P55317 (FOXA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hepatocyte nuclear factor 3-alpha
Short name=HNF-3-alpha
Short name=HNF-3A

Alternative name(s):
Forkhead box protein A1
Transcription factor 3A
Short name=TCF-3A

Gene names

Name:	FOXA1
Synonyms:	HNF3A, TCF3A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles By similarity. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Ref.10 Ref.11 Ref.13 Ref.14 Ref.16
Subunit structure	Binds DNA as a monomer By similarity. Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 By similarity. Ref.12 Ref.15 Ref.16
Subcellular location	Nucleus Ref.9 Ref.11.
Tissue specificity	Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. Ref.8 Ref.9 Ref.11
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator Chromatin regulator Developmental protein Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin remodeling Inferred from sequence or structural similarity. Source: UniProtKB embryo development Inferred from Biological aspect of Ancestor. Source: RefGenome epithelial cell maturation involved in prostate gland development Inferred from Biological aspect of Ancestor. Source: RefGenome epithelial tube branching involved in lung morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome epithelial-mesenchymal signaling involved in prostate gland development Inferred from Biological aspect of Ancestor. Source: RefGenome glucose homeostasis Inferred from Biological aspect of Ancestor. Source: RefGenome hormone metabolic process Inferred from electronic annotation. Source: Compara lung epithelial cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 20160041. Source: BHF-UCL neuron fate specification Inferred from Biological aspect of Ancestor. Source: RefGenome pattern specification process Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell-cell adhesion mediated by cadherin Inferred by curator PubMed 20160041. Source: BHF-UCL positive regulation of intracellular estrogen receptor signaling pathway Inferred from mutant phenotype Ref.10. Source: UniProtKB positive regulation of mitotic cell cycle Inferred from mutant phenotype Ref.10. Source: UniProtKB positive regulation of neuron differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype Ref.10. Source: UniProtKB prostate gland epithelium morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome prostate gland stromal morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of hormone levels Inferred from Biological aspect of Ancestor. Source: RefGenome response to estradiol stimulus Inferred from direct assay Ref.10. Source: UniProtKB secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from sequence or structural similarity. Source: BHF-UCL RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome protein domain specific binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: Compara transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome transcription regulatory region DNA binding Inferred from direct assay Ref.10Ref.11Ref.14. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 472	472	Hepatocyte nuclear factor 3-alpha		PRO_0000091792
Regions
	DNA binding	169 – 260	92	Fork-head
Amino acid modifications
	Modified residue	343	1	Phosphothreonine By similarity
Natural variations
	Natural variant	72	1	G → A. Ref.1 Ref.2		VAR_015183
	Natural variant	83	1	A → T. Ref.2 Corresponds to variant rs7144658 [ dbSNP | Ensembl ].		VAR_013457
	Natural variant	87	1	G → E. Corresponds to variant rs35220193 [ dbSNP | Ensembl ].		VAR_055835
	Natural variant	124	1	M → MM. Ref.1 Ref.2		VAR_015184
	Natural variant	185	1	Q → R. Ref.1 Ref.2		VAR_015185
	Natural variant	448	1	S → N. Ref.2		VAR_013458

