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Protein

Stathmin-2

Gene

Stmn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-2
Alternative name(s):
Superior cervical ganglion-10 protein
Short name:
Protein SCG10
Gene namesi
Name:Stmn2
Synonyms:Scg10, Scgn10, Stmb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:98241. Stmn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 179178Stathmin-2PRO_0000182397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei16 – 161PhosphoserineSequence analysis
Lipidationi22 – 221S-palmitoyl cysteineBy similarity
Lipidationi24 – 241S-palmitoyl cysteineBy similarity
Modified residuei43 – 431N6-acetyllysineBy similarity
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei62 – 621PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei80 – 801PhosphoserineSequence analysisBy similarity
Modified residuei97 – 971PhosphoserineSequence analysisBy similarity
Modified residuei134 – 1341N6-acetyllysineBy similarity

Post-translational modificationi

Sumoylated.By similarity
Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex.1 Publication
N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP55821.
PaxDbiP55821.
PeptideAtlasiP55821.
PRIDEiP55821.

PTM databases

iPTMnetiP55821.
PhosphoSiteiP55821.

Expressioni

Tissue specificityi

Neuron specific.

Developmental stagei

At 15.5 dpc, mid to low expression throughout the midbrain, with more prominent levels in the telencephalon, especially in the intermediate zone, the midbrain roof, the olfactory epithelium, the inferior colliculus, and the medulla oblongata. telencephalon revealed concentrated (at protein level).1 Publication

Gene expression databases

BgeeiP55821.
CleanExiMM_STMN2.
ExpressionAtlasiP55821. baseline and differential.
GenevisibleiP55821. MM.

Interactioni

Subunit structurei

Interacts with ITM2C. Interacts with MAPK8. Interacts with KIF1BP. Interacts (via the N-terminal region) with CIB1 (via C-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the neurite outgrowth inhibition of STMN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203093. 3 interactions.
IntActiP55821. 1 interaction.
MINTiMINT-1212338.
STRINGi10090.ENSMUSP00000029002.

Structurei

3D structure databases

ProteinModelPortaliP55821.
SMRiP55821. Positions 40-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 179142SLDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2625Membrane attachmentSequence analysisAdd
BLAST
Regioni39 – 9658Regulatory/phosphorylation domainSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili75 – 179105Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ9S. Eukaryota.
ENOG410YFK3. LUCA.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP55821.
OMAiVCEFEDM.
OrthoDBiEOG744TBN.
PhylomeDBiP55821.
TreeFamiTF326935.

Family and domain databases

InterProiIPR026729. Stathmin-2.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS
60 70 80 90 100
GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA
110 120 130 140 150
QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL
160 170
AAIIERLQEK ERHAAEVRRN KELQVELSG
Length:179
Mass (Da):20,828
Last modified:November 1, 1997 - v1
Checksum:iF9A258A1B57E620D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20259 Genomic DNA. No translation available.
L20260 Genomic DNA. No translation available.
L20261 Genomic DNA. No translation available.
L20262 Genomic DNA. No translation available.
L20263 Genomic DNA. No translation available.
BC026538 mRNA. Translation: AAH26538.1.
CCDSiCCDS17231.1.
PIRiA48917.
RefSeqiNP_079561.1. NM_025285.2.
UniGeneiMm.29580.

Genome annotation databases

EnsembliENSMUST00000029002; ENSMUSP00000029002; ENSMUSG00000027500.
GeneIDi20257.
KEGGimmu:20257.
UCSCiuc008oon.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20259 Genomic DNA. No translation available.
L20260 Genomic DNA. No translation available.
L20261 Genomic DNA. No translation available.
L20262 Genomic DNA. No translation available.
L20263 Genomic DNA. No translation available.
BC026538 mRNA. Translation: AAH26538.1.
CCDSiCCDS17231.1.
PIRiA48917.
RefSeqiNP_079561.1. NM_025285.2.
UniGeneiMm.29580.

3D structure databases

ProteinModelPortaliP55821.
SMRiP55821. Positions 40-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203093. 3 interactions.
IntActiP55821. 1 interaction.
MINTiMINT-1212338.
STRINGi10090.ENSMUSP00000029002.

PTM databases

iPTMnetiP55821.
PhosphoSiteiP55821.

Proteomic databases

EPDiP55821.
PaxDbiP55821.
PeptideAtlasiP55821.
PRIDEiP55821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029002; ENSMUSP00000029002; ENSMUSG00000027500.
GeneIDi20257.
KEGGimmu:20257.
UCSCiuc008oon.1. mouse.

Organism-specific databases

CTDi11075.
MGIiMGI:98241. Stmn2.

Phylogenomic databases

eggNOGiENOG410IJ9S. Eukaryota.
ENOG410YFK3. LUCA.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP55821.
OMAiVCEFEDM.
OrthoDBiEOG744TBN.
PhylomeDBiP55821.
TreeFamiTF326935.

Miscellaneous databases

PROiP55821.
SOURCEiSearch...

Gene expression databases

BgeeiP55821.
CleanExiMM_STMN2.
ExpressionAtlasiP55821. baseline and differential.
GenevisibleiP55821. MM.

Family and domain databases

InterProiIPR026729. Stathmin-2.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF18. PTHR10104:SF18. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length."
    Tararuk T., Ostman N., Li W., Bjorkblom B., Padzik A., Zdrojewska J., Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T.
    J. Cell Biol. 173:265-277(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiSTMN2_MOUSE
AccessioniPrimary (citable) accession number: P55821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.