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P55336 (FABG_VIBHA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
OrganismVibrio harveyi (Beneckea harveyi)
Taxonomic identifier669 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2442443-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054695

Regions

Nucleotide binding12 – 154NADP By similarity
Nucleotide binding59 – 602NADP By similarity
Nucleotide binding151 – 1555NADP By similarity

Sites

Active site1511Proton acceptor By similarity
Binding site371NADP By similarity
Binding site861NADP; via carbonyl oxygen By similarity
Binding site1381Substrate By similarity
Binding site1841NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P55336 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FC41A1C65B8CDAAA

FASTA24425,519
        10         20         30         40         50         60 
MNLEGKIALV TGASRGIGRA IAELLVERGA TVIGTATSEG GAAAISEYLG ENGKGLALNV 

        70         80         90        100        110        120 
TDVESIEATL KTINDECGAI DILVNNAGIT RDNLLMRMKD DEWNDIINTN LTPIYRMSKA 

       130        140        150        160        170        180 
VLRGMMKKRA GRIINVGSVV GTMGNAGQTN YAAAKAGVIG FTKSMAREVA SRGVTVNTVA 

       190        200        210        220        230        240 
PGFIETDMTK ALNDDQRAAT LSNVPAGRLG DPREIASAVV FLASPEAAYI TGETLHVNGG 


MYMV 

« Hide

References

[1]"Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis."
Shen Z., Byers D.M.
J. Bacteriol. 178:571-573(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33843 / 392 / MAV.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39441 Genomic DNA. Translation: AAC43589.1.
PIRT12051.

3D structure databases

ProteinModelPortalP55336.
SMRP55336. Positions 2-244.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP55336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_VIBHA
AccessionPrimary (citable) accession number: P55336
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways