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P55464

- RMLA_RHISN

UniProt

P55464 - RMLA_RHISN

Protein

Probable glucose-1-phosphate thymidylyltransferase

Gene

rmlA

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.By similarity

    Catalytic activityi

    dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi108 – 1081MagnesiumBy similarity
    Metal bindingi223 – 2231MagnesiumBy similarity

    GO - Molecular functioni

    1. glucose-1-phosphate thymidylyltransferase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. extracellular polysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-760-MONOMER.
    SFRE394:GBYN-6407-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucose-1-phosphate thymidylyltransferase (EC:2.7.7.24)
    Alternative name(s):
    dTDP-glucose pyrophosphorylase
    dTDP-glucose synthase
    Gene namesi
    Name:rmlA
    Ordered Locus Names:NGR_a03560
    ORF Names:y4gH
    Encoded oniPlasmid sym pNGR234a0 Publication
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Plasmid sym pNGR234a

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Probable glucose-1-phosphate thymidylyltransferasePRO_0000208003Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi394.NGR_a03560.

    Structurei

    3D structure databases

    ProteinModelPortaliP55464.
    SMRiP55464. Positions 2-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1209.
    HOGENOMiHOG000283473.
    KOiK00973.
    OMAiFIVGRDF.
    OrthoDBiEOG6RC3RN.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005907. G1P_thy_trans_s.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR22572:SF13. PTHR22572:SF13. 1 hit.
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01207. rmlA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P55464-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGIILAGGS GTRLHPMTLV MSKQILPVYD KPMIFYPLTT LMLAGIREIL    50
    IISTPHHMPL FQALLGDGSQ WGISLRYAVQ PSPNGLAQAY VIGADFVAGS 100
    PSCLILGDNI YFGHGLQGLL QQAAALQQGA TIFAYHVNDP ERYGVVEFDE 150
    GMNALSIEEK PAAPKSTWAV TGLYFYDSEV VDIAANLKPS ARGEYEITDV 200
    NRIYLERGKL KVAVLGRGYA WLDTGTPDSL LEAAEFVRTL EKRQAFKVAC 250
    PEEVALAMGF ISVEEFARIA ERAGKGDYGA YLRRLA 286
    Length:286
    Mass (Da):31,205
    Last modified:November 1, 1997 - v1
    Checksum:i2FD7BFF7575914F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91682.1.
    RefSeqiNP_443870.1. NC_000914.2.
    WP_010875370.1. NC_000914.2.

    Genome annotation databases

    EnsemblBacteriaiAAB91682; AAB91682; NGR_a03560.
    GeneIDi962578.
    KEGGirhi:NGR_a03560.
    PATRICi32301457. VBIRhiSp122450_0364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91682.1 .
    RefSeqi NP_443870.1. NC_000914.2.
    WP_010875370.1. NC_000914.2.

    3D structure databases

    ProteinModelPortali P55464.
    SMRi P55464. Positions 2-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_a03560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91682 ; AAB91682 ; NGR_a03560 .
    GeneIDi 962578.
    KEGGi rhi:NGR_a03560.
    PATRICi 32301457. VBIRhiSp122450_0364.

    Phylogenomic databases

    eggNOGi COG1209.
    HOGENOMi HOG000283473.
    KOi K00973.
    OMAi FIVGRDF.
    OrthoDBi EOG6RC3RN.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-760-MONOMER.
    SFRE394:GBYN-6407-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005907. G1P_thy_trans_s.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR22572:SF13. PTHR22572:SF13. 1 hit.
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01207. rmlA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular basis of symbiosis between Rhizobium and legumes."
      Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
      Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiRMLA_RHISN
    AccessioniPrimary (citable) accession number: P55464
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. Rhizobium plasmid pNGR234a
      Rhizobium plasmid pNGR234a: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3