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Protein

Apolipoprotein C-IV

Gene

Apoc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in lipoprotein metabolism.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
Apolipoprotein E-linked
ECL
Gene namesi
Name:Apoc4
Synonyms:Ecl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi70959. Apoc4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 12497Apolipoprotein C-IVPRO_0000002039Add
BLAST

Proteomic databases

PaxDbiP55797.
PRIDEiP55797.

PTM databases

PhosphoSiteiP55797.

Expressioni

Gene expression databases

GenevisibleiP55797. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024832.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55797.
OMAiKTHSLCP.
OrthoDBiEOG76MKBG.
PhylomeDBiP55797.
TreeFamiTF336879.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55797-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLRCRQQT LPSLCLSVLF LACFVASMPT ESLTPTPGPE NSRWSLVRAR
60 70 80 90 100
VMEMVEPLVT RTRDRWRWFW GPRAIQGFVQ TYYEDHLKDL GPRTQAWLQS
110 120
SRDHLLNKTH SLCPRLLCRD WTQG
Note: No experimental confirmation available.
Length:124
Mass (Da):14,532
Last modified:December 12, 2006 - v2
Checksum:i8C7CB8975D95D81F
GO
Isoform 2 (identifier: P55797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-124: Missing.

Note: No experimental confirmation available.
Show »
Length:69
Mass (Da):8,056
Checksum:iBDC2402FCF3F6311
GO

Sequence cautioni

The sequence CAA39653.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 12455Missing in isoform 2. 1 PublicationVSP_022002Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56190 mRNA. Translation: CAA39653.1. Sequence problems.
AA945171 mRNA. No translation available.
PIRiS25719.
RefSeqiNP_001102889.1. NM_001109419.1. [P55797-1]
UniGeneiRn.33157.

Genome annotation databases

EnsembliENSRNOT00000024832; ENSRNOP00000024832; ENSRNOG00000018405. [P55797-1]
GeneIDi680551.
KEGGirno:680551.
UCSCiRGD:70959. rat. [P55797-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56190 mRNA. Translation: CAA39653.1. Sequence problems.
AA945171 mRNA. No translation available.
PIRiS25719.
RefSeqiNP_001102889.1. NM_001109419.1. [P55797-1]
UniGeneiRn.33157.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024832.

PTM databases

PhosphoSiteiP55797.

Proteomic databases

PaxDbiP55797.
PRIDEiP55797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024832; ENSRNOP00000024832; ENSRNOG00000018405. [P55797-1]
GeneIDi680551.
KEGGirno:680551.
UCSCiRGD:70959. rat. [P55797-1]

Organism-specific databases

CTDi346.
RGDi70959. Apoc4.

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiP55797.
OMAiKTHSLCP.
OrthoDBiEOG76MKBG.
PhylomeDBiP55797.
TreeFamiTF336879.

Miscellaneous databases

NextBioi718962.
PROiP55797.

Gene expression databases

GenevisibleiP55797. RN.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two coding regions closely linked to the rat apolipoprotein E gene: nucleotide sequences of rat apolipoprotein C-I and ECL cDNA."
    Shen P., Howlett G.J.
    Arch. Biochem. Biophys. 297:345-353(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J., Kerlavage A.R., Adams M.D.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiAPOC4_RAT
AccessioniPrimary (citable) accession number: P55797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: November 11, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.