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P55317

- FOXA1_HUMAN

UniProt

P55317 - FOXA1_HUMAN

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Protein
Hepatocyte nuclear factor 3-alpha
Gene
FOXA1, HNF3A, TCF3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles By similarity. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi169 – 26092Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. double-stranded DNA binding Source: RefGenome
  6. sequence-specific DNA binding Source: Ensembl
  7. sequence-specific DNA binding transcription factor activity Source: ProtInc
  8. transcription factor binding Source: RefGenome
  9. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: Ensembl
  2. chromatin remodeling Source: UniProtKB
  3. dorsal/ventral neural tube patterning Source: Ensembl
  4. epithelial cell maturation involved in prostate gland development Source: RefGenome
  5. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  6. epithelial-mesenchymal signaling involved in prostate gland development Source: RefGenome
  7. glucose homeostasis Source: Ensembl
  8. hormone metabolic process Source: Ensembl
  9. lung epithelial cell differentiation Source: Ensembl
  10. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
  11. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  12. neuron fate specification Source: RefGenome
  13. pattern specification process Source: RefGenome
  14. positive regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
  15. positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  16. positive regulation of mitotic cell cycle Source: UniProtKB
  17. positive regulation of neuron differentiation Source: Ensembl
  18. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  19. positive regulation of smoothened signaling pathway Source: Ensembl
  20. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  21. prostate gland epithelium morphogenesis Source: RefGenome
  22. prostate gland stromal morphogenesis Source: RefGenome
  23. regulation of cell cycle Source: Ensembl
  24. response to estradiol Source: UniProtKB
  25. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: RefGenome
  26. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP55317.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-alpha
Short name:
HNF-3-alpha
Short name:
HNF-3A
Alternative name(s):
Forkhead box protein A1
Transcription factor 3A
Short name:
TCF-3A
Gene namesi
Name:FOXA1
Synonyms:HNF3A, TCF3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:5021. FOXA1.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA201090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Hepatocyte nuclear factor 3-alpha
PRO_0000091792Add
BLAST

Proteomic databases

MaxQBiP55317.
PaxDbiP55317.
PRIDEiP55317.

PTM databases

PhosphoSiteiP55317.

Expressioni

Tissue specificityi

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.3 Publications

Gene expression databases

ArrayExpressiP55317.
BgeeiP55317.
CleanExiHS_FOXA1.
GenevestigatoriP55317.

Organism-specific databases

HPAiCAB011595.

Interactioni

Subunit structurei

Binds DNA as a monomer By similarity. Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 By similarity.3 Publications

Protein-protein interaction databases

BioGridi109411. 9 interactions.
DIPiDIP-57138N.
IntActiP55317. 4 interactions.
MINTiMINT-2804254.
STRINGi9606.ENSP00000250448.

Structurei

3D structure databases

ProteinModelPortaliP55317.
SMRiP55317. Positions 168-267.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
InParanoidiP55317.
KOiK09387.
OMAiMNTMNTY.
OrthoDBiEOG7C8GHD.
PhylomeDBiP55317.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55317-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM    50
NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG 100
VTAMGTALSP SGMGAMGAQQ AASMNGLGPY AAAMNPCMSP MAYAPSNLGR 150
SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI 200
MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS 250
GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 300
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK 350
TPASSTAPPI SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF 400
SINNLMSSSE QQHKLDFKAY EQALQYSPYG STLPASLPLG SASVTTRSPI 450
EPSALEPAYY QGVYSRPVLN TS 472
Length:472
Mass (Da):49,148
Last modified:May 18, 2010 - v2
Checksum:iB2489523459EEB4C
GO
Isoform 2 (identifier: P55317-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):45,468
Checksum:i170DF8E54E6FC73C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721G → A.2 Publications
VAR_015183
Natural varianti83 – 831A → T.1 Publication
Corresponds to variant rs7144658 [ dbSNP | Ensembl ].
VAR_013457
Natural varianti87 – 871G → E.
Corresponds to variant rs35220193 [ dbSNP | Ensembl ].
VAR_055835
Natural varianti124 – 1241M → MM.2 Publications
VAR_015184
Natural varianti185 – 1851Q → R.2 Publications
VAR_015185
Natural varianti448 – 4481S → N.1 Publication
Corresponds to variant rs33984772 [ dbSNP | Ensembl ].
VAR_013458

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333Missing in isoform 2.
VSP_055094Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39840 mRNA. Translation: AAB06493.1.
AF176112, AF176111 Genomic DNA. Translation: AAD51979.1.
AF303743, AF303742 Genomic DNA. Translation: AAG40847.1.
AK313785 mRNA. Translation: BAG36523.1.
AK316360 mRNA. Translation: BAH14731.1.
AL121790 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65844.1.
BC033890 mRNA. Translation: AAH33890.1.
CCDSiCCDS9665.1. [P55317-1]
PIRiS70357.
RefSeqiNP_004487.2. NM_004496.3.
UniGeneiHs.163484.

