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P55808 (XG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycoprotein Xg
Alternative name(s):
Protein PBDX
Gene names
Name:XG
Synonyms:PBDX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.6.

Tissue specificity

Expressed in erythroid tissues, including thymus, bone marrow and fetal liver, and in several nonerythroid tissues, such as heart, placenta, skeletal muscle, thyroid and trachea, as well as in skin fibroblasts. Expression is low or undetectable in other tissues. Ref.7

Post-translational modification

O-glycosylated Probable.

Polymorphism

XG is responsible for the Xg blood group system.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the CD99 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionBlood group antigen
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of plasma membrane

Inferred from direct assay Ref.6. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55808-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55808-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-85: G → GS
Note: No experimental confirmation available.
Isoform 3 (identifier: P55808-3)

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: G → GRGGYRLNSRYGNTYG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 180159Glycoprotein Xg
PRO_0000022693

Regions

Topological domain22 – 142121Extracellular Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 18017Cytoplasmic Potential

Natural variations

Alternative sequence851G → GS in isoform 2.
VSP_037319
Alternative sequence1251G → GRGGYRLNSRYGNTYG in isoform 3.
VSP_037320
Natural variant601D → N. Ref.5
Corresponds to variant rs5939319 [ dbSNP | Ensembl ].
VAR_054063

Experimental info

Isoform 3:
Sequence conflict1311L → P in AAI00766. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DADAA9E6859C4530

FASTA18019,723
        10         20         30         40         50         60 
MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP PYYPQPENPD 

        70         80         90        100        110        120 
SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR PRPRPPAGGG GGGYSSYGNS 

       130        140        150        160        170        180 
DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV VVVTLLGAAA SYFKLNNRRN CFRTHEPENV 

« Hide

Isoform 2 [UniParc].

Checksum: 8B4531340686355C
Show »

FASTA18119,810
Isoform 3 [UniParc].

Checksum: B823CA02B7EEB8DF
Show »

FASTA19521,439

References

« Hide 'large scale' references
[1]"Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp."
Ellis N.A., Ye T.Z., Patton S., German J., Goodfellow P.N., Weller P.
Nat. Genet. 6:394-400(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Bone marrow.
[2]"Identification of PBDX gene highly expressed in human cornea."
Naoko S., Fujiki K., Kanai A., Tanaka Y., Iwata T.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Naoko S., Tanaka Y., Iwata T.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASN-60.
[6]"PBDX is the XG blood group gene."
Ellis N.A., Tippett P., Petty A., Reid M., Weller P.A., Ye T.Z., German J., Goodfellow P.N., Thomas S., Banting G.
Nat. Genet. 8:285-290(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells."
Fouchet C., Gane P., Huet M., Fellous M., Rouger P., Banting G., Cartron J.P., Lopez C.
Blood 95:1819-1826(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

dbRBC/BGMUT

Blood group antigen gene mutation database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96421 Genomic DNA. No translation available.
AF380356 mRNA. Translation: AAL04055.1.
AF534880 mRNA. Translation: AAN03481.1.
AC006209 Genomic DNA. No translation available.
AC138085 Genomic DNA. No translation available.
BC100765 mRNA. Translation: AAI00766.1.
BC100766 mRNA. Translation: AAI00767.1.
BC100767 mRNA. Translation: AAI00768.1.
PIRS43791.
RefSeqNP_001135391.1. NM_001141919.1.
NP_001135392.1. NM_001141920.1.
NP_780778.1. NM_175569.2.
UniGeneHs.179675.

3D structure databases

ProteinModelPortalP55808.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000411004.

PTM databases

PhosphoSiteP55808.

Polymorphism databases

DMDM2499136.

Proteomic databases

PaxDbP55808.
PRIDEP55808.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381174; ENSP00000370566; ENSG00000124343. [P55808-1]
ENST00000419513; ENSP00000411004; ENSG00000124343. [P55808-3]
ENST00000426774; ENSP00000398503; ENSG00000124343. [P55808-2]
GeneID7499.
KEGGhsa:7499.
UCSCuc004cqp.3. human. [P55808-3]
uc011mhg.2. human. [P55808-1]

Organism-specific databases

CTD7499.
GeneCardsGC0XP002663.
H-InvDBHIX0213635.
HGNCHGNC:12806. XG.
HPAHPA021539.
MIM300879. gene.
314700. phenotype.
neXtProtNX_P55808.
PharmGKBPA37405.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG124417.
HOGENOMHOG000233665.
HOVERGENHBG086239.
OMAGGNIYPR.
OrthoDBEOG780RPH.
PhylomeDBP55808.
TreeFamTF336273.

Gene expression databases

ArrayExpressP55808.
BgeeP55808.
CleanExHS_XG.
GenevestigatorP55808.

Family and domain databases

InterProIPR022078. CD99L2.
[Graphical view]
PfamPF12301. CD99L2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSXG. human.
GenomeRNAi7499.
NextBio29368.
PROP55808.
SOURCESearch...

Entry information

Entry nameXG_HUMAN
AccessionPrimary (citable) accession number: P55808
Secondary accession number(s): E9PCH1 expand/collapse secondary AC list , Q496N8, Q496N9, Q496P0, Q71BZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Blood group antigen proteins

Nomenclature of blood group antigens and list of entries