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P55464 (RMLA_RHISN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-1-phosphate thymidylyltransferase

EC=2.7.7.24
Alternative name(s):
dTDP-glucose pyrophosphorylase
dTDP-glucose synthase
Gene names
Name:rmlA
Ordered Locus Names:NGR_a03560
ORF Names:y4gH
Encoded onPlasmid sym pNGR234a
OrganismRhizobium sp. (strain NGR234) [Complete proteome] [HAMAP]
Taxonomic identifier394 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis By similarity.

Catalytic activity

dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the glucose-1-phosphate thymidylyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Probable glucose-1-phosphate thymidylyltransferase
PRO_0000208003

Sites

Metal binding1081Magnesium By similarity
Metal binding2231Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P55464 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2FD7BFF7575914F2

FASTA28631,205
        10         20         30         40         50         60 
MKGIILAGGS GTRLHPMTLV MSKQILPVYD KPMIFYPLTT LMLAGIREIL IISTPHHMPL 

        70         80         90        100        110        120 
FQALLGDGSQ WGISLRYAVQ PSPNGLAQAY VIGADFVAGS PSCLILGDNI YFGHGLQGLL 

       130        140        150        160        170        180 
QQAAALQQGA TIFAYHVNDP ERYGVVEFDE GMNALSIEEK PAAPKSTWAV TGLYFYDSEV 

       190        200        210        220        230        240 
VDIAANLKPS ARGEYEITDV NRIYLERGKL KVAVLGRGYA WLDTGTPDSL LEAAEFVRTL 

       250        260        270        280 
EKRQAFKVAC PEEVALAMGF ISVEEFARIA ERAGKGDYGA YLRRLA 

« Hide

References

[1]"Molecular basis of symbiosis between Rhizobium and legumes."
Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NGR234.
[2]"Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems."
Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A., Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A., Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A., Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.
Appl. Environ. Microbiol. 75:4035-4045(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NGR234.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00090 Genomic DNA. Translation: AAB91682.1.
RefSeqNP_443870.1. NC_000914.2.

3D structure databases

ProteinModelPortalP55464.
SMRP55464. Positions 2-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394.NGR_a03560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB91682; AAB91682; NGR_a03560.
GeneID962578.
KEGGrhi:NGR_a03560.
PATRIC32301457. VBIRhiSp122450_0364.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1209.
HOGENOMHOG000283473.
KOK00973.
OMAFIVGRDF.
OrthoDBEOG6RC3RN.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-760-MONOMER.
SFRE394:GBYN-6407-MONOMER.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR005907. G1P_thy_trans_s.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR22572:SF13. PTHR22572:SF13. 1 hit.
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR01207. rmlA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRMLA_RHISN
AccessionPrimary (citable) accession number: P55464
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rhizobium plasmid pNGR234a

Rhizobium plasmid pNGR234a: entries and gene names