P55320 (GIH_HOMAM) Reviewed, UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gonad-inhibiting hormone Short name=GIH Alternative name(s): Vitellogenesis-inhibiting hormone Short name=VIH |
| Organism | Homarus americanus (American lobster) |
| Taxonomic identifier | 6706 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Crustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Pleocyemata › Astacidea › Nephropoidea › Nephropidae › Homarus |
Protein attributes
| Sequence length | 112 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Inhibits vitellogenesis in female animals. Plays a prominent role in the regulation of reproduction/molting processes. |
| Subcellular location | |
| Tissue specificity | Produced in the eyestalk X-organ sinus gland complex of male and female lobsters. |
| Sequence similarities | Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. |
| Mass spectrometry | Molecular mass is 9135 Da from positions 32 - 109. Determined by FAB. Ref.2 |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hormone Neuropeptide |
| PTM | Amidation Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | neuropeptide hormone activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 31 | 31 | Ref.2 | ||||||||
| Peptide | 32 – 109 | 78 | Gonad-inhibiting hormone | PRO_0000019075 | |||||||
Amino acid modifications | |||||||||||
| Modified residue | 109 | 1 | Alanine amide Potential | ||||||||
| Disulfide bond | 41 ↔ 78 | By similarity | |||||||||
| Disulfide bond | 58 ↔ 74 | By similarity | |||||||||
| Disulfide bond | 61 ↔ 87 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 83 | 1 | D → W AA sequence Ref.2 | ||||||||
Sequences
References
| [1] | "Cloning and expression of mRNA encoding prepro-gonad-inhibiting hormone (GIH) in the lobster Homarus americanus." de Kleijn D.P.V., Sleutels F.J.G.T., Martens G.J.M., van Herp F. FEBS Lett. 353:255-258(1994) [PubMed: 7957869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Eyestalk. |
| [2] | "Primary structure of two isoforms of the vitellogenesis inhibiting hormone from the lobster Homarus americanus." Soyez D., Le Caer J.-P., Noel P.Y., Rossier J. Neuropeptides 20:25-32(1991) [PubMed: 1791922] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-108, MASS SPECTROMETRY. Tissue: Sinus gland. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X87192 mRNA. Translation: CAA60644.1. |
| PIR | A45586. S48747. |
3D structure databases | |
| ProteinModelPortal | P55320. |
| SMR | P55320. Positions 34-111. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR001166. Crust_neurhormone. IPR018251. Crust_neurhormone_CS. IPR001262. Crust_neurhormone_MIH/MOIH/GIH. [Graphical view] |
| Gene3D | G3DSA:1.10.2010.10. CHH_MIH_GIH. 1 hit. |
| Pfam | PF01147. Crust_neurohorm. 1 hit. [Graphical view] |
| PRINTS | PR00549. HYPRGLYCEMC2. PR00550. HYPRGLYCEMIC. |
| SUPFAM | SSF81778. Crust_neurhormone. 1 hit. |
| PROSITE | PS01250. CHH_MIH_GIH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GIH_HOMAM | ||||||||
| Accession | Primary (citable) accession number: P55320 Secondary accession number(s): Q25013 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with