Genome annotation databases

EnsembliENST00000250448; ENSP00000250448; ENSG00000129514.
ENST00000540786; ENSP00000440178; ENSG00000129514.
GeneIDi3169.
KEGGihsa:3169.
UCSCiuc001wuf.4. human. [P55317-1]

Polymorphism databases

DMDMi296434509.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39840 mRNA. Translation: AAB06493.1 .
AF176112 , AF176111 Genomic DNA. Translation: AAD51979.1 .
AF303743 , AF303742 Genomic DNA. Translation: AAG40847.1 .
AK313785 mRNA. Translation: BAG36523.1 .
AK316360 mRNA. Translation: BAH14731.1 .
AL121790 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65844.1 .
BC033890 mRNA. Translation: AAH33890.1 .
CCDSi CCDS9665.1. [P55317-1 ]
PIRi S70357.
RefSeqi NP_004487.2. NM_004496.3.
UniGenei Hs.163484.

3D structure databases

ProteinModelPortali P55317.
SMRi P55317. Positions 168-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109411. 9 interactions.
DIPi DIP-57138N.
IntActi P55317. 4 interactions.
MINTi MINT-2804254.
STRINGi 9606.ENSP00000250448.

PTM databases

PhosphoSitei P55317.

Polymorphism databases

DMDMi 296434509.

Proteomic databases

MaxQBi P55317.
PaxDbi P55317.
PRIDEi P55317.

Protocols and materials databases

DNASUi 3169.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250448 ; ENSP00000250448 ; ENSG00000129514 .
ENST00000540786 ; ENSP00000440178 ; ENSG00000129514 .
GeneIDi 3169.
KEGGi hsa:3169.
UCSCi uc001wuf.4. human. [P55317-1 ]

Organism-specific databases

CTDi 3169.
GeneCardsi GC14M038059.
H-InvDB HIX0011609.
HGNCi HGNC:5021. FOXA1.
HPAi CAB011595.
MIMi 602294. gene.
neXtProti NX_P55317.
PharmGKBi PA201090.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231817.
HOVERGENi HBG006621.
InParanoidi P55317.
KOi K09387.
OMAi MNTMNTY.
OrthoDBi EOG7C8GHD.
PhylomeDBi P55317.
TreeFami TF316127.

Enzyme and pathway databases

SignaLinki P55317.

Miscellaneous databases

ChiTaRSi FOXA1. human.
GeneWikii FOXA1.
GenomeRNAii 3169.
NextBioi 12564.
PROi P55317.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55317.
Bgeei P55317.
CleanExi HS_FOXA1.
Genevestigatori P55317.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line."
    Bingle C.D., Gowan S.
    Biochim. Biophys. Acta 1307:17-20(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-72; MET-124 INS AND ARG-185.
    Tissue: Lung.
  2. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
    Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
    Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448.
  3. "Genetic variation in the HNF-3alpha gene."
    Yu L., Takeda J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland and Trachea.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  8. "The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas."
    Lin L., Miller C.T., Contreras J.I., Prescott M.S., Dagenais S.L., Wu R., Yee J., Orringer M.B., Misek D.E., Hanash S.M., Glover T.W., Beer D.G.
    Cancer Res. 62:5273-5279(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation."
    Gao N., Ishii K., Mirosevich J., Kuwajima S., Oppenheimer S.R., Roberts R.L., Jiang M., Yu X., Shappell S.B., Caprioli R.M., Stoffel M., Hayward S.W., Matusik R.J.
    Development 132:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response."
    Laganiere J., Deblois G., Lefebvre C., Bataille A.R., Robert F., Giguere V.
    Proc. Natl. Acad. Sci. U.S.A. 102:11651-11656(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)."
    Williamson E.A., Wolf I., O'Kelly J., Bose S., Tanosaki S., Koeffler H.P.
    Oncogene 25:1391-1399(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL CYCLE REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  12. "Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells."
    Minoo P., Hu L., Xing Y., Zhu N.L., Chen H., Li M., Borok Z., Li C.
    Mol. Cell. Biol. 27:2155-2165(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NKX2-1.
  13. "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription."
    Lupien M., Eeckhoute J., Meyer C.A., Wang Q., Zhang Y., Li W., Carroll J.S., Liu X.S., Brown M.
    Cell 132:958-970(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL TYPE-SPECIFIC TRANSCRIPTION, DIFFERENTIAL RECRUITMENT TO CHROMATIN.
  14. "Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes."
    Song L., Wei X., Zhang B., Luo X., Liu J., Feng Y., Xiao X.
    Cell Stress Chaperones 14:417-425(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF APOPTOSIS.
  15. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
    Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C.
    Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXA2.
  16. "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM."
    Malik S., Jiang S., Garee J.P., Verdin E., Lee A.V., O'Malley B.W., Zhang M., Belaguli N.S., Oesterreich S.
    Mol. Cell. Biol. 30:399-412(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ESR1-MEDIATED TRANSCRIPTION REPRESSION, DIFFERENTIAL RECRUITMENT TO CHROMATIN, INTERACTION WITH HDAC7.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFOXA1_HUMAN
AccessioniPrimary (citable) accession number: P55317
Secondary accession number(s): B2R9H6, B7ZAP5, Q9H2A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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