationi

Entry nameiDSC1_MOUSE
AccessioniPrimary (citable) accession number: P55849
Secondary accession number(s): E9QJX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.