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Protein

C-C motif chemokine 18

Gene

CCL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.2 Publications

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell communication Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: ProtInc
  • inflammatory response Source: GO_Central
  • lymphocyte chemotaxis Source: GO_Central
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • positive regulation of inflammatory response Source: GO_Central
  • response to biotic stimulus Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 18
Alternative name(s):
Alternative macrophage activation-associated CC chemokine 1
Short name:
AMAC-1
CC chemokine PARC
Dendritic cell chemokine 1
Short name:
DC-CK1
Macrophage inflammatory protein 4
Short name:
MIP-4
Pulmonary and activation-regulated chemokine
Small-inducible cytokine A18
Cleaved into the following 3 chains:
Gene namesi
Name:CCL18
Synonyms:AMAC1, DCCK1, MIP4, PARC, SCYA18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10616. CCL18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6362.
OpenTargetsiENSG00000275385.
ENSG00000278006.
ENSG00000278167.
PharmGKBiPA35549.

Polymorphism and mutation databases

BioMutaiCCL18.
DMDMi2493666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000521221 – 89C-C motif chemokine 18Add BLAST69
ChainiPRO_000004185121 – 88CCL18(1-68)Add BLAST68
ChainiPRO_000004185223 – 89CCL18(3-69)Add BLAST67
ChainiPRO_000004185324 – 89CCL18(4-69)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 541 Publication
Disulfide bondi31 ↔ 701 Publication

Post-translational modificationi

The Cys-30/Cys-54 disulfide bond is required for activity.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55774.
PeptideAtlasiP55774.
PRIDEiP55774.

Expressioni

Tissue specificityi

Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.1 Publication

Inductioni

Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.1 Publication

Gene expression databases

BgeeiENSG00000006074.
CleanExiHS_AMAC1.
HS_CCL18.
GenevisibleiP55774. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PITPNM3Q9BZ714EBI-711240,EBI-2815766

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi112265. 6 interactors.
IntActiP55774. 7 interactors.
MINTiMINT-1373449.
STRINGi9606.ENSP00000004921.

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Helixi26 – 29Combined sources4
Helixi41 – 43Combined sources3
Beta strandi44 – 49Combined sources6
Beta strandi59 – 63Combined sources5
Beta strandi68 – 71Combined sources4
Helixi76 – 86Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHEX-ray2.10A/B/C/D21-89[»]
ProteinModelPortaliP55774.
SMRiP55774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
InParanoidiP55774.
KOiK05514.
OMAiYSETSPQ.
OrthoDBiEOG091G14Y2.
PhylomeDBiP55774.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLAAALLV LVCTMALCSC AQVGTNKELC CLVYTSWQIP QKFIVDYSET
60 70 80
SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA
Length:89
Mass (Da):9,849
Last modified:November 1, 1997 - v1
Checksum:iC287B94B9C0518E4
GO

Mass spectrometryi

Molecular mass is 7849.4 Da from positions 21 - 89. Determined by ESI. 1 Publication
Molecular mass is 7652.1 Da from positions 23 - 89. Determined by ESI. 1 Publication
Molecular mass is 7552.0 Da from positions 24 - 89. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000221 mRNA. Translation: BAA21670.1.
Y13710 mRNA. Translation: CAA74039.1.
AB012113 Genomic DNA. Translation: BAA34368.1.
AF082214, AF082212, AF082213 Genomic DNA. Translation: AAC32287.1.
AF111198 Genomic DNA. Translation: AAD30390.1.
CR407660 mRNA. Translation: CAG28588.1.
AB451458 mRNA. Translation: BAG70272.1.
CH471147 Genomic DNA. Translation: EAW80102.1.
BC069700 mRNA. Translation: AAH69700.1.
BC096124 mRNA. Translation: AAH96124.1.
BC096125 mRNA. Translation: AAH96125.1.
BC096126 mRNA. Translation: AAH96126.1.
BC096127 mRNA. Translation: AAH96127.1.
CCDSiCCDS11306.1.
RefSeqiNP_002979.1. NM_002988.3.
UniGeneiHs.143961.

Genome annotation databases

EnsembliENST00000614828; ENSP00000483144; ENSG00000278167.
ENST00000615723; ENSP00000483347; ENSG00000278006.
ENST00000616054; ENSP00000479955; ENSG00000275385.
GeneIDi6362.
KEGGihsa:6362.
UCSCiuc002hku.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CCL18 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000221 mRNA. Translation: BAA21670.1.
Y13710 mRNA. Translation: CAA74039.1.
AB012113 Genomic DNA. Translation: BAA34368.1.
AF082214, AF082212, AF082213 Genomic DNA. Translation: AAC32287.1.
AF111198 Genomic DNA. Translation: AAD30390.1.
CR407660 mRNA. Translation: CAG28588.1.
AB451458 mRNA. Translation: BAG70272.1.
CH471147 Genomic DNA. Translation: EAW80102.1.
BC069700 mRNA. Translation: AAH69700.1.
BC096124 mRNA. Translation: AAH96124.1.
BC096125 mRNA. Translation: AAH96125.1.
BC096126 mRNA. Translation: AAH96126.1.
BC096127 mRNA. Translation: AAH96127.1.
CCDSiCCDS11306.1.
RefSeqiNP_002979.1. NM_002988.3.
UniGeneiHs.143961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHEX-ray2.10A/B/C/D21-89[»]
ProteinModelPortaliP55774.
SMRiP55774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112265. 6 interactors.
IntActiP55774. 7 interactors.
MINTiMINT-1373449.
STRINGi9606.ENSP00000004921.

Polymorphism and mutation databases

BioMutaiCCL18.
DMDMi2493666.

Proteomic databases

PaxDbiP55774.
PeptideAtlasiP55774.
PRIDEiP55774.

Protocols and materials databases

DNASUi6362.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614828; ENSP00000483144; ENSG00000278167.
ENST00000615723; ENSP00000483347; ENSG00000278006.
ENST00000616054; ENSP00000479955; ENSG00000275385.
GeneIDi6362.
KEGGihsa:6362.
UCSCiuc002hku.4. human.

Organism-specific databases

CTDi6362.
DisGeNETi6362.
GeneCardsiCCL18.
HGNCiHGNC:10616. CCL18.
MIMi603757. gene.
neXtProtiNX_P55774.
OpenTargetsiENSG00000275385.
ENSG00000278006.
ENSG00000278167.
PharmGKBiPA35549.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XH. Eukaryota.
ENOG410ZUYI. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
InParanoidiP55774.
KOiK05514.
OMAiYSETSPQ.
OrthoDBiEOG091G14Y2.
PhylomeDBiP55774.
TreeFamiTF334888.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000006074-MONOMER.

Miscellaneous databases

GenomeRNAii6362.
PROiP55774.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006074.
CleanExiHS_AMAC1.
HS_CCL18.
GenevisibleiP55774. HS.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL18_HUMAN
AccessioniPrimary (citable) accession number: P55774
Secondary accession number(s): B5BUM2, Q53X71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.