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Protein

NHP2-like protein 1

Gene

Snu13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
NHP2-like protein 1
Alternative name(s):
High mobility group-like nuclear protein 2 homolog 1
OTK27
U4/U6.U5 small nuclear ribonucleoprotein SNU13Imported
U4/U6.U5 tri-snRNP 15.5 kDa protein
Cleaved into the following chain:
Gene namesi
Name:Snu13Imported
Synonyms:Nhp2l1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 7

Organism-specific databases

RGDi1303103 Snu13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367801 – 128NHP2-like protein 1Add BLAST128
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004232632 – 128NHP2-like protein 1, N-terminally processedAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in NHP2-like protein 1, N-terminally processedBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP55770
PRIDEiP55770

PTM databases

iPTMnetiP55770
PhosphoSitePlusiP55770

Expressioni

Gene expression databases

BgeeiENSRNOG00000006762
GenevisibleiP55770 RN

Interactioni

Subunit structurei

Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61Interaction with U4 snRNA and U4atac snRNABy similarity1
Sitei86Interaction with U4 snRNA and U4atac snRNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051559

Structurei

3D structure databases

ProteinModelPortaliP55770
SMRiP55770
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 48Interaction with U4 snRNA and U4atac snRNABy similarityAdd BLAST13
Regioni96 – 128Important for U4 snRNA-bindingBy similarityAdd BLAST33

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3387 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00550000074840
HOGENOMiHOG000055226
HOVERGENiHBG000328
InParanoidiP55770
KOiK12845
OMAiKPFYVRF
OrthoDBiEOG091G0YVI
PhylomeDBiP55770
TreeFamiTF300184

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI
60 70 80 90 100
SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI
110 120
ACSVTIKEGS QLKQQIQSIQ QSIERLLV
Length:128
Mass (Da):14,174
Last modified:January 23, 2007 - v4
Checksum:i78849EBB497089ED
GO

Sequence cautioni

The sequence H35080 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058493 mRNA Translation: AAH58493.1
H35080 mRNA No translation available.
RefSeqiNP_997680.1, NM_212515.2
XP_008758813.1, XM_008760591.2
XP_008773113.1, XM_008774891.2
UniGeneiRn.1293

Genome annotation databases

EnsembliENSRNOT00000009152; ENSRNOP00000009152; ENSRNOG00000006762
ENSRNOT00000030108; ENSRNOP00000051559; ENSRNOG00000025154
GeneIDi100359574
300092
KEGGirno:100359574
rno:300092
UCSCiRGD:1303103 rat

Similar proteinsi

Entry informationi

Entry nameiNH2L1_RAT
AccessioniPrimary (citable) accession number: P55770
Secondary accession number(s): Q6PDV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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