P55305 (CATA_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase A
EC=1.11.1.6

Alternative name(s):
Spore-specific catalase

Gene names

Name:	catA
ORF Names:	AN8637

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella › Emericella nidulans › mitosporic Emericella nidulans

Protein attributes

Sequence length	744 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Developmental stage	Sporulation-specific.
Sequence similarities	Belongs to the catalase family.
Sequence caution	The sequence AAC49254.1 differs from that shown. Reason: Frameshift at positions 583 and 592.

Ontologies

Keywords
Biological process	Hydrogen peroxide Sporulation
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 744	744	Catalase A		PRO_0000084921
Sites
	Active site	93	1	By similarity
	Active site	166	1	By similarity
	Metal binding	380	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	582	1	Q → A in AAC49254. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P55305 [UniParc]. Last modified May 26, 2009. Version 2. Checksum: 3933E190CCBB0713	FASTA	744	83,990
	10 20 30 40 50 60 MATSITAGLQ KAQQAVQDTA TKNKKIVDIS HDTVNVHTDQ EQRTDFGVAI TDPDHWLRVT 70 80 90 100 110 120 NETHSGPSLL EDHIARERIH RFDHERIPER VVHARGTGAY GNFTLKESIE DLTYAGVLTD 130 140 150 160 170 180 TSRNTPVFVR FSTVQGSRGS ADTVRDVRGF AVKFYTDEGN WDIVGNNIPV FFIQDAIKFP 190 200 210 220 230 240 DFVHAVKPEP HNEVPQAQTA HNNFWDFVYL HPEATHMFMW AMSDRAIPRS YRMMQGFGVN 250 260 270 280 290 300 TFSLVNKEGK RHFVKFHWIP HLGVHSLVWD EALKLAGQDP DFHRKDLMEA IDNKAYPKWD 310 320 330 340 350 360 FAIQAIPEED QDKFEFDIFD ATKVWPEEQV PLRVVGELEL NRNIDEFFPE TEQVAFCTSH 370 380 390 400 410 420 IVPGIDFSDD PLLQGRNFSY QDTQISRLGV NWEEIPINRP VCPFLNHNRD GAKRHRITKG 430 440 450 460 470 480 TVNYWPNRFE ANPPASDKGF KSHPAPITGR KRRDLTPKFK EYHNQAQLFY NSLSEVEKVH 490 500 510 520 530 540 VKKAFSFELD HCDDPIVYER LAGQRLAEID LPLAQAVAEM VGAPIPTKAL RDNHGKTSVR 550 560 570 580 590 600 LSQFDFTPKA PGIISRRIAI IIGDGYDKIA FNGMKAAILA AQALPFVIGT KRSAIYAQGE 610 620 630 640 650 660 DKNSSKGVIP DHMYDGMRST MFDATFIPGG SHIETLQKNG QIRYWIAETF GHLKALGAMG 670 680 690 700 710 720 EAAQLVKEVL GNVMGVQIAG ADSAEPVEWY GVVTARGPES AESLSEGFKV LKDAGDFTSK 730 740 FFYQISQHRN WQRELDGLAS TVAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase." Navarro R.E., Stringer M.A., Hansberg W., Timberlake W.E., Aguirre J. Curr. Genet. 29:352-359(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FGSC 26.
[2]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U37803 Genomic DNA. Translation: AAC49254.1. Frameshift. AACD01000158 Genomic DNA. Translation: EAA60671.1. BN001303 Genomic DNA. Translation: CBF78282.1.
PIR	S68115.
RefSeq	XP_681906.1. XM_676814.1.
3D structure databases
ProteinModelPortal	P55305.
SMR	P55305. Positions 44-744.
ModBase	Search...
Protein-protein interaction databases
STRING	162425.CADANIAP00006410.
Protein family/group databases
PeroxiBase	5213. AniKat01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00006410; CADANIAP00006410; CADANIAG00006410.
GeneID	2868532.
KEGG	ani:AN8637.2.
Phylogenomic databases
eggNOG	COG0753.
HOGENOM	HOG000087851.
KO	K03781.
OMA	NHNRDGA.
OrthoDB	EOG4B8NN5.
Family and domain databases
Gene3D	2.40.180.10. 1 hit.
InterPro	IPR018028. Catalase. IPR020835. Catalase-like_dom. IPR024708. Catalase_AS. IPR024712. Catalase_clade2. IPR011614. Catalase_core. IPR002226. Catalase_haem_BS. IPR010582. Catalase_immune_responsive. [Graphical view]
PANTHER	PTHR11465. PTHR11465. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PIRSF	PIRSF038927. Catalase_clade2. 1 hit.
PRINTS	PR00067. CATALASE.
SMART	SM01060. Catalase. 1 hit. [Graphical view]
SUPFAM	SSF56634. Catalase_N. 1 hit.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_EMENI

Accession

Primary (citable) accession number: P55305
Secondary accession number(s): C8VAD2, Q5ASU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 26, 2009
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program