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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

HNRNPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126945-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
FTP-3
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Gene namesi
Name:HNRNPH2
Synonyms:FTP3, HNRPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5042. HNRNPH2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3188.
OpenTargetsiENSG00000126945.
PharmGKBiPA162391316.

Polymorphism and mutation databases

BioMutaiHNRNPH2.
DMDMi2500576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818591 – 449Heterogeneous nuclear ribonucleoprotein H2Add BLAST449
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343852 – 449Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP55795.
MaxQBiP55795.
PaxDbiP55795.
PeptideAtlasiP55795.
PRIDEiP55795.

2D gel databases

REPRODUCTION-2DPAGEIPI00026230.

PTM databases

iPTMnetiP55795.
PhosphoSitePlusiP55795.
SwissPalmiP55795.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiENSG00000126945.
CleanExiHS_HNRNPH2.
GenevisibleiP55795. HS.

Organism-specific databases

HPAiCAB004436.
HPA000914.
HPA001359.
HPA016884.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MSI2Q96DH65EBI-352823,EBI-2462339
TEKT1Q969V45EBI-352823,EBI-10180409

Protein-protein interaction databases

BioGridi109429. 115 interactors.
IntActiP55795. 94 interactors.
MINTiMINT-2804293.
STRINGi9606.ENSP00000361927.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi112 – 117Combined sources6
Helixi124 – 130Combined sources7
Turni131 – 133Combined sources3
Beta strandi136 – 142Combined sources7
Beta strandi147 – 149Combined sources3
Beta strandi153 – 161Combined sources9
Helixi162 – 169Combined sources8
Turni170 – 173Combined sources4
Beta strandi176 – 179Combined sources4
Beta strandi182 – 186Combined sources5
Turni188 – 190Combined sources3
Beta strandi286 – 288Combined sources3
Beta strandi290 – 295Combined sources6
Helixi302 – 307Combined sources6
Beta strandi315 – 325Combined sources11
Beta strandi327 – 334Combined sources8
Beta strandi336 – 338Combined sources3
Helixi339 – 345Combined sources7
Beta strandi352 – 355Combined sources4
Beta strandi358 – 362Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
ProteinModelPortaliP55795.
SMRiP55795.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP55795.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP55795.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,264
Last modified:November 1, 1997 - v1
Checksum:iC892523A638F07C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA. No translation available.
U78027 Genomic DNA. Translation: AAB64202.1.
AL035422 Genomic DNA. Translation: CAB55879.2.
CH471115 Genomic DNA. Translation: EAX02864.1.
BC130343 mRNA. Translation: AAI30344.1.
BC130345 mRNA. Translation: AAI30346.1.
CCDSiCCDS14485.1.
RefSeqiNP_001027565.1. NM_001032393.2.
NP_062543.1. NM_019597.4.
UniGeneiHs.432485.

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945.
GeneIDi3188.
KEGGihsa:3188.
UCSCiuc004ehm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA. No translation available.
U78027 Genomic DNA. Translation: AAB64202.1.
AL035422 Genomic DNA. Translation: CAB55879.2.
CH471115 Genomic DNA. Translation: EAX02864.1.
BC130343 mRNA. Translation: AAI30344.1.
BC130345 mRNA. Translation: AAI30346.1.
CCDSiCCDS14485.1.
RefSeqiNP_001027565.1. NM_001032393.2.
NP_062543.1. NM_019597.4.
UniGeneiHs.432485.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
ProteinModelPortaliP55795.
SMRiP55795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109429. 115 interactors.
IntActiP55795. 94 interactors.
MINTiMINT-2804293.
STRINGi9606.ENSP00000361927.

PTM databases

iPTMnetiP55795.
PhosphoSitePlusiP55795.
SwissPalmiP55795.

Polymorphism and mutation databases

BioMutaiHNRNPH2.
DMDMi2500576.

2D gel databases

REPRODUCTION-2DPAGEIPI00026230.

Proteomic databases

EPDiP55795.
MaxQBiP55795.
PaxDbiP55795.
PeptideAtlasiP55795.
PRIDEiP55795.

Protocols and materials databases

DNASUi3188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945.
GeneIDi3188.
KEGGihsa:3188.
UCSCiuc004ehm.4. human.

Organism-specific databases

CTDi3188.
DisGeNETi3188.
GeneCardsiHNRNPH2.
HGNCiHGNC:5042. HNRNPH2.
HPAiCAB004436.
HPA000914.
HPA001359.
HPA016884.
MIMi300610. gene.
neXtProtiNX_P55795.
OpenTargetsiENSG00000126945.
PharmGKBiPA162391316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP55795.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP55795.
TreeFamiTF316157.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126945-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

EvolutionaryTraceiP55795.
GeneWikiiHNRPH2.
GenomeRNAii3188.
PROiP55795.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126945.
CleanExiHS_HNRNPH2.
GenevisibleiP55795. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH2_HUMAN
AccessioniPrimary (citable) accession number: P55795
Secondary accession number(s): A1L400, Q9HHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 181 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.