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Protein

SH3 domain-binding glutamic acid-rich protein

Gene

SH3BGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  • positive regulation of signal transduction Source: GOC
  • protein complex assembly Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich protein
Short name:
SH3BGR protein
Alternative name(s):
21-glutamic acid-rich protein
Short name:
21-GARP
Gene namesi
Name:SH3BGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:10822. SH3BGR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35730.

Polymorphism and mutation databases

BioMutaiSH3BGR.
DMDMi215274184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239SH3 domain-binding glutamic acid-rich proteinPRO_0000220743Add
BLAST

Proteomic databases

MaxQBiP55822.
PaxDbiP55822.
PRIDEiP55822.

PTM databases

PhosphoSiteiP55822.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiP55822.
CleanExiHS_SH3BGR.
ExpressionAtlasiP55822. baseline and differential.
GenevisibleiP55822. HS.

Organism-specific databases

HPAiCAB003685.
HPA030690.

Interactioni

Protein-protein interaction databases

BioGridi112348. 2 interactions.
IntActiP55822. 2 interactions.
MINTiMINT-4718377.
STRINGi9606.ENSP00000332513.

Structurei

3D structure databases

ProteinModelPortaliP55822.
SMRiP55822. Positions 64-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi124 – 1307SH3-bindingSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 23970Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG284884.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000037924.
HOVERGENiHBG054781.
InParanoidiP55822.
OMAiLCHCQDL.
OrthoDBiEOG7GTT63.
PhylomeDBiP55822.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12232. PTHR12232. 1 hit.
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55822-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD
60 70 80 90 100
RGVLGGVLFP TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL
110 120 130 140 150
DIAGDEDNRR WMRENVPGEK KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE
160 170 180 190 200
ENIIYSFLGL APPPDSKGSE KAEEGGETEA QKEGSEDVGN LPEAQEKNEE
210 220 230
EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS
Length:239
Mass (Da):26,086
Last modified:November 25, 2008 - v3
Checksum:iBA57B1C8034D6BBC
GO
Isoform 2 (identifier: P55822-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):13,976
Checksum:i1E2E0AADFFAC0B28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321E → EE in BM474020 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231D → E.1 Publication
Corresponds to variant rs11575939 [ dbSNP | Ensembl ].
VAR_057182
Natural varianti50 – 501D → N.2 Publications
Corresponds to variant rs6517549 [ dbSNP | Ensembl ].
VAR_057183
Natural varianti188 – 1881V → A.1 Publication
Corresponds to variant rs9974333 [ dbSNP | Ensembl ].
VAR_028233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_045788Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93498 mRNA. Translation: CAB57259.1.
AL163279 Genomic DNA. Translation: CAB90456.1.
AL163280 Genomic DNA. Translation: CAB90445.1.
AF121781 Genomic DNA. Translation: AAD12067.1.
AF121897 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09638.1.
CH471079 Genomic DNA. Translation: EAX09639.1.
CH471079 Genomic DNA. Translation: EAX09640.1.
BC006371 mRNA. Translation: AAH06371.1.
BM474020 mRNA. No translation available.
CCDSiCCDS13666.1. [P55822-1]
CCDS33560.1. [P55822-2]
RefSeqiNP_001001713.1. NM_001001713.1. [P55822-2]
NP_031367.1. NM_007341.2.
XP_005261081.1. XM_005261024.1. [P55822-2]
XP_005261082.1. XM_005261025.3. [P55822-2]
XP_006724104.1. XM_006724041.2. [P55822-2]
XP_006724105.1. XM_006724042.2. [P55822-2]
UniGeneiHs.473847.

Genome annotation databases

EnsembliENST00000333634; ENSP00000332513; ENSG00000185437.
ENST00000380631; ENSP00000370005; ENSG00000185437. [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437. [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437. [P55822-2]
GeneIDi6450.
KEGGihsa:6450.
UCSCiuc002yxz.3. human. [P55822-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93498 mRNA. Translation: CAB57259.1.
AL163279 Genomic DNA. Translation: CAB90456.1.
AL163280 Genomic DNA. Translation: CAB90445.1.
AF121781 Genomic DNA. Translation: AAD12067.1.
AF121897 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09638.1.
CH471079 Genomic DNA. Translation: EAX09639.1.
CH471079 Genomic DNA. Translation: EAX09640.1.
BC006371 mRNA. Translation: AAH06371.1.
BM474020 mRNA. No translation available.
CCDSiCCDS13666.1. [P55822-1]
CCDS33560.1. [P55822-2]
RefSeqiNP_001001713.1. NM_001001713.1. [P55822-2]
NP_031367.1. NM_007341.2.
XP_005261081.1. XM_005261024.1. [P55822-2]
XP_005261082.1. XM_005261025.3. [P55822-2]
XP_006724104.1. XM_006724041.2. [P55822-2]
XP_006724105.1. XM_006724042.2. [P55822-2]
UniGeneiHs.473847.

3D structure databases

ProteinModelPortaliP55822.
SMRiP55822. Positions 64-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112348. 2 interactions.
IntActiP55822. 2 interactions.
MINTiMINT-4718377.
STRINGi9606.ENSP00000332513.

PTM databases

PhosphoSiteiP55822.

Polymorphism and mutation databases

BioMutaiSH3BGR.
DMDMi215274184.

Proteomic databases

MaxQBiP55822.
PaxDbiP55822.
PRIDEiP55822.

Protocols and materials databases

DNASUi6450.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333634; ENSP00000332513; ENSG00000185437.
ENST00000380631; ENSP00000370005; ENSG00000185437. [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437. [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437. [P55822-2]
GeneIDi6450.
KEGGihsa:6450.
UCSCiuc002yxz.3. human. [P55822-1]

Organism-specific databases

CTDi6450.
GeneCardsiGC21P040817.
HGNCiHGNC:10822. SH3BGR.
HPAiCAB003685.
HPA030690.
MIMi602230. gene.
neXtProtiNX_P55822.
PharmGKBiPA35730.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284884.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000037924.
HOVERGENiHBG054781.
InParanoidiP55822.
OMAiLCHCQDL.
OrthoDBiEOG7GTT63.
PhylomeDBiP55822.
TreeFamiTF105574.

Miscellaneous databases

ChiTaRSiSH3BGR. human.
GeneWikiiSH3BGR.
GenomeRNAii6450.
NextBioi25069.
PROiP55822.
SOURCEiSearch...

Gene expression databases

BgeeiP55822.
CleanExiHS_SH3BGR.
ExpressionAtlasiP55822. baseline and differential.
GenevisibleiP55822. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12232. PTHR12232. 1 hit.
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle."
    Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D., Taramelli R., Rasore-Quartino A.
    Hum. Genet. 99:387-392(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-50.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-23; ASN-50 AND ALA-188.
    Tissue: Leiomyosarcoma and Muscle.

Entry informationi

Entry nameiSH3BG_HUMAN
AccessioniPrimary (citable) accession number: P55822
Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-64 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.