Reviewed, UniProtKB/Swiss-Prot P55800 (MTLD_MYCMS)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	MSC_0017

Organism

Mycoplasma mycoides subsp. mycoides SC [Complete proteome] [HAMAP]

Taxonomic identifier

44101 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170711
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity
Experimental info
	Sequence conflict	176	1	S → R in AAC44573. Ref.2
	Sequence conflict	190	1	F → L in AAC44573. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P55800-1 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: 9995F74B7577876C	FASTA	328	38,565
	10 20 30 40 50 60 MNLIHFGAGN IGCGFIAPIL SSIVDHIYFV DNNIDIVNKI NTQKLIKIHT SDSKKISITN 70 80 90 100 110 120 ISAWLLTDFI NYKKTWNEVS LLTISIGIKN LKHIIYYVNQ LIDYKIKNNQ KLIIMCCENG 130 140 150 160 170 180 IRVSSLFKSY FSNLNNNIYF VDVLVDRIVS NKNILNDYLE CEDYYLWIVD KTQLPSDFKQ 190 200 210 220 230 240 VPNLTYTTSF DIQITKKIYM LNALHCSLAW FVFKNFSFNK YLYVYQALKN DKVVEFVNNY 250 260 270 280 290 300 LNEVILVLNH KYNINLDELN NYKNQIIKRL NSNFIKDDLK RLARNTELKL SKNERILTIL 310 320 DYAKDNNLKH DILLLSYQNG LEYLKNNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP)." Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M. Genome Res. 14:221-227(2004) [PubMed: 14762060] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PG1.
[2]	"Characterization of the gene for an immunodominant 72 kDa lipoprotein of Mycoplasma mycoides subsp. mycoides small colony type." Cheng X., Nicolet J., Miserez R., Kuhnert P., Krampe M., Pilloud T., Abdo E.-M., Griot C., Frey J. Microbiology 142:3515-3524(1996) [PubMed: 9004514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-328. Strain: L2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX293980 Genomic DNA. Translation: CAE76670.1. U61140 Genomic DNA. Translation: AAC44573.1.
RefSeq	NP_975028.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2744562.
GenomeReviews	Gene locus MSC_0017 in contig BX293980_GR.
KEGG	mmy:MSC_0017.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P55800.
Enzyme and pathway databases
BioCyc	MMYC272632:MSC_0017-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_MYCMS

Accession

Primary (citable) accession number: P55800

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 26, 2004
Last modified:	November 25, 2008
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)