ID   Y4RA_SINFN              Reviewed;         409 AA.
AC   P55634;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Putative integrase/recombinase y4rA;
GN   OrderedLocusNames=NGR_a01860; ORFNames=y4rA;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; U00090; AAB92467.1; -; Genomic_DNA.
DR   RefSeq; NP_444039.1; NC_000914.2.
DR   RefSeq; WP_010875220.1; NC_000914.2.
DR   AlphaFoldDB; P55634; -.
DR   SMR; P55634; -.
DR   KEGG; rhi:NGR_a01860; -.
DR   PATRIC; fig|394.7.peg.184; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_027562_23_3_5; -.
DR   OrthoDB; 67979at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   CDD; cd01188; INT_RitA_C_like; 1.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid;
KW   Reference proteome; Transposable element; Viral genome integration;
KW   Virus entry into host cell.
FT   CHAIN           1..409
FT                   /note="Putative integrase/recombinase y4rA"
FT                   /id="PRO_0000197577"
FT   DOMAIN          112..197
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          220..402
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        260
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        284
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        354
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        357
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        380
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        389
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   409 AA;  45528 MW;  EC531CCC43C84B36 CRC64;
     MKYFVNADFA LSRPPEGPVA IYIIPFAEWL VDRGYGLVST RNQVLMAAGF SSWLRQKGIG
     LSDINGEHAG RYLLDRVQRP KLGDDAALRH LLAFLRSQNA IAEEIEVDHN PSAVEQHVQA
     YERHLRDARA LSRQTIINYR PVVRDFLSFR FGDGEISLAQ LRAADVTDFV QKKVSRLNMR
     RAKIVTTALR SFLSYARYRG DITSDLAAAV PIVANWSLSS IPRAIGRDDV SRLLSSIDRD
     TPIGCRDYAM ILALARLGLR SSEVVTLELD DIDWVAGRIR VRGKHGRNEL PLPADVGEAI
     ADYLWRARPR NASRRVFLRD KAPIRGFVGP SGLGSIVRRS LKRTGIDSPT KGTHQFRHGL
     ASEMLRGGAS LGEIGEVLGH RHVQTTAIYA KVDLDALRTL ALPWPGEAQ
//