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P55653

- GABD_RHISN

UniProt

P55653 - GABD_RHISN

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Protein

Probable succinate-semialdehyde dehydrogenase [NADP(+)]

Gene
gabD, NGR_a01630, y4sJ
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADP+ dependent oxidation of succinate semialdehyde to succinate By similarity.

Catalytic activityi

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631Proton acceptor By similarity
Binding sitei264 – 2641NADP; via carbonyl oxygen By similarity
Active sitei297 – 2971Nucleophile By similarity
Binding sitei394 – 3941NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi163 – 1642NADP By similarity
Nucleotide bindingi187 – 1904NADP By similarity
Nucleotide bindingi241 – 2422NADP By similarity

GO - Molecular functioni

  1. succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSFRE394:GBYN-6214-MONOMER.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.79)
Short name:
SSDH
Gene namesi
Name:gabD
Ordered Locus Names:NGR_a01630
ORF Names:y4sJ
Encoded oniPlasmid sym pNGR234a0 Publication
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Plasmid sym pNGR234a

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056573Add
BLAST

Proteomic databases

PRIDEiP55653.

Interactioni

Protein-protein interaction databases

STRINGi394.NGR_a01630.

Structurei

3D structure databases

ProteinModelPortaliP55653.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271509.
KOiK00135.
OMAiVEWTRYY.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55653-1 [UniParc]FASTAAdd to Basket

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MTLTSALTRH LKCPELFRNL ANEPHPSVAG QRQRFSVFNP STGELLAEVP    50
DMGAADAHAA IERADAAQEP WSGLTARARS DILWKWHRFI LEHSDDLAAI 100
LTAEMGKPLG EAKSEVQHAA AYLQWYAEEA NRIYGETISA PSTDRRMLVI 150
KQPIGVVGAI TPWNFPASMV ARKISPALAA GCTVVLKPAE QTPLVAGAMF 200
ALAKLAGFPD GVLNLVYASE GDAIGRELCT NPKVRKISFT GSTEVGRLLM 250
RQCSDQIKRI SFELGGNAPF IVFDDADIDA AVDGAIQAKF RNAGQTCVSA 300
NRIYVQSGVY AEFAEKFTER VRTLKVGDGF DPNVAIGPLI NQEALKKIEL 350
HISDAVQKGA RVRSGGRRTG SSGTFFEPTV VTDVSKTMRL AEEETFGPLA 400
PLLRFDDADH VVREANDTIY GLAAYFYASN LKRVWRVAEA LEYGMVGINT 450
GRMSSEAAPF GGVKQSGIGR EGSRHGLEDY LDMKYLCVGG L 491
Length:491
Mass (Da):53,254
Last modified:November 1, 1997 - v1
Checksum:iFC54C5DF7B4D1B14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91849.1.
PIRiS43963.
RefSeqiNP_444062.1. NC_000914.2.
WP_010875199.1. NC_000914.2.

Genome annotation databases

EnsemblBacteriaiAAB91849; AAB91849; NGR_a01630.
GeneIDi962447.
KEGGirhi:NGR_a01630.
PATRICi32301035. VBIRhiSp122450_0153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91849.1 .
PIRi S43963.
RefSeqi NP_444062.1. NC_000914.2.
WP_010875199.1. NC_000914.2.

3D structure databases

ProteinModelPortali P55653.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_a01630.

Proteomic databases

PRIDEi P55653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91849 ; AAB91849 ; NGR_a01630 .
GeneIDi 962447.
KEGGi rhi:NGR_a01630.
PATRICi 32301035. VBIRhiSp122450_0153.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271509.
KOi K00135.
OMAi VEWTRYY.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00733 .
BioCyci SFRE394:GBYN-6214-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01780. SSADH. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular basis of symbiosis between Rhizobium and legumes."
    Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
    Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiGABD_RHISN
AccessioniPrimary (citable) accession number: P55653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. Rhizobium plasmid pNGR234a
    Rhizobium plasmid pNGR234a: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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