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P55822

- SH3BG_HUMAN

UniProt

P55822 - SH3BG_HUMAN

Protein

SH3 domain-binding glutamic acid-rich protein

Gene

SH3BGR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. SH3/SH2 adaptor activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of signal transduction Source: GOC
    2. protein complex assembly Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-binding glutamic acid-rich protein
    Short name:
    SH3BGR protein
    Alternative name(s):
    21-glutamic acid-rich protein
    Short name:
    21-GARP
    Gene namesi
    Name:SH3BGR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:10822. SH3BGR.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239SH3 domain-binding glutamic acid-rich proteinPRO_0000220743Add
    BLAST

    Proteomic databases

    MaxQBiP55822.
    PaxDbiP55822.
    PRIDEiP55822.

    PTM databases

    PhosphoSiteiP55822.

    Expressioni

    Tissue specificityi

    Expressed in heart and skeletal muscle.

    Gene expression databases

    ArrayExpressiP55822.
    BgeeiP55822.
    CleanExiHS_SH3BGR.
    GenevestigatoriP55822.

    Organism-specific databases

    HPAiCAB003685.

    Interactioni

    Protein-protein interaction databases

    BioGridi112348. 3 interactions.
    IntActiP55822. 2 interactions.
    MINTiMINT-4718377.
    STRINGi9606.ENSP00000332513.

    Structurei

    3D structure databases

    ProteinModelPortaliP55822.
    SMRiP55822. Positions 64-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi124 – 1307SH3-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi170 – 23970Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the SH3BGR family.Curated

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiNOG284884.
    HOGENOMiHOG000037924.
    HOVERGENiHBG054781.
    InParanoidiP55822.
    OMAiLCHCQDL.
    OrthoDBiEOG7GTT63.
    PhylomeDBiP55822.
    TreeFamiTF105574.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR006993. Glut_rich_SH3-bd.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR12232. PTHR12232. 1 hit.
    PfamiPF04908. SH3BGR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55822-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD    50
    RGVLGGVLFP TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL 100
    DIAGDEDNRR WMRENVPGEK KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE 150
    ENIIYSFLGL APPPDSKGSE KAEEGGETEA QKEGSEDVGN LPEAQEKNEE 200
    EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS 239
    Length:239
    Mass (Da):26,086
    Last modified:November 25, 2008 - v3
    Checksum:iBA57B1C8034D6BBC
    GO
    Isoform 2 (identifier: P55822-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:128
    Mass (Da):13,976
    Checksum:i1E2E0AADFFAC0B28
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321E → EE in BM474020. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231D → E.1 Publication
    Corresponds to variant rs11575939 [ dbSNP | Ensembl ].
    VAR_057182
    Natural varianti50 – 501D → N.2 Publications
    Corresponds to variant rs6517549 [ dbSNP | Ensembl ].
    VAR_057183
    Natural varianti188 – 1881V → A.1 Publication
    Corresponds to variant rs9974333 [ dbSNP | Ensembl ].
    VAR_028233

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_045788Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X93498 mRNA. Translation: CAB57259.1.
    AL163279 Genomic DNA. Translation: CAB90456.1.
    AL163280 Genomic DNA. Translation: CAB90445.1.
    AF121781 Genomic DNA. Translation: AAD12067.1.
    AF121897 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09638.1.
    CH471079 Genomic DNA. Translation: EAX09639.1.
    CH471079 Genomic DNA. Translation: EAX09640.1.
    BC006371 mRNA. Translation: AAH06371.1.
    BM474020 mRNA. No translation available.
    CCDSiCCDS13666.1. [P55822-1]
    CCDS33560.1. [P55822-2]
    RefSeqiNP_001001713.1. NM_001001713.1. [P55822-2]
    NP_031367.1. NM_007341.2.
    XP_005261081.1. XM_005261024.1. [P55822-2]
    XP_005261082.1. XM_005261025.2. [P55822-2]
    XP_006724104.1. XM_006724041.1. [P55822-2]
    XP_006724105.1. XM_006724042.1. [P55822-2]
    UniGeneiHs.473847.

