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P55785

- HEPS2_GEOSE

UniProt

P55785 - HEPS2_GEOSE

Protein

Heptaprenyl diphosphate synthase component 2

Gene

hepT

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    • Comment

    Functioni

    Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451Isopentenyl diphosphateBy similarity
    Binding sitei48 – 481Isopentenyl diphosphateBy similarity
    Binding sitei77 – 771Isopentenyl diphosphateBy similarity
    Metal bindingi84 – 841Magnesium 1By similarity
    Metal bindingi84 – 841Magnesium 2By similarity
    Metal bindingi88 – 881Magnesium 1By similarity
    Metal bindingi88 – 881Magnesium 2By similarity
    Binding sitei93 – 931Hexaprenyl diphosphateBy similarity
    Binding sitei94 – 941Isopentenyl diphosphateBy similarity
    Binding sitei170 – 1701Hexaprenyl diphosphateBy similarity
    Binding sitei171 – 1711Hexaprenyl diphosphateBy similarity
    Binding sitei208 – 2081Hexaprenyl diphosphateBy similarity
    Metal bindingi211 – 2111Magnesium 3By similarity

    GO - Molecular functioni

    1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW
    2. menaquinone biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heptaprenyl diphosphate synthase component 2 (EC:2.5.1.30)
    Short name:
    HepPP synthase subunit 2
    Gene namesi
    Name:hepT
    Synonyms:hepS-2
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Heptaprenyl diphosphate synthase component 2PRO_0000124003Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of component I and II.

    Structurei

    3D structure databases

    ProteinModelPortaliP55785.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR014119. GerC3_HepT.
    IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PANTHERiPTHR12001. PTHR12001. 1 hit.
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR02748. GerC3_HepT. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55785-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLKAMYSFL SDDLAAVEEE LERAVQSEYG PLGEAALHLL QAGGKRIRPV    50
    FVLLAARFGQ YDLERMKHVA VALELIHMAS LVHDDVIDDA DLRRGRPTIK 100
    AKWSNRFAMY TGDYLFARSL ERMAELGNPR AHQVLAKTIV EVCRGEIEQI 150
    KDKYRFDQPL RTYLRRIRRK TALLIAASCQ LGALAAGAPE PIVKRLYWFG 200
    HYVGMSFQIT DDILDFTGTE EQLGKPAGSD LLQGNVTLPV LYALSDERVK 250
    AAIAAVGPET DVAEMAAVIS AIKRTDAIER SYALSDRYLD KALHLLDGLP 300
    MNEARGLLRD LALYIGKRDY 320
    Length:320
    Mass (Da):35,808
    Last modified:November 1, 1997 - v1
    Checksum:iA51B6630E6B88F46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49976 Genomic DNA. Translation: BAA08725.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49976 Genomic DNA. Translation: BAA08725.1 .

    3D structure databases

    ProteinModelPortali P55785.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR014119. GerC3_HepT.
    IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    PANTHERi PTHR12001. PTHR12001. 1 hit.
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR02748. GerC3_HepT. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
      Koike-Takeshita A., Koyama T., Obata S., Ogura K.
      J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

    Entry informationi

    Entry nameiHEPS2_GEOSE
    AccessioniPrimary (citable) accession number: P55785
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3