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Protein

Serine carboxypeptidase II-2

Gene

CXP;2-2

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149By similarity1
Active sitei350By similarity1
Active sitei403By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihorvu-cp22. Carboxypeptidase_S10.
MEROPSiS10.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase II-2 (EC:3.4.16.6)
Alternative name(s):
CP-MII.2
Cleaved into the following 2 chains:
Gene namesi
Name:CXP;2-2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004317‹1 – 256Serine carboxypeptidase II-2 chain AAdd BLAST›256
PropeptideiPRO_0000004318257 – 270Linker peptideBy similarityAdd BLAST14
ChainiPRO_0000004319271 – 436Serine carboxypeptidase II-2 chain BAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 313Interchain (between A and B chains)By similarity
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi217 ↔ 229By similarity
Disulfide bondi253 ↔ 281Interchain (between A and B chains)By similarity

Post-translational modificationi

The linker peptide is endoproteolytically excised during enzyme maturation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Developmental stagei

Expressed in the germinating embryo. Low levels in the developing aleurone and embryo. Also found in the roots and shoots of the growing seedling.

Interactioni

Subunit structurei

Carboxypeptidase II is a dimer, where each monomer is composed of two chains linked by a disulfide bond.By similarity

Protein-protein interaction databases

STRINGi4513.MLOC_36826.2.

Structurei

3D structure databases

ProteinModelPortaliP55748.
SMRiP55748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VPRVPGQAFD ASFAHYAGYV TVSEDRGAAL FYWFFEAAHD PASKPLLLWL
60 70 80 90 100
NGGPGCSSIA FGVGEEVGPF HVNADGKGVH MNPYSWNQVA NILFLDSPVG
110 120 130 140 150
VGYSYSNTSA DILSNGDERT AKDSLVFLTK WLERFPQYKE REFYLTGESY
160 170 180 190 200
AGHYVPQLAQ AIKRHHEATG DKSINLKGYM VGNALTDDFH DHYGIFQYMW
210 220 230 240 250
TTGLISDQTY KLLNIFCDFE SFVHTSPQCD KILDIASTEA GNIDSYSIFT
260 270 280 290 300
PTCHSSFASS RNKVVKRLRS VGKMGEQYDP CTEKHSIVYF NLHEVQKALH
310 320 330 340 350
VNPVIGKSKW ETCSEVINTN WKDCERSVLH IYHELIQYGL RIWMFSGDTD
360 370 380 390 400
AVIPVTSTRY SIDALKLPTV TPWHAWYDDD GEVGGWTQGY KGLNFVTVRG
410 420 430
AGHEVPLHRP KQALTLIKSF LAGRPMPVLS DLRSDM
Length:436
Mass (Da):48,952
Last modified:November 1, 1997 - v1
Checksum:iE0F82D97E0C34DC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78878 mRNA. Translation: CAB59202.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78878 mRNA. Translation: CAB59202.1.

3D structure databases

ProteinModelPortaliP55748.
SMRiP55748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4513.MLOC_36826.2.

Protein family/group databases

ESTHERihorvu-cp22. Carboxypeptidase_S10.
MEROPSiS10.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBP22_HORVU
AccessioniPrimary (citable) accession number: P55748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.