ID   XG_HUMAN                Reviewed;         180 AA.
AC   P55808; E9PCH1; Q496N8; Q496N9; Q496P0; Q71BZ5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-JAN-2012, entry version 88.
DE   RecName: Full=Glycoprotein Xg;
DE   AltName: Full=Protein PBDX;
DE   Flags: Precursor;
GN   Name=XG; Synonyms=PBDX;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Bone marrow;
RX   MEDLINE=94332149; PubMed=8054981; DOI=10.1038/ng0494-394;
RA   Ellis N.A., Ye T.Z., Patton S., German J., Goodfellow P.N., Weller P.;
RT   "Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal
RT   boundary on chromosome Xp.";
RL   Nat. Genet. 6:394-400(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Naoko S., Fujiki K., Kanai A., Tanaka Y., Iwata T.;
RT   "Identification of PBDX gene highly expressed in human cornea.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Naoko S., Tanaka Y., Iwata T.;
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND
RP   VARIANT ASN-60.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=7533029; DOI=10.1038/ng1194-285;
RA   Ellis N.A., Tippett P., Petty A., Reid M., Weller P.A., Ye T.Z.,
RA   German J., Goodfellow P.N., Thomas S., Banting G.;
RT   "PBDX is the XG blood group gene.";
RL   Nat. Genet. 8:285-290(1994).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P55808-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P55808-2; Sequence=VSP_037319;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=P55808-3; Sequence=VSP_037320;
CC         Note=No experimental confirmation available. Ref.5 (AAI00766)
CC         sequence is in conflict in position: 131:L->P;
CC   -!- PTM: O-glycosylated (Probable).
CC   -!- POLYMORPHISM: XG is responsible for the Xg blood group system.
CC   -!- MISCELLANEOUS: The gene encoding for this protein is located in
CC       the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
CC   -!- SIMILARITY: Belongs to the CD99 family.
CC   -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene
CC       mutation database;
CC       URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=xg";
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DR   EMBL; X96421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF380356; AAL04055.1; -; mRNA.
DR   EMBL; AF534880; AAN03481.1; -; mRNA.
DR   EMBL; AC006209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC138085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC100765; AAI00766.1; -; mRNA.
DR   EMBL; BC100766; AAI00767.1; -; mRNA.
DR   EMBL; BC100767; AAI00768.1; -; mRNA.
DR   IPI; IPI00026514; -.
DR   IPI; IPI00844291; -.
DR   IPI; IPI00915408; -.
DR   PIR; S43791; S43791.
DR   RefSeq; NP_001135391.1; NM_001141919.1.
DR   RefSeq; NP_001135392.1; NM_001141920.1.
DR   RefSeq; NP_780778.1; NM_175569.2.
DR   UniGene; Hs.179675; -.
DR   ProteinModelPortal; P55808; -.
DR   STRING; P55808; -.
DR   PhosphoSite; P55808; -.
DR   DMDM; 2499136; -.
DR   Ensembl; ENST00000381174; ENSP00000370566; ENSG00000124343.
DR   GeneID; 7499; -.
DR   KEGG; hsa:7499; -.
DR   NMPDR; fig|9606.3.peg.32391; -.
DR   UCSC; uc004cqq.1; human.
DR   CTD; 7499; -.
DR   GeneCards; GC0XP002663; -.
DR   H-InvDB; HIX0056172; -.
DR   HGNC; HGNC:12806; XG.
DR   HPA; HPA021539; -.
DR   MIM; 314700; gene+phenotype.
DR   neXtProt; NX_P55808; -.
DR   eggNOG; prNOG20237; -.
DR   HOVERGEN; HBG086239; -.
DR   OrthoDB; EOG4PK29G; -.
DR   NextBio; 29368; -.
DR   ArrayExpress; P55808; -.
DR   Bgee; P55808; -.
DR   CleanEx; HS_XG; -.
DR   Genevestigator; P55808; -.
DR   GermOnline; ENSG00000124343; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022078; CD99L2.
DR   Pfam; PF12301; CD99L2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Blood group antigen; Cell membrane;
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    180       Glycoprotein Xg.
FT                                /FTId=PRO_0000022693.
FT   TOPO_DOM     22    142       Extracellular (Potential).
FT   TRANSMEM    143    163       Helical; (Potential).
FT   TOPO_DOM    164    180       Cytoplasmic (Potential).
FT   VAR_SEQ      85     85       G -> GS (in isoform 2).
FT                                /FTId=VSP_037319.
FT   VAR_SEQ     125    125       G -> GRGGYRLNSRYGNTYG (in isoform 3).
FT                                /FTId=VSP_037320.
FT   VARIANT      60     60       D -> N (in dbSNP:rs5939319).
FT                                /FTId=VAR_054063.
SQ   SEQUENCE   180 AA;  19723 MW;  DADAA9E6859C4530 CRC64;
     MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP PYYPQPENPD
     SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR PRPRPPAGGG GGGYSSYGNS
     DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV VVVTLLGAAA SYFKLNNRRN CFRTHEPENV
//