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Protein

Hydroxysqualene synthase

Gene

NGR_a00430

Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the hopanoid precursor squalene (SQ) from farnesyl diphosphate (FPP). Catalyzes the second step, the conversion of presqualene diphosphate (PSPP) to hydroxysqualene (HSQ).By similarity

Catalytic activityi

Presqualene diphosphate + H2O = hydroxysqualene + diphosphate.By similarity

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

UniPathwayiUPA00337.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysqualene synthaseBy similarity (EC:4.2.3.156By similarity)
Short name:
HSQ synthaseBy similarity
Short name:
HSQaseBy similarity
Gene namesi
Ordered Locus Names:NGR_a00430
ORF Names:y4aD
Encoded oniPlasmid sym pNGR234a0 Publication
OrganismiSinorhizobium fredii (strain NBRC 101917 / NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001054 Componenti: Plasmid sym pNGR234a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002007981 – 292Hydroxysqualene synthaseAdd BLAST292

Structurei

3D structure databases

ProteinModelPortaliP55351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000003801.
KOiK21679.
OMAiALQLINF.
OrthoDBiPOG091H0EAX.

Family and domain databases

CDDicd00683. Trans_IPPS_HH. 1 hit.
Gene3Di1.10.600.10. 1 hit.
InterProiView protein in InterPro
IPR017827. HSQ_synthase_HpnC.
IPR008949. Isoprenoid_synthase_dom_sf.
IPR002060. Squ/phyt_synthse.
IPR033904. Trans_IPPS_HH.
PfamiView protein in Pfam
PF00494. SQS_PSY. 1 hit.
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03464. HpnC. 1 hit.

Sequencei

Sequence statusi: Complete.

P55351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGSGPRSD AMHREKNFPV ASWIIHPRHR ALILAFYRFV RMADDIADHA
60 70 80 90 100
TLAPDEKLLY LDLLEAELLG KGETRAEAVH LRTALDRRGM PPRHALDLLT
110 120 130 140 150
AFRMDVTKQR YENWDEVIDY CRYSAMPVGR FVLDVHGESA ATWPASDVLC
160 170 180 190 200
AGLQVCNHLQ DCGKDFLNLN RVYIPRDALS ASGASIEELG AAKSSLQMLQ
210 220 230 240 250
CLRSLAAKAE VLLNGGGALV SQVKDFRLRF EVSVILSFAD KIVSMLKMRD
260 270 280 290
PLRERVHLSP LELLLHGVGA MANEAARRAF GRGTRFKTTV DV
Length:292
Mass (Da):32,540
Last modified:November 1, 1997 - v1
Checksum:i1055E5E7F3614379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00090 Genomic DNA. Translation: AAB91602.1.
RefSeqiNP_443764.1. NC_000914.2.
WP_010875085.1. NC_000914.2.

Genome annotation databases

EnsemblBacteriaiAAB91602; AAB91602; NGR_a00430.
GeneIDi962253.
KEGGirhi:NGR_a00430.
PATRICifig|394.7.peg.40.

Similar proteinsi

Entry informationi

Entry nameiHPNC_SINFN
AccessioniPrimary (citable) accession number: P55351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. Rhizobium plasmid pNGR234a
    Rhizobium plasmid pNGR234a: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families