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P55784

- HEPS1_GEOSE

UniProt

P55784 - HEPS1_GEOSE

Protein

Heptaprenyl diphosphate synthase component 1

Gene

hepS

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 40 (13 Nov 2013)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7).

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate.

    GO - Molecular functioni

    1. heptaprenyl diphosphate synthase activity Source: UniProtKB-EC
    2. transferase activity, transferring alkyl or aryl (other than methyl) groups Source: UniProtKB

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW
    2. menaquinone biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heptaprenyl diphosphate synthase component 1 (EC:2.5.1.30)
    Short name:
    HepPP synthase subunit 1
    Gene namesi
    Name:hepS
    Synonyms:hepS-1
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Heptaprenyl diphosphate synthase component 1PRO_0000124001Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of component I and II.

    Family & Domainsi

    Family and domain databases

    InterProiIPR009920. HEPPP_synth_su1.
    [Graphical view]
    PfamiPF07307. HEPPP_synt_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55784-1 [UniParc]FASTAAdd to Basket

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    MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD    50
    LYSGLYYELL ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA 100
    VGTIESALLV KLADRMAAPQ WGQFAYSYLL MRRLLLEQEA FIRTGASVLF 150
    EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI DGCREALFAA KLPVNGLLQL 200
    RVAELSGGFQ AIAKKTVEEG 220
    Length:220
    Mass (Da):24,636
    Last modified:May 30, 2000 - v2
    Checksum:iB536580918437D20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49975 Genomic DNA. Translation: BAA08724.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49975 Genomic DNA. Translation: BAA08724.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR009920. HEPPP_synth_su1.
    [Graphical view ]
    Pfami PF07307. HEPPP_synt_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis."
      Koike-Takeshita A., Koyama T., Obata S., Ogura K.
      J. Biol. Chem. 270:18396-18400(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10149 / DSM 6790 / JCM 11297 / NRS T15.

    Entry informationi

    Entry nameiHEPS1_GEOSE
    AccessioniPrimary (citable) accession number: P55784
    Secondary accession number(s): P94455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: November 13, 2013
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program