    Genome annotation databases

    EnsembliENST00000333634; ENSP00000332513; ENSG00000185437. [P55822-1]
    ENST00000380631; ENSP00000370005; ENSG00000185437. [P55822-2]
    ENST00000380634; ENSP00000370008; ENSG00000185437. [P55822-2]
    ENST00000380637; ENSP00000370011; ENSG00000185437. [P55822-2]
    GeneIDi6450.
    KEGGihsa:6450.
    UCSCiuc002yxz.3. human. [P55822-1]

    Polymorphism databases

    DMDMi215274184.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X93498 mRNA. Translation: CAB57259.1 .
    AL163279 Genomic DNA. Translation: CAB90456.1 .
    AL163280 Genomic DNA. Translation: CAB90445.1 .
    AF121781 Genomic DNA. Translation: AAD12067.1 .
    AF121897 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09638.1 .
    CH471079 Genomic DNA. Translation: EAX09639.1 .
    CH471079 Genomic DNA. Translation: EAX09640.1 .
    BC006371 mRNA. Translation: AAH06371.1 .
    BM474020 mRNA. No translation available.
    CCDSi CCDS13666.1. [P55822-1 ]
    CCDS33560.1. [P55822-2 ]
    RefSeqi NP_001001713.1. NM_001001713.1. [P55822-2 ]
    NP_031367.1. NM_007341.2.
    XP_005261081.1. XM_005261024.1. [P55822-2 ]
    XP_005261082.1. XM_005261025.2. [P55822-2 ]
    XP_006724104.1. XM_006724041.1. [P55822-2 ]
    XP_006724105.1. XM_006724042.1. [P55822-2 ]
    UniGenei Hs.473847.

    3D structure databases

    ProteinModelPortali P55822.
    SMRi P55822. Positions 64-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112348. 3 interactions.
    IntActi P55822. 2 interactions.
    MINTi MINT-4718377.
    STRINGi 9606.ENSP00000332513.

    PTM databases

    PhosphoSitei P55822.

    Polymorphism databases

    DMDMi 215274184.

    Proteomic databases

    MaxQBi P55822.
    PaxDbi P55822.
    PRIDEi P55822.

    Protocols and materials databases

    DNASUi 6450.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333634 ; ENSP00000332513 ; ENSG00000185437 . [P55822-1 ]
    ENST00000380631 ; ENSP00000370005 ; ENSG00000185437 . [P55822-2 ]
    ENST00000380634 ; ENSP00000370008 ; ENSG00000185437 . [P55822-2 ]
    ENST00000380637 ; ENSP00000370011 ; ENSG00000185437 . [P55822-2 ]
    GeneIDi 6450.
    KEGGi hsa:6450.
    UCSCi uc002yxz.3. human. [P55822-1 ]

    Organism-specific databases

    CTDi 6450.
    GeneCardsi GC21P040817.
    HGNCi HGNC:10822. SH3BGR.
    HPAi CAB003685.
    MIMi 602230. gene.
    neXtProti NX_P55822.
    PharmGKBi PA35730.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284884.
    HOGENOMi HOG000037924.
    HOVERGENi HBG054781.
    InParanoidi P55822.
    OMAi LCHCQDL.
    OrthoDBi EOG7GTT63.
    PhylomeDBi P55822.
    TreeFami TF105574.

    Miscellaneous databases

    ChiTaRSi SH3BGR. human.
    GeneWikii SH3BGR.
    GenomeRNAii 6450.
    NextBioi 25069.
    PROi P55822.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55822.
    Bgeei P55822.
    CleanExi HS_SH3BGR.
    Genevestigatori P55822.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR006993. Glut_rich_SH3-bd.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR12232. PTHR12232. 1 hit.
    Pfami PF04908. SH3BGR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle."
      Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D., Taramelli R., Rasore-Quartino A.
      Hum. Genet. 99:387-392(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-50.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-23; ASN-50 AND ALA-188.
      Tissue: Leiomyosarcoma and Muscle.

    Entry informationi

    Entry nameiSH3BG_HUMAN
    AccessioniPrimary (citable) accession number: P55822
    Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3