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Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene

Entpd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei174Proton acceptorBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nucleoside-diphosphatase activity Source: MGI
  • nucleoside-triphosphatase activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • platelet activation Source: MGI
  • purine ribonucleoside diphosphate catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.1.5. 3474.
ReactomeiR-MMU-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
Short name:
NTPDase 1
Alternative name(s):
Ecto-ATP diphosphohydrolase 1
Short name:
Ecto-ATPDase 1
Short name:
Ecto-ATPase 1
Ecto-apyrase
Lymphoid cell activation antigen
CD_antigen: CD39
Gene namesi
Name:Entpd1
Synonyms:Cd39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:102805. Entpd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 478ExtracellularSequence analysisAdd BLAST441
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 510CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • basal lamina Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099031 – 510Ectonucleoside triphosphate diphosphohydrolase 1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi84 ↔ 108By similarity
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi254 ↔ 300By similarity
Disulfide bondi281 ↔ 324By similarity
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi337 ↔ 342By similarity
Disulfide bondi391 ↔ 414By similarity
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP55772.
PaxDbiP55772.
PRIDEiP55772.

PTM databases

iPTMnetiP55772.
PhosphoSitePlusiP55772.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048120.
CleanExiMM_ENTPD1.
ExpressionAtlasiP55772. baseline and differential.
GenevisibleiP55772. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107850.

Structurei

3D structure databases

ProteinModelPortaliP55772.
SMRiP55772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
InParanoidiP55772.
KOiK01510.
PhylomeDBiP55772.
TreeFamiTF332859.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG
60 70 80 90 100
IVLDAGSSHT NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE
110 120 130 140 150
IGAYLAECME LSTELIPTSK HHQTPVYLGA TAGMRLLRME SEQSADEVLA
160 170 180 190 200
AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI TINYLLGRFT QEQSWLSLIS
210 220 230 240 250
DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL YGEDYTVYTH
260 270 280 290 300
SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC
310 320 330 340 350
TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP
360 370 380 390 400
PLHGSFGAFS AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT
410 420 430 440 450
SYPSVKEKYL SEYCFSGAYI LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW
460 470 480 490 500
TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL MVLFSLLLVA VAITGLFIYS
510
KPSYFWKEAV
Length:510
Mass (Da):57,205
Last modified:November 1, 1997 - v1
Checksum:i8E6A6113D2E13930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037366 mRNA. Translation: AAB92259.1.
AF041818
, AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA. Translation: AAC83203.1.
CCDSiCCDS50434.1.
RefSeqiNP_033978.1. NM_009848.4.
UniGeneiMm.2824.

Genome annotation databases

EnsembliENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120.
GeneIDi12495.
KEGGimmu:12495.
UCSCiuc008hlf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037366 mRNA. Translation: AAB92259.1.
AF041818
, AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA. Translation: AAC83203.1.
CCDSiCCDS50434.1.
RefSeqiNP_033978.1. NM_009848.4.
UniGeneiMm.2824.

3D structure databases

ProteinModelPortaliP55772.
SMRiP55772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107850.

PTM databases

iPTMnetiP55772.
PhosphoSitePlusiP55772.

Proteomic databases

EPDiP55772.
PaxDbiP55772.
PRIDEiP55772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120.
GeneIDi12495.
KEGGimmu:12495.
UCSCiuc008hlf.2. mouse.

Organism-specific databases

CTDi953.
MGIiMGI:102805. Entpd1.

Phylogenomic databases

eggNOGiKOG1386. Eukaryota.
COG5371. LUCA.
GeneTreeiENSGT00550000074435.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
InParanoidiP55772.
KOiK01510.
PhylomeDBiP55772.
TreeFamiTF332859.

Enzyme and pathway databases

BRENDAi3.6.1.5. 3474.
ReactomeiR-MMU-8850843. Phosphate bond hydrolysis by NTPDase proteins.

Miscellaneous databases

ChiTaRSiEntpd1. mouse.
PROiP55772.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048120.
CleanExiMM_ENTPD1.
ExpressionAtlasiP55772. baseline and differential.
GenevisibleiP55772. MM.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTP1_MOUSE
AccessioniPrimary (citable) accession number: P55772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.