ID   GIH_HOMAM               Reviewed;         112 AA.
AC   P55320; Q25013;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Gonad-inhibiting hormone;
DE            Short=GIH;
DE   AltName: Full=Vitellogenesis-inhibiting hormone;
DE            Short=VIH;
DE   Flags: Precursor;
OS   Homarus americanus (American lobster).
OC   Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca;
OC   Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Nephropoidea; Nephropidae; Homarus.
OX   NCBI_TaxID=6706;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   MEDLINE=95046270; PubMed=7957869; DOI=10.1016/0014-5793(94)01055-2;
RA   de Kleijn D.P.V., Sleutels F.J.G.T., Martens G.J.M., van Herp F.;
RT   "Cloning and expression of mRNA encoding prepro-gonad-inhibiting
RT   hormone (GIH) in the lobster Homarus americanus.";
RL   FEBS Lett. 353:255-258(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 32-108, AND MASS SPECTROMETRY.
RC   TISSUE=Sinus gland;
RX   MEDLINE=92168329; PubMed=1791922; DOI=10.1016/0143-4179(91)90036-I;
RA   Soyez D., Le Caer J.-P., Noel P.Y., Rossier J.;
RT   "Primary structure of two isoforms of the vitellogenesis inhibiting
RT   hormone from the lobster Homarus americanus.";
RL   Neuropeptides 20:25-32(1991).
CC   -!- FUNCTION: Inhibits vitellogenesis in female animals. Plays a
CC       prominent role in the regulation of reproduction/molting
CC       processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced in the eyestalk X-organ sinus gland
CC       complex of male and female lobsters.
CC   -!- MASS SPECTROMETRY: Mass=9135; Method=FAB; Range=32-109;
CC       Source=PubMed:1791922;
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone
CC       family.
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DR   EMBL; X87192; CAA60644.1; -; mRNA.
DR   PIR; A45586; A45586.
DR   PIR; S48747; S48747.
DR   HSSP; P55847; 1J0T.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR001166; Crust_neurhormone.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR001262; Crust_neurhormone_MIH/MOIH/GIH.
DR   Gene3D; G3DSA:1.10.2010.10; CHH_MIH_GIH; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL        1     31
FT   PEPTIDE      32    109       Gonad-inhibiting hormone.
FT                                /FTId=PRO_0000019075.
FT   MOD_RES     109    109       Alanine amide (Potential).
FT   DISULFID     41     78       By similarity.
FT   DISULFID     58     74       By similarity.
FT   DISULFID     61     87       By similarity.
FT   CONFLICT     83     83       D -> W (in Ref. 2; AA sequence).
SQ   SEQUENCE   112 AA;  12841 MW;  8C1955EF737747F6 CRC64;
     MVTRVGSGFS VQRVWLLLVI VVVLCGSVTQ QASAWFTNDE CPGVMGNRDL YEKVAWVCND
     CANIFRNNDV GVMCKKDCFH TMDFLWCVYA TERHGEIDQF RKWVSILRAG RK
//