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P55748

- CBP22_HORVU

UniProt

P55748 - CBP22_HORVU

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Protein

Serine carboxypeptidase II-2

Gene
CXP;2-2
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491 By similarity
Active sitei350 – 3501 By similarity
Active sitei403 – 4031 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase II-2 (EC:3.4.16.6)
Alternative name(s):
CP-MII.2
Cleaved into the following 2 chains:
Gene namesi
Name:CXP;2-2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP55748.

Subcellular locationi

GO - Cellular componenti

  1. vacuole Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 256›256Serine carboxypeptidase II-2 chain APRO_0000004317Add
BLAST
Propeptidei257 – 27014Linker peptide By similarityPRO_0000004318Add
BLAST
Chaini271 – 436166Serine carboxypeptidase II-2 chain BPRO_0000004319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 313Interchain (between A and B chains) By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi217 ↔ 229 By similarity
Disulfide bondi253 ↔ 281Interchain (between A and B chains) By similarity

Post-translational modificationi

The linker peptide is endoproteolytically excised during enzyme maturation By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Developmental stagei

Expressed in the germinating embryo. Low levels in the developing aleurone and embryo. Also found in the roots and shoots of the growing seedling.

Gene expression databases

GenevestigatoriP55748.

Interactioni

Subunit structurei

Carboxypeptidase II is a dimer, where each monomer is composed of two chains linked by a disulfide bond By similarity.

Structurei

3D structure databases

ProteinModelPortaliP55748.
SMRiP55748. Positions 1-254, 278-427.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55748-1 [UniParc]FASTAAdd to Basket

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VPRVPGQAFD ASFAHYAGYV TVSEDRGAAL FYWFFEAAHD PASKPLLLWL    50
NGGPGCSSIA FGVGEEVGPF HVNADGKGVH MNPYSWNQVA NILFLDSPVG 100
VGYSYSNTSA DILSNGDERT AKDSLVFLTK WLERFPQYKE REFYLTGESY 150
AGHYVPQLAQ AIKRHHEATG DKSINLKGYM VGNALTDDFH DHYGIFQYMW 200
TTGLISDQTY KLLNIFCDFE SFVHTSPQCD KILDIASTEA GNIDSYSIFT 250
PTCHSSFASS RNKVVKRLRS VGKMGEQYDP CTEKHSIVYF NLHEVQKALH 300
VNPVIGKSKW ETCSEVINTN WKDCERSVLH IYHELIQYGL RIWMFSGDTD 350
AVIPVTSTRY SIDALKLPTV TPWHAWYDDD GEVGGWTQGY KGLNFVTVRG 400
AGHEVPLHRP KQALTLIKSF LAGRPMPVLS DLRSDM 436
Length:436
Mass (Da):48,952
Last modified:November 1, 1997 - v1
Checksum:iE0F82D97E0C34DC9
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78878 mRNA. Translation: CAB59202.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78878 mRNA. Translation: CAB59202.1 .

3D structure databases

ProteinModelPortali P55748.
SMRi P55748. Positions 1-254, 278-427.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P55748.

Gene expression databases

Genevestigatori P55748.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The expression of serine carboxypeptidases during maturation and germination of the barley grain."
    Dal Degan F., Rocher A., Cameron-Mills V., von Wettstein D.
    Proc. Natl. Acad. Sci. U.S.A. 91:8209-8213(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Alexis.
    Tissue: Grain.

Entry informationi

Entry nameiCBP22_HORVU
AccessioniPrimary (citable) accession number: P55748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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