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P55653

- GABD_RHISN

UniProt

P55653 - GABD_RHISN

Protein

Probable succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

gabD

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate.By similarity

    Catalytic activityi

    Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei263 – 2631Proton acceptorPROSITE-ProRule annotation
    Binding sitei264 – 2641NADP; via carbonyl oxygenBy similarity
    Active sitei297 – 2971NucleophilePROSITE-ProRule annotation
    Binding sitei394 – 3941NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi163 – 1642NADPBy similarity
    Nucleotide bindingi187 – 1904NADPBy similarity
    Nucleotide bindingi241 – 2422NADPBy similarity

    GO - Molecular functioni

    1. succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSFRE394:GBYN-6214-MONOMER.
    UniPathwayiUPA00733.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.79)
    Short name:
    SSDH
    Gene namesi
    Name:gabD
    Ordered Locus Names:NGR_a01630
    ORF Names:y4sJ
    Encoded oniPlasmid sym pNGR234a0 Publication
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Plasmid sym pNGR234a

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Probable succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056573Add
    BLAST

    Proteomic databases

    PRIDEiP55653.

    Interactioni

    Protein-protein interaction databases

    STRINGi394.NGR_a01630.

    Structurei

    3D structure databases

    ProteinModelPortaliP55653.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271509.
    KOiK00135.
    OMAiVEWTRYY.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010102. Succ_semiAld_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01780. SSADH. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55653-1 [UniParc]FASTAAdd to Basket

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    MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP    50
    DMGAADAHAA IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI 100
    LTAEMGKPLG EAKSEVQHAA AYLQWYAEEA NRIYGETISA PSTDRRMLVI 150
    KQPIGVVGAI TPWNFPASMV ARKISPALAA GCTVVLKPAE QTPLVAGAMF 200
    ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT GSTEVGRLLM 250
    RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA 300
    NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL 350
    HISDAVQKGA RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA 400
    PLLRFDDADH VVREANDTIY GLAAYFYASN LKRVWRVAEA LEYGMVGINT 450
    GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY LDMKYLCVGG L 491
    Length:491
    Mass (Da):53,254
    Last modified:November 1, 1997 - v1
    Checksum:iFC54C5DF7B4D1B14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91849.1.
    PIRiS43963.
    RefSeqiNP_444062.1. NC_000914.2.
    WP_010875199.1. NC_000914.2.

    Genome annotation databases

    EnsemblBacteriaiAAB91849; AAB91849; NGR_a01630.
    GeneIDi962447.
    KEGGirhi:NGR_a01630.
    PATRICi32301035. VBIRhiSp122450_0153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91849.1 .
    PIRi S43963.
    RefSeqi NP_444062.1. NC_000914.2.
    WP_010875199.1. NC_000914.2.

    3D structure databases

    ProteinModelPortali P55653.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_a01630.

    Proteomic databases

    PRIDEi P55653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91849 ; AAB91849 ; NGR_a01630 .
    GeneIDi 962447.
    KEGGi rhi:NGR_a01630.
    PATRICi 32301035. VBIRhiSp122450_0153.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271509.
    KOi K00135.
    OMAi VEWTRYY.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00733 .
    BioCyci SFRE394:GBYN-6214-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010102. Succ_semiAld_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01780. SSADH. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular basis of symbiosis between Rhizobium and legumes."
      Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
      Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiGABD_RHISN
    AccessioniPrimary (citable) accession number: P55653
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. Rhizobium plasmid pNGR234a
      Rhizobium plasmid pNGR234a: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3