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P55316

- FOXG1_HUMAN

UniProt

P55316 - FOXG1_HUMAN

Protein

Forkhead box protein G1

Gene

FOXG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi181 – 27595Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. aging Source: Ensembl
    2. axon midline choice point recognition Source: Ensembl
    3. brain development Source: ProtInc
    4. dorsal/ventral pattern formation Source: Ensembl
    5. inner ear morphogenesis Source: Ensembl
    6. negative regulation of neuron differentiation Source: Ensembl
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. neuron fate determination Source: Ensembl
    9. positive regulation of cell cycle Source: Ensembl
    10. positive regulation of neuroblast proliferation Source: Ensembl
    11. pyramidal neuron migration Source: Ensembl
    12. regulation of mitotic cell cycle Source: Ensembl
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein G1
    Alternative name(s):
    Brain factor 1
    Short name:
    BF-1
    Short name:
    BF1
    Brain factor 2
    Short name:
    BF-2
    Short name:
    BF2
    Short name:
    hBF-2
    Forkhead box protein G1A
    Forkhead box protein G1B
    Forkhead box protein G1C
    Forkhead-related protein FKHL1
    Short name:
    HFK1
    Forkhead-related protein FKHL2
    Short name:
    HFK2
    Forkhead-related protein FKHL3
    Short name:
    HFK3
    Gene namesi
    Name:FOXG1
    Synonyms:FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:3811. FOXG1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Rett syndrome congenital variant (RTTCV) [MIM:613454]: A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti215 – 2151F → L in RTTCV. 1 Publication
    VAR_063885
    Natural varianti244 – 2441R → C in RTTCV; the mutant protein extensively, although not fully, localizes in nuclear speckles, while the wild-type is more widely dispersed throughout the nucleus. 1 Publication
    VAR_064396

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi388 – 3892VP → AA: Abolishes interaction with KDM5B.
    Mutagenesisi394 – 3952VP → AA: Abolishes interaction with KDM5B.
    Mutagenesisi404 – 4041P → A: Abolishes interaction with KDM5B. 1 Publication

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi613454. phenotype.
    Orphaneti261229. 14q11.2 microduplication syndrome.
    261144. 14q12 microdeletion syndrome.
    3095. Atypical Rett syndrome.
    PharmGKBiPA162388806.
    PA28228.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Forkhead box protein G1PRO_0000091835Add
    BLAST

    Proteomic databases

    PaxDbiP55316.
    PRIDEiP55316.

    PTM databases

    PhosphoSiteiP55316.

    Expressioni

    Tissue specificityi

    Expression is restricted to the neurons of the developing telencephalon.1 Publication

    Gene expression databases

    BgeeiP55316.
    CleanExiHS_FOXG1.
    GenevestigatoriP55316.

    Interactioni

    Subunit structurei

    Interacts with KDM5B.1 Publication

    Protein-protein interaction databases

    BioGridi108580. 10 interactions.
    IntActiP55316. 2 interactions.
    MINTiMINT-1407364.
    STRINGi9606.ENSP00000339004.

    Structurei

    3D structure databases

    ProteinModelPortaliP55316.
    SMRiP55316. Positions 181-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni383 – 40624Interaction with KDM5BAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 5725His-richAdd
    BLAST
    Compositional biasi58 – 11255Pro-richAdd
    BLAST
    Compositional biasi118 – 17760Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000112629.
    HOVERGENiHBG051645.
    InParanoidiP55316.
    KOiK09385.
    OMAiHPMSYST.
    OrthoDBiEOG7N37DT.
    PhylomeDBiP55316.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55316-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH    50
    HHHHHHHPPP PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ 100
    QLLLPPPPPP PPAAALDGAK ADGLGGKGEP GGGPGELAPV GPDEKEKGAG 150
    AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE KPPFSYNALI MMAIRQSPEK 200
    RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV KVPRHYDDPG 250
    KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM 300
    DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL 350
    GNNHSFSTAN GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY 400
    SLNPCSVNLL AGQTSYFFPH VPHPSMTSQS STSMSARAAS SSTSPQAPST 450
    LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ GSSSNPLIH 489
    Length:489
    Mass (Da):52,352
    Last modified:July 10, 2007 - v2
    Checksum:i897945F9CE4F2A71
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 282AV → GL in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti27 – 282AV → GL in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti27 – 282AV → GL in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti69 – 757PQQQQPP → RAAQQQQ in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti79 – 13860PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA52240. (PubMed:7959731)CuratedAdd
    BLAST
    Sequence conflicti79 – 13860PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA55038. (PubMed:7599184)CuratedAdd
    BLAST
    Sequence conflicti81 – 9616APQPP…AADDD → LAPQAGGAAQSNDE in CAA52239. (PubMed:7959731)CuratedAdd
    BLAST
    Sequence conflicti101 – 1011Q → L in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti107 – 11711PPPPPPAAALD → TDHHRPPS in CAA52239. (PubMed:7959731)CuratedAdd
    BLAST
    Sequence conflicti122 – 13312DGLGG…EPGGG → GGCCR in CAA52239. (PubMed:7959731)CuratedAdd
    BLAST
    Sequence conflicti122 – 1221D → V in AAH50072. (PubMed:15489334)Curated
    Sequence conflicti138 – 1381A → G in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti148 – 1503GAG → AR in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti148 – 1503GAG → AR in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti183 – 1831P → PP in CAA52241. (PubMed:7959731)Curated
    Sequence conflicti194 – 1941I → M in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti194 – 1941I → M in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti226 – 2261Q → H in CAA52241. (PubMed:7959731)Curated
    Sequence conflicti231 – 2311H → D in CAA52241. (PubMed:7959731)Curated
    Sequence conflicti237 – 2371K → M in AAH50072. (PubMed:15489334)Curated
    Sequence conflicti274 – 2741Missing in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti274 – 2741Missing in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti276 – 2761Missing in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti276 – 2761Missing in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti281 – 2811R → P in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti281 – 2811R → P in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti281 – 2811R → P in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti284 – 2841L → P in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti284 – 2841L → P in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti286 – 2916FKRGAR → AFRWCA in CAA52241. (PubMed:7959731)Curated
    Sequence conflicti291 – 2911R → A in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti291 – 2911R → A in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti291 – 2911R → A in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti302 – 32019RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA52240. (PubMed:7959731)CuratedAdd
    BLAST
    Sequence conflicti302 – 32019RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA55038. (PubMed:7599184)CuratedAdd
    BLAST
    Sequence conflicti356 – 3561F → S in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti356 – 3561F → S in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti371 – 3711E → G in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti371 – 3711E → G in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti385 – 3851A → T in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti385 – 3851A → T in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti393 – 3931S → L in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti393 – 3931S → L in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti439 – 4391A → T in AAH50072. (PubMed:15489334)Curated
    Sequence conflicti446 – 4505QAPST → AGPPRP in CAA52240. (PubMed:7959731)Curated
    Sequence conflicti446 – 4505QAPST → AGPPRP in CAA55038. (PubMed:7599184)Curated
    Sequence conflicti446 – 4461Q → P in CAA52239. (PubMed:7959731)Curated
    Sequence conflicti449 – 4502ST → RP in CAA52239. (PubMed:7959731)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091P → L.1 Publication
    VAR_064395
    Natural varianti215 – 2151F → L in RTTCV. 1 Publication
    VAR_063885
    Natural varianti244 – 2441R → C in RTTCV; the mutant protein extensively, although not fully, localizes in nuclear speckles, while the wild-type is more widely dispersed throughout the nucleus. 1 Publication
    VAR_064396

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74142 mRNA. Translation: CAA52239.1.
    X74143 mRNA. Translation: CAA52240.1.
    X74144 mRNA. Translation: CAA52241.1.
    X78202 Genomic DNA. Translation: CAA55038.1.
    AL049777 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65978.1.
    BC050072 mRNA. Translation: AAH50072.1.
    CCDSiCCDS9636.1.
    PIRiB54743.
    I37451.
    RefSeqiNP_005240.3. NM_005249.4.
    UniGeneiHs.632336.
    Hs.740590.
    Hs.741222.

    Genome annotation databases

    EnsembliENST00000313071; ENSP00000339004; ENSG00000176165.
    GeneIDi2290.
    KEGGihsa:2290.
    UCSCiuc001wqe.4. human.

    Polymorphism databases

    DMDMi152031604.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    FOXG1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74142 mRNA. Translation: CAA52239.1 .
    X74143 mRNA. Translation: CAA52240.1 .
    X74144 mRNA. Translation: CAA52241.1 .
    X78202 Genomic DNA. Translation: CAA55038.1 .
    AL049777 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65978.1 .
    BC050072 mRNA. Translation: AAH50072.1 .
    CCDSi CCDS9636.1.
    PIRi B54743.
    I37451.
    RefSeqi NP_005240.3. NM_005249.4.
    UniGenei Hs.632336.
    Hs.740590.
    Hs.741222.

    3D structure databases

    ProteinModelPortali P55316.
    SMRi P55316. Positions 181-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108580. 10 interactions.
    IntActi P55316. 2 interactions.
    MINTi MINT-1407364.
    STRINGi 9606.ENSP00000339004.

    PTM databases

    PhosphoSitei P55316.

    Polymorphism databases

    DMDMi 152031604.

    Proteomic databases

    PaxDbi P55316.
    PRIDEi P55316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313071 ; ENSP00000339004 ; ENSG00000176165 .
    GeneIDi 2290.
    KEGGi hsa:2290.
    UCSCi uc001wqe.4. human.

    Organism-specific databases

    CTDi 2290.
    GeneCardsi GC14P029235.
    HGNCi HGNC:3811. FOXG1.
    MIMi 164874. gene.
    613454. phenotype.
    neXtProti NX_P55316.
    Orphaneti 261229. 14q11.2 microduplication syndrome.
    261144. 14q12 microdeletion syndrome.
    3095. Atypical Rett syndrome.
    PharmGKBi PA162388806.
    PA28228.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000112629.
    HOVERGENi HBG051645.
    InParanoidi P55316.
    KOi K09385.
    OMAi HPMSYST.
    OrthoDBi EOG7N37DT.
    PhylomeDBi P55316.
    TreeFami TF316127.

    Miscellaneous databases

    GeneWikii FOXG1.
    GenomeRNAii 2290.
    NextBioi 9307.
    PROi P55316.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55316.
    CleanExi HS_FOXG1.
    Genevestigatori P55316.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human brain factor 1, a new member of the fork head gene family."
      Murphy D.B., Wiese S., Burfeind P., Schmundt D., Mattei M.-G., Schulz-Schaeffer W., Thies U.
      Genomics 21:551-557(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q."
      Wiese S., Murphy D.B., Schlung A., Burfeind P., Schmundt D., Schnulle V., Mattei M.-G., Thies U.
      Biochim. Biophys. Acta 1262:105-112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9."
      Tan K., Shaw A.L., Madsen B., Jensen K., Taylor-Papadimitriou J., Freemont P.S.
      J. Biol. Chem. 278:20507-20513(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KDM5B, MUTAGENESIS OF 388-VAL-PRO-389; 394-VAL-PRO-395 AND PRO-404, FUNCTION.
    7. "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation."
      Bredenkamp N., Seoighe C., Illing N.
      Dev. Genes Evol. 217:227-233(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FOXG1 AS A SINGLE-COPY GENE.
    8. "A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization."
      Guen T.L., Fichou Y., Nectoux J., Bahi-Buisson N., Rivier F., Boddaert N., Diebold B., Heron D., Chelly J., Bienvenu T.
      Hum. Mutat. 32:E2026-E2035(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, VARIANT RTTCV CYS-244, VARIANT LEU-109, CHARACTERIZATION OF VARIANT RTTCV CYS-244.
    9. Cited for: VARIANT RTTCV LEU-215.

    Entry informationi

    Entry nameiFOXG1_HUMAN
    AccessioniPrimary (citable) accession number: P55316
    Secondary accession number(s): A6NFY2
    , P55315, Q14488, Q86XT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3