Reviewed, UniProtKB/Swiss-Prot P55789 (ALR_HUMAN)

Names and origin

Protein names

Recommended name:
    FAD-linked sulfhydryl oxidase ALR
    EC=1.8.3.2
Alternative name(s):
    Augmenter of liver regeneration
      Short name=hERV1
    Hepatopoietin

Gene names

Name:	GFER
Synonyms:	ALR, HERV1, HPO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	FAD By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Contains 1 ERV/ALR sulfhydryl oxidase domain.
Sequence caution	The sequence AAA96390.2 differs from that shown. Reason: Frameshift at position 70.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Disulfide bond Phosphoprotein
Gene Ontology (GO)
Biological process	cell proliferation Non-traceable author statement. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB thiol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	FAD-linked sulfhydryl oxidase ALR		PRO_0000208548
Regions
	Domain	95 – 195	101	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Modified residue	59	1	Phosphoserine Ref.7
	Disulfide bond	95		Interchain (with C-124) By similarity
	Disulfide bond	142 ↔ 145		Redox-active Potential
	Disulfide bond	171 ↔ 188		By similarity
	Disulfide bond	204		Interchain (with C-15) By similarity
Experimental info
	Sequence conflict	30	1	L → S in AAA96390. Ref.5
	Sequence conflict	127	1	Q → R in AAG38105. Ref.2
	Sequence conflict	180	1	K → E in AAG38105. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P55789-1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 43CBF8CCB5BA91C8	FASTA	205	23,449
	10 20 30 40 50 60 MAAPGERGRF HGGNLFFLPG GARSEMMDDL ATDARGRGAG RRDAAASAST PAQAPTSDSP 70 80 90 100 110 120 VAEDASRRRP CRACVDFKTW MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL 130 140 150 160 170 180 PTPEQQQDMA QFIHLFSKFY PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK 190 200 LGKPDFDCSK VDERWRDGWK DGSCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure, chromosomal localization, and characterization of a functional promoter for human hepatopoietin (HPO) gene." Liu M.-M., He F.-C., Wei H.-D., Zhou W.-Q. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Isolation of human HPO cDNA from human liver tissue." Jun L., Wangxiang X., Xiaoming Y. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-205. Tissue: Placenta and Skin.
[5]	"Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis." Cheng J., Zhong Y. Zhonghua Gan Zang Bing Za Zhi 8:12-14(2000) [PubMed: 10712775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-205.
[6]	"A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast." Lisowsky T., Weinstat-Saslow D.L., Barton N., Reeders S.T., Schneider M.C. Genomics 29:690-697(1995) [PubMed: 8575761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-205. Tissue: Renal cyst lining cell.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF183892 Genomic DNA. Translation: AAD56538.1. Different initiation. AF306863 mRNA. Translation: AAG38105.1. AC005606 Genomic DNA. No translation available. BC002429 mRNA. Translation: AAH02429.1. Different initiation. BC028348 mRNA. Translation: AAH28348.2. Different initiation. AF146394 Genomic DNA. Translation: AAD36986.1. Different initiation. U31176 mRNA. Translation: AAA96390.2. Frameshift.
IPI	IPI00902969.
RefSeq	NP_005253.3.
UniGene	Hs.27184
3D structure databases
HSSP	HSSP built from PDB template 1OQC based on UniProtKB Q63042.
SMR	P55789. Positions 13-124.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55789. 1 interaction.
Proteomic databases
PRIDE	P55789.
Genome annotation databases
Ensembl	ENSG00000127554. Homo sapiens. [Contig view]
GeneID	2671.
Organism-specific databases
GeneCards	GC16P001974.
H-InvDB	HIX0012707.
HGNC	HGNC:4236. GFER.
MIM	600924. gene.
PharmGKB	PA28648.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P55789.
OMA	P55789. CTDFKSW.
Enzyme and pathway databases
BRENDA	1.8.3.2. 247.
Gene expression databases
ArrayExpress	P55789.
Bgee	P55789.
CleanEx	HS_GFER.
GermOnline	ENSG00000127554. Homo sapiens.
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit.
Pfam	PF04777. Evr1_Alr. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	10542.
SOURCE	Search...

Entry information

Entry name

ALR_HUMAN

Accession

Primary (citable) accession number: P55789
Secondary accession number(s): Q8TAH6, Q9H290, Q9UK40

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 16, 2008
Last modified:	June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)