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Protein

NHP2-like protein 1

Gene

SNU13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.2 Publications

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • box C/D snoRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • U3 snoRNA binding Source: GO_Central
  • U4atac snRNA binding Source: GO_Central
  • U4 snRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
NHP2-like protein 1
Alternative name(s):
High mobility group-like nuclear protein 2 homolog 1
OTK27
SNU13 homolog
Short name:
hSNU13
U4/U6.U5 small nuclear ribonucleoprotein SNU13Imported
U4/U6.U5 tri-snRNP 15.5 kDa protein
Cleaved into the following chain:
Gene namesi
Name:SNU13Imported
Synonyms:NHP2L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100138.13.
HGNCiHGNC:7819. SNU13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38G → K: Abolishes completely RNA-binding. 1 Publication1
Mutagenesisi57A → F: Abolishes completely RNA-binding. 1 Publication1
Mutagenesisi80Y → A: Abolishes 50% of RNA-binding. 1 Publication1
Mutagenesisi96 – 128Missing : Abolishes completely RNA-binding. Add BLAST33

Organism-specific databases

DisGeNETi4809.
OpenTargetsiENSG00000100138.
PharmGKBiPA31621.

Chemistry databases

DrugBankiDB02494. Alpha-Hydroxy-Beta-Phenyl-Propionic Acid.
DB07374. Anisomycin.

Polymorphism and mutation databases

BioMutaiNHP2L1.
DMDMi2500345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232601 – 128NHP2-like protein 1Add BLAST128
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00001367782 – 128NHP2-like protein 1, N-terminally processedAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in NHP2-like protein 1, N-terminally processedCombined sources1 Publication1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP55769.
PaxDbiP55769.
PeptideAtlasiP55769.
PRIDEiP55769.
TopDownProteomicsiP55769.

2D gel databases

SWISS-2DPAGEiP55769.

PTM databases

iPTMnetiP55769.
PhosphoSitePlusiP55769.
SwissPalmiP55769.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100138.
CleanExiHS_NHP2L1.
ExpressionAtlasiP55769. baseline and differential.
GenevisibleiP55769. HS.

Organism-specific databases

HPAiHPA029199.

Interactioni

Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110874. 174 interactors.
CORUMiP55769.
IntActiP55769. 29 interactors.
MINTiMINT-1382515.
STRINGi9606.ENSP00000215956.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Helixi16 – 31Combined sources16
Beta strandi35 – 38Combined sources4
Helixi39 – 48Combined sources10
Beta strandi51 – 57Combined sources7
Helixi63 – 65Combined sources3
Helixi68 – 76Combined sources9
Beta strandi80 – 84Combined sources5
Helixi86 – 92Combined sources7
Beta strandi100 – 105Combined sources6
Helixi113 – 124Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7KX-ray2.90A/B1-128[»]
2JNBNMR-A1-128[»]
2OZBX-ray2.60A/D1-128[»]
3JCRelectron microscopy7.00I1-128[»]
3SIUX-ray2.63A/D1-128[»]
3SIVX-ray3.30A/D/G/J1-128[»]
5O9Zelectron microscopy4.50O1-128[»]
ProteinModelPortaliP55769.
SMRiP55769.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55769.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3387. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00550000074840.
HOGENOMiHOG000055226.
HOVERGENiHBG000328.
InParanoidiP55769.
KOiK12845.
PhylomeDBiP55769.
TreeFamiTF300184.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
PfamiView protein in Pfam
PF01248. Ribosomal_L7Ae. 1 hit.
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiView protein in PROSITE
PS01082. RIBOSOMAL_L7AE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI
60 70 80 90 100
SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI
110 120
ACSVTIKEGS QLKQQIQSIQ QSIERLLV
Length:128
Mass (Da):14,174
Last modified:January 23, 2007 - v3
Checksum:i78849EBB497089ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03415519T → N. Corresponds to variant dbSNP:rs1802521Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50420 mRNA. Translation: BAA23363.1.
AF155235 mRNA. Translation: AAF06959.1.
AF091076 mRNA. Translation: AAC72945.1.
CR456531 mRNA. Translation: CAG30417.1.
Z83840 Genomic DNA. No translation available.
BC005358 mRNA. Translation: AAH05358.1.
BC019282 mRNA. Translation: AAH19282.1.
CCDSiCCDS14022.1.
CCDS33653.1.
RefSeqiNP_001003796.1. NM_001003796.1.
NP_004999.1. NM_005008.3.
UniGeneiHs.182255.

Genome annotation databases

EnsembliENST00000215956; ENSP00000215956; ENSG00000100138.
ENST00000355257; ENSP00000347401; ENSG00000100138.
ENST00000401959; ENSP00000383949; ENSG00000100138.
GeneIDi4809.
KEGGihsa:4809.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNH2L1_HUMAN
AccessioniPrimary (citable) accession number: P55769
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families