P55319 (AKH1_LOCMI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Adipokinetic prohormone type 1 Cleaved into the following 2 chains: Adipokinetic hormone 1 Alternative name(s): Adipokinetic hormone I Short name=AKH-I Adipokinetic hormone precursor-related peptide alpha chain Short name=APRP-alpha Alternative name(s): 6 kDa dimeric peptide A
Organism	Locusta migratoria (Migratory locust)
Taxonomic identifier	7004 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This hormone, released from cells in the corpora cardiaca after the beginning of flight, causes release of diglycerides from the fat body and then stimulates the flight muscles to use these diglycerides as an energy source.
Subcellular location	Secreted.
Sequence similarities	Belongs to the AKH/HRTH/RPCH family.

Ontologies

Keywords
Biological process	Flight
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone Neuropeptide
PTM	Amidation Cleavage on pair of basic residues Disulfide bond Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	flight behavior Inferred from electronic annotation. Source: UniProtKB-KW neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.2
	Chain	23 – 63	41	Adipokinetic prohormone type 1		PRO_0000000905
	Peptide	23 – 32	10	Adipokinetic hormone 1 Ref.2		PRO_0000000906
	Peptide	36 – 63	28	Adipokinetic hormone precursor-related peptide alpha chain Ref.4		PRO_0000000907
Amino acid modifications
	Modified residue	23	1	Pyrrolidone carboxylic acid Ref.2
	Modified residue	32	1	Threonine amide Ref.2
	Disulfide bond	61		Interchain

Sequences

	Sequence		Length	Mass (Da)
	P55319-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D7D4DD01252E8CAD	FASTA	63	6,824
	10 20 30 40 50 60 MVQRCALVVL LVVAVAAALC SAQLNFTPNW GTGKRDAADF ADPYSFLYRL IQAEARKMSG CSN

References

[1]	"Molecular cloning of three distinct cDNAs, each encoding a different adipokinetic hormone precursor, of the migratory locust, Locusta migratoria. Differential expression of the distinct adipokinetic hormone precursor genes during flight activity." Bogerd J., Kooiman F.P., Pijnenburg M.A.P., Hekking L.H., Oudejans R.C., Vander Horst D.J. J. Biol. Chem. 270:23038-23043(1995) [PubMed: 7559443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Corpora cardiaca.
[2]	"Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight." Stone J.V., Mordue W., Batley K.E., Morris H.R. Nature 263:207-211(1976) [PubMed: 958472] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-32.
[3]	"Isolation, identification, and synthesis of AKH-I4-10 from Locusta migratoria." Schoofs L., Holman G.M., Proost P., van Damme J., Neven H., Oudejans R.C., de Loof A. Gen. Comp. Endocrinol. 90:364-371(1993) [PubMed: 8224763] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-32.
[4]	"Isolation and structure of two novel 6-kDa dimeric peptides from the corpora cardiaca of the insect Locusta migratoria. Molecular mass determination by mass spectrometry." Hietter H., Luu B., Goltzene F., Zachary D., Hoffmann J.A., van Dorsselaer A. Eur. J. Biochem. 182:77-84(1989) [PubMed: 2731552] [Abstract] Cited for: PROTEIN SEQUENCE OF 36-63.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86799 mRNA. Translation: CAA60494.1.
PIR	AKLQ. A58652.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR010475. Adipokinetic_2. IPR002047. Adipokinetic_hormone_CS. [Graphical view]
Pfam	PF06377. Adipokin_hormo. 1 hit. [Graphical view]
PROSITE	PS00256. AKH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AKH1_LOCMI

Accession

Primary (citable) accession number: P55319
Secondary accession number(s): P01271, P10616

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)