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Reviewed, UniProtKB/Swiss-Prot P55316 (FOXG1_HUMAN)

Last modified November 25, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Forkhead box protein G1
Alternative name(s):
    Forkhead box protein G1A
    Forkhead box protein G1B
    Forkhead box protein G1C
    Forkhead-related protein FKHL1
      Short name=HFK1
    Forkhead-related protein FKHL2
      Short name=HFK2
    Forkhead-related protein FKHL3
      Short name=HFK3
    Transcription factor BF-1
    Brain factor 1
      Short name=BF1
    Transcription factor BF-2
    Brain factor 2
      Short name=hBF-2
      Short name=BF2
Gene names
Name: FOXG1
Synonyms: FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.

Subunit structure

Interacts with JARID1B.

Subcellular location

Nucleus.

Tissue specificity

Expression is restricted to the neurons of the developing telencephalon.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Caution

Ref.1 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.

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Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein

Gene Ontology (GO)

   Biological processregulation of transcription, DNA-dependent

Non-traceable author statement. Source: UniProtKB

   Cellular componentnucleus

Non-traceable author statement. Source: UniProtKB

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor activity

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Forkhead box protein G1
PRO_0000091835

Regions

DNA binding181 – 27595Fork-head
Region383 – 40624Interaction with JARID1B
Compositional bias33 – 5725His-rich
Compositional bias58 – 11255Pro-rich
Compositional bias118 – 17760Gly-rich

Experimental info

Mutagenesis388 – 3892VP → AA: Abolishes interaction with JARID1B
Mutagenesis394 – 3952VP → AA: Abolishes interaction with JARID1B
Mutagenesis4041P → A: Abolishes interaction with JARID1B
Sequence conflict27 – 282AV → GL in CAA52239 and CAA52240. Ref.1
Sequence conflict27 – 282AV → GL in CAA55038. Ref.2
Sequence conflict69 – 757PQQQQPP → RAAQQQQ in CAA52239. Ref.1
Sequence conflict79 – 13860PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA52240. Ref.1
Sequence conflict79 – 13860PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA55038. Ref.2
Sequence conflict81 – 9616APQPP…AADDD → LAPQAGGAAQSNDE in CAA52239. Ref.1
Sequence conflict1011Q → L in CAA52239. Ref.1
Sequence conflict107 – 11711PPPPPPAAALD → TDHHRPPS in CAA52239. Ref.1
Sequence conflict122 – 13312DGLGG…EPGGG → GGCCR in CAA52239. Ref.1
Sequence conflict1221D → V in AAH50072. Ref.5
Sequence conflict1381A → G in CAA52239. Ref.1
Sequence conflict148 – 1503GAG → AR in CAA52240. Ref.1
Sequence conflict148 – 1503GAG → AR in CAA55038. Ref.2
Sequence conflict1831P → PP in CAA52241. Ref.1
Sequence conflict1941I → M in CAA52240. Ref.1
Sequence conflict1941I → M in CAA55038. Ref.2
Sequence conflict2261Q → H in CAA52241. Ref.1
Sequence conflict2311H → D in CAA52241. Ref.1
Sequence conflict2371K → M in AAH50072. Ref.5
Sequence conflict2741Missing in CAA52240. Ref.1
Sequence conflict2741Missing in CAA55038. Ref.2
Sequence conflict2761Missing in CAA52240. Ref.1
Sequence conflict2761Missing in CAA55038. Ref.2
Sequence conflict2811R → P in CAA52239 and CAA52240. Ref.1
Sequence conflict2811R → P in CAA55038. Ref.2
Sequence conflict2841L → P in CAA52240. Ref.1
Sequence conflict2841L → P in CAA55038. Ref.2
Sequence conflict286 – 2916FKRGAR → AFRWCA in CAA52241. Ref.1
Sequence conflict2911R → A in CAA52239 and CAA52240. Ref.1
Sequence conflict2911R → A in CAA55038. Ref.2
Sequence conflict302 – 32019RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA52240. Ref.1
Sequence conflict302 – 32019RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA55038. Ref.2
Sequence conflict3561F → S in CAA52240. Ref.1
Sequence conflict3561F → S in CAA55038. Ref.2
Sequence conflict3711E → G in CAA52240. Ref.1
Sequence conflict3711E → G in CAA55038. Ref.2
Sequence conflict3851A → T in CAA52240. Ref.1
Sequence conflict3851A → T in CAA55038. Ref.2
Sequence conflict3931S → L in CAA52240. Ref.1
Sequence conflict3931S → L in CAA55038. Ref.2
Sequence conflict4391A → T in AAH50072. Ref.5
Sequence conflict446 – 4505QAPST → AGPPRP in CAA52240. Ref.1
Sequence conflict446 – 4505QAPST → AGPPRP in CAA55038. Ref.2
Sequence conflict4461Q → P in CAA52239. Ref.1
Sequence conflict449 – 4502ST → RP in CAA52239. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P55316-1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 897945F9CE4F2A71

FASTA48952,352
        10         20         30         40         50         60 
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP 

        70         80         90        100        110        120 
PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK 

       130        140        150        160        170        180 
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE 

       190        200        210        220        230        240 
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV 

       250        260        270        280        290        300 
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM 

       310        320        330        340        350        360 
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN 

       370        380        390        400        410        420 
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH 

       430        440        450        460        470        480 
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ 


GSSSNPLIH

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References

« Hide 'large scale' references
[1]"Human brain factor 1, a new member of the fork head gene family."
Murphy D.B., Wiese S., Burfeind P., Schmundt D., Mattei M.-G., Schulz-Schaeffer W., Thies U.
Genomics 21:551-557(1994) [PubMed: 7959731] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q."
Wiese S., Murphy D.B., Schlung A., Burfeind P., Schmundt D., Schnulle V., Mattei M.-G., Thies U.
Biochim. Biophys. Acta 1262:105-112(1995) [PubMed: 7599184] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9."
Tan K., Shaw A.L., Madsen B., Jensen K., Taylor-Papadimitriou J., Freemont P.S.
J. Biol. Chem. 278:20507-20513(2003) [PubMed: 12657635] [Abstract]
Cited for: INTERACTION WITH JARID1B, MUTAGENESIS OF 388-VAL-PRO-389; 394-VAL-PRO-395 AND PRO-404, FUNCTION.
[7]"Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation."
Bredenkamp N., Seoighe C., Illing N.
Dev. Genes Evol. 217:227-233(2007) [PubMed: 17260156] [Abstract]
Cited for: IDENTIFICATION OF FOXG1 AS A SINGLE-COPY GENE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X74142 mRNA. Translation: CAA52239.1.
X74143 mRNA. Translation: CAA52240.1.
X74144 mRNA. Translation: CAA52241.1.
X78202 Genomic DNA. Translation: CAA55038.1.
AL049777 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65978.1.
BC050072 mRNA. Translation: AAH50072.1.
PIRB54743.
I37451.
RefSeqNP_005240.3.
UniGeneHs.695962
Hs.701530

3D structure databases

HSSPHSSP built from PDB template 1D5V based on UniProtKB Q99958.
ModBaseSearch...

Protein-protein interaction databases

IntActP55316.

PTM databases

PhosphoSiteP55316.

Genome annotation databases

EnsemblENSG00000176165. Homo sapiens. [Contig view]
GeneID2290.
KEGGhsa:2290.

Organism-specific databases

HGNCHGNC:3811. FOXG1.
MIM164874. gene.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP55316.

Gene expression databases

ArrayExpressP55316.
CleanExHS_FOXG1.
GermOnlineENSG00000176165. Homo sapiens.

Family and domain databases

InterProIPR001766. TF_Fork_head.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]