Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P55785 (HEPS2_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heptaprenyl diphosphate synthase component 2

Short name=HepPP synthase subunit 2
EC=2.5.1.30
Gene names
Name:hepT
Synonyms:hepS-2
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

Catalytic activity

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subunit structure

Heterodimer of component I and II.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Heptaprenyl diphosphate synthase component 2
PRO_0000124003

Sites

Metal binding841Magnesium 1 By similarity
Metal binding841Magnesium 2 By similarity
Metal binding881Magnesium 1 By similarity
Metal binding881Magnesium 2 By similarity
Metal binding2111Magnesium 3 By similarity
Binding site451Isopentenyl diphosphate By similarity
Binding site481Isopentenyl diphosphate By similarity
Binding site771Isopentenyl diphosphate By similarity
Binding site931Hexaprenyl diphosphate By similarity
Binding site941Isopentenyl diphosphate By similarity
Binding site1701Hexaprenyl diphosphate By similarity
Binding site1711Hexaprenyl diphosphate By similarity
Binding site2081Hexaprenyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P55785 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A51B6630E6B88F46

FASTA32035,808
        10         20         30         40         50         60 
MKLKAMYSFL SDDLAAVEEE LERAVQSEYG PLGEAALHLL QAGGKRIRPV FVLLAARFGQ 

        70         80         90        100        110        120 
YDLERMKHVA VALELIHMAS LVHDDVIDDA DLRRGRPTIK AKWSNRFAMY TGDYLFARSL 

       130        140        150        160        170        180 
ERMAELGNPR AHQVLAKTIV EVCRGEIEQI KDKYRFDQPL RTYLRRIRRK TALLIAASCQ 

       190        200        210        220        230        240 
LGALAAGAPE PIVKRLYWFG HYVGMSFQIT DDILDFTGTE EQLGKPAGSD LLQGNVTLPV 

       250        260        270        280        290        300 
LYALSDERVK AAIAAVGPET DVAEMAAVIS AIKRTDAIER SYALSDRYLD KALHLLDGLP 

       310        320 
MNEARGLLRD LALYIGKRDY 

« Hide

References

[1]"Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
Koike-Takeshita A., Koyama T., Obata S., Ogura K.
J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49976 Genomic DNA. Translation: BAA08725.1.

3D structure databases

ProteinModelPortalP55785.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR014119. GerC3_HepT.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERPTHR12001. PTHR12001. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR02748. GerC3_HepT. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEPS2_GEOSE
AccessionPrimary (citable) accession number: P55785
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families