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P55317 (FOXA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatocyte nuclear factor 3-alpha

Short name=HNF-3-alpha
Short name=HNF-3A
Alternative name(s):
Forkhead box protein A1
Transcription factor 3A
Short name=TCF-3A
Gene names
Name:FOXA1
Synonyms:HNF3A, TCF3A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles By similarity. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Ref.10 Ref.11 Ref.13 Ref.14 Ref.16

Subunit structure

Binds DNA as a monomer By similarity. Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 By similarity. Ref.12 Ref.15 Ref.16

Subcellular location

Nucleus Ref.9 Ref.11.

Tissue specificity

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. Ref.8 Ref.9 Ref.11

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandDNA-binding
   Molecular functionActivator
Chromatin regulator
Developmental protein
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure formation involved in morphogenesis

Inferred from electronic annotation. Source: Ensembl

chromatin remodeling

Inferred from sequence or structural similarity. Source: UniProtKB

dorsal/ventral neural tube patterning

Inferred from electronic annotation. Source: Ensembl

epithelial cell maturation involved in prostate gland development

Inferred from Biological aspect of Ancestor. Source: RefGenome

epithelial tube branching involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

epithelial-mesenchymal signaling involved in prostate gland development

Inferred from Biological aspect of Ancestor. Source: RefGenome

glucose homeostasis

Inferred from electronic annotation. Source: Ensembl

hormone metabolic process

Inferred from electronic annotation. Source: Ensembl

lung epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 20160041. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

neuron fate specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of cell-cell adhesion mediated by cadherin

Inferred by curator PubMed 20160041. Source: BHF-UCL

positive regulation of intracellular estrogen receptor signaling pathway

Inferred from mutant phenotype Ref.10. Source: UniProtKB

positive regulation of mitotic cell cycle

Inferred from mutant phenotype Ref.10. Source: UniProtKB

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from mutant phenotype Ref.10. Source: UniProtKB

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.11Ref.14. Source: UniProtKB

prostate gland epithelium morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

prostate gland stromal morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to estradiol

Inferred from direct assay Ref.10. Source: UniProtKB

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from direct assay PubMed 9931457. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from direct assay PubMed 9931457. Source: UniProtKB

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from sequence or structural similarity. Source: BHF-UCL

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription regulatory region DNA binding

Inferred from direct assay Ref.10Ref.11Ref.14. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55317-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55317-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 472472Hepatocyte nuclear factor 3-alpha
PRO_0000091792

Regions

DNA binding169 – 26092Fork-head

Natural variations

Alternative sequence1 – 3333Missing in isoform 2.
VSP_055094
Natural variant721G → A. Ref.1 Ref.2
VAR_015183
Natural variant831A → T. Ref.2
Corresponds to variant rs7144658 [ dbSNP | Ensembl ].
VAR_013457
Natural variant871G → E.
Corresponds to variant rs35220193 [ dbSNP | Ensembl ].
VAR_055835
Natural variant1241M → MM. Ref.1 Ref.2
VAR_015184
Natural variant1851Q → R. Ref.1 Ref.2
VAR_015185
Natural variant4481S → N. Ref.2
Corresponds to variant rs33984772 [ dbSNP | Ensembl ].
VAR_013458

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: B2489523459EEB4C

FASTA47249,148
        10         20         30         40         50         60 
MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 

        70         80         90        100        110        120 
PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 

       130        140        150        160        170        180 
AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 

       190        200        210        220        230        240 
MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK 

       250        260        270        280        290        300 
GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 

       310        320        330        340        350        360 
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK TPASSTAPPI 

       370        380        390        400        410        420 
SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF SINNLMSSSE QQHKLDFKAY 

       430        440        450        460        470 
EQALQYSPYG STLPASLPLG SASVTTRSPI EPSALEPAYY QGVYSRPVLN TS 

« Hide

Isoform 2 [UniParc].

