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P55305

- CATA_EMENI

UniProt

P55305 - CATA_EMENI

Protein

Catalase A

Gene

catA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931PROSITE-ProRule annotation
    Active sitei166 – 1661PROSITE-ProRule annotation
    Metal bindingi380 – 3801Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: ASPGD
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to heat Source: ASPGD
    2. cellular response to hydrogen peroxide Source: ASPGD
    3. cellular response to iron ion starvation Source: ASPGD
    4. hydrogen peroxide catabolic process Source: UniProtKB-KW
    5. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide, Sporulation

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Protein family/group databases

    PeroxiBasei5213. AniKat01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase A (EC:1.11.1.6)
    Alternative name(s):
    Spore-specific catalase
    Gene namesi
    Name:catA
    ORF Names:AN8637
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome III

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Catalase APRO_0000084921Add
    BLAST

    Expressioni

    Developmental stagei

    Sporulation-specific.

    Interactioni

    Protein-protein interaction databases

    STRINGi162425.CADANIAP00006410.

    Structurei

    3D structure databases

    ProteinModelPortaliP55305.
    SMRiP55305. Positions 44-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    HOGENOMiHOG000087851.
    KOiK03781.
    OMAiSMSEHEK.
    OrthoDBiEOG7K9KBN.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    3.40.50.880. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024712. Catalase_clade2.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    IPR029062. Class_I_gatase-like.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038927. Catalase_clade2. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSITAGLQ KAQQAVQDTA TKNKKIVDIS HDTVNVHTDQ EQRTDFGVAI    50
    TDPDHWLRVT NETHSGPSLL EDHIARERIH RFDHERIPER VVHARGTGAY 100
    GNFTLKESIE DLTYAGVLTD TSRNTPVFVR FSTVQGSRGS ADTVRDVRGF 150
    AVKFYTDEGN WDIVGNNIPV FFIQDAIKFP DFVHAVKPEP HNEVPQAQTA 200
    HNNFWDFVYL HPEATHMFMW AMSDRAIPRS YRMMQGFGVN TFSLVNKEGK 250
    RHFVKFHWIP HLGVHSLVWD EALKLAGQDP DFHRKDLMEA IDNKAYPKWD 300
    FAIQAIPEED QDKFEFDIFD ATKVWPEEQV PLRVVGELEL NRNIDEFFPE 350
    TEQVAFCTSH IVPGIDFSDD PLLQGRNFSY QDTQISRLGV NWEEIPINRP 400
    VCPFLNHNRD GAKRHRITKG TVNYWPNRFE ANPPASDKGF KSHPAPITGR 450
    KRRDLTPKFK EYHNQAQLFY NSLSEVEKVH VKKAFSFELD HCDDPIVYER 500
    LAGQRLAEID LPLAQAVAEM VGAPIPTKAL RDNHGKTSVR LSQFDFTPKA 550
    PGIISRRIAI IIGDGYDKIA FNGMKAAILA AQALPFVIGT KRSAIYAQGE 600
    DKNSSKGVIP DHMYDGMRST MFDATFIPGG SHIETLQKNG QIRYWIAETF 650
    GHLKALGAMG EAAQLVKEVL GNVMGVQIAG ADSAEPVEWY GVVTARGPES 700
    AESLSEGFKV LKDAGDFTSK FFYQISQHRN WQRELDGLAS TVAF 744
    Length:744
    Mass (Da):83,990
    Last modified:May 26, 2009 - v2
    Checksum:i3933E190CCBB0713
    GO

    Sequence cautioni

    The sequence AAC49254.1 differs from that shown. Reason: Frameshift at positions 583 and 592.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti582 – 5821Q → A in AAC49254. (PubMed:8598056)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37803 Genomic DNA. Translation: AAC49254.1. Frameshift.
    AACD01000158 Genomic DNA. Translation: EAA60671.1.
    BN001303 Genomic DNA. Translation: CBF78282.1.
    PIRiS68115.
    RefSeqiXP_681906.1. XM_676814.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00006410; CADANIAP00006410; CADANIAG