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P55773

- CCL23_HUMAN

UniProt

P55773 - CCL23_HUMAN

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Protein

C-C motif chemokine 23

Gene
CCL23, MIP3, MPIF1, SCYA23
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.1 Publication

GO - Molecular functioni

  1. CCR1 chemokine receptor binding Source: UniProtKB
  2. chemokine activity Source: UniProtKB
  3. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cellular calcium ion homeostasis Source: ProtInc
  3. chemotaxis Source: ProtInc
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. immune response Source: ProtInc
  6. inflammatory response Source: ProtInc
  7. monocyte chemotaxis Source: UniProtKB
  8. negative regulation of C-C chemokine binding Source: UniProtKB
  9. negative regulation of cell proliferation Source: ProtInc
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 23
Alternative name(s):
CK-beta-8
Short name:
CKB-8
Macrophage inflammatory protein 3
Short name:
MIP-3
Myeloid progenitor inhibitory factor 1
Short name:
MPIF-1
Small-inducible cytokine A23
Cleaved into the following 4 chains:
Gene namesi
Name:CCL23
Synonyms:MIP3, MPIF1, SCYA23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10622. CCL23.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 12099C-C motif chemokine 23PRO_0000005229Add
BLAST
Chaini40 – 12081CCL23(19-99)PRO_0000041847Add
BLAST
Chaini43 – 12078CCL23(22-99)PRO_0000041848Add
BLAST
Chaini48 – 12073CCL23(27-99)PRO_0000041849Add
BLAST
Chaini51 – 12070CCL23(30-99)PRO_0000041850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 78
Disulfide bondi55 ↔ 94
Disulfide bondi65 ↔ 105

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55773.
PRIDEiP55773.

PTM databases

PhosphoSiteiP55773.

Expressioni

Tissue specificityi

High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.1 Publication

Gene expression databases

BgeeiP55773.
CleanExiHS_CCL23.
GenevestigatoriP55773.

Organism-specific databases

HPAiHPA042015.

Interactioni

Protein-protein interaction databases

BioGridi112271. 1 interaction.
STRINGi9606.ENSP00000293280.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 503
Helixi65 – 673
Beta strandi70 – 734
Beta strandi78 – 803
Beta strandi83 – 864
Beta strandi92 – 954
Helixi100 – 10910
Turni113 – 1153

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G91NMR-A45-120[»]
ProteinModelPortaliP55773.
SMRiP55773. Positions 44-120.

Miscellaneous databases

EvolutionaryTraceiP55773.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG136395.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP55773.
KOiK05511.
OMAiFMEDYFE.
OrthoDBiEOG7CVQ1F.
PhylomeDBiP55773.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Short (identifier: P55773-1) [UniParc]FASTAAdd to Basket

Also known as: CKB-8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKVSVAALSC LMLVTALGSQ ARVTKDAETE FMMSKLPLEN PVLLDRFHAT    50
SADCCISYTP RSIPCSLLES YFETNSECSK PGVIFLTKKG RRFCANPSDK 100
QVQVCVRMLK LDTRIKTRKN 120
Length:120
Mass (Da):13,411
Last modified:October 5, 2010 - v3
Checksum:i6CA622DD3A4B3A1A
GO
Isoform Long (identifier: P55773-2) [UniParc]FASTAAdd to Basket

Also known as: CKB-8-1

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: R → MLWRRKIGPQMTLSHAAG

Show »
Length:137
Mass (Da):15,290
Checksum:i932413D6B2E52C5D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061V → M.6 Publications
Corresponds to variant rs1003645 [ dbSNP | Ensembl ].
VAR_011916

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 461R → MLWRRKIGPQMTLSHAAG in isoform Long. VSP_001063

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 4433MLVTA…NPVLL → HAFLLPLVPGPGHKRCRDRV HECQSFHWKIQYFW1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85767 mRNA. Translation: AAB51134.1.
U58913 mRNA. Translation: AAD10846.1.
U67128 mRNA. Translation: AAD00161.1.
AF088219 Genomic DNA. Translation: AAC63326.1.
AF088219 Genomic DNA. Translation: AAC63327.1.
AC069363 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80103.1.
BC093970 mRNA. Translation: AAH93970.1.
BC143310 mRNA. Translation: AAI43311.1.
CCDSiCCDS11305.1. [P55773-2]
CCDS59282.1. [P55773-1]
RefSeqiNP_005055.3. NM_005064.5.
NP_665905.2. NM_145898.3.
UniGeneiHs.169191.

