Reviewed,
UniProtKB/Swiss-Prot P55789 (ALR_HUMAN)
Last modified
November 25, 2008.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: FAD-linked sulfhydryl oxidase ALR EC=1.8.3.2 Alternative name(s): Augmenter of liver regeneration Short name=hERV1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 125 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity. |
| Catalytic activity | 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O. |
| Cofactor | FAD By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Contains 1 ERV/ALR sulfhydryl oxidase domain. |
Ontologies
Keywords | |
|---|---|
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | cell proliferation Non-traceable author statement. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: InterPro spermatogenesisNon-traceable author statement. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB thiol oxidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 125 | 125 | FAD-linked sulfhydryl oxidase ALR | PRO_0000208548 | |||||||
Regions | |||||||||||
| Domain | 15 – 115 | 101 | ERV/ALR sulfhydryl oxidase | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 15 | Interchain (with C-124) By similarity | |||||||||
| Disulfide bond | 62 ↔ 65 | Redox-active Potential | |||||||||
| Disulfide bond | 91 ↔ 108 | By similarity | |||||||||
| Disulfide bond | 124 | Interchain (with C-15) By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast." Lisowsky T., Weinstat-Saslow D.L., Barton N., Reeders S.T., Schneider M.C. Genomics 29:690-697(1995) [PubMed: 8575761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Renal cyst lining cell. |
| [2] | "Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis." Cheng J., Zhong Y. Zhonghua Gan Zang Bing Za Zhi 8:12-14(2000) [PubMed: 10712775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U31176 mRNA. Translation: AAA96390.2. AF146394 Genomic DNA. Translation: AAD36986.1. BC002429 mRNA. Translation: AAH02429.1. BC028348 mRNA. Translation: AAH28348.2. | |
| UniGene | Hs.27184 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OQC based on UniProtKB Q63042. |
| SMR | P55789. Positions 13-124. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P55789. |
Genome annotation databases | |
| Ensembl | ENSG00000127554. Homo sapiens. [Contig view] |
Organism-specific databases | |
| H-InvDB | HIX0012707. |
| HGNC | HGNC:4236. GFER. |
| MIM | 600924. gene. |
| PharmGKB | PA28648. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P55789. |
Gene expression databases | |
| ArrayExpress | P55789. |
| CleanEx | HS_GFER. |
| GermOnline | ENSG00000127554. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006863. Evr1_Alr. [Graphical view] |
| Gene3D | G3DSA:1.20.120.310. Evr1_Alr. 1 hit. |
| Pfam | PF04777. Evr1_Alr. 1 hit. [Graphical view] |
| PROSITE | PS51324. ERV_ALR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ALR_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P55789 Secondary accession number(s): Q8TAH6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


