ID   BLVRB_RANCA             Reviewed;          24 AA.
AC   P55736;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 34.
DE   RecName: Full=Flavin reductase;
DE            EC=1.6.99.1;
DE   AltName: Full=NADPH-dependent diaphorase;
DE   AltName: Full=NADPH-methemoglobin reductase;
DE   AltName: Full=NADPH-dehydrogenase;
DE   Flags: Fragment;
OS   Rana catesbeiana (Bull frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana;
OC   Aquarana.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Erythrocyte;
RX   MEDLINE=91035356; PubMed=2172227;
RA   Abe Y., Ito T., Okazaki T.;
RT   "Purification and characterization of NADPH-dependent methemoglobin
RT   reductase from the nucleated erythrocytes of bullfrog, Rana
RT   catesbeiana.";
RL   J. Biochem. 108:255-260(1990).
CC   -!- FUNCTION: Catalyzes electron transfer from reduced pyridine
CC       nucleotides to flavins as well as methylene blue, pyrroloquinoline
CC       quinone, riboflavin, or methemoglobin. Possible role in protecting
CC       cells from oxidative damage or in regulating iron metabolism (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: NADPH + acceptor = NADP(+) + reduced acceptor.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 5.0 for NADPH-methemoglobin reductase activity,
CC         and 6.5 for NADPH-diaphorase activity;
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PIR; PX0038; PX0038.
DR   HOVERGEN; P55736; -.
DR   BRENDA; 1.6.99.1; 829.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003959; F:NADPH dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase.
FT   CHAIN         1    >24       Flavin reductase.
FT                                /FTId=PRO_0000064950.
FT   NON_TER      24     24
SQ   SEQUENCE   24 AA;  2417 MW;  7B6CD31436FAC4EC CRC64;
     APKNIVLFGA TGMTGQVTLG QALE
//