P55653 (GABD_RHISN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable succinate-semialdehyde dehydrogenase [NADP(+)]
Short name=SSDH
EC=1.2.1.79

Gene names

Name:	gabD
Ordered Locus Names:	NGR_a01630
ORF Names:	y4sJ

Encoded on

Plasmid sym pNGR234a

Organism

Rhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]

Taxonomic identifier

394 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium › Sinorhizobium fredii group › Rhizobium fredii

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate By similarity.
Catalytic activity	Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Probable succinate-semialdehyde dehydrogenase [NADP(+)]		PRO_0000056573
Regions
	Nucleotide binding	163 – 164	2	NADP By similarity
	Nucleotide binding	187 – 190	4	NADP By similarity
	Nucleotide binding	241 – 242	2	NADP By similarity
Sites
	Active site	263	1	Proton acceptor By similarity
	Active site	297	1	Nucleophile By similarity
	Binding site	264	1	NADP; via carbonyl oxygen By similarity
	Binding site	394	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55653 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: FC54C5DF7B4D1B14	FASTA	491	53,254
	10 20 30 40 50 60 MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP DMGAADAHAA 70 80 90 100 110 120 IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI LTAEMGKPLG EAKSEVQHAA 130 140 150 160 170 180 AYLQWYAEEA NRIYGETISA PSTDRRMLVI KQPIGVVGAI TPWNFPASMV ARKISPALAA 190 200 210 220 230 240 GCTVVLKPAE QTPLVAGAMF ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT 250 260 270 280 290 300 GSTEVGRLLM RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA 310 320 330 340 350 360 NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL HISDAVQKGA 370 380 390 400 410 420 RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA PLLRFDDADH VVREANDTIY 430 440 450 460 470 480 GLAAYFYASN LKRVWRVAEA LEYGMVGINT GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY 490 LDMKYLCVGG L

References

[1]

"Molecular basis of symbiosis between Rhizobium and legumes." Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X. Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NGR234.

[2]

"Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems." Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A., Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A., Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A., Broughton W.J., Perret X., Strittmatter A.W., Streit W.R. Appl. Environ. Microbiol. 75:4035-4045(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NGR234.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00090 Genomic DNA. Translation: AAB91849.1.
PIR	S43963.
RefSeq	NP_444062.1. NC_000914.2.
3D structure databases
ProteinModelPortal	P55653.
ModBase	Search...
Protein-protein interaction databases
STRING	394.NGR_a01630.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB91849; AAB91849; NGR_a01630.
GeneID	962447.
KEGG	rhi:NGR_a01630.
PATRIC	32301035. VBIRhiSp122450_0153.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271509.
KO	K00135.
OMA	IRANQDD.
ProtClustDB	CLSK784552.
Enzyme and pathway databases
BioCyc	SFRE394:GBYN-6214-MONOMER.
UniPathway	UPA00733.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR010102. Succ_semiAld_DH. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01780. SSADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD_RHISN

Accession

Primary (citable) accession number: P55653

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program