Forkhead box protein G1 - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Forkhead box protein G1
Alternative name(s):
    Forkhead box protein G1A
    Forkhead box protein G1B
    Forkhead box protein G1C
    Forkhead-related protein FKHL1
      Short name=HFK1
    Forkhead-related protein FKHL2
      Short name=HFK2
    Forkhead-related protein FKHL3
      Short name=HFK3
    Transcription factor BF-1
    Brain factor 1
      Short name=BF1
    Transcription factor BF-2
    Brain factor 2
      Short name=hBF-2
      Short name=BF2

Gene names

Name:	FOXG1
Synonyms:	FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Ref.6
Subunit structure	Interacts with KDM5B.
Subcellular location	Nucleus.
Tissue specificity	Expression is restricted to the neurons of the developing telencephalon. Ref.1
Sequence similarities	Contains 1 fork-head DNA-binding domain.
Caution	Ref.1 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 489

489

Forkhead box protein G1

PRO_0000091835

Regions

DNA binding

181 – 275

95

Fork-head

Region

383 – 406

24

Interaction with KDM5B

Compositional bias

33 – 57

25

His-rich

Compositional bias

58 – 112

55

Pro-rich

Compositional bias

118 – 177

60

Gly-rich

Experimental info

Mutagenesis

388 – 389

2

VP → AA: Abolishes interaction with KDM5B.

Mutagenesis

394 – 395

2

VP → AA: Abolishes interaction with KDM5B.

Mutagenesis

404

1

P → A: Abolishes interaction with KDM5B.

Sequence conflict

27 – 28

2

AV → GL in CAA52239. Ref.1

Sequence conflict

27 – 28

2

AV → GL in CAA52240. Ref.1

Sequence conflict

27 – 28

2

AV → GL in CAA55038. Ref.2

Sequence conflict

69 – 75

7

PQQQQPP → RAAQQQQ in CAA52239. Ref.1

Sequence conflict

79 – 138

60

PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA52240. Ref.1

Sequence conflict

79 – 138

60

PPAPQ…PGELA → RRGARRRRRRGPSSCCSAAH AHGAPEGQRQLAQGDRRGRG IC in CAA55038. Ref.2

Sequence conflict

81 – 96

16

APQPP…AADDD → LAPQAGGAAQSNDE in CAA52239. Ref.1

Sequence conflict

101

1

Q → L in CAA52239. Ref.1

Sequence conflict

107 – 117

11

PPPPPPAAALD → TDHHRPPS in CAA52239. Ref.1

Sequence conflict

122 – 133

12

DGLGG…EPGGG → GGCCR in CAA52239. Ref.1

Sequence conflict

122

1

D → V in AAH50072. Ref.5

Sequence conflict

138

1

A → G in CAA52239. Ref.1

Sequence conflict

148 – 150

3

GAG → AR in CAA52240. Ref.1

Sequence conflict

148 – 150

3

GAG → AR in CAA55038. Ref.2

Sequence conflict

183

1

P → PP in CAA52241. Ref.1

Sequence conflict

194

1

I → M in CAA52240. Ref.1

Sequence conflict

194

1

I → M in CAA55038. Ref.2

Sequence conflict

226

1

Q → H in CAA52241. Ref.1

Sequence conflict

231

1

H → D in CAA52241. Ref.1

Sequence conflict

237

1

K → M in AAH50072. Ref.5

Sequence conflict

274

1

Missing in CAA52240. Ref.1

Sequence conflict

274

1

Missing in CAA55038. Ref.2

Sequence conflict

276

1

Missing in CAA52240. Ref.1

Sequence conflict

276

1

Missing in CAA55038. Ref.2

Sequence conflict

281

1

R → P in CAA52239. Ref.1

Sequence conflict

281

1

R → P in CAA52240. Ref.1

Sequence conflict

281

1

R → P in CAA55038. Ref.2

Sequence conflict

284

1

L → P in CAA52240. Ref.1

Sequence conflict

284

1

L → P in CAA55038. Ref.2

Sequence conflict

286 – 291

6

FKRGAR → AFRWCA in CAA52241. Ref.1

Sequence conflict

291

1

R → A in CAA52239. Ref.1

Sequence conflict

291

1

R → A in CAA52240. Ref.1

Sequence conflict

291

1

R → A in CAA55038. Ref.2

Sequence conflict

302 – 320

19

RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA52240. Ref.1

Sequence conflict

302 – 320

19

RAGSL…LHHPR → APAPSTGPCRPSCPCTTP in CAA55038. Ref.2

Sequence conflict

356

1

F → S in CAA52240. Ref.1

Sequence conflict

356

1

F → S in CAA55038. Ref.2

Sequence conflict

371

1

E → G in CAA52240. Ref.1

Sequence conflict

371

1

E → G in CAA55038. Ref.2

Sequence conflict

385

1

A → T in CAA52240. Ref.1

Sequence conflict

385

1

A → T in CAA55038. Ref.2

Sequence conflict

393

1

S → L in CAA52240. Ref.1

Sequence conflict

393

1

S → L in CAA55038. Ref.2

Sequence conflict

439

1

A → T in AAH50072. Ref.5

Sequence conflict

446 – 450

5

QAPST → AGPPRP in CAA52240. Ref.1

Sequence conflict

446 – 450

5

QAPST → AGPPRP in CAA55038. Ref.2

Sequence conflict

446

1

Q → P in CAA52239. Ref.1

Sequence conflict

449 – 450

2

ST → RP in CAA52239. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P55316-1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 897945F9CE4F2A71
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FASTA

489

52,352

        10         20         30         40         50         60 
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP 

        70         80         90        100        110        120 
PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK 

       130        140        150        160        170        180 
ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE 

       190        200        210        220        230        240 
KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV 

       250        260        270        280        290        300 
KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM 

       310        320        330        340        350        360 
DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN 

       370        380        390        400        410        420 
GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH 

       430        440        450        460        470        480 
VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ 


GSSSNPLIH

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human brain factor 1, a new member of the fork head gene family." Murphy D.B., Wiese S., Burfeind P., Schmundt D., Mattei M.-G., Schulz-Schaeffer W., Thies U. Genomics 21:551-557(1994) [PubMed: 7959731] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q." Wiese S., Murphy D.B., Schlung A., Burfeind P., Schmundt D., Schnulle V., Mattei M.-G., Thies U. Biochim. Biophys. Acta 1262:105-112(1995) [PubMed: 7599184] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9." Tan K., Shaw A.L., Madsen B., Jensen K., Taylor-Papadimitriou J., Freemont P.S. J. Biol. Chem. 278:20507-20513(2003) [PubMed: 12657635] [Abstract] Cited for: INTERACTION WITH KDM5B, MUTAGENESIS OF 388-VAL-PRO-389; 394-VAL-PRO-395 AND PRO-404, FUNCTION.
[7]	"Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation." Bredenkamp N., Seoighe C., Illing N. Dev. Genes Evol. 217:227-233(2007) [PubMed: 17260156] [Abstract] Cited for: IDENTIFICATION OF FOXG1 AS A SINGLE-COPY GENE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X74142 mRNA. Translation: CAA52239.1. X74143 mRNA. Translation: CAA52240.1. X74144 mRNA. Translation: CAA52241.1. X78202 Genomic DNA. Translation: CAA55038.1. AL049777 Genomic DNA. No translation available. CH471078 Genomic DNA. Translation: EAW65978.1. BC050072 mRNA. Translation: AAH50072.1.
IPI	IPI00024386.
PIR	B54743. I37451.
RefSeq	NP_005240.3.
UniGene	Hs.695962 Hs.708841
3D structure databases
HSSP	HSSP built from PDB template 1D5V based on UniProtKB Q99958.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55316. 2 interactions.
PTM databases
PhosphoSite	P55316.
Proteomic databases
PRIDE	P55316.
Genome annotation databases
Ensembl	ENSG00000176165. Homo sapiens. [Contig view]
GeneID	2290.
KEGG	hsa:2290.
Organism-specific databases
GeneCards	GC14P028306.
HGNC	HGNC:3811. FOXG1.
MIM	164874. gene.
Orphanet	3095. Rett-like syndrome.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P55316.
OMA	P55316. KYEKPPF.
Enzyme and pathway databases
Pathway_Interaction_DB	smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.
Gene expression databases
ArrayExpress	P55316.
Bgee	P55316.
CleanEx	HS_FOXG1.
GermOnline	ENSG00000176165. Homo sapiens.
Family and domain databases
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHER	PTHR11829. Fork_box_protein. 1 hit.
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
ProDom	PD000425. TF_Fork_head. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	9307.
SOURCE	Search...

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Entry information

Entry name

FOXG1_HUMAN

Accession

Primary (citable) accession number: P55316
Secondary accession number(s): A6NFY2

Q86XT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents