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Protein

Catalase

Gene

cta1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60PROSITE-ProRule annotation1
Active sitei133PROSITE-ProRule annotation1
Metal bindingi344Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: PomBase
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular detoxification of hydrogen peroxide Source: PomBase
  • hydrogen peroxide catabolic process Source: PomBase
  • response to hydrogen peroxide Source: GO_Central

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-3299685 Detoxification of Reactive Oxygen Species
R-SPO-6798695 Neutrophil degranulation
R-SPO-9033241 Peroxisomal protein import

Protein family/group databases

PeroxiBasei5261 SpomKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:cta1
ORF Names:SPCC757.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC757.07c
PomBaseiSPCC757.07c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849271 – 512CatalaseAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei363Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP55306
PaxDbiP55306
PRIDEiP55306

PTM databases

iPTMnetiP55306

Interactioni

Protein-protein interaction databases

BioGridi275983, 6 interactors
STRINGi4896.SPCC757.07c.1

Structurei

3D structure databases

ProteinModelPortaliP55306
SMRiP55306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

HOGENOMiHOG000087852
InParanoidiP55306
KOiK03781
OMAiHADFGRM
OrthoDBiEOG092C0NOX
PhylomeDBiP55306

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P55306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKDSNTVP VYTTNTGCPI FNPMAAARVG KGGPVLLQDS HLIDVFQHFD
60 70 80 90 100
RERIPERVVH AKGSGAFGEF ECTDDITKYT KHTMFSKVGK KTPMVARFST
110 120 130 140 150
VGGERGTPDT ARDPRGFALK FYTDEGIFDM VGNNTPVFFL RDPAKFPLFI
160 170 180 190 200
HTQKRNPQND MKDATMFWDY LSQNAESIHQ VMILFSDLGG TPYSYRFMDG
210 220 230 240 250
FSSHTYKFVN DKGEFYYCKW HFITNQGTKG LTNEEAAALD GSNPDHARQD
260 270 280 290 300
LFEAIERGDY PSWTLYVQVM TPQEAEKYRY NIFDLTKVWP HKDVPMQRVG
310 320 330 340 350
RFTLNQNPTN FFADIEQAGF SPSHMVPGIE VSADPVLQVR TFSYPDTHRH
360 370 380 390 400
RLGANFEQIP VNSPKCPVFN YSRDGPMNVN GNQGNWPNYP SSIRPLAKVQ
410 420 430 440 450
YEPDEGHEKW VGQVTYHMDE ITDVDFEQPR AFWQNVLGKK PGQQDNFVKN
460 470 480 490 500
VAGHLSGAIS PVRERQYGVF TRVDSELGRR IREATEAEVK KMEEKAPKPI
510
NKGEPHMFQG SS
Length:512
Mass (Da):58,279
Last modified:October 1, 1996 - v1
Checksum:i1F00ECE327C1AB08
GO

Sequence cautioni

The sequence BAA13788 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55675 Genomic DNA Translation: BAA09526.1
D89126 mRNA Translation: BAA13788.1 Different initiation.
CU329672 Genomic DNA Translation: CAA21232.1
PIRiJC4164
T42369
RefSeqiNP_587682.1, NM_001022677.2

Genome annotation databases

EnsemblFungiiSPCC757.07c.1; SPCC757.07c.1:pep; SPCC757.07c
GeneIDi2539418
KEGGispo:SPCC757.07c

Similar proteinsi

Entry informationi

Entry nameiCATA_SCHPO
AccessioniPrimary (citable) accession number: P55306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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