Sequences

	Sequence		Length	Mass (Da)
	P55317 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: B2489523459EEB4C	FASTA	472	49,148
	10 20 30 40 50 60 MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 70 80 90 100 110 120 PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 130 140 150 160 170 180 AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 190 200 210 220 230 240 MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK 250 260 270 280 290 300 GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 310 320 330 340 350 360 SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK TPASSTAPPI 370 380 390 400 410 420 SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF SINNLMSSSE QQHKLDFKAY 430 440 450 460 470 EQALQYSPYG STLPASLPLG SASVTTRSPI EPSALEPAYY QGVYSRPVLN TS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line." Bingle C.D., Gowan S. Biochim. Biophys. Acta 1307:17-20(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-72; MET-124 INS AND ARG-185. Tissue: Lung.
[2]	"The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis." Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M. Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448.
[3]	"Genetic variation in the HNF-3alpha gene." Yu L., Takeda J. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[8]	"The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas." Lin L., Miller C.T., Contreras J.I., Prescott M.S., Dagenais S.L., Wu R., Yee J., Orringer M.B., Misek D.E., Hanash S.M., Glover T.W., Beer D.G. Cancer Res. 62:5273-5279(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation." Gao N., Ishii K., Mirosevich J., Kuwajima S., Oppenheimer S.R., Roberts R.L., Jiang M., Yu X., Shappell S.B., Caprioli R.M., Stoffel M., Hayward S.W., Matusik R.J. Development 132:3431-3443(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[10]	"Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response." Laganiere J., Deblois G., Lefebvre C., Bataille A.R., Robert F., Giguere V. Proc. Natl. Acad. Sci. U.S.A. 102:11651-11656(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ESR1-MEDIATED TRANSCRIPTION ACTIVATION.
[11]	"BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)." Williamson E.A., Wolf I., O'Kelly J., Bose S., Tanosaki S., Koeffler H.P. Oncogene 25:1391-1399(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN CELL CYCLE REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]	"Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells." Minoo P., Hu L., Xing Y., Zhu N.L., Chen H., Li M., Borok Z., Li C. Mol. Cell. Biol. 27:2155-2165(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NKX2-1.
[13]	"FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription." Lupien M., Eeckhoute J., Meyer C.A., Wang Q., Zhang Y., Li W., Carroll J.S., Liu X.S., Brown M. Cell 132:958-970(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN CELL TYPE-SPECIFIC TRANSCRIPTION, DIFFERENTIAL RECRUITMENT TO CHROMATIN.
[14]	"Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes." Song L., Wei X., Zhang B., Luo X., Liu J., Feng Y., Xiao X. Cell Stress Chaperones 14:417-425(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN REGULATION OF APOPTOSIS.
[15]	"Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq." Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C. Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FOXA2.
[16]	"Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM." Malik S., Jiang S., Garee J.P., Verdin E., Lee A.V., O'Malley B.W., Zhang M., Belaguli N.S., Oesterreich S. Mol. Cell. Biol. 30:399-412(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ESR1-MEDIATED TRANSCRIPTION REPRESSION, DIFFERENTIAL RECRUITMENT TO CHROMATIN, INTERACTION WITH HDAC7.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Wikipedia

Hepatocyte nuclear factors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39840 mRNA. Translation: AAB06493.1. AF176112, AF176111 Genomic DNA. Translation: AAD51979.1. AF303743, AF303742 Genomic DNA. Translation: AAG40847.1. AK313785 mRNA. Translation: BAG36523.1. AL121790 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW65844.1. BC033890 mRNA. Translation: AAH33890.1.
IPI	IPI01014973.
PIR	S70357.
RefSeq	NP_004487.2. NM_004496.3.
UniGene	Hs.163484.
3D structure databases
ProteinModelPortal	P55317.
SMR	P55317. Positions 168-267.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-57138N.
IntAct	P55317. 2 interactions.
MINT	MINT-2804254.
STRING	9606.ENSP00000250448.
PTM databases
PhosphoSite	P55317.
Polymorphism databases
DMDM	296434509.
Proteomic databases
PaxDb	P55317.
PRIDE	P55317.
Protocols and materials databases
DNASU	3169.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000250448; ENSP00000250448; ENSG00000129514.
GeneID	3169.
KEGG	hsa:3169.
UCSC	uc001wuf.3. human.
Organism-specific databases
CTD	3169.
GeneCards	GC14M038059.
H-InvDB	HIX0011609.
HGNC	HGNC:5021. FOXA1.
HPA	CAB011595.
MIM	602294. gene.
neXtProt	NX_P55317.
PharmGKB	PA201090.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000231817.
HOVERGEN	HBG006621.
InParanoid	P55317.
KO	K09387.
OMA	ALEPSYY.
OrthoDB	EOG4C2HCT.
PhylomeDB	P55317.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3pathway. FOXA transcription factor networks. hnf3apathway. FOXA1 transcription factor network. hnf3bpathway. FOXA2 and FOXA3 transcription factor networks.
SignaLink	P55317.
Gene expression databases
ArrayExpress	P55317.
Bgee	P55317.
CleanEx	HS_FOXA1.
Genevestigator	P55317.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR013638. Fork-head_N. IPR018533. Forkhead_box_C. IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. PF08430. Fork_head_N. 1 hit. PF09354. HNF_C. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FOXA1. human.
GenomeRNAi	3169.
NextBio	12564.
SOURCE	Search...

Entry information

Entry name

FOXA1_HUMAN

Accession

Primary (citable) accession number: P55317
Secondary accession number(s): B2R9H6, Q9H2A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 126 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.