Reviewed, UniProtKB/Swiss-Prot P55336 (FABG_VIBHA)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:

fabG

Organism

Vibrio harveyi

Taxonomic identifier

669 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000054695
Regions
	Nucleotide binding	10 – 34	25	NADP By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55336-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FC41A1C65B8CDAAA	FASTA	244	25,519
	10 20 30 40 50 60 MNLEGKIALV TGASRGIGRA IAELLVERGA TVIGTATSEG GAAAISEYLG ENGKGLALNV 70 80 90 100 110 120 TDVESIEATL KTINDECGAI DILVNNAGIT RDNLLMRMKD DEWNDIINTN LTPIYRMSKA 130 140 150 160 170 180 VLRGMMKKRA GRIINVGSVV GTMGNAGQTN YAAAKAGVIG FTKSMAREVA SRGVTVNTVA 190 200 210 220 230 240 PGFIETDMTK ALNDDQRAAT LSNVPAGRLG DPREIASAVV FLASPEAAYI TGETLHVNGG MYMV

References

[1]	"Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis." Shen Z., Byers D.M. J. Bacteriol. 178:571-573(1996) [PubMed: 8550484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33843 / 392 / MAV.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U39441 Genomic DNA. Translation: AAC43589.1.
PIR	T12051.
3D structure databases
HSSP	HSSP built from PDB template 1EDO based on UniProtKB Q93X62.
SMR	P55336. Positions 2-244.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.100. 351.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_VIBHA

Accession

Primary (citable) accession number: P55336

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)