Reviewed, UniProtKB/Swiss-Prot P55789 (ALR_HUMAN)

Names and origin

Protein names

Recommended name:
    FAD-linked sulfhydryl oxidase ALR
    EC=1.8.3.2
Alternative name(s):
    Augmenter of liver regeneration
      Short name=hERV1

Gene names

Name:	GFER
Synonyms:	ALR, HERV1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.
Cofactor	FAD By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cell proliferation Non-traceable author statement. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: InterPro spermatogenesis Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB thiol oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	FAD-linked sulfhydryl oxidase ALR		PRO_0000208548
Regions
	Domain	15 – 115	101	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Disulfide bond	15		Interchain (with C-124) By similarity
	Disulfide bond	62 ↔ 65		Redox-active Potential
	Disulfide bond	91 ↔ 108		By similarity
	Disulfide bond	124		Interchain (with C-15) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55789-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 3F0B927DC64EF606	FASTA	125	15,029
	10 20 30 40 50 60 MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL PTPEQQQDMA QFIHLFSKFY 70 80 90 100 110 120 PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK LGKPDFDCSK VDERWRDGWK DGSCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast." Lisowsky T., Weinstat-Saslow D.L., Barton N., Reeders S.T., Schneider M.C. Genomics 29:690-697(1995) [PubMed: 8575761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Renal cyst lining cell.
[2]	"Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis." Cheng J., Zhong Y. Zhonghua Gan Zang Bing Za Zhi 8:12-14(2000) [PubMed: 10712775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U31176 mRNA. Translation: AAA96390.2. AF146394 Genomic DNA. Translation: AAD36986.1. BC002429 mRNA. Translation: AAH02429.1. BC028348 mRNA. Translation: AAH28348.2.
UniGene	Hs.27184
3D structure databases
HSSP	HSSP built from PDB template 1OQC based on UniProtKB Q63042.
SMR	P55789. Positions 13-124.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55789.
Genome annotation databases
Ensembl	ENSG00000127554. Homo sapiens. [Contig view]
Organism-specific databases
H-InvDB	HIX0012707.
HGNC	HGNC:4236. GFER.
MIM	600924. gene.
PharmGKB	PA28648.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P55789.
Gene expression databases
ArrayExpress	P55789.
CleanEx	HS_GFER.
GermOnline	ENSG00000127554. Homo sapiens.
Family and domain databases
InterPro	IPR006863. Evr1_Alr. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit.
Pfam	PF04777. Evr1_Alr. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ALR_HUMAN

Accession

Primary (citable) accession number: P55789
Secondary accession number(s): Q8TAH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)