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P55784 (HEPS1_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Heptaprenyl diphosphate synthase component 1

Short name=HepPP synthase subunit 1
EC=2.5.1.30
Gene names
Name:hepS
Synonyms:hepS-1
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

Catalytic activity

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

Subunit structure

Heterodimer of component I and II.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Heptaprenyl diphosphate synthase component 1
PRO_0000124001

Sequences

Sequence LengthMass (Da)Tools
P55784 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: B536580918437D20

FASTA22024,636
        10         20         30         40         50         60 
MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD LYSGLYYELL 

        70         80         90        100        110        120 
ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA VGTIESALLV KLADRMAAPQ 

       130        140        150        160        170        180 
WGQFAYSYLL MRRLLLEQEA FIRTGASVLF EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI 

       190        200        210        220 
DGCREALFAA KLPVNGLLQL RVAELSGGFQ AIAKKTVEEG 

« Hide

References

[1]"Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
Koike-Takeshita A., Koyama T., Obata S., Ogura K.
J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49975 Genomic DNA. Translation: BAA08724.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR009920. HEPPP_synth_su1.
[Graphical view]
PfamPF07307. HEPPP_synt_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEPS1_GEOSE
AccessionPrimary (citable) accession number: P55784
Secondary accession number(s): P94455
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 13, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program