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P55464

- RMLA_RHISN

UniProt

P55464 - RMLA_RHISN

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Protein
Probable glucose-1-phosphate thymidylyltransferase
Gene
rmlA, NGR_a03560, y4gH
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis By similarity.

Catalytic activityi

dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Magnesium By similarity
Metal bindingi223 – 2231Magnesium By similarity

GO - Molecular functioni

  1. glucose-1-phosphate thymidylyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. extracellular polysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-760-MONOMER.
SFRE394:GBYN-6407-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-1-phosphate thymidylyltransferase (EC:2.7.7.24)
Alternative name(s):
dTDP-glucose pyrophosphorylase
dTDP-glucose synthase
Gene namesi
Name:rmlA
Ordered Locus Names:NGR_a03560
ORF Names:y4gH
Encoded oniPlasmid sym pNGR234a0 Publication
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Plasmid sym pNGR234a

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Probable glucose-1-phosphate thymidylyltransferase
PRO_0000208003Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi394.NGR_a03560.

Structurei

3D structure databases

ProteinModelPortaliP55464.
SMRiP55464. Positions 2-285.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1209.
HOGENOMiHOG000283473.
KOiK00973.
OMAiFIVGRDF.
OrthoDBiEOG6RC3RN.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22572:SF13. PTHR22572:SF13. 1 hit.
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01207. rmlA. 1 hit.

Sequencei

Sequence statusi: Complete.

P55464-1 [UniParc]FASTAAdd to Basket

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MKGIILAGGS GTRLHPMTLV MSKQILPVYD KPMIFYPLTT LMLAGIREIL    50
IISTPHHMPL FQALLGDGSQ WGISLRYAVQ PSPNGLAQAY VIGADFVAGS 100
PSCLILGDNI YFGHGLQGLL QQAAALQQGA TIFAYHVNDP ERYGVVEFDE 150
GMNALSIEEK PAAPKSTWAV TGLYFYDSEV VDIAANLKPS ARGEYEITDV 200
NRIYLERGKL KVAVLGRGYA WLDTGTPDSL LEAAEFVRTL EKRQAFKVAC 250
PEEVALAMGF ISVEEFARIA ERAGKGDYGA YLRRLA 286
Length:286
Mass (Da):31,205
Last modified:November 1, 1997 - v1
Checksum:i2FD7BFF7575914F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91682.1.
RefSeqiNP_443870.1. NC_000914.2.
WP_010875370.1. NC_000914.2.

Genome annotation databases

EnsemblBacteriaiAAB91682; AAB91682; NGR_a03560.
GeneIDi962578.
KEGGirhi:NGR_a03560.
PATRICi32301457. VBIRhiSp122450_0364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91682.1 .
RefSeqi NP_443870.1. NC_000914.2.
WP_010875370.1. NC_000914.2.

3D structure databases

ProteinModelPortali P55464.
SMRi P55464. Positions 2-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_a03560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91682 ; AAB91682 ; NGR_a03560 .
GeneIDi 962578.
KEGGi rhi:NGR_a03560.
PATRICi 32301457. VBIRhiSp122450_0364.

Phylogenomic databases

eggNOGi COG1209.
HOGENOMi HOG000283473.
KOi K00973.
OMAi FIVGRDF.
OrthoDBi EOG6RC3RN.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-760-MONOMER.
SFRE394:GBYN-6407-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR22572:SF13. PTHR22572:SF13. 1 hit.
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01207. rmlA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular basis of symbiosis between Rhizobium and legumes."
    Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
    Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiRMLA_RHISN
AccessioniPrimary (citable) accession number: P55464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. Rhizobium plasmid pNGR234a
    Rhizobium plasmid pNGR234a: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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