Reviewed, UniProtKB/Swiss-Prot P55653 (GABD_RHISN)

Names and origin

Protein names

Recommended name:
    Probable succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSDH
    EC=1.2.1.16

Gene names

Name:	gabD
ORF Names:	y4sJ

Encoded on

Plasmid sym pNGR234a

Organism

Rhizobium sp. (strain NGR234)

Taxonomic identifier

394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Probable succinate-semialdehyde dehydrogenase [NADP+]		PRO_0000056573
Regions
	Nucleotide binding	241 – 246	6	NADP By similarity
Sites
	Active site	263	1	By similarity
	Active site	297	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55653-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FC54C5DF7B4D1B14	FASTA	491	53,254
	10 20 30 40 50 60 MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP DMGAADAHAA 70 80 90 100 110 120 IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI LTAEMGKPLG EAKSEVQHAA 130 140 150 160 170 180 AYLQWYAEEA NRIYGETISA PSTDRRMLVI KQPIGVVGAI TPWNFPASMV ARKISPALAA 190 200 210 220 230 240 GCTVVLKPAE QTPLVAGAMF ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT 250 260 270 280 290 300 GSTEVGRLLM RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA 310 320 330 340 350 360 NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL HISDAVQKGA 370 380 390 400 410 420 RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA PLLRFDDADH VVREANDTIY 430 440 450 460 470 480 GLAAYFYASN LKRVWRVAEA LEYGMVGINT GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY 490 LDMKYLCVGG L

References

[1]	"Molecular basis of symbiosis between Rhizobium and legumes." Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X. Nature 387:394-401(1997) [PubMed: 9163424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00090 Genomic DNA. Translation: AAB91849.1.
PIR	S43963.
RefSeq	NP_444062.1.
3D structure databases
HSSP	HSSP built from PDB template 1O01 based on UniProtKB P05091.
ModBase	Search...
Genome annotation databases
GeneID	962447.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR010102. Succ_semiAld_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01780. SSADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD_RHISN

Accession

Primary (citable) accession number: P55653

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 4, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)