P55784 (HEPS1_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heptaprenyl diphosphate synthase component 1
Short name=HepPP synthase subunit 1
EC=2.5.1.30

Gene names

Name:	hepS
Synonyms:	hepS-1

Organism

Geobacillus stearothermophilus (Bacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).
Catalytic activity	(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.
Subunit structure	Heterodimer of component I and II.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW menaquinone biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	trans-hexaprenyltranstransferase activity Inferred from electronic annotation. Source: EC transferase activity, transferring alkyl or aryl (other than methyl) groups Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Heptaprenyl diphosphate synthase component 1		PRO_0000124001

Sequences

	Sequence		Length	Mass (Da)
	P55784 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: B536580918437D20	FASTA	220	24,636
	10 20 30 40 50 60 MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD LYSGLYYELL 70 80 90 100 110 120 ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA VGTIESALLV KLADRMAAPQ 130 140 150 160 170 180 WGQFAYSYLL MRRLLLEQEA FIRTGASVLF EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI 190 200 210 220 DGCREALFAA KLPVNGLLQL RVAELSGGFQ AIAKKTVEEG

References

[1]

"Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis." Koike-Takeshita A., Koyama T., Obata S., Ogura K. J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49975 Genomic DNA. Translation: BAA08724.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009920. HEPPP_synth_su1. [Graphical view]
Pfam	PF07307. HEPPP_synt_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEPS1_GEOSE

Accession

Primary (citable) accession number: P55784
Secondary accession number(s): P94455

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	April 3, 2013
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program