Reviewed, UniProtKB/Swiss-Prot P55808 (XG_HUMAN)

Names and origin

Protein names

Recommended name:
    Glycoprotein Xg
Alternative name(s):
    Protein PBDX

Gene names

Name:	XG
Synonyms:	PBDX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane proteinPotential.
Post-translational modification	O-glycosylated Probable.
Polymorphism	XG is responsible for the Xg blood group system.
Miscellaneous	The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Sequence similarities	Belongs to the CD99 family.
Caution	Ref.3 sequence incorrectly indicated as originating from mouse.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Blood group antigen
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 180	159	Glycoprotein Xg		PRO_0000022693
Regions
	Topological domain	22 – 142	121	Extracellular Potential
	Transmembrane	143 – 163	21	Potential
	Topological domain	164 – 180	17	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P55808-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DADAA9E6859C4530	FASTA	180	19,723
	10 20 30 40 50 60 MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP PYYPQPENPD 70 80 90 100 110 120 SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR PRPRPPAGGG GGGYSSYGNS 130 140 150 160 170 180 DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV VVVTLLGAAA SYFKLNNRRN CFRTHEPENV

References

[1]	"Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp." Ellis N.A., Ye T.Z., Patton S., German J., Goodfellow P.N., Weller P. Nat. Genet. 6:394-400(1994) [PubMed: 8054981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Bone marrow.
[2]	"Identification of PBDX gene highly expressed in human cornea." Naoko S., Fujiki K., Kanai A., Tanaka Y., Iwata T. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning and characterization of mouse PBDX." Naoko S., Tanaka Y., Iwata T. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Web resources

BGMUT

Blood group antigen gene mutation database"

Cross-references

Sequence databases
EMBLGenBankDDBJ	X96421 Genomic DNA. No translation available. AF380356 mRNA. Translation: AAL04055.1. AF534880 mRNA. Translation: AAN03481.1.
PIR	S43791.
RefSeq	NP_780778.1.
UniGene	Hs.179675
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	P55808.
Genome annotation databases
Ensembl	ENSG00000124343. Homo sapiens. [Contig view]
GeneID	7499.
KEGG	hsa:7499.
NMPDR	fig|9606.3.peg.32391.
Organism-specific databases
H-InvDB	HIX0056172.
HGNC	HGNC:12806. XG.
MIM	314700. gene+phenotype.
PharmGKB	PA37405.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P55808.
Gene expression databases
ArrayExpress	P55808.
CleanEx	HS_XG.
GermOnline	ENSG00000124343. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
LinkHub	P55808.
NextBio	29368.
SOURCE	Search...

Entry information

Entry name

XG_HUMAN

Accession

Primary (citable) accession number: P55808
Secondary accession number(s): Q71BZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)