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P55772

- ENTP1_MOUSE

UniProt

P55772 - ENTP1_MOUSE

Protein

Ectonucleoside triphosphate diphosphohydrolase 1

Gene

Entpd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

    Catalytic activityi

    A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

    Cofactori

    Ca2+ or Mg2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei174 – 1741Proton acceptorBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-diphosphatase activity Source: MGI
    3. nucleoside-triphosphatase activity Source: MGI

    GO - Biological processi

    1. ATP catabolic process Source: MGI
    2. G-protein coupled receptor signaling pathway Source: MGI
    3. platelet activation Source: MGI
    4. purine ribonucleoside diphosphate catabolic process Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)
    Short name:
    NTPDase 1
    Alternative name(s):
    Ecto-ATP diphosphohydrolase 1
    Short name:
    Ecto-ATPDase 1
    Short name:
    Ecto-ATPase 1
    Ecto-apyrase
    Lymphoid cell activation antigen
    CD_antigen: CD39
    Gene namesi
    Name:Entpd1
    Synonyms:Cd39
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:102805. Entpd1.

    Subcellular locationi

    GO - Cellular componenti

    1. basal lamina Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Ectonucleoside triphosphate diphosphohydrolase 1PRO_0000209903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi84 ↔ 108By similarity
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi254 ↔ 300By similarity
    Disulfide bondi281 ↔ 324By similarity
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi337 ↔ 342By similarity
    Disulfide bondi391 ↔ 414By similarity
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP55772.
    PaxDbiP55772.
    PRIDEiP55772.

    PTM databases

    PhosphoSiteiP55772.

    Expressioni

    Gene expression databases

    ArrayExpressiP55772.
    BgeeiP55772.
    CleanExiMM_ENTPD1.
    GenevestigatoriP55772.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP55772.
    SMRiP55772. Positions 46-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 478441ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini500 – 51011CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei479 – 49921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDA1/CD39 NTPase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5371.
    HOGENOMiHOG000059572.
    HOVERGENiHBG018982.
    KOiK01510.
    PhylomeDBiP55772.
    TreeFamiTF332859.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 1 hit.
    [Graphical view]
    PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55772-1 [UniParc]FASTAAdd to Basket

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    MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG    50
    IVLDAGSSHT NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE 100
    IGAYLAECME LSTELIPTSK HHQTPVYLGA TAGMRLLRME SEQSADEVLA 150
    AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI TINYLLGRFT QEQSWLSLIS 200
    DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL YGEDYTVYTH 250
    SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC 300
    TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP 350
    PLHGSFGAFS AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT 400
    SYPSVKEKYL SEYCFSGAYI LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW 450
    TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL MVLFSLLLVA VAITGLFIYS 500
    KPSYFWKEAV 510
    Length:510
    Mass (Da):57,205
    Last modified:November 1, 1997 - v1
    Checksum:i8E6A6113D2E13930
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037366 mRNA. Translation: AAB92259.1.
    AF041818
    , AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA. Translation: AAC83203.1.
    CCDSiCCDS50434.1.
    RefSeqiNP_033978.1. NM_009848.3.
    UniGeneiMm.2824.

    Genome annotation databases

    EnsembliENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120.
    GeneIDi12495.
    KEGGimmu:12495.
    UCSCiuc008hlf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF037366 mRNA. Translation: AAB92259.1 .
    AF041818
    , AF041812 , AF041813 , AF041814 , AF041815 , AF041816 , AF041817 Genomic DNA. Translation: AAC83203.1 .
    CCDSi CCDS50434.1.
    RefSeqi NP_033978.1. NM_009848.3.
    UniGenei Mm.2824.

    3D structure databases

    ProteinModelPortali P55772.
    SMRi P55772. Positions 46-461.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P55772.

    Proteomic databases

    MaxQBi P55772.
    PaxDbi P55772.
    PRIDEi P55772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112231 ; ENSMUSP00000107850 ; ENSMUSG00000048120 .
    GeneIDi 12495.
    KEGGi mmu:12495.
    UCSCi uc008hlf.1. mouse.

    Organism-specific databases

    CTDi 953.
    MGIi MGI:102805. Entpd1.

    Phylogenomic databases

    eggNOGi COG5371.
    HOGENOMi HOG000059572.
    HOVERGENi HBG018982.
    KOi K01510.
    PhylomeDBi P55772.
    TreeFami TF332859.

    Miscellaneous databases

    ChiTaRSi ENTPD1. mouse.
    NextBioi 281428.
    PROi P55772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55772.
    Bgeei P55772.
    CleanExi MM_ENTPD1.
    Genevestigatori P55772.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 1 hit.
    [Graphical view ]
    PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."
      Maliszewski C.R., Delespesse G.J.T., Schoenborn M.A., Armitage R.J., Fanslow W.C., Nakajima T., Baker E., Sutherland G.R., Poindexter K., Birks C., Alpert A., Friend D., Gimpel S.D., Gayle R.B. III
      J. Immunol. 153:3574-3583(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gene structure and chromosome location of mouse Cd39 coding for an ecto-apyrase."
      Schoenborn M.A., Jenkins N.A., Copeland N.G., Gilbert D.J., Gayle R.B. III, Maliszewski C.R.
      Cytogenet. Cell Genet. 81:287-289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.

    Entry informationi

    Entry nameiENTP1_MOUSE
    AccessioniPrimary (citable) accession number: P55772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3