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P55317

- FOXA1_HUMAN

UniProt

P55317 - FOXA1_HUMAN

Protein

Hepatocyte nuclear factor 3-alpha

Gene

FOXA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles By similarity. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.By similarity5 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi169 – 26092Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: Ensembl
    2. chromatin remodeling Source: UniProtKB
    3. dorsal/ventral neural tube patterning Source: Ensembl
    4. epithelial cell maturation involved in prostate gland development Source: Ensembl
    5. epithelial-mesenchymal signaling involved in prostate gland development Source: Ensembl
    6. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    7. glucose homeostasis Source: Ensembl
    8. hormone metabolic process Source: Ensembl
    9. lung epithelial cell differentiation Source: Ensembl
    10. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
    11. neuron fate specification Source: Ensembl
    12. positive regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
    13. positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
    14. positive regulation of mitotic cell cycle Source: UniProtKB
    15. positive regulation of neuron differentiation Source: Ensembl
    16. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    17. positive regulation of smoothened signaling pathway Source: Ensembl
    18. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    19. prostate gland epithelium morphogenesis Source: Ensembl
    20. prostate gland stromal morphogenesis Source: Ensembl
    21. response to estradiol Source: UniProtKB
    22. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP55317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte nuclear factor 3-alpha
    Short name:
    HNF-3-alpha
    Short name:
    HNF-3A
    Alternative name(s):
    Forkhead box protein A1
    Transcription factor 3A
    Short name:
    TCF-3A
    Gene namesi
    Name:FOXA1
    Synonyms:HNF3A, TCF3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:5021. FOXA1.

    Subcellular locationi

    Nucleus 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA201090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Hepatocyte nuclear factor 3-alphaPRO_0000091792Add
    BLAST

    Proteomic databases

    MaxQBiP55317.
    PaxDbiP55317.
    PRIDEiP55317.

    PTM databases

    PhosphoSiteiP55317.

    Expressioni

    Tissue specificityi

    Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.3 Publications

    Gene expression databases

    ArrayExpressiP55317.
    BgeeiP55317.
    CleanExiHS_FOXA1.
    GenevestigatoriP55317.

    Organism-specific databases

    HPAiCAB011595.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer By similarity. Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109411. 9 interactions.
    DIPiDIP-57138N.
    IntActiP55317. 4 interactions.
    MINTiMINT-2804254.
    STRINGi9606.ENSP00000250448.

    Structurei

    3D structure databases

    ProteinModelPortaliP55317.
    SMRiP55317. Positions 168-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000231817.
    HOVERGENiHBG006621.
    InParanoidiP55317.
    KOiK09387.
    OMAiMNTMNTY.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiP55317.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55317-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM    50
    NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG 100
    VTAMGTALSP SGMGAMGAQQ AASMNGLGPY AAAMNPCMSP MAYAPSNLGR 150
    SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI 200
    MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS 250
    GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 300
    SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK 350
    TPASSTAPPI SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF 400
    SINNLMSSSE QQHKLDFKAY EQALQYSPYG STLPASLPLG SASVTTRSPI 450
    EPSALEPAYY QGVYSRPVLN TS 472
    Length:472
    Mass (Da):49,148
    Last modified:May 18, 2010 - v2
    Checksum:iB2489523459EEB4C
    GO
    Isoform 2 (identifier: P55317-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:439
    Mass (Da):45,468
    Checksum:i170DF8E54E6FC73C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721G → A.2 Publications
    VAR_015183
    Natural varianti83 – 831A → T.1 Publication
    Corresponds to variant rs7144658 [ dbSNP | Ensembl ].
    VAR_013457
    Natural varianti87 – 871G → E.
    Corresponds to variant rs35220193 [ dbSNP | Ensembl ].
    VAR_055835
    Natural varianti124 – 1241M → MM.2 Publications
    VAR_015184
    Natural varianti185 – 1851Q → R.2 Publications
    VAR_015185
    Natural varianti448 – 4481S → N.1 Publication
    Corresponds to variant rs33984772 [ dbSNP | Ensembl ].
    VAR_013458

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3333Missing in isoform 2. 1 PublicationVSP_055094Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39840 mRNA. Translation: AAB06493.1.
    AF176112, AF176111 Genomic DNA. Translation: AAD51979.1.
    AF303743, AF303742 Genomic DNA. Translation: AAG40847.1.
    AK313785 mRNA. Translation: BAG36523.1.
    AK316360 mRNA. Translation: BAH14731.1.
    AL121790 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65844.1.
    BC033890 mRNA. Translation: AAH33890.1.
    CCDSiCCDS9665.1. [P55317-1]
    PIRiS70357.
    RefSeqiNP_004487.2. NM_004496.3.
    UniGeneiHs.163484.

    Genome annotation databases

    EnsembliENST00000250448; ENSP00000250448; ENSG00000129514. [P55317-1]
    GeneIDi3169.
    KEGGihsa:3169.
    UCSCiuc001wuf.4. human. [P55317-1]

    Polymorphism databases

    DMDMi296434509.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Hepatocyte nuclear factors entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39840 mRNA. Translation: AAB06493.1 .
    AF176112 , AF176111 Genomic DNA. Translation: AAD51979.1 .
    AF303743 , AF303742 Genomic DNA. Translation: AAG40847.1 .
    AK313785 mRNA. Translation: BAG36523.1 .
    AK316360 mRNA. Translation: BAH14731.1 .
    AL121790 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65844.1 .
    BC033890 mRNA. Translation: AAH33890.1 .
    CCDSi CCDS9665.1. [P55317-1 ]
    PIRi S70357.
    RefSeqi NP_004487.2. NM_004496.3.
    UniGenei Hs.163484.

    3D structure databases

    ProteinModelPortali P55317.
    SMRi P55317. Positions 168-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109411. 9 interactions.
    DIPi DIP-57138N.
    IntActi P55317. 4 interactions.
    MINTi MINT-2804254.
    STRINGi 9606.ENSP00000250448.

    PTM databases

    PhosphoSitei P55317.

    Polymorphism databases

    DMDMi 296434509.

    Proteomic databases

    MaxQBi P55317.
    PaxDbi P55317.
    PRIDEi P55317.

    Protocols and materials databases

    DNASUi 3169.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250448 ; ENSP00000250448 ; ENSG00000129514 . [P55317-1 ]
    GeneIDi 3169.
    KEGGi hsa:3169.
    UCSCi uc001wuf.4. human. [P55317-1 ]

    Organism-specific databases

    CTDi 3169.
    GeneCardsi GC14M038059.
    H-InvDB HIX0011609.
    HGNCi HGNC:5021. FOXA1.
    HPAi CAB011595.
    MIMi 602294. gene.
    neXtProti NX_P55317.
    PharmGKBi PA201090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000231817.
    HOVERGENi HBG006621.
    InParanoidi P55317.
    KOi K09387.
    OMAi MNTMNTY.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi P55317.
    TreeFami TF316127.

    Enzyme and pathway databases

    SignaLinki P55317.

    Miscellaneous databases

    ChiTaRSi FOXA1. human.
    GeneWikii FOXA1.
    GenomeRNAii 3169.
    NextBioi 12564.
    PROi P55317.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55317.
    Bgeei P55317.
    CleanExi HS_FOXA1.
    Genevestigatori P55317.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line."
      Bingle C.D., Gowan S.
      Biochim. Biophys. Acta 1307:17-20(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-72; MET-124 INS AND ARG-185.
      Tissue: Lung.
    2. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
      Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
      Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448.
    3. "Genetic variation in the HNF-3alpha gene."
      Yu L., Takeda J.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary gland and Trachea.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. "The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas."
      Lin L., Miller C.T., Contreras J.I., Prescott M.S., Dagenais S.L., Wu R., Yee J., Orringer M.B., Misek D.E., Hanash S.M., Glover T.W., Beer D.G.
      Cancer Res. 62:5273-5279(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation."
      Gao N., Ishii K., Mirosevich J., Kuwajima S., Oppenheimer S.R., Roberts R.L., Jiang M., Yu X., Shappell S.B., Caprioli R.M., Stoffel M., Hayward S.W., Matusik R.J.
      Development 132:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    10. "Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response."
      Laganiere J., Deblois G., Lefebvre C., Bataille A.R., Robert F., Giguere V.
      Proc. Natl. Acad. Sci. U.S.A. 102:11651-11656(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)."
      Williamson E.A., Wolf I., O'Kelly J., Bose S., Tanosaki S., Koeffler H.P.
      Oncogene 25:1391-1399(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL CYCLE REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    12. "Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells."
      Minoo P., Hu L., Xing Y., Zhu N.L., Chen H., Li M., Borok Z., Li C.
      Mol. Cell. Biol. 27:2155-2165(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NKX2-1.
    13. "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription."
      Lupien M., Eeckhoute J., Meyer C.A., Wang Q., Zhang Y., Li W., Carroll J.S., Liu X.S., Brown M.
      Cell 132:958-970(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL TYPE-SPECIFIC TRANSCRIPTION, DIFFERENTIAL RECRUITMENT TO CHROMATIN.
    14. "Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes."
      Song L., Wei X., Zhang B., Luo X., Liu J., Feng Y., Xiao X.
      Cell Stress Chaperones 14:417-425(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF APOPTOSIS.
    15. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
      Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C.
      Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FOXA2.
    16. "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM."
      Malik S., Jiang S., Garee J.P., Verdin E., Lee A.V., O'Malley B.W., Zhang M., Belaguli N.S., Oesterreich S.
      Mol. Cell. Biol. 30:399-412(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ESR1-MEDIATED TRANSCRIPTION REPRESSION, DIFFERENTIAL RECRUITMENT TO CHROMATIN, INTERACTION WITH HDAC7.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFOXA1_HUMAN
    AccessioniPrimary (citable) accession number: P55317
    Secondary accession number(s): B2R9H6, B7ZAP5, Q9H2A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3