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P55463

- RMLD_RHISN

UniProt

P55463 - RMLD_RHISN

Protein

Probable dTDP-4-dehydrorhamnose reductase

Gene

NGR_a03570

Organism
Rhizobium sp. (strain NGR234)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well By similarity.By similarity

    Catalytic activityi

    dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH.

    Cofactori

    Binds 1 magnesium ion per monomer.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei149 – 1491Substrate; via amide nitrogenBy similarity
    Binding sitei150 – 1501NAD; via amide nitrogenBy similarity
    Binding sitei221 – 2211SubstrateBy similarity
    Binding sitei256 – 2561SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 115NADBy similarity
    Nucleotide bindingi11 – 122NADPBy similarity
    Nucleotide bindingi30 – 312NADBy similarity
    Nucleotide bindingi35 – 362NAD/NADPBy similarity
    Nucleotide bindingi58 – 614NADBy similarity
    Nucleotide bindingi59 – 613NADPBy similarity
    Nucleotide bindingi124 – 1285NAD/NADPBy similarity

    GO - Molecular functioni

    1. dTDP-4-dehydrorhamnose reductase activity Source: UniProtKB

    GO - Biological processi

    1. dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
    2. extracellular polysaccharide biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciSFRE394:GBYN-6408-MONOMER.
    UniPathwayiUPA00124.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dTDP-4-dehydrorhamnose reductase (EC:1.1.1.133)
    Alternative name(s):
    dTDP-4-keto-L-rhamnose reductase
    dTDP-6-deoxy-L-lyxo-4-hexulose reductase
    dTDP-6-deoxy-L-mannose dehydrogenase
    dTDP-L-rhamnose synthase
    Gene namesi
    Ordered Locus Names:NGR_a03570
    ORF Names:y4gG
    Encoded oniPlasmid sym pNGR234a0 Publication
    OrganismiRhizobium sp. (strain NGR234)
    Taxonomic identifieri394 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001054: Plasmid sym pNGR234a

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Probable dTDP-4-dehydrorhamnose reductasePRO_0000207988Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi394.NGR_a03570.

    Structurei

    3D structure databases

    ProteinModelPortaliP55463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni100 – 1012Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1091.
    HOGENOMiHOG000227712.
    KOiK00067.
    OMAiAWVFSEY.
    OrthoDBiEOG6HTP2V.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005913. dTDP_dehydrorham_reduct.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF04321. RmlD_sub_bind. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01214. rmlD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P55463-1 [UniParc]FASTAAdd to Basket

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    MRLAVTGKNG QIALALKAQA RPDVEILTLG RPNFDLACRS TVASSIRDAA    50
    PDIIVSLAAY TAVDKAESEP YEAFAVNRDG VQALAEAAAG LGVPVIHLST 100
    DYVFDGAKPV PYCEEDRTGP ISVYGRSKLE GEFAVASANP NHTILRTSWV 150
    YSRYGQNFVK KMLRLADTND ELNVVADQLG CPTSADDISV AVMTIARRML 200
    SSSSADLRGI FHLSGSGEAS WAAFAKYVFS VYDEITGRQI KVHDISAAEY 250
    PTPARRPANS RLHCDKLERT FGIRLPNWEE STRRLVWALL LEGKDA 296
    Length:296
    Mass (Da):32,236
    Last modified:November 1, 1997 - v1
    Checksum:i36B97283479F2164
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91681.1.
    RefSeqiNP_443869.1. NC_000914.2.
    WP_010875371.1. NC_000914.2.

    Genome annotation databases

    EnsemblBacteriaiAAB91681; AAB91681; NGR_a03570.
    GeneIDi962163.
    KEGGirhi:NGR_a03570.
    PATRICi32301459. VBIRhiSp122450_0365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00090 Genomic DNA. Translation: AAB91681.1 .
    RefSeqi NP_443869.1. NC_000914.2.
    WP_010875371.1. NC_000914.2.

    3D structure databases

    ProteinModelPortali P55463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394.NGR_a03570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91681 ; AAB91681 ; NGR_a03570 .
    GeneIDi 962163.
    KEGGi rhi:NGR_a03570.
    PATRICi 32301459. VBIRhiSp122450_0365.

    Phylogenomic databases

    eggNOGi COG1091.
    HOGENOMi HOG000227712.
    KOi K00067.
    OMAi AWVFSEY.
    OrthoDBi EOG6HTP2V.

    Enzyme and pathway databases

    UniPathwayi UPA00124 .
    BioCyci SFRE394:GBYN-6408-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005913. dTDP_dehydrorham_reduct.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF04321. RmlD_sub_bind. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01214. rmlD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular basis of symbiosis between Rhizobium and legumes."
      Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A., Perret X.
      Nature 387:394-401(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NGR234.

    Entry informationi

    Entry nameiRMLD_RHISN
    AccessioniPrimary (citable) accession number: P55463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. Rhizobium plasmid pNGR234a
      Rhizobium plasmid pNGR234a: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3