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Reviewed, UniProtKB/Swiss-Prot P55772 (ENTP1_MOUSE)

Last modified February 9, 2010. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ectonucleoside triphosphate diphosphohydrolase 1
      Short name=NTPDase 1
    EC=3.6.1.5
Alternative name(s):
    Ecto-ATP diphosphohydrolase 1
      Short name=Ecto-ATPDase 1
      Short name=Ecto-ATPase 1
    Lymphoid cell activation antigen
    Ecto-apyrase
    CD_antigen=CD39
Gene names
Name: Entpd1
Synonyms: Cd39
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.

Catalytic activity

ATP + 2 H2O = AMP + 2 phosphate.

Cofactor

Calcium By similarity.

Magnesium By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Ectonucleoside triphosphate diphosphohydrolase 1
PRO_0000209903

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721 Potential
Topological domain38 – 478441Extracellular Potential
Transmembrane479 – 49921 Potential
Topological domain500 – 51011Cytoplasmic Potential

Amino acid modifications

Modified residue491Phosphotyrosine By similarity
Modified residue651Phosphotyrosine By similarity
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P55772-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8E6A6113D2E13930

FASTA51057,205
        10         20         30         40         50         60 
MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG IVLDAGSSHT 

        70         80         90        100        110        120 
NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE IGAYLAECME LSTELIPTSK 

       130        140        150        160        170        180 
HHQTPVYLGA TAGMRLLRME SEQSADEVLA AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI 

       190        200        210        220        230        240 
TINYLLGRFT QEQSWLSLIS DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL 

       250        260        270        280        290        300 
YGEDYTVYTH SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC 

       310        320        330        340        350        360 
TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP PLHGSFGAFS 

       370        380        390        400        410        420 
AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT SYPSVKEKYL SEYCFSGAYI 

       430        440        450        460        470        480 
LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL 

       490        500        510 
MVLFSLLLVA VAITGLFIYS KPSYFWKEAV

« Hide

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References

[1]"The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."
Maliszewski C.R., Delespesse G.J.T., Schoenborn M.A., Armitage R.J., Fanslow W.C., Nakajima T., Baker E., Sutherland G.R., Poindexter K., Birks C., Alpert A., Friend D., Gimpel S.D., Gayle R.B. III
J. Immunol. 153:3574-3583(1994) [PubMed: 7930580] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene structure and chromosome location of mouse Cd39 coding for an ecto-apyrase."
Schoenborn M.A., Jenkins N.A., Copeland N.G., Gilbert D.J., Gayle R.B. III, Maliszewski C.R.
Cytogenet. Cell Genet. 81:287-289(1998) [PubMed: 9730622] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF037366 mRNA. Translation: AAB92259.1.
AF041818 expand/collapse EMBL AC list , AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA. Translation: AAC83203.1.
IPIIPI00853836.
RefSeqNP_033978.1.
UniGeneMm.2824

3D structure databases

SMRP55772. Positions 46-474.
ModBaseSearch...

Protein-protein interaction databases

STRINGP55772.

PTM databases

PhosphoSiteP55772.

Proteomic databases

PRIDEP55772.

Genome annotation databases

EnsemblENSMUST00000052414; ENSMUSP00000055338; ENSMUSG00000048120; Mus musculus. [Genome view]
GeneID12495.
KEGGmmu:12495.
UCSCuc008hlf.1. mouse.

Organism-specific databases

CTD12495.
MGIMGI:102805. Entpd1.

Phylogenomic databases

eggNOGroNOG11899.
HOVERGENP55772.

Enzyme and pathway databases

BRENDA3.6.1.5. 244.

Gene expression databases

ArrayExpressP55772.
BgeeP55772.
CleanExMM_ENTPD1.
GenevestigatorP55772.
GermOnlineENSMUSG00000048120. Mus musculus.

Family and domain databases

InterProIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERPTHR11782. GDA1_CD39_NTPase. 1 hit.
PfamPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio281428.
SOURCESearch...

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Entry information

Entry nameENTP1_MOUSE
AccessionPrimary (citable) accession number: P55772
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 9, 2010
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents