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P55785

- HEPS2_GEOSE

UniProt

P55785 - HEPS2_GEOSE

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Protein
Heptaprenyl diphosphate synthase component 2
Gene
hepT, hepS-2
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

Cofactori

Binds 3 magnesium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Isopentenyl diphosphate By similarity
Binding sitei48 – 481Isopentenyl diphosphate By similarity
Binding sitei77 – 771Isopentenyl diphosphate By similarity
Metal bindingi84 – 841Magnesium 1 By similarity
Metal bindingi84 – 841Magnesium 2 By similarity
Metal bindingi88 – 881Magnesium 1 By similarity
Metal bindingi88 – 881Magnesium 2 By similarity
Binding sitei93 – 931Hexaprenyl diphosphate By similarity
Binding sitei94 – 941Isopentenyl diphosphate By similarity
Binding sitei170 – 1701Hexaprenyl diphosphate By similarity
Binding sitei171 – 1711Hexaprenyl diphosphate By similarity
Binding sitei208 – 2081Hexaprenyl diphosphate By similarity
Metal bindingi211 – 2111Magnesium 3 By similarity

GO - Molecular functioni

  1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. menaquinone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heptaprenyl diphosphate synthase component 2 (EC:2.5.1.30)
Short name:
HepPP synthase subunit 2
Gene namesi
Name:hepT
Synonyms:hepS-2
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Heptaprenyl diphosphate synthase component 2
PRO_0000124003Add
BLAST

Interactioni

Subunit structurei

Heterodimer of component I and II.

Structurei

3D structure databases

ProteinModelPortaliP55785.

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR014119. GerC3_HepT.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR02748. GerC3_HepT. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55785-1 [UniParc]FASTAAdd to Basket

« Hide

MKLKAMYSFL SDDLAAVEEE LERAVQSEYG PLGEAALHLL QAGGKRIRPV    50
FVLLAARFGQ YDLERMKHVA VALELIHMAS LVHDDVIDDA DLRRGRPTIK 100
AKWSNRFAMY TGDYLFARSL ERMAELGNPR AHQVLAKTIV EVCRGEIEQI 150
KDKYRFDQPL RTYLRRIRRK TALLIAASCQ LGALAAGAPE PIVKRLYWFG 200
HYVGMSFQIT DDILDFTGTE EQLGKPAGSD LLQGNVTLPV LYALSDERVK 250
AAIAAVGPET DVAEMAAVIS AIKRTDAIER SYALSDRYLD KALHLLDGLP 300
MNEARGLLRD LALYIGKRDY 320
Length:320
Mass (Da):35,808
Last modified:November 1, 1997 - v1
Checksum:iA51B6630E6B88F46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49976 Genomic DNA. Translation: BAA08725.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49976 Genomic DNA. Translation: BAA08725.1 .

3D structure databases

ProteinModelPortali P55785.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR014119. GerC3_HepT.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR02748. GerC3_HepT. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
    Koike-Takeshita A., Koyama T., Obata S., Ogura K.
    J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Entry informationi

Entry nameiHEPS2_GEOSE
AccessioniPrimary (citable) accession number: P55785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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