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P55653 (GABD_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable succinate-semialdehyde dehydrogenase [NADP(+)]

Short name=SSDH
EC=1.2.1.79
Gene names
Name:gabD
Ordered Locus Names:NGR_a01630
ORF Names:y4sJ
Encoded onPlasmid sym pNGR234a
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Pathway

Amino-acid degradation; 4-aminobutanoate degradation.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processgamma-aminobutyric acid catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionsuccinate-semialdehyde dehydrogenase [NAD(P)+] activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Probable succinate-semialdehyde dehydrogenase [NADP(+)]
PRO_0000056573

Regions

Nucleotide binding163 – 1642NADP By similarity
Nucleotide binding187 – 1904NADP By similarity
Nucleotide binding241 – 2422NADP By similarity

Sites

Active site2631Proton acceptor By similarity
Active site2971Nucleophile By similarity
Binding site2641NADP; via carbonyl oxygen By similarity
Binding site3941NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
P55653 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: FC54C5DF7B4D1B14

FASTA49153,254
        10         20         30         40         50         60 
MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP DMGAADAHAA 

        70         80         90        100        110        120 
IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI LTAEMGKPLG EAKSEVQHAA 

       130        140        150        160        170        180 
AYLQWYAEEA NRIYGETISA PSTDRRMLVI KQPIGVVGAI TPWNFPASMV ARKISPALAA 

       190        200        210        220        230        240 
GCTVVLKPAE QTPLVAGAMF ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT 

       250        260        270        280        290        300 
GSTEVGRLLM RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA 

       310        320        330        340        350        360 
NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL HISDAVQKGA 

       370        380        390        400        410        420 
RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA PLLRFDDADH VVREANDTIY 

       430        440        450        460        470        480 
GLAAYFYASN LKRVWRVAEA LEYGMVGINT GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY 

       490 
LDMKYLCVGG L 

« Hide

References

[1]"Molecular basis of symbiosis between Rhizobium and legumes."
Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NGR234.
[2]"Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems."
Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A., Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A., Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A., Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.
Appl. Environ. Microbiol. 75:4035-4045(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NGR234.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00090 Genomic DNA. Translation: AAB91849.1.
PIRS43963.
RefSeqNP_444062.1. NC_000914.2.

3D structure databases

ProteinModelPortalP55653.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_a01630.

Proteomic databases

PRIDEP55653.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB91849; AAB91849; NGR_a01630.
GeneID962447.
KEGGrhi:NGR_a01630.
PATRIC32301035. VBIRhiSp122450_0153.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271509.
KOK00135.
OMACSDQIKR.
OrthoDBEOG6BS8QW.
ProtClustDBCLSK784552.

Enzyme and pathway databases

BioCycSFRE394:GBYN-6214-MONOMER.
UniPathwayUPA00733.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01780. SSADH. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD_RHISN
AccessionPrimary (citable) accession number: P55653
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rhizobium plasmid pNGR234a

Rhizobium plasmid pNGR234a: entries and gene names