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P55784

- HEPS1_GEOSE

UniProt

P55784 - HEPS1_GEOSE

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Protein
Heptaprenyl diphosphate synthase component 1
Gene
hepS, hepS-1
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

GO - Molecular functioni

  1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
  2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. menaquinone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Heptaprenyl diphosphate synthase component 1 (EC:2.5.1.30)
Short name:
HepPP synthase subunit 1
Gene namesi
Name:hepS
Synonyms:hepS-1
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Heptaprenyl diphosphate synthase component 1
PRO_0000124001Add
BLAST

Interactioni

Subunit structurei

Heterodimer of component I and II.

Family & Domainsi

Family and domain databases

InterProiIPR009920. HEPPP_synth_su1.
[Graphical view]
PfamiPF07307. HEPPP_synt_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55784-1 [UniParc]FASTAAdd to Basket

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MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD    50
LYSGLYYELL ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA 100
VGTIESALLV KLADRMAAPQ WGQFAYSYLL MRRLLLEQEA FIRTGASVLF 150
EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI DGCREALFAA KLPVNGLLQL 200
RVAELSGGFQ AIAKKTVEEG 220
Length:220
Mass (Da):24,636
Last modified:May 30, 2000 - v2
Checksum:iB536580918437D20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49975 Genomic DNA. Translation: BAA08724.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49975 Genomic DNA. Translation: BAA08724.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR009920. HEPPP_synth_su1.
[Graphical view ]
Pfami PF07307. HEPPP_synt_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
    Koike-Takeshita A., Koyama T., Obata S., Ogura K.
    J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Entry informationi

Entry nameiHEPS1_GEOSE
AccessioniPrimary (citable) accession number: P55784
Secondary accession number(s): P94455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 13, 2013
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program