Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

dTDP-4-dehydrorhamnose 3,5-epimerase

Gene

NGR_a03520

Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.By similarity

Catalytic activityi

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.

Pathwayi: dTDP-L-rhamnose biosynthesis

This protein is involved in the pathway dTDP-L-rhamnose biosynthesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway dTDP-L-rhamnose biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31SubstrateBy similarity1
Binding sitei36SubstrateBy similarity1
Binding sitei54SubstrateBy similarity1
Binding sitei56SubstrateBy similarity1
Binding sitei67SubstrateBy similarity1
Binding sitei70SubstrateBy similarity1
Sitei70Important in abstrating the protons in C3' and C5'By similarity1
Binding sitei80SubstrateBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Sitei140May have a key role in proton donation to C5'By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciSFRE394:GBYN-6379-MONOMER
UniPathwayiUPA00124

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose 3,5-epimerase (EC:5.1.3.13)
Alternative name(s):
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
dTDP-4-keto-6-deoxyglucose 3,5-epimerase
dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
dTDP-L-rhamnose synthase
Gene namesi
Ordered Locus Names:NGR_a03520
ORF Names:y4gL
Encoded oniPlasmid sym pNGR234a0 Publication
OrganismiSinorhizobium fredii (strain NBRC 101917 / NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001054 Componenti: Plasmid sym pNGR234a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002079821 – 195dTDP-4-dehydrorhamnose 3,5-epimeraseAdd BLAST195

Structurei

3D structure databases

ProteinModelPortaliP55468
SMRiP55468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 177Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227724
KOiK01790
OMAiGDDRGYF
OrthoDBiPOG091H04OS

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR000888 dTDP_sugar_isom
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR21047 PTHR21047, 1 hit
PfamiView protein in Pfam
PF00908 dTDP_sugar_isom, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001462 dTDP_sugar_isom, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01221 rmlC, 1 hit

Sequencei

Sequence statusi: Complete.

P55468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTELDEMY FQSLSIAEVK LIRPRKFGDC RGYFSEVFRE KWFRKNVADV
60 70 80 90 100
GLVQDNESLS AQIGTVRGLH FQLEPFAQGK LVRCTRGALF DVAVDVRVGS
110 120 130 140 150
PTYGKWVSAE LSQENGAQLW VPAGFAHGFM TLKADTVISY KVTAPYSAEH
160 170 180 190
DRGLKWDDPA IGINWPKMTT YVLSEKDSSQ PSLCELPVSF QYVKV
Length:195
Mass (Da):21,852
Last modified:November 1, 1997 - v1
Checksum:i77176926984CC1A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00090 Genomic DNA Translation: AAB91686.1
RefSeqiNP_443874.1, NC_000914.2
WP_010875366.1, NC_000914.2

Genome annotation databases

EnsemblBacteriaiAAB91686; AAB91686; NGR_a03520
GeneIDi962164
KEGGirhi:NGR_a03520
PATRICifig|394.7.peg.360

Similar proteinsi

Entry informationi

Entry nameiRMLC_SINFN
AccessioniPrimary (citable) accession number: P55468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health