P55336 (FABG_VIBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG
EC=1.1.1.100

Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase

Gene names

Name:

fabG

Organism

Vibrio harveyi (Beneckea harveyi)

Taxonomic identifier

669 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	fatty acid elongation Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Inferred from sequence or structural similarity. Source: UniProtKB NAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	3-oxoacyl-[acyl-carrier-protein] reductase FabG		PRO_0000054695
Regions
	Nucleotide binding	12 – 15	4	NADP By similarity
	Nucleotide binding	59 – 60	2	NADP By similarity
	Nucleotide binding	151 – 155	5	NADP By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	37	1	NADP By similarity
	Binding site	86	1	NADP; via carbonyl oxygen By similarity
	Binding site	138	1	Substrate By similarity
	Binding site	184	1	NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55336 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FC41A1C65B8CDAAA	FASTA	244	25,519
	10 20 30 40 50 60 MNLEGKIALV TGASRGIGRA IAELLVERGA TVIGTATSEG GAAAISEYLG ENGKGLALNV 70 80 90 100 110 120 TDVESIEATL KTINDECGAI DILVNNAGIT RDNLLMRMKD DEWNDIINTN LTPIYRMSKA 130 140 150 160 170 180 VLRGMMKKRA GRIINVGSVV GTMGNAGQTN YAAAKAGVIG FTKSMAREVA SRGVTVNTVA 190 200 210 220 230 240 PGFIETDMTK ALNDDQRAAT LSNVPAGRLG DPREIASAVV FLASPEAAYI TGETLHVNGG MYMV

References

[1]	"Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis." Shen Z., Byers D.M. J. Bacteriol. 178:571-573(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33843 / 392 / MAV.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39441 Genomic DNA. Translation: AAC43589.1.
PIR	T12051.
3D structure databases
ProteinModelPortal	P55336.
SMR	P55336. Positions 2-244.
ModBase	Search...
Proteomic databases
PRIDE	P55336.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00094.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_VIBHA

Accession

Primary (citable) accession number: P55336

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program