P55739 (PPP5_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 5
Short name=PP5
EC=3.1.3.16

Alternative name(s):
Protein phosphatase T
Short name=PPT

Gene names

Name:	PPP5C
Synonyms:	PPP5

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	42 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in the regulation of RNA biogenesis and/or mitosis.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subunit structure	Interacts with CDC16 and CDC27 By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara protein dephosphorylation Inferred from electronic annotation. Source: InterPro response to morphine Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 42	›42	Serine/threonine-protein phosphatase 5		PRO_0000058896
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P55739 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 5B85BC402EF4692F	FASTA	42	4,719
	10 20 30 40 KASYIHLRGS DLRPQFHQFT AVPHPNVKPM AYANALLQLG VM

References

[1]

"A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus." Chen M.X., McPartlin A.E., Brown L., Chen Y.H., Barker H.M., Cohen P.T.W. EMBO J. 13:4278-4290(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver.

Cross-references

3D structure databases
ProteinModelPortal	P55739.
SMR	P55739. Positions 1-42.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000018147.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000172698.
OrthoDB	EOG4PVNZ1.
Family and domain databases
InterPro	IPR011236. Ser/Thr_PPase_5. [Graphical view]
PANTHER	PTHR11668:SF12. PTHR11668:SF12. 1 hit.
PROSITE	PS00125. SER_THR_PHOSPHATASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPP5_RABIT

Accession

Primary (citable) accession number: P55739

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program