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P55463

- RMLD_RHISN

UniProt

P55463 - RMLD_RHISN

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Protein

Probable dTDP-4-dehydrorhamnose reductase

Gene
NGR_a03570, y4gG
Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well By similarity.

Catalytic activityi

dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH.

Cofactori

Binds 1 magnesium ion per monomer By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei149 – 1491Substrate; via amide nitrogen By similarity
Binding sitei150 – 1501NAD; via amide nitrogen By similarity
Binding sitei221 – 2211Substrate By similarity
Binding sitei256 – 2561Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115NAD By similarity
Nucleotide bindingi11 – 122NADP By similarity
Nucleotide bindingi30 – 312NAD By similarity
Nucleotide bindingi35 – 362NAD/NADP By similarity
Nucleotide bindingi58 – 614NAD By similarity
Nucleotide bindingi59 – 613NADP By similarity
Nucleotide bindingi124 – 1285NAD/NADP By similarity

GO - Molecular functioni

  1. dTDP-4-dehydrorhamnose reductase activity Source: UniProtKB

GO - Biological processi

  1. dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
  2. extracellular polysaccharide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSFRE394:GBYN-6408-MONOMER.
UniPathwayiUPA00124.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dTDP-4-dehydrorhamnose reductase (EC:1.1.1.133)
Alternative name(s):
dTDP-4-keto-L-rhamnose reductase
dTDP-6-deoxy-L-lyxo-4-hexulose reductase
dTDP-6-deoxy-L-mannose dehydrogenase
dTDP-L-rhamnose synthase
Gene namesi
Ordered Locus Names:NGR_a03570
ORF Names:y4gG
Encoded oniPlasmid sym pNGR234a0 Publication
OrganismiRhizobium sp. (strain NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001054: Plasmid sym pNGR234a

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Probable dTDP-4-dehydrorhamnose reductasePRO_0000207988Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi394.NGR_a03570.

Structurei

3D structure databases

ProteinModelPortaliP55463.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 1012Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1091.
HOGENOMiHOG000227712.
KOiK00067.
OMAiAWVFSEY.
OrthoDBiEOG6HTP2V.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF04321. RmlD_sub_bind. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01214. rmlD. 1 hit.

Sequencei

Sequence statusi: Complete.

P55463-1 [UniParc]FASTAAdd to Basket

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MRLAVTGKNG QIALALKAQA RPDVEILTLG RPNFDLACRS TVASSIRDAA    50
PDIIVSLAAY TAVDKAESEP YEAFAVNRDG VQALAEAAAG LGVPVIHLST 100
DYVFDGAKPV PYCEEDRTGP ISVYGRSKLE GEFAVASANP NHTILRTSWV 150
YSRYGQNFVK KMLRLADTND ELNVVADQLG CPTSADDISV AVMTIARRML 200
SSSSADLRGI FHLSGSGEAS WAAFAKYVFS VYDEITGRQI KVHDISAAEY 250
PTPARRPANS RLHCDKLERT FGIRLPNWEE STRRLVWALL LEGKDA 296
Length:296
Mass (Da):32,236
Last modified:November 1, 1997 - v1
Checksum:i36B97283479F2164
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91681.1.
RefSeqiNP_443869.1. NC_000914.2.
WP_010875371.1. NC_000914.2.

Genome annotation databases

EnsemblBacteriaiAAB91681; AAB91681; NGR_a03570.
GeneIDi962163.
KEGGirhi:NGR_a03570.
PATRICi32301459. VBIRhiSp122450_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00090 Genomic DNA. Translation: AAB91681.1 .
RefSeqi NP_443869.1. NC_000914.2.
WP_010875371.1. NC_000914.2.

3D structure databases

ProteinModelPortali P55463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394.NGR_a03570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91681 ; AAB91681 ; NGR_a03570 .
GeneIDi 962163.
KEGGi rhi:NGR_a03570.
PATRICi 32301459. VBIRhiSp122450_0365.

Phylogenomic databases

eggNOGi COG1091.
HOGENOMi HOG000227712.
KOi K00067.
OMAi AWVFSEY.
OrthoDBi EOG6HTP2V.

Enzyme and pathway databases

UniPathwayi UPA00124 .
BioCyci SFRE394:GBYN-6408-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005913. dTDP_dehydrorham_reduct.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF04321. RmlD_sub_bind. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01214. rmlD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular basis of symbiosis between Rhizobium and legumes."
    Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
    Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NGR234.

Entry informationi

Entry nameiRMLD_RHISN
AccessioniPrimary (citable) accession number: P55463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. Rhizobium plasmid pNGR234a
    Rhizobium plasmid pNGR234a: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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