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UniProtKB - P55795 (HNRH2_HUMAN)

UniProt

P55795 - HNRH2_HUMAN

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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

HNRNPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
FTP-3
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
Gene namesi
Name:HNRNPH2
Synonyms:FTP3, HNRPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5042. HNRNPH2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391316.

Polymorphism and mutation databases

BioMutaiHNRNPH2.
DMDMi2500576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Heterogeneous nuclear ribonucleoprotein H2PRO_0000081859Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 449448Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedPRO_0000434385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication
Modified residuei2 – 21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei233 – 2331Dimethylated arginine; alternateBy similarity
Modified residuei233 – 2331Omega-N-methylarginine; alternateBy similarity
Modified residuei246 – 2461PhosphotyrosineBy similarity
Modified residuei310 – 3101PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP55795.
MaxQBiP55795.
PaxDbiP55795.
PeptideAtlasiP55795.
PRIDEiP55795.

2D gel databases

REPRODUCTION-2DPAGEIPI00026230.

PTM databases

iPTMnetiP55795.
PhosphoSiteiP55795.
SwissPalmiP55795.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiENSG00000126945.
CleanExiHS_HNRNPH2.
GenevisibleiP55795. HS.

Organism-specific databases

HPAiCAB004436.
HPA000914.
HPA001359.
HPA016884.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MSI2Q96DH63EBI-352823,EBI-2462339
TEKT1Q969V43EBI-352823,EBI-10180409

Protein-protein interaction databases

BioGridi109429. 114 interactions.
IntActiP55795. 92 interactions.
MINTiMINT-2804293.
STRINGi9606.ENSP00000361927.

Structurei

Secondary structure

1
449
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi112 – 1176Combined sources
Helixi124 – 1307Combined sources
Turni131 – 1333Combined sources
Beta strandi136 – 1427Combined sources
Beta strandi147 – 1493Combined sources
Beta strandi153 – 1619Combined sources
Helixi162 – 1698Combined sources
Turni170 – 1734Combined sources
Beta strandi176 – 1794Combined sources
Beta strandi182 – 1865Combined sources
Turni188 – 1903Combined sources
Beta strandi286 – 2883Combined sources
Beta strandi290 – 2956Combined sources
Helixi302 – 3076Combined sources
Beta strandi315 – 32511Combined sources
Beta strandi327 – 3348Combined sources
Beta strandi336 – 3383Combined sources
Helixi339 – 3457Combined sources
Beta strandi352 – 3554Combined sources
Beta strandi358 – 3625Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
ProteinModelPortaliP55795.
SMRiP55795. Positions 4-193, 277-401.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9080RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18878RRM 2PROSITE-ProRule annotationAdd
BLAST
Repeati234 – 249161-1Add
BLAST
Domaini289 – 36476RRM 3PROSITE-ProRule annotationAdd
BLAST
Repeati354 – 372192-1Add
BLAST
Repeati374 – 392192-2Add
BLAST
Repeati418 – 433161-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 4332002 X 16 AA Gly-rich approximate repeatsAdd
BLAST
Regioni354 – 392392 X 19 AA perfect repeatsAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP55795.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP55795.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE 
        60         70         80         90        100
GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT 
       110        120        130        140        150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR 
       160        170        180        190        200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 
       210        220        230        240        250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN 
       260        270        280        290        300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 
       310        320        330        340        350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA 
       360        370        380        390        400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM 
       410        420        430        440 
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,264
Last modified:November 1, 1997 - v1
Checksum:iC892523A638F07C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA. No translation available.
U78027 Genomic DNA. Translation: AAB64202.1.
AL035422 Genomic DNA. Translation: CAB55879.2.
CH471115 Genomic DNA. Translation: EAX02864.1.
BC130343 mRNA. Translation: AAI30344.1.
BC130345 mRNA. Translation: AAI30346.1.
CCDSiCCDS14485.1.
RefSeqiNP_001027565.1. NM_001032393.2.
NP_062543.1. NM_019597.4.
UniGeneiHs.432485.

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945.
GeneIDi3188.
KEGGihsa:3188.
UCSCiuc004ehm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA. No translation available.
U78027 Genomic DNA. Translation: AAB64202.1.
AL035422 Genomic DNA. Translation: CAB55879.2.
CH471115 Genomic DNA. Translation: EAX02864.1.
BC130343 mRNA. Translation: AAI30344.1.
BC130345 mRNA. Translation: AAI30346.1.
CCDSiCCDS14485.1.
RefSeqiNP_001027565.1. NM_001032393.2.
NP_062543.1. NM_019597.4.
UniGeneiHs.432485.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
ProteinModelPortaliP55795.
SMRiP55795. Positions 4-193, 277-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109429. 114 interactions.
IntActiP55795. 92 interactions.
MINTiMINT-2804293.
STRINGi9606.ENSP00000361927.

PTM databases

iPTMnetiP55795.
PhosphoSiteiP55795.
SwissPalmiP55795.

Polymorphism and mutation databases

BioMutaiHNRNPH2.
DMDMi2500576.

2D gel databases

REPRODUCTION-2DPAGEIPI00026230.

Proteomic databases

EPDiP55795.
MaxQBiP55795.
PaxDbiP55795.
PeptideAtlasiP55795.
PRIDEiP55795.

Protocols and materials databases

DNASUi3188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945.
GeneIDi3188.
KEGGihsa:3188.
UCSCiuc004ehm.4. human.

Organism-specific databases

CTDi3188.
GeneCardsiHNRNPH2.
HGNCiHGNC:5042. HNRNPH2.
HPAiCAB004436.
HPA000914.
HPA001359.
HPA016884.
MIMi300610. gene.
neXtProtiNX_P55795.
PharmGKBiPA162391316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP55795.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP55795.
TreeFamiTF316157.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

EvolutionaryTraceiP55795.
GeneWikiiHNRPH2.
GenomeRNAii3188.
PROiP55795.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126945.
CleanExiHS_HNRNPH2.
GenevisibleiP55795. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH2_HUMAN
AccessioniPrimary (citable) accession number: P55795
Secondary accession number(s): A1L400, Q9HHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.