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Protein

Heptaprenyl diphosphate synthase component 1

Gene

hepS

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

GO - Molecular functioni

  1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
  2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
  2. menaquinone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis

Enzyme and pathway databases

BRENDAi2.5.1.30. 623.

Names & Taxonomyi

Protein namesi
Recommended name:
Heptaprenyl diphosphate synthase component 1 (EC:2.5.1.30)
Short name:
HepPP synthase subunit 1
Gene namesi
Name:hepS
Synonyms:hepS-1
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Heptaprenyl diphosphate synthase component 1PRO_0000124001Add
BLAST

Interactioni

Subunit structurei

Heterodimer of component I and II.

Family & Domainsi

Family and domain databases

InterProiIPR009920. HEPPP_synth_su1.
[Graphical view]
PfamiPF07307. HEPPP_synt_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD
60 70 80 90 100
LYSGLYYELL ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA
110 120 130 140 150
VGTIESALLV KLADRMAAPQ WGQFAYSYLL MRRLLLEQEA FIRTGASVLF
160 170 180 190 200
EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI DGCREALFAA KLPVNGLLQL
210 220
RVAELSGGFQ AIAKKTVEEG
Length:220
Mass (Da):24,636
Last modified:May 29, 2000 - v2
Checksum:iB536580918437D20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49975 Genomic DNA. Translation: BAA08724.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49975 Genomic DNA. Translation: BAA08724.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.5.1.30. 623.

Family and domain databases

InterProiIPR009920. HEPPP_synth_su1.
[Graphical view]
PfamiPF07307. HEPPP_synt_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
    Koike-Takeshita A., Koyama T., Obata S., Ogura K.
    J. Biol. Chem. 270:18396-18400(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Entry informationi

Entry nameiHEPS1_GEOSE
AccessioniPrimary (citable) accession number: P55784
Secondary accession number(s): P94455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: May 29, 2000
Last modified: March 31, 2015
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.