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P55822

- SH3BG_HUMAN

UniProt

P55822 - SH3BG_HUMAN

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Protein

SH3 domain-binding glutamic acid-rich protein

Gene

SH3BGR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  1. positive regulation of signal transduction Source: GOC
  2. protein complex assembly Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich protein
Short name:
SH3BGR protein
Alternative name(s):
21-glutamic acid-rich protein
Short name:
21-GARP
Gene namesi
Name:SH3BGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:10822. SH3BGR.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239SH3 domain-binding glutamic acid-rich proteinPRO_0000220743Add
BLAST

Proteomic databases

MaxQBiP55822.
PaxDbiP55822.
PRIDEiP55822.

PTM databases

PhosphoSiteiP55822.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiP55822.
CleanExiHS_SH3BGR.
ExpressionAtlasiP55822. baseline and differential.
GenevestigatoriP55822.

Organism-specific databases

HPAiCAB003685.

Interactioni

Protein-protein interaction databases

BioGridi112348. 3 interactions.
IntActiP55822. 2 interactions.
MINTiMINT-4718377.
STRINGi9606.ENSP00000332513.

Structurei

3D structure databases

ProteinModelPortaliP55822.
SMRiP55822. Positions 64-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi124 – 1307SH3-bindingSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 23970Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG284884.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000037924.
HOVERGENiHBG054781.
InParanoidiP55822.
OMAiLCHCQDL.
OrthoDBiEOG7GTT63.
PhylomeDBiP55822.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12232. PTHR12232. 1 hit.
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55822-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD
60 70 80 90 100
RGVLGGVLFP TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL
110 120 130 140 150
DIAGDEDNRR WMRENVPGEK KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE
160 170 180 190 200
ENIIYSFLGL APPPDSKGSE KAEEGGETEA QKEGSEDVGN LPEAQEKNEE
210 220 230
EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS
Length:239
Mass (Da):26,086
Last modified:November 25, 2008 - v3
Checksum:iBA57B1C8034D6BBC
GO
Isoform 2 (identifier: P55822-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.

Show »
Length:128
Mass (Da):13,976
Checksum:i1E2E0AADFFAC0B28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321E → EE in BM474020. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231D → E.1 Publication
Corresponds to variant rs11575939 [ dbSNP | Ensembl ].
VAR_057182
Natural varianti50 – 501D → N.2 Publications
Corresponds to variant rs6517549 [ dbSNP | Ensembl ].
VAR_057183
Natural varianti188 – 1881V → A.1 Publication
Corresponds to variant rs9974333 [ dbSNP | Ensembl ].
VAR_028233

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_045788Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93498 mRNA. Translation: CAB57259.1.
AL163279 Genomic DNA. Translation: CAB90456.1.
AL163280 Genomic DNA. Translation: CAB90445.1.
AF121781 Genomic DNA. Translation: AAD12067.1.
AF121897 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09638.1.
CH471079 Genomic DNA. Translation: EAX09639.1.
CH471079 Genomic DNA. Translation: EAX09640.1.
BC006371 mRNA. Translation: AAH06371.1.
BM474020 mRNA. No translation available.
CCDSiCCDS13666.1. [P55822-1]
CCDS33560.1. [P55822-2]
RefSeqiNP_001001713.1. NM_001001713.1. [P55822-2]
NP_031367.1. NM_007341.2.
XP_005261081.1. XM_005261024.1. [P55822-2]
XP_005261082.1. XM_005261025.2. [P55822-2]
XP_006724104.1. XM_006724041.1. [P55822-2]
XP_006724105.1. XM_006724042.1. [P55822-2]
UniGeneiHs.473847.

Genome annotation databases

EnsembliENST00000333634; ENSP00000332513; ENSG00000185437. [P55822-1]
ENST00000380631; ENSP00000370005; ENSG00000185437. [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437. [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437. [P55822-2]
GeneIDi6450.
KEGGihsa:6450.
UCSCiuc002yxz.3. human. [P55822-1]

Polymorphism databases

DMDMi215274184.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93498 mRNA. Translation: CAB57259.1 .
AL163279 Genomic DNA. Translation: CAB90456.1 .
AL163280 Genomic DNA. Translation: CAB90445.1 .
AF121781 Genomic DNA. Translation: AAD12067.1 .
AF121897 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09638.1 .
CH471079 Genomic DNA. Translation: EAX09639.1 .
CH471079 Genomic DNA. Translation: EAX09640.1 .
BC006371 mRNA. Translation: AAH06371.1 .
BM474020 mRNA. No translation available.
CCDSi CCDS13666.1. [P55822-1 ]
CCDS33560.1. [P55822-2 ]
RefSeqi NP_001001713.1. NM_001001713.1. [P55822-2 ]
NP_031367.1. NM_007341.2.
XP_005261081.1. XM_005261024.1. [P55822-2 ]
XP_005261082.1. XM_005261025.2. [P55822-2 ]
XP_006724104.1. XM_006724041.1. [P55822-2 ]
XP_006724105.1. XM_006724042.1. [P55822-2 ]
UniGenei Hs.473847.

3D structure databases

ProteinModelPortali P55822.
SMRi P55822. Positions 64-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112348. 3 interactions.
IntActi P55822. 2 interactions.
MINTi MINT-4718377.
STRINGi 9606.ENSP00000332513.

PTM databases

PhosphoSitei P55822.

Polymorphism databases

DMDMi 215274184.

Proteomic databases

MaxQBi P55822.
PaxDbi P55822.
PRIDEi P55822.

Protocols and materials databases

DNASUi 6450.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333634 ; ENSP00000332513 ; ENSG00000185437 . [P55822-1 ]
ENST00000380631 ; ENSP00000370005 ; ENSG00000185437 . [P55822-2 ]
ENST00000380634 ; ENSP00000370008 ; ENSG00000185437 . [P55822-2 ]
ENST00000380637 ; ENSP00000370011 ; ENSG00000185437 . [P55822-2 ]
GeneIDi 6450.
KEGGi hsa:6450.
UCSCi uc002yxz.3. human. [P55822-1 ]

Organism-specific databases

CTDi 6450.
GeneCardsi GC21P040817.
HGNCi HGNC:10822. SH3BGR.
HPAi CAB003685.
MIMi 602230. gene.
neXtProti NX_P55822.
PharmGKBi PA35730.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284884.
GeneTreei ENSGT00440000039098.
HOGENOMi HOG000037924.
HOVERGENi HBG054781.
InParanoidi P55822.
OMAi LCHCQDL.
OrthoDBi EOG7GTT63.
PhylomeDBi P55822.
TreeFami TF105574.

Miscellaneous databases

ChiTaRSi SH3BGR. human.
GeneWikii SH3BGR.
GenomeRNAii 6450.
NextBioi 25069.
PROi P55822.
SOURCEi Search...

Gene expression databases

Bgeei P55822.
CleanExi HS_SH3BGR.
ExpressionAtlasi P55822. baseline and differential.
Genevestigatori P55822.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR006993. Glut_rich_SH3-bd.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR12232. PTHR12232. 1 hit.
Pfami PF04908. SH3BGR. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle."
    Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D., Taramelli R., Rasore-Quartino A.
    Hum. Genet. 99:387-392(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-50.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-23; ASN-50 AND ALA-188.
    Tissue: Leiomyosarcoma and Muscle.

Entry informationi

Entry nameiSH3BG_HUMAN
AccessioniPrimary (citable) accession number: P55822
Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3