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Reviewed, UniProtKB/Swiss-Prot P55789 (ALR_HUMAN)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    FAD-linked sulfhydryl oxidase ALR
    EC=1.8.3.2
Alternative name(s):
    Augmenter of liver regeneration
      Short name=hERV1
    Hepatopoietin
Gene names
Name: GFER
Synonyms: ALR, HERV1, HPO
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.

Catalytic activity

4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.

Cofactor

FAD By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Sequence caution

The sequence AAA96390.2 differs from that shown. Reason: Frameshift at position 70.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205FAD-linked sulfhydryl oxidase ALR
PRO_0000208548

Regions

Domain95 – 195101ERV/ALR sulfhydryl oxidase

Amino acid modifications

Modified residue591Phosphoserine Ref.7
Disulfide bond95Interchain (with C-124) By similarity
Disulfide bond142 ↔ 145Redox-active Potential
Disulfide bond171 ↔ 188 By similarity
Disulfide bond204Interchain (with C-15) By similarity

Experimental info

Sequence conflict301L → S in AAA96390. Ref.5
Sequence conflict1271Q → R in AAG38105. Ref.2
Sequence conflict1801K → E in AAG38105. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55789-1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 43CBF8CCB5BA91C8

FASTA20523,449
        10         20         30         40         50         60 
MAAPGERGRF HGGNLFFLPG GARSEMMDDL ATDARGRGAG RRDAAASAST PAQAPTSDSP 

        70         80         90        100        110        120 
VAEDASRRRP CRACVDFKTW MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL 

       130        140        150        160        170        180 
PTPEQQQDMA QFIHLFSKFY PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK 

       190        200 
LGKPDFDCSK VDERWRDGWK DGSCD 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure, chromosomal localization, and characterization of a functional promoter for human hepatopoietin (HPO) gene."
Liu M.-M., He F.-C., Wei H.-D., Zhou W.-Q.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Isolation of human HPO cDNA from human liver tissue."
Jun L., Wangxiang X., Xiaoming Y.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed: 15616553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-205.
Tissue: Placenta and Skin.
[5]"Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis."
Cheng J., Zhong Y.
Zhonghua Gan Zang Bing Za Zhi 8:12-14(2000) [PubMed: 10712775] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-205.
[6]"A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast."
Lisowsky T., Weinstat-Saslow D.L., Barton N., Reeders S.T., Schneider M.C.
Genomics 29:690-697(1995) [PubMed: 8575761] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-205.
Tissue: Renal cyst lining cell.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF183892 Genomic DNA. Translation: AAD56538.1. Different initiation.
AF306863 mRNA. Translation: AAG38105.1.
AC005606 Genomic DNA. No translation available.
BC002429 mRNA. Translation: AAH02429.1. Different initiation.
BC028348 mRNA. Translation: AAH28348.2. Different initiation.
AF146394 Genomic DNA. Translation: AAD36986.1. Different initiation.
U31176 mRNA. Translation: AAA96390.2. Frameshift.
IPIIPI00902969.
RefSeqNP_005253.3.
UniGeneHs.27184

3D structure databases

HSSPHSSP built from PDB template 1OQC based on UniProtKB Q63042.
SMRP55789. Positions 13-124.
ModBaseSearch...

Protein-protein interaction databases

IntActP55789. 1 interaction.

Proteomic databases

PRIDEP55789.

Genome annotation databases

EnsemblENSG00000127554. Homo sapiens. [Contig view]
GeneID2671.

Organism-specific databases

GeneCardsGC16P001974.
H-InvDBHIX0012707.
HGNCHGNC:4236. GFER.
MIM600924. gene.
PharmGKBPA28648.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP55789.
OMAP55789. CTDFKSW.

Enzyme and pathway databases

BRENDA1.8.3.2. 247.

Gene expression databases

ArrayExpressP55789.
BgeeP55789.
CleanExHS_GFER.
GermOnlineENSG00000127554. Homo sapiens.

Family and domain databases

InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR006863. Evr1_Alr.
[Graphical view]
Gene3DG3DSA:1.20.120.310. Evr1_Alr. 1 hit.
PfamPF04777. Evr1_Alr. 1 hit.
[Graphical view]
PROSITEPS51324. ERV_ALR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio10542.
SOURCESearch...

Entry information

Entry nameALR_HUMAN
AccessionPrimary (citable) accession number: P55789
Secondary accession number(s): Q8TAH6, Q9H290, Q9UK40
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 16, 2008
Last modified: June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents