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Reviewed, UniProtKB/Swiss-Prot P55317 (FOXA1_HUMAN)

Last modified November 25, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Hepatocyte nuclear factor 3-alpha
      Short name=HNF-3-alpha
      Short name=HNF-3A
Alternative name(s):
    Forkhead box protein A1
Gene names
Name: FOXA1
Synonyms: HNF3A, TCF3A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein

Gene Ontology (GO)

   Cellular componentnucleus

Inferred from electronic annotation. Source: InterPro

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Hepatocyte nuclear factor 3-alpha
PRO_0000091792

Regions

DNA binding170 – 26192Fork-head

Amino acid modifications

Modified residue3441Phosphothreonine By similarity

Natural variations

Natural variant721A → G
VAR_015183
Natural variant831A → T
VAR_013457
Natural variant1251Missing
VAR_015184
Natural variant1861R → Q
VAR_015185
Natural variant4491S → N
VAR_013458

Sequences

Sequence LengthMass (Da)Tools
P55317-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 38F99B59002C4A5F

FASTA47349,321
        10         20         30         40         50         60 
MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 

        70         80         90        100        110        120 
PASFNMSYAN PALGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 

       130        140        150        160        170        180 
AASMMNGLGP YAAAMNPCMS PMAYAPSNLG RSRAGGGGDA KTFKRSYPHA KPPYSYISLI 

       190        200        210        220        230        240 
TMAIQRAPSK MLTLSEIYQW IMDLFPYYRQ NQQRWQNSIR HSLSFNDCFV KVARSPDKPG 

       250        260        270        280        290        300 
KGSYWTLHPD SGNMFENGCY LRRQKRFKCE KQPGAGGGGG SGSGGSGAKG GPESRKDPSG 

       310        320        330        340        350        360 
ASNPSADSPL HRGVHGKTGQ LEGAPAPGPA ASPQTLDHSG ATATGGASEL KTPASSTAPP 

       370        380        390        400        410        420 
ISSGPGALAS VPASHPAHGL APHESQLHLK GDPHYSFNHP FSINNLMSSS EQQHKLDFKA 

       430        440        450        460        470 
YEQALQYSPY GSTLPASLPL GSASVTTRSP IEPSALEPAY YQGVYSRPVL NTS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line."
Bingle C.D., Gowan S.
Biochim. Biophys. Acta 1307:17-20(1996) [PubMed: 8652662] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
Hum. Hered. 50:370-381(2000) [PubMed: 10899756] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-83 AND ASN-449.
[3]"Genetic variation in the HNF-3alpha gene."
Yu L., Takeda J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-72; MET-125 DEL AND GLN-186.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-72; MET-125 DEL AND GLN-186.
Tissue: Testis.
+Additional computationally mapped references.

Web resources

Wikipedia

Hepatocyte nuclear factors entry

Cross-references

Sequence databases

U39840 mRNA. Translation: AAB06493.1.
AF176112, AF176111 Genomic DNA. Translation: AAD51979.1.
AF303743, AF303742 Genomic DNA. Translation: AAG40847.1.
BC033890 mRNA. Translation: AAH33890.1.
PIRS70357.
RefSeqNP_004487.2.
UniGeneHs.163484

3D structure databases

HSSPHSSP built from PDB template 1D5V based on UniProtKB Q99958.
SMRP55317. Positions 171-261.
ModBaseSearch...

PTM databases

PhosphoSiteP55317.

Genome annotation databases

EnsemblENSG00000129514. Homo sapiens. [Contig view]
GeneID3169.
KEGGhsa:3169.

Organism-specific databases

H-InvDBHIX0011609.
HGNCHGNC:5021. FOXA1.
HPACAB011595.
MIM602294. gene.
PharmGKBPA201090.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP55317.
HOVERGENP55317.

Gene expression databases

ArrayExpressP55317.
CleanExHS_FOXA1.

Family and domain databases

InterProIPR013638. Fork-head_N.
IPR001766. TF_Fork_head.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHERPTHR11829. Fork_box_protein. 1 hit.
PfamPF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
ProDomPD000425. TF_Fork_head. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio12564.
SOURCESearch...

Entry information

Entry nameFOXA1_HUMAN
AccessionPrimary (citable) accession number: P55317
Secondary accession number(s): Q9H2A0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents