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UniProtKB - P55795 (HNRH2_HUMAN)

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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

HNRNPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

GO - Molecular functioni

  • RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
FTP-3
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
Gene namesi
Name:HNRNPH2
Synonyms:FTP3, HNRPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5042. HNRNPH2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked, syndromic, Bain type (MRXSB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSB patients manifest developmental delay, intellectual disability, autism, hypotonia, seizures, and dysmorphic facial features. Only females are affected.
See also OMIM:300986
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077233206R → Q in MRXSB. 1 Publication1
Natural variantiVAR_077234206R → W in MRXSB. 1 Publication1
Natural variantiVAR_077235209P → L in MRXSB. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi3188.
MIMi300986. phenotype.
OpenTargetsiENSG00000126945.
PharmGKBiPA162391316.

Polymorphism and mutation databases

BioMutaiHNRNPH2.
DMDMi2500576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818591 – 449Heterogeneous nuclear ribonucleoprotein H2Add BLAST449
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343852 – 449Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei90PhosphoserineBy similarity1
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP55795.
MaxQBiP55795.
PaxDbiP55795.
PeptideAtlasiP55795.
PRIDEiP55795.

2D gel databases

REPRODUCTION-2DPAGEiIPI00026230.

PTM databases

iPTMnetiP55795.
PhosphoSitePlusiP55795.
SwissPalmiP55795.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiENSG00000126945.
CleanExiHS_HNRNPH2.
GenevisibleiP55795. HS.

Organism-specific databases

HPAiCAB004436.
HPA000914.
HPA001359.
HPA016884.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109429. 116 interactors.
IntActiP55795. 95 interactors.
MINTiMINT-2804293.
STRINGi9606.ENSP00000361927.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi112 – 117Combined sources6
Helixi124 – 130Combined sources7
Turni131 – 133Combined sources3
Beta strandi136 – 142Combined sources7
Beta strandi147 – 149Combined sources3
Beta strandi153 – 161Combined sources9
Helixi162 – 169Combined sources8
Turni170 – 173Combined sources4
Beta strandi176 – 179Combined sources4
Beta strandi182 – 186Combined sources5
Turni188 – 190Combined sources3
Beta strandi286 – 288Combined sources3
Beta strandi290 – 295Combined sources6
Helixi302 – 307Combined sources6
Beta strandi315 – 325Combined sources11
Beta strandi327 – 334Combined sources8
Beta strandi336 – 338Combined sources3
Helixi339 – 345Combined sources7
Beta strandi352 – 355Combined sources4
Beta strandi358 – 362Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
ProteinModelPortaliP55795.
SMRiP55795.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP55795.
KOiK12898.
OMAiWSATHKE.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP55795.
TreeFamiTF316157.

Family and domain databases

InterProiView protein in InterPro
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
PfamiView protein in Pfam
PF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE 
        60         70         80         90        100
GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT 
       110        120        130        140        150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR 
       160        170        180        190        200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 
       210        220        230        240        250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN 
       260        270        280        290        300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 
       310        320        330        340        350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA 
       360        370        380        390        400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM 
       410        420        430        440 
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,264
Last modified:November 1, 1997 - v1
Checksum:iC892523A638F07C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077233206R → Q in MRXSB. 1 Publication1
Natural variantiVAR_077234206R → W in MRXSB. 1 Publication1
Natural variantiVAR_077235209P → L in MRXSB. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA. No translation available.
U78027 Genomic DNA. Translation: AAB64202.1.
AL035422 Genomic DNA. No translation available.
CH471115 Genomic DNA. Translation: EAX02864.1.
BC130343 mRNA. Translation: AAI30344.1.
BC130345 mRNA. Translation: AAI30346.1.
CCDSiCCDS14485.1.
RefSeqiNP_001027565.1. NM_001032393.2.
NP_062543.1. NM_019597.4.
UniGeneiHs.432485.

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945.
GeneIDi3188.
KEGGihsa:3188.
UCSCiuc004ehm.4. human.

Similar proteinsi

Entry informationi

Entry nameiHNRH2_HUMAN
AccessioniPrimary (citable) accession number: P55795
Secondary accession number(s): A1L400, Q9HHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references