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P55808

- XG_HUMAN

UniProt

P55808 - XG_HUMAN

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Protein

Glycoprotein Xg

Gene

XG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Blood group antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein Xg
Alternative name(s):
Protein PBDX
Gene namesi
Name:XG
Synonyms:PBDX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:12806. XG.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 142121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 18017CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi314700. phenotype.
PharmGKBiPA37405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 180159Glycoprotein XgPRO_0000022693Add
BLAST

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55808.
PRIDEiP55808.

PTM databases

PhosphoSiteiP55808.

Expressioni

Tissue specificityi

Expressed in erythroid tissues, including thymus, bone marrow and fetal liver, and in several nonerythroid tissues, such as heart, placenta, skeletal muscle, thyroid and trachea, as well as in skin fibroblasts. Expression is low or undetectable in other tissues.1 Publication

Gene expression databases

BgeeiP55808.
CleanExiHS_XG.
ExpressionAtlasiP55808. baseline and differential.
GenevestigatoriP55808.

Organism-specific databases

HPAiHPA021539.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000411004.

Structurei

3D structure databases

ProteinModelPortaliP55808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG124417.
GeneTreeiENSGT00510000049811.
HOGENOMiHOG000233665.
HOVERGENiHBG086239.
InParanoidiP55808.
OMAiGGNIYPR.
OrthoDBiEOG780RPH.
PhylomeDBiP55808.
TreeFamiTF336273.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55808-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP
60 70 80 90 100
PYYPQPENPD SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR
110 120 130 140 150
PRPRPPAGGG GGGYSSYGNS DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV
160 170 180
VVVTLLGAAA SYFKLNNRRN CFRTHEPENV
Length:180
Mass (Da):19,723
Last modified:November 1, 1997 - v1
Checksum:iDADAA9E6859C4530
GO
Isoform 2 (identifier: P55808-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-85: G → GS

Note: No experimental confirmation available.

Show »
Length:181
Mass (Da):19,810
Checksum:i8B4531340686355C
GO
Isoform 3 (identifier: P55808-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: G → GRGGYRLNSRYGNTYG

Note: No experimental confirmation available.Curated

Show »
Length:195
Mass (Da):21,439
Checksum:iB823CA02B7EEB8DF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: P55808-3)
Sequence conflicti131 – 1311L → P in AAI00766. (PubMed:15489334)Curated

Polymorphismi

XG is responsible for the Xg blood group system.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601D → N.1 Publication
Corresponds to variant rs5939319 [ dbSNP | Ensembl ].
VAR_054063

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 851G → GS in isoform 2. 1 PublicationVSP_037319
Alternative sequencei125 – 1251G → GRGGYRLNSRYGNTYG in isoform 3. 1 PublicationVSP_037320

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96421 Genomic DNA. No translation available.
AF380356 mRNA. Translation: AAL04055.1.
AF534880 mRNA. Translation: AAN03481.1.
AC006209 Genomic DNA. No translation available.
AC138085 Genomic DNA. No translation available.
BC100765 mRNA. Translation: AAI00766.1.
BC100766 mRNA. Translation: AAI00767.1.
BC100767 mRNA. Translation: AAI00768.1.
CCDSiCCDS14120.1. [P55808-1]
CCDS48073.1. [P55808-3]
PIRiS43791.
RefSeqiNP_001135391.1. NM_001141919.1. [P55808-3]
NP_001135392.1. NM_001141920.1. [P55808-2]
NP_780778.1. NM_175569.2. [P55808-1]
UniGeneiHs.179675.

Genome annotation databases

EnsembliENST00000381174; ENSP00000370566; ENSG00000124343. [P55808-1]
ENST00000419513; ENSP00000411004; ENSG00000124343. [P55808-3]
GeneIDi7499.
KEGGihsa:7499.
UCSCiuc004cqp.3. human. [P55808-3]
uc011mhg.2. human. [P55808-1]

Polymorphism databases

DMDMi2499136.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96421 Genomic DNA. No translation available.
AF380356 mRNA. Translation: AAL04055.1 .
AF534880 mRNA. Translation: AAN03481.1 .
AC006209 Genomic DNA. No translation available.
AC138085 Genomic DNA. No translation available.
BC100765 mRNA. Translation: AAI00766.1 .
BC100766 mRNA. Translation: AAI00767.1 .
BC100767 mRNA. Translation: AAI00768.1 .
CCDSi CCDS14120.1. [P55808-1 ]
CCDS48073.1. [P55808-3 ]
PIRi S43791.
RefSeqi NP_001135391.1. NM_001141919.1. [P55808-3 ]
NP_001135392.1. NM_001141920.1. [P55808-2 ]
NP_780778.1. NM_175569.2. [P55808-1 ]
UniGenei Hs.179675.

3D structure databases

ProteinModelPortali P55808.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000411004.

PTM databases

PhosphoSitei P55808.

Polymorphism databases

DMDMi 2499136.

Proteomic databases

PaxDbi P55808.
PRIDEi P55808.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381174 ; ENSP00000370566 ; ENSG00000124343 . [P55808-1 ]
ENST00000419513 ; ENSP00000411004 ; ENSG00000124343 . [P55808-3 ]
GeneIDi 7499.
KEGGi hsa:7499.
UCSCi uc004cqp.3. human. [P55808-3 ]
uc011mhg.2. human. [P55808-1 ]

Organism-specific databases

CTDi 7499.
GeneCardsi GC0XP002663.
H-InvDB HIX0213635.
HGNCi HGNC:12806. XG.
HPAi HPA021539.
MIMi 300879. gene.
314700. phenotype.
neXtProti NX_P55808.
PharmGKBi PA37405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG124417.
GeneTreei ENSGT00510000049811.
HOGENOMi HOG000233665.
HOVERGENi HBG086239.
InParanoidi P55808.
OMAi GGNIYPR.
OrthoDBi EOG780RPH.
PhylomeDBi P55808.
TreeFami TF336273.

Miscellaneous databases

ChiTaRSi XG. human.
GenomeRNAii 7499.
NextBioi 29368.
PROi P55808.
SOURCEi Search...

Gene expression databases

Bgeei P55808.
CleanExi HS_XG.
ExpressionAtlasi P55808. baseline and differential.
Genevestigatori P55808.

Family and domain databases

InterProi IPR022078. CD99L2.
[Graphical view ]
Pfami PF12301. CD99L2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp."
    Ellis N.A., Ye T.Z., Patton S., German J., Goodfellow P.N., Weller P.
    Nat. Genet. 6:394-400(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Bone marrow.
  2. "Identification of PBDX gene highly expressed in human cornea."
    Naoko S., Fujiki K., Kanai A., Tanaka Y., Iwata T.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Naoko S., Tanaka Y., Iwata T.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASN-60.
  6. Cited for: SUBCELLULAR LOCATION.
  7. "A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells."
    Fouchet C., Gane P., Huet M., Fellous M., Rouger P., Banting G., Cartron J.P., Lopez C.
    Blood 95:1819-1826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiXG_HUMAN
AccessioniPrimary (citable) accession number: P55808
Secondary accession number(s): E9PCH1
, Q496N8, Q496N9, Q496P0, Q71BZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3