Genome annotation databases

EnsembliENST00000293280; ENSP00000293280; ENSG00000167236. [P55773-2]
ENST00000591423; ENSP00000465954; ENSG00000167236. [P55773-1]
GeneIDi6368.
KEGGihsa:6368.
UCSCiuc002hks.1. human. [P55773-2]
uc002hkt.1. human. [P55773-1]

Polymorphism databases

DMDMi308153623.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL23 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85767 mRNA. Translation: AAB51134.1 .
U58913 mRNA. Translation: AAD10846.1 .
U67128 mRNA. Translation: AAD00161.1 .
AF088219 Genomic DNA. Translation: AAC63326.1 .
AF088219 Genomic DNA. Translation: AAC63327.1 .
AC069363 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80103.1 .
BC093970 mRNA. Translation: AAH93970.1 .
BC143310 mRNA. Translation: AAI43311.1 .
CCDSi CCDS11305.1. [P55773-2 ]
CCDS59282.1. [P55773-1 ]
RefSeqi NP_005055.3. NM_005064.5.
NP_665905.2. NM_145898.3.
UniGenei Hs.169191.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1G91 NMR - A 45-120 [» ]
ProteinModelPortali P55773.
SMRi P55773. Positions 44-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112271. 1 interaction.
STRINGi 9606.ENSP00000293280.

Chemistry

DrugBanki DB00374. Treprostinil.

PTM databases

PhosphoSitei P55773.

Polymorphism databases

DMDMi 308153623.

Proteomic databases

PaxDbi P55773.
PRIDEi P55773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293280 ; ENSP00000293280 ; ENSG00000167236 . [P55773-2 ]
ENST00000591423 ; ENSP00000465954 ; ENSG00000167236 . [P55773-1 ]
GeneIDi 6368.
KEGGi hsa:6368.
UCSCi uc002hks.1. human. [P55773-2 ]
uc002hkt.1. human. [P55773-1 ]

Organism-specific databases

CTDi 6368.
GeneCardsi GC17M034340.
HGNCi HGNC:10622. CCL23.
HPAi HPA042015.
MIMi 602494. gene.
neXtProti NX_P55773.
PharmGKBi PA35554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136395.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P55773.
KOi K05511.
OMAi FMEDYFE.
OrthoDBi EOG7CVQ1F.
PhylomeDBi P55773.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

EvolutionaryTracei P55773.
GenomeRNAii 6368.
NextBioi 24742.
PROi P55773.
SOURCEi Search...

Gene expression databases

Bgeei P55773.
CleanExi HS_CCL23.
Genevestigatori P55773.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Macrophage inflammatory protein-3 and -4."
    Li H., Ruben S.
    Patent number US5504003, 02-APR-1996
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-106.
  2. "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors."
    Patel V.P., Kreider B.L., Li Y., Li H., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., Parmelee D., Gentz R., Garotta G.
    J. Exp. Med. 185:1163-1172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), PROTEIN SEQUENCE OF 22-36, VARIANT MET-106.
    Tissue: Aortic endothelium.
  3. "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1."
    Youn B.-S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M. Jr., Kwon B.S.
    Blood 91:3118-3126(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SHORT AND LONG), ALTERNATIVE SPLICING, VARIANT MET-106.
    Tissue: Monocyte.
  4. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT MET-106.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-106.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT), VARIANT MET-106.
    Tissue: Liver.
  8. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."
    Wells T.N.C., Peitsch M.C.
    J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  9. "Proteolytic activation of alternative CCR1 ligands in inflammation."
    Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
    J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF CCL23(19-99); CCL23(22-99); CCL23(27-99) AND CCL23(30-99), PROTEOLYTIC PROCESSING OF N-TERMINUS, TISSUE SPECIFICITY, FUNCTION.
  10. "Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine."
    Rajarathnam K., Li Y., Rohrer T., Gentz R.
    J. Biol. Chem. 276:4909-4916(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 45-120.

Entry informationi

Entry nameiCCL23_HUMAN
AccessioniPrimary (citable) accession number: P55773
Secondary accession number(s): B7ZKQ3
, O00174, O75950, Q52LD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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