Checksum: 170DF8E54E6FC73C
Show »

FASTA43945,468

References

« Hide 'large scale' references
[1]"Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line."
Bingle C.D., Gowan S.
Biochim. Biophys. Acta 1307:17-20(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-72; MET-124 INS AND ARG-185.
Tissue: Lung.
[2]"The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-72; THR-83; MET-124 INS; ARG-185 AND ASN-448.
[3]"Genetic variation in the HNF-3alpha gene."
Yu L., Takeda J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Mammary gland and Trachea.
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[8]"The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas."
Lin L., Miller C.T., Contreras J.I., Prescott M.S., Dagenais S.L., Wu R., Yee J., Orringer M.B., Misek D.E., Hanash S.M., Glover T.W., Beer D.G.
Cancer Res. 62:5273-5279(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation."
Gao N., Ishii K., Mirosevich J., Kuwajima S., Oppenheimer S.R., Roberts R.L., Jiang M., Yu X., Shappell S.B., Caprioli R.M., Stoffel M., Hayward S.W., Matusik R.J.
Development 132:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[10]"Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response."
Laganiere J., Deblois G., Lefebvre C., Bataille A.R., Robert F., Giguere V.
Proc. Natl. Acad. Sci. U.S.A. 102:11651-11656(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1)."
Williamson E.A., Wolf I., O'Kelly J., Bose S., Tanosaki S., Koeffler H.P.
Oncogene 25:1391-1399(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CELL CYCLE REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]"Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells."
Minoo P., Hu L., Xing Y., Zhu N.L., Chen H., Li M., Borok Z., Li C.
Mol. Cell. Biol. 27:2155-2165(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NKX2-1.
[13]"FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription."
Lupien M., Eeckhoute J., Meyer C.A., Wang Q., Zhang Y., Li W., Carroll J.S., Liu X.S., Brown M.
Cell 132:958-970(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CELL TYPE-SPECIFIC TRANSCRIPTION, DIFFERENTIAL RECRUITMENT TO CHROMATIN.
[14]"Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes."
Song L., Wei X., Zhang B., Luo X., Liu J., Feng Y., Xiao X.
Cell Stress Chaperones 14:417-425(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN REGULATION OF APOPTOSIS.
[15]"Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C.
Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FOXA2.
[16]"Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM."
Malik S., Jiang S., Garee J.P., Verdin E., Lee A.V., O'Malley B.W., Zhang M., Belaguli N.S., Oesterreich S.
Mol. Cell. Biol. 30:399-412(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN ESR1-MEDIATED TRANSCRIPTION REPRESSION, DIFFERENTIAL RECRUITMENT TO CHROMATIN, INTERACTION WITH HDAC7.
[17]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39840 mRNA. Translation: AAB06493.1.
AF176112, AF176111 Genomic DNA. Translation: AAD51979.1.
AF303743, AF303742 Genomic DNA. Translation: AAG40847.1.
AK313785 mRNA. Translation: BAG36523.1.
AK316360 mRNA. Translation: BAH14731.1.
AL121790 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65844.1.
BC033890 mRNA. Translation: AAH33890.1.
CCDSCCDS9665.1.
PIRS70357.
RefSeqNP_004487.2. NM_004496.3.
UniGeneHs.163484.

3D structure databases

ProteinModelPortalP55317.
SMRP55317. Positions 168-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109411. 9 interactions.
DIPDIP-57138N.
IntActP55317. 4 interactions.
MINTMINT-2804254.
STRING9606.ENSP00000250448.

PTM databases

PhosphoSiteP55317.

Polymorphism databases

DMDM296434509.

Proteomic databases

MaxQBP55317.
PaxDbP55317.
PRIDEP55317.

Protocols and materials databases

DNASU3169.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000250448; ENSP00000250448; ENSG00000129514.
ENST00000540786; ENSP00000440178; ENSG00000129514.
GeneID3169.
KEGGhsa:3169.
UCSCuc001wuf.4. human.

Organism-specific databases

CTD3169.
GeneCardsGC14M038059.
H-InvDBHIX0011609.
HGNCHGNC:5021. FOXA1.
HPACAB011595.
MIM602294. gene.
neXtProtNX_P55317.
PharmGKBPA201090.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000231817.
HOVERGENHBG006621.
InParanoidP55317.
KOK09387.
OMAMNTMNTY.
OrthoDBEOG7C8GHD.
PhylomeDBP55317.
TreeFamTF316127.

Enzyme and pathway databases

SignaLinkP55317.

Gene expression databases

ArrayExpressP55317.
BgeeP55317.
CleanExHS_FOXA1.
GenevestigatorP55317.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOXA1. human.
GeneWikiFOXA1.
GenomeRNAi3169.
NextBio12564.
PROP55317.
SOURCESearch...

Entry information

Entry nameFOXA1_HUMAN
AccessionPrimary (citable) accession number: P55317
Secondary accession number(s): B2R9H6, B7ZAP5, Q9H2A0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM