Reviewed, UniProtKB/Swiss-Prot P55736 (BLVRB_RANCA)

Names and origin

Protein names	Recommended name:     Flavin reductase     EC=1.6.99.1 Alternative name(s):     NADPH-dependent diaphorase     NADPH-methemoglobin reductase     NADPH-dehydrogenase
Organism	Rana catesbeiana (Bull frog)
Taxonomic identifier	8400 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Rana › Aquarana

Protein attributes

Sequence length	24 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism By similarity.
Catalytic activity	NADPH + acceptor = NADP+ + reduced acceptor.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential.
biophysicochemical properties	pH dependence: Optimum pH is 5.0 for NADPH-methemoglobin reductase activity, and 6.5 for NADPH-diaphorase activity.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›24	›24	Flavin reductase		PRO_0000064950
Experimental info
	Non-terminal residue	24	1

Sequences

	Sequence		Length	Mass (Da)
	P55736-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7B6CD31436FAC4EC	FASTA	24	2,417
	10 20 APKNIVLFGA TGMTGQVTLG QALE

References

[1]	"Purification and characterization of NADPH-dependent methemoglobin reductase from the nucleated erythrocytes of bullfrog, Rana catesbeiana." Abe Y., Ito T., Okazaki T. J. Biochem. 108:255-260(1990) [PubMed: 2172227] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Erythrocyte.

Cross-references

Sequence databases
PIR	PX0038.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P55736.
Enzyme and pathway databases
BRENDA	1.6.99.1. 829.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BLVRB_RANCA

Accession

Primary (citable) accession number: P55736

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)