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P55808

- XG_HUMAN

UniProt

P55808 - XG_HUMAN

Protein

Glycoprotein Xg

Gene

XG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Keywords - Molecular functioni

    Blood group antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycoprotein Xg
    Alternative name(s):
    Protein PBDX
    Gene namesi
    Name:XG
    Synonyms:PBDX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:12806. XG.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi314700. phenotype.
    PharmGKBiPA37405.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 180159Glycoprotein XgPRO_0000022693Add
    BLAST

    Post-translational modificationi

    O-glycosylated.Curated

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP55808.
    PRIDEiP55808.

    PTM databases

    PhosphoSiteiP55808.

    Expressioni

    Tissue specificityi

    Expressed in erythroid tissues, including thymus, bone marrow and fetal liver, and in several nonerythroid tissues, such as heart, placenta, skeletal muscle, thyroid and trachea, as well as in skin fibroblasts. Expression is low or undetectable in other tissues.1 Publication

    Gene expression databases

    ArrayExpressiP55808.
    BgeeiP55808.
    CleanExiHS_XG.
    GenevestigatoriP55808.

    Organism-specific databases

    HPAiHPA021539.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000411004.

    Structurei

    3D structure databases

    ProteinModelPortaliP55808.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 142121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 18017CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD99 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG124417.
    HOGENOMiHOG000233665.
    HOVERGENiHBG086239.
    OMAiGGNIYPR.
    OrthoDBiEOG780RPH.
    PhylomeDBiP55808.
    TreeFamiTF336273.

    Family and domain databases

    InterProiIPR022078. CD99L2.
    [Graphical view]
    PfamiPF12301. CD99L2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55808-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP    50
    PYYPQPENPD SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR 100
    PRPRPPAGGG GGGYSSYGNS DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV 150
    VVVTLLGAAA SYFKLNNRRN CFRTHEPENV 180
    Length:180
    Mass (Da):19,723
    Last modified:November 1, 1997 - v1
    Checksum:iDADAA9E6859C4530
    GO
    Isoform 2 (identifier: P55808-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-85: G → GS

    Note: No experimental confirmation available.

    Show »
    Length:181
    Mass (Da):19,810
    Checksum:i8B4531340686355C
    GO
    Isoform 3 (identifier: P55808-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         125-125: G → GRGGYRLNSRYGNTYG

    Note: No experimental confirmation available.Curated

    Show »
    Length:195
    Mass (Da):21,439
    Checksum:iB823CA02B7EEB8DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 3 (identifier: P55808-3)
    Sequence conflicti131 – 1311L → P in AAI00766. (PubMed:15489334)Curated

    Polymorphismi

    XG is responsible for the Xg blood group system.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601D → N.1 Publication
    Corresponds to variant rs5939319 [ dbSNP | Ensembl ].
    VAR_054063

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei85 – 851G → GS in isoform 2. 1 PublicationVSP_037319
    Alternative sequencei125 – 1251G → GRGGYRLNSRYGNTYG in isoform 3. 1 PublicationVSP_037320

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96421 Genomic DNA. No translation available.
    AF380356 mRNA. Translation: AAL04055.1.
    AF534880 mRNA. Translation: AAN03481.1.
    AC006209 Genomic DNA. No translation available.
    AC138085 Genomic DNA. No translation available.
    BC100765 mRNA. Translation: AAI00766.1.
    BC100766 mRNA. Translation: AAI00767.1.
    BC100767 mRNA. Translation: AAI00768.1.
    CCDSiCCDS14120.1. [P55808-1]
    CCDS48073.1. [P55808-3]
    PIRiS43791.
    RefSeqiNP_001135391.1. NM_001141919.1. [P55808-3]
    NP_001135392.1. NM_001141920.1. [P55808-2]
    NP_780778.1. NM_175569.2. [P55808-1]
    UniGeneiHs.179675.

    Genome annotation databases

    EnsembliENST00000381174; ENSP00000370566; ENSG00000124343. [P55808-1]
    ENST00000419513; ENSP00000411004; ENSG00000124343. [P55808-3]
    GeneIDi7499.
    KEGGihsa:7499.
    UCSCiuc004cqp.3. human. [P55808-3]
    uc011mhg.2. human. [P55808-1]

    Polymorphism databases

    DMDMi2499136.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96421 Genomic DNA. No translation available.
    AF380356 mRNA. Translation: AAL04055.1 .
    AF534880 mRNA. Translation: AAN03481.1 .
    AC006209 Genomic DNA. No translation available.
    AC138085 Genomic DNA. No translation available.
    BC100765 mRNA. Translation: AAI00766.1 .
    BC100766 mRNA. Translation: AAI00767.1 .
    BC100767 mRNA. Translation: AAI00768.1 .
    CCDSi CCDS14120.1. [P55808-1 ]
    CCDS48073.1. [P55808-3 ]
    PIRi S43791.
    RefSeqi NP_001135391.1. NM_001141919.1. [P55808-3 ]
    NP_001135392.1. NM_001141920.1. [P55808-2 ]
    NP_780778.1. NM_175569.2. [P55808-1 ]
    UniGenei Hs.179675.

    3D structure databases

    ProteinModelPortali P55808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000411004.

    PTM databases

    PhosphoSitei P55808.

    Polymorphism databases

    DMDMi 2499136.

    Proteomic databases

    PaxDbi P55808.
    PRIDEi P55808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381174 ; ENSP00000370566 ; ENSG00000124343 . [P55808-1 ]
    ENST00000419513 ; ENSP00000411004 ; ENSG00000124343 . [P55808-3 ]
    GeneIDi 7499.
    KEGGi hsa:7499.
    UCSCi uc004cqp.3. human. [P55808-3 ]
    uc011mhg.2. human. [P55808-1 ]

    Organism-specific databases

    CTDi 7499.
    GeneCardsi GC0XP002663.
    H-InvDB HIX0213635.
    HGNCi HGNC:12806. XG.
    HPAi HPA021539.
    MIMi 300879. gene.
    314700. phenotype.
    neXtProti NX_P55808.
    PharmGKBi PA37405.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG124417.
    HOGENOMi HOG000233665.
    HOVERGENi HBG086239.
    OMAi GGNIYPR.
    OrthoDBi EOG780RPH.
    PhylomeDBi P55808.
    TreeFami TF336273.

    Miscellaneous databases

    ChiTaRSi XG. human.
    GenomeRNAii 7499.
    NextBioi 29368.
    PROi P55808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55808.
    Bgeei P55808.
    CleanExi HS_XG.
    Genevestigatori P55808.

    Family and domain databases

    InterProi IPR022078. CD99L2.
    [Graphical view ]
    Pfami PF12301. CD99L2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp."
      Ellis N.A., Ye T.Z., Patton S., German J., Goodfellow P.N., Weller P.
      Nat. Genet. 6:394-400(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Bone marrow.
    2. "Identification of PBDX gene highly expressed in human cornea."
      Naoko S., Fujiki K., Kanai A., Tanaka Y., Iwata T.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Naoko S., Tanaka Y., Iwata T.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASN-60.
    6. Cited for: SUBCELLULAR LOCATION.
    7. "A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells."
      Fouchet C., Gane P., Huet M., Fellous M., Rouger P., Banting G., Cartron J.P., Lopez C.
      Blood 95:1819-1826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiXG_HUMAN
    AccessioniPrimary (citable) accession number: P55808
    Secondary accession number(s): E9PCH1
    , Q496N8, Q496N9, Q496P0, Q71BZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3