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P55333

- XYNB_EMENI

UniProt

P55333 - XYNB_EMENI

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Protein

Endo-1,4-beta-xylanase B

Gene
xlnB, xynB, xynG1, AN9365
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.1 Publication

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Nucleophile By similarity
Active sitei208 – 2081Proton donor By similarity

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: ASPGD

GO - Biological processi

  1. xylan catabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH11. Glycoside Hydrolase Family 11.
mycoCLAPiXYN11B_EMENI.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase B (EC:3.2.1.8)
Short name:
Xylanase B
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase B
24 kDa xylanase
Endo-1,4-beta-xylanase G1
Short name:
Xylanase G1
Xylanase X24
Gene namesi
Name:xlnB
Synonyms:xynB, xynG1
ORF Names:AN9365
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 221203Endo-1,4-beta-xylanase BPRO_0000008005Add
BLAST

Expressioni

Inductioni

Expressed in the presence of D-xylose under conditions of acidic ambient pH, probably under the regulation of the pacC transcription factor. Repressed in presence of glucose through the action of the creA transcription repressor.3 Publications

Structurei

3D structure databases

ProteinModelPortaliP55333.
SMRiP55333. Positions 39-221.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG05353.
HOGENOMiHOG000179135.
KOiK01181.
OMAiEYYIVET.
OrthoDBiEOG7VQJQX.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view]
PfamiPF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSiPR00911. GLHYDRLASE11.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55333-1 [UniParc]FASTAAdd to Basket

« Hide

MVSFSSLLLA CSAVTAFAAP SDQSIAERSL SERSTPSSTG TSGGYYYSFW    50
TDGGGDVTYT NGDGGSYTVE WTNVGNFVGG KGWNPGSSQT ISYSGSFNPS 100
GNGYLSVYGW TQNPLIEYYI VESYGDYNPG TAGTHQGTLE SDGSTYDIYT 150
ATRENAPSIE GTATFTQFWS VRQSKRTSGS VTTQNHFDAW SQLGMTLGTH 200
NYQIVAVEGY QSSGSASITV S 221
Length:221
Mass (Da):23,504
Last modified:May 1, 2007 - v2
Checksum:iB762F0BB4B3F77C3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731N → K in CAA90074. 1 Publication
Sequence conflicti98 – 981N → I in CAA90074. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49893 Genomic DNA. Translation: CAA90074.1.
AACD01000172 Genomic DNA. Translation: EAA66432.1.
BN001308 Genomic DNA. Translation: CBF87481.1.
PIRiS57469.
RefSeqiXP_682634.1. XM_677542.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001152; CADANIAP00001152; CADANIAG00001152.
GeneIDi2867930.
KEGGiani:AN9365.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49893 Genomic DNA. Translation: CAA90074.1 .
AACD01000172 Genomic DNA. Translation: EAA66432.1 .
BN001308 Genomic DNA. Translation: CBF87481.1 .
PIRi S57469.
RefSeqi XP_682634.1. XM_677542.1.

3D structure databases

ProteinModelPortali P55333.
SMRi P55333. Positions 39-221.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH11. Glycoside Hydrolase Family 11.
mycoCLAPi XYN11B_EMENI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00001152 ; CADANIAP00001152 ; CADANIAG00001152 .
GeneIDi 2867930.
KEGGi ani:AN9365.2.

Phylogenomic databases

eggNOGi NOG05353.
HOGENOMi HOG000179135.
KOi K01181.
OMAi EYYIVET.
OrthoDBi EOG7VQJQX.

Enzyme and pathway databases

UniPathwayi UPA00114 .

Family and domain databases

Gene3Di 2.60.120.180. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view ]
Pfami PF00457. Glyco_hydro_11. 1 hit.
[Graphical view ]
PRINTSi PR00911. GLHYDRLASE11.
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression in Saccharomyces cerevisiae of two Aspergillus nidulans xylanase genes."
    Perez-Gonzalez J.A., de Graaff L.H., Visser J., Ramon D.
    Appl. Environ. Microbiol. 62:2179-2182(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  4. "Opposite patterns of expression of two Aspergillus nidulans xylanase genes with respect to ambient pH."
    MacCabe A.P., Orejas M., Perez-Gonzalez J.A., Ramon D.
    J. Bacteriol. 180:1331-1333(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "The wide-domain carbon catabolite repressor CreA indirectly controls expression of the Aspergillus nidulans xlnB gene, encoding the acidic endo-beta-(1,4)-xylanase X(24)."
    Orejas M., MacCabe A.P., Perez-Gonzalez J.A., Kumar S., Ramon D.
    J. Bacteriol. 183:1517-1523(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans."
    Tamayo E.N., Villanueva A., Hasper A.A., de Graaff L.H., Ramon D., Orejas M.
    Fungal Genet. Biol. 45:984-993(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiXYNB_EMENI
AccessioniPrimary (citable) accession number: P55333
Secondary accession number(s): C8VR70, Q00176, Q5AQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: May 14, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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