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Protein

Apolipoprotein C-IV

Gene

Apoc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in lipoprotein metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8866423 VLDL assembly
R-RNO-8964046 VLDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C4
Apolipoprotein E-linked
ECL
Gene namesi
Name:Apoc4
Synonyms:Ecl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi70959 Apoc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000203928 – 124Apolipoprotein C-IVAdd BLAST97

Proteomic databases

PaxDbiP55797
PRIDEiP55797

PTM databases

iPTMnetiP55797
PhosphoSitePlusiP55797

Expressioni

Gene expression databases

BgeeiENSRNOG00000018405
GenevisibleiP55797 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024832

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGNY Eukaryota
ENOG41118WT LUCA
GeneTreeiENSGT00390000015914
HOGENOMiHOG000034003
HOVERGENiHBG050550
InParanoidiP55797
OMAiKTHSLCP
OrthoDBiEOG091G12IF
PhylomeDBiP55797
TreeFamiTF336879

Family and domain databases

InterProiView protein in InterPro
IPR028120 APOC4
PANTHERiPTHR32288 PTHR32288, 1 hit
PfamiView protein in Pfam
PF15119 APOC4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55797-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLRCRQQT LPSLCLSVLF LACFVASMPT ESLTPTPGPE NSRWSLVRAR
60 70 80 90 100
VMEMVEPLVT RTRDRWRWFW GPRAIQGFVQ TYYEDHLKDL GPRTQAWLQS
110 120
SRDHLLNKTH SLCPRLLCRD WTQG
Note: No experimental confirmation available.
Length:124
Mass (Da):14,532
Last modified:December 12, 2006 - v2
Checksum:i8C7CB8975D95D81F
GO
Isoform 2 (identifier: P55797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-124: Missing.

Note: No experimental confirmation available.
Show »
Length:69
Mass (Da):8,056
Checksum:iBDC2402FCF3F6311
GO

Sequence cautioni

The sequence CAA39653 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02200270 – 124Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56190 mRNA Translation: CAA39653.1 Sequence problems.
AA945171 mRNA No translation available.
PIRiS25719
RefSeqiNP_001102889.1, NM_001109419.1 [P55797-1]
UniGeneiRn.33157

Genome annotation databases

EnsembliENSRNOT00000024832; ENSRNOP00000024832; ENSRNOG00000018405 [P55797-1]
GeneIDi680551
KEGGirno:680551
UCSCiRGD:70959 rat [P55797-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPOC4_RAT
AccessioniPrimary (citable) accession number: P55797
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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