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P55772

- ENTP1_MOUSE

UniProt

P55772 - ENTP1_MOUSE

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Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene
Entpd1, Cd39
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+ or Mg2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-diphosphatase activity Source: MGI
  3. nucleoside-triphosphatase activity Source: MGI

GO - Biological processi

  1. ATP catabolic process Source: MGI
  2. G-protein coupled receptor signaling pathway Source: MGI
  3. platelet activation Source: MGI
  4. purine ribonucleoside diphosphate catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
Short name:
NTPDase 1
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name:
Ecto-ATPDase 1
Short name:
Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen: CD39
Gene namesi
Name:Entpd1
Synonyms:Cd39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:102805. Entpd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Topological domaini38 – 478441Extracellular Reviewed predictionAdd
BLAST
Transmembranei479 – 49921Helical; Reviewed predictionAdd
BLAST
Topological domaini500 – 51011Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basal lamina Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Ectonucleoside triphosphate diphosphohydrolase 1PRO_0000209903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi84 ↔ 108 By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi254 ↔ 300 By similarity
Disulfide bondi281 ↔ 324 By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi337 ↔ 342 By similarity
Disulfide bondi391 ↔ 414 By similarity
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP55772.
PaxDbiP55772.
PRIDEiP55772.

PTM databases

PhosphoSiteiP55772.

Expressioni

Gene expression databases

ArrayExpressiP55772.
BgeeiP55772.
CleanExiMM_ENTPD1.
GenevestigatoriP55772.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliP55772.
SMRiP55772. Positions 46-461.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
KOiK01510.
PhylomeDBiP55772.
TreeFamiTF332859.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55772-1 [UniParc]FASTAAdd to Basket

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MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG    50
IVLDAGSSHT NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE 100
IGAYLAECME LSTELIPTSK HHQTPVYLGA TAGMRLLRME SEQSADEVLA 150
AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI TINYLLGRFT QEQSWLSLIS 200
DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL YGEDYTVYTH 250
SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC 300
TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP 350
PLHGSFGAFS AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT 400
SYPSVKEKYL SEYCFSGAYI LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW 450
TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL MVLFSLLLVA VAITGLFIYS 500
KPSYFWKEAV 510
Length:510
Mass (Da):57,205
Last modified:November 1, 1997 - v1
Checksum:i8E6A6113D2E13930
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037366 mRNA. Translation: AAB92259.1.
AF041818
, AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA. Translation: AAC83203.1.
CCDSiCCDS50434.1.
RefSeqiNP_033978.1. NM_009848.3.
UniGeneiMm.2824.

Genome annotation databases

EnsembliENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120.
GeneIDi12495.
KEGGimmu:12495.
UCSCiuc008hlf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF037366 mRNA. Translation: AAB92259.1 .
AF041818
, AF041812 , AF041813 , AF041814 , AF041815 , AF041816 , AF041817 Genomic DNA. Translation: AAC83203.1 .
CCDSi CCDS50434.1.
RefSeqi NP_033978.1. NM_009848.3.
UniGenei Mm.2824.

3D structure databases

ProteinModelPortali P55772.
SMRi P55772. Positions 46-461.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P55772.

Proteomic databases

MaxQBi P55772.
PaxDbi P55772.
PRIDEi P55772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112231 ; ENSMUSP00000107850 ; ENSMUSG00000048120 .
GeneIDi 12495.
KEGGi mmu:12495.
UCSCi uc008hlf.1. mouse.

Organism-specific databases

CTDi 953.
MGIi MGI:102805. Entpd1.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000059572.
HOVERGENi HBG018982.
KOi K01510.
PhylomeDBi P55772.
TreeFami TF332859.

Miscellaneous databases

ChiTaRSi ENTPD1. mouse.
NextBioi 281428.
PROi P55772.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55772.
Bgeei P55772.
CleanExi MM_ENTPD1.
Genevestigatori P55772.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."
    Maliszewski C.R., Delespesse G.J.T., Schoenborn M.A., Armitage R.J., Fanslow W.C., Nakajima T., Baker E., Sutherland G.R., Poindexter K., Birks C., Alpert A., Friend D., Gimpel S.D., Gayle R.B. III
    J. Immunol. 153:3574-3583(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene structure and chromosome location of mouse Cd39 coding for an ecto-apyrase."
    Schoenborn M.A., Jenkins N.A., Copeland N.G., Gilbert D.J., Gayle R.B. III, Maliszewski C.R.
    Cytogenet. Cell Genet. 81:287-289(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiENTP1_MOUSE
AccessioniPrimary (citable) accession number: P55772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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