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Protein

60S ribosomal protein L14

Gene

RpL14

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • negative regulation of neuron apoptotic process Source: FlyBase
  • ribosomal large subunit biogenesis Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14
Gene namesi
Name:RpL14
ORF Names:CG6253
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0017579. RpL14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001320341 – 16660S ribosomal protein L14Add BLAST166

Proteomic databases

PaxDbiP55841.
PRIDEiP55841.

Expressioni

Gene expression databases

BgeeiFBgn0017579.
GenevisibleiP55841. DM.

Interactioni

Protein-protein interaction databases

BioGridi64391. 30 interactors.
DIPiDIP-20649N.
IntActiP55841. 14 interactors.
MINTiMINT-1570153.
STRINGi7227.FBpp0076359.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CM1-166[»]
ProteinModelPortaliP55841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3421. Eukaryota.
COG2163. LUCA.
InParanoidiP55841.
KOiK02875.
OMAiSDFERFQ.
OrthoDBiEOG091G0VTN.
PhylomeDBiP55841.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14e_dom.
IPR008991. Translation_prot_SH3-like.
PfamiView protein in Pfam
PF01929. Ribosomal_L14e. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

P55841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFERFVQTG RIAKASAGPL KGRLVAIVDV IDQNRVLVDG PLTGVPRQEY
60 70 80 90 100
RLNNLHLTKY RIKFPYTAPT RIVRKAWTES DLKAQWKVSP WSVKAQNICK
110 120 130 140 150
RSSLNDFDRF KLRYAKRQRN KLLTIAFNTL KKRTKADGTP RVLKKDRRER
160
LRAEKAKGGK KAAAKK
Length:166
Mass (Da):19,174
Last modified:November 1, 1997 - v1
Checksum:i8600358A902E6A67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10015 Genomic DNA. Translation: CAA71121.1.
Y10017 mRNA. Translation: CAA71124.1.
Y09766 mRNA. Translation: CAA70905.1.
AE014296 Genomic DNA. Translation: AAF50393.1.
RefSeqiNP_523975.1. NM_079251.4.
UniGeneiDm.895.

Genome annotation databases

EnsemblMetazoaiFBtr0076633; FBpp0076359; FBgn0017579.
GeneIDi38983.
KEGGidme:Dmel_CG6253.

Similar proteinsi

Entry informationi

Entry nameiRL14_DROME
AccessioniPrimary (citable) accession number: P55841
Secondary accession number(s): Q9VSM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families