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P55305

- CATA_EMENI

UniProt

P55305 - CATA_EMENI

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Protein

Catalase A

Gene
catA, AN8637
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931 By similarity
Active sitei166 – 1661 By similarity
Metal bindingi380 – 3801Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. catalase activity Source: ASPGD
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to heat Source: ASPGD
  2. cellular response to hydrogen peroxide Source: ASPGD
  3. cellular response to iron ion starvation Source: ASPGD
  4. hydrogen peroxide catabolic process Source: UniProtKB-KW
  5. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide, Sporulation

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei5213. AniKat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase A (EC:1.11.1.6)
Alternative name(s):
Spore-specific catalase
Gene namesi
Name:catA
ORF Names:AN8637
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome III

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Catalase APRO_0000084921Add
BLAST

Expressioni

Developmental stagei

Sporulation-specific.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006410.

Structurei

3D structure databases

ProteinModelPortaliP55305.
SMRiP55305. Positions 44-744.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.

Phylogenomic databases

eggNOGiCOG0753.
HOGENOMiHOG000087851.
KOiK03781.
OMAiSMSEHEK.
OrthoDBiEOG7K9KBN.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024712. Catalase_clade2.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
IPR029062. Class_I_gatase-like.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038927. Catalase_clade2. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55305-1 [UniParc]FASTAAdd to Basket

« Hide

MATSITAGLQ KAQQAVQDTA TKNKKIVDIS HDTVNVHTDQ EQRTDFGVAI    50
TDPDHWLRVT NETHSGPSLL EDHIARERIH RFDHERIPER VVHARGTGAY 100
GNFTLKESIE DLTYAGVLTD TSRNTPVFVR FSTVQGSRGS ADTVRDVRGF 150
AVKFYTDEGN WDIVGNNIPV FFIQDAIKFP DFVHAVKPEP HNEVPQAQTA 200
HNNFWDFVYL HPEATHMFMW AMSDRAIPRS YRMMQGFGVN TFSLVNKEGK 250
RHFVKFHWIP HLGVHSLVWD EALKLAGQDP DFHRKDLMEA IDNKAYPKWD 300
FAIQAIPEED QDKFEFDIFD ATKVWPEEQV PLRVVGELEL NRNIDEFFPE 350
TEQVAFCTSH IVPGIDFSDD PLLQGRNFSY QDTQISRLGV NWEEIPINRP 400
VCPFLNHNRD GAKRHRITKG TVNYWPNRFE ANPPASDKGF KSHPAPITGR 450
KRRDLTPKFK EYHNQAQLFY NSLSEVEKVH VKKAFSFELD HCDDPIVYER 500
LAGQRLAEID LPLAQAVAEM VGAPIPTKAL RDNHGKTSVR LSQFDFTPKA 550
PGIISRRIAI IIGDGYDKIA FNGMKAAILA AQALPFVIGT KRSAIYAQGE 600
DKNSSKGVIP DHMYDGMRST MFDATFIPGG SHIETLQKNG QIRYWIAETF 650
GHLKALGAMG EAAQLVKEVL GNVMGVQIAG ADSAEPVEWY GVVTARGPES 700
AESLSEGFKV LKDAGDFTSK FFYQISQHRN WQRELDGLAS TVAF 744
Length:744
Mass (Da):83,990
Last modified:May 26, 2009 - v2
Checksum:i3933E190CCBB0713
GO

Sequence cautioni

The sequence AAC49254.1 differs from that shown. Reason: Frameshift at positions 583 and 592.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti582 – 5821Q → A in AAC49254. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37803 Genomic DNA. Translation: AAC49254.1. Frameshift.
AACD01000158 Genomic DNA. Translation: EAA60671.1.
BN001303 Genomic DNA. Translation: CBF78282.1.
PIRiS68115.
RefSeqiXP_681906.1. XM_676814.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006410; CADANIAP00006410; CADANIAG00006410.
GeneIDi2868532.
KEGGiani:AN8637.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37803 Genomic DNA. Translation: AAC49254.1 . Frameshift.
AACD01000158 Genomic DNA. Translation: EAA60671.1 .
BN001303 Genomic DNA. Translation: CBF78282.1 .
PIRi S68115.
RefSeqi XP_681906.1. XM_676814.1.

3D structure databases

ProteinModelPortali P55305.
SMRi P55305. Positions 44-744.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00006410.

Protein family/group databases

PeroxiBasei 5213. AniKat01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00006410 ; CADANIAP00006410 ; CADANIAG00006410 .
GeneIDi 2868532.
KEGGi ani:AN8637.2.

Phylogenomic databases

eggNOGi COG0753.
HOGENOMi HOG000087851.
KOi K03781.
OMAi SMSEHEK.
OrthoDBi EOG7K9KBN.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
3.40.50.880. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024712. Catalase_clade2.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
IPR029062. Class_I_gatase-like.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038927. Catalase_clade2. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase."
    Navarro R.E., Stringer M.A., Hansberg W., Timberlake W.E., Aguirre J.
    Curr. Genet. 29:352-359(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FGSC 26.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiCATA_EMENI
AccessioniPrimary (citable) accession number: P55305
Secondary accession number(s): C8VAD2, Q5ASU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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