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P55822 (SH3BG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 domain-binding glutamic acid-rich protein

Short name=SH3BGR protein
Alternative name(s):
21-glutamic acid-rich protein
Short name=21-GARP
Gene names
Name:SH3BGR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in heart and skeletal muscle.

Sequence similarities

Belongs to the SH3BGR family.

Caution

It is uncertain whether Met-1 or Met-64 is the initiator.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSH3-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of signal transduction

Traceable author statement Ref.1. Source: GOC

protein complex assembly

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcytosol

Inferred from direct assay PubMed 16780588. Source: UniProtKB

   Molecular_functionSH3/SH2 adaptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55822-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55822-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239SH3 domain-binding glutamic acid-rich protein
PRO_0000220743

Regions

Motif124 – 1307SH3-binding Potential
Compositional bias170 – 23970Glu-rich (acidic)

Natural variations

Alternative sequence1 – 111111Missing in isoform 2.
VSP_045788
Natural variant231D → E. Ref.4
Corresponds to variant rs11575939 [ dbSNP | Ensembl ].
VAR_057182
Natural variant501D → N. Ref.3 Ref.4
Corresponds to variant rs6517549 [ dbSNP | Ensembl ].
VAR_057183
Natural variant1881V → A. Ref.4
Corresponds to variant rs9974333 [ dbSNP | Ensembl ].
VAR_028233

Experimental info

Sequence conflict2321E → EE in BM474020. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: BA57B1C8034D6BBC

FASTA23926,086
        10         20         30         40         50         60 
MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP 

        70         80         90        100        110        120 
TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK 

       130        140        150        160        170        180 
KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA 

       190        200        210        220        230 
QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS 

« Hide

Isoform 2 [UniParc].

Checksum: 1E2E0AADFFAC0B28
Show »

FASTA12813,976

References

« Hide 'large scale' references
[1]"Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle."
Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D., Taramelli R., Rasore-Quartino A.
Hum. Genet. 99:387-392(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[2]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-50.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-23; ASN-50 AND ALA-188.
Tissue: Leiomyosarcoma and Muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X93498 mRNA. Translation: CAB57259.1.
AL163279 Genomic DNA. Translation: CAB90456.1.
AL163280 Genomic DNA. Translation: CAB90445.1.
AF121781 Genomic DNA. Translation: AAD12067.1.
AF121897 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09638.1.
CH471079 Genomic DNA. Translation: EAX09639.1.
CH471079 Genomic DNA. Translation: EAX09640.1.
BC006371 mRNA. Translation: AAH06371.1.
BM474020 mRNA. No translation available.
CCDSCCDS13666.1. [P55822-1]
CCDS33560.1. [P55822-2]
RefSeqNP_001001713.1. NM_001001713.1. [P55822-2]
NP_031367.1. NM_007341.2.
XP_005261081.1. XM_005261024.1. [P55822-2]
XP_005261082.1. XM_005261025.2. [P55822-2]
XP_006724104.1. XM_006724041.1. [P55822-2]
XP_006724105.1. XM_006724042.1. [P55822-2]
UniGeneHs.473847.

3D structure databases

ProteinModelPortalP55822.
SMRP55822. Positions 64-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112348. 3 interactions.
IntActP55822. 2 interactions.
MINTMINT-4718377.
STRING9606.ENSP00000332513.

PTM databases

PhosphoSiteP55822.

Polymorphism databases

DMDM215274184.

Proteomic databases

MaxQBP55822.
PaxDbP55822.
PRIDEP55822.

Protocols and materials databases

DNASU6450.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333634; ENSP00000332513; ENSG00000185437. [P55822-1]
ENST00000380631; ENSP00000370005; ENSG00000185437. [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437. [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437. [P55822-2]
GeneID6450.
KEGGhsa:6450.
UCSCuc002yxz.3. human. [P55822-1]

Organism-specific databases

CTD6450.
GeneCardsGC21P040817.
HGNCHGNC:10822. SH3BGR.
HPACAB003685.
MIM602230. gene.
neXtProtNX_P55822.
PharmGKBPA35730.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284884.
HOGENOMHOG000037924.
HOVERGENHBG054781.
InParanoidP55822.
OMALCHCQDL.
OrthoDBEOG7GTT63.
PhylomeDBP55822.
TreeFamTF105574.

Gene expression databases

ArrayExpressP55822.
BgeeP55822.
CleanExHS_SH3BGR.
GenevestigatorP55822.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR12232. PTHR12232. 1 hit.
PfamPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSH3BGR. human.
GeneWikiSH3BGR.
GenomeRNAi6450.
NextBio25069.
PROP55822.
SOURCESearch...

Entry information

Entry nameSH3BG_HUMAN
AccessionPrimary (citable) accession number: P55822
Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM