P55822 (SH3BG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 domain-binding glutamic acid-rich protein
Short name=SH3BGR protein

Alternative name(s):
21-glutamic acid-rich protein
Short name=21-GARP

Gene names

Name:

SH3BGR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in heart and skeletal muscle.
Sequence similarities	Belongs to the SH3BGR family.
Caution	It is uncertain whether Met-1 or Met-64 is the initiator.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH3-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein complex assembly Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytosol Inferred from direct assay PubMed 16780588. Source: UniProtKB
Molecular_function	SH3/SH2 adaptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55822-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55822-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	SH3 domain-binding glutamic acid-rich protein		PRO_0000220743
Regions
	Motif	124 – 130	7	SH3-binding Potential
	Compositional bias	170 – 239	70	Glu-rich (acidic)
Natural variations
	Alternative sequence	1 – 111	111	Missing in isoform 2.		VSP_045788
	Natural variant	23	1	D → E. Ref.4 Corresponds to variant rs11575939 [ dbSNP | Ensembl ].		VAR_057182
	Natural variant	50	1	D → N. Ref.3 Ref.4 Corresponds to variant rs6517549 [ dbSNP | Ensembl ].		VAR_057183
	Natural variant	188	1	V → A. Ref.4 Corresponds to variant rs9974333 [ dbSNP | Ensembl ].		VAR_028233
Experimental info
	Sequence conflict	232	1	E → EE in BM474020. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: BA57B1C8034D6BBC	FASTA	239	26,086
	10 20 30 40 50 60 MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP 70 80 90 100 110 120 TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK 130 140 150 160 170 180 KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA 190 200 210 220 230 QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS
	Isoform 2 [UniParc]. Checksum: 1E2E0AADFFAC0B28	FASTA	128	13,976
	10 20 30 40 50 60 MRENVPGEKK PQNGIPLPPQ IFNEEQYCGD FDSFFSAKEE NIIYSFLGLA PPPDSKGSEK 70 80 90 100 110 120 AEEGGETEAQ KEGSEDVGNL PEAQEKNEEE GETATEETEE IAMEGAEGEA EEEEETAEGE EPGEDEDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle." Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D., Taramelli R., Rasore-Quartino A. Hum. Genet. 99:387-392(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-50.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-23; ASN-50 AND ALA-188. Tissue: Leiomyosarcoma and Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X93498 mRNA. Translation: CAB57259.1. AL163279 Genomic DNA. Translation: CAB90456.1. AL163280 Genomic DNA. Translation: CAB90445.1. AF121781 Genomic DNA. Translation: AAD12067.1. AF121897 Genomic DNA. No translation available. CH471079 Genomic DNA. Translation: EAX09638.1. CH471079 Genomic DNA. Translation: EAX09639.1. CH471079 Genomic DNA. Translation: EAX09640.1. BC006371 mRNA. Translation: AAH06371.1. BM474020 mRNA. No translation available.
IPI	IPI00026538. IPI00418589.
RefSeq	NP_001001713.1. NM_001001713.1. NP_031367.1. NM_007341.2.
UniGene	Hs.473847.
3D structure databases
ProteinModelPortal	P55822.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55822. 2 interactions.
STRING	9606.ENSP00000332513.
PTM databases
PhosphoSite	P55822.
Polymorphism databases
DMDM	215274184.
Proteomic databases
PaxDb	P55822.
PRIDE	P55822.
Protocols and materials databases
DNASU	6450.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333634; ENSP00000332513; ENSG00000185437. ENST00000380631; ENSP00000370005; ENSG00000185437. ENST00000380634; ENSP00000370008; ENSG00000185437. ENST00000380637; ENSP00000370011; ENSG00000185437.
GeneID	6450.
KEGG	hsa:6450.
UCSC	uc002yxz.3. human.
Organism-specific databases
CTD	6450.
GeneCards	GC21P040817.
HGNC	HGNC:10822. SH3BGR.
HPA	CAB003685.
MIM	602230. gene.
neXtProt	NX_P55822.
PharmGKB	PA35730.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284884.
HOGENOM	HOG000037924.
HOVERGEN	HBG054781.
InParanoid	P55822.
OMA	PDSKGSE.
PhylomeDB	P55822.
Gene expression databases
ArrayExpress	P55822.
Bgee	P55822.
CleanEx	HS_SH3BGR.
Genevestigator	P55822.
GermOnline	ENSG00000185437. Homo sapiens.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR006993. Glut_rich_SH3-bd. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR12232. PTHR12232. 1 hit.
Pfam	PF04908. SH3BGR. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SH3BGR. human.
GenomeRNAi	6450.
NextBio	25069.
SOURCE	Search...

Entry information

Entry name

SH3BG_HUMAN

Accession

Primary (citable) accession number: P55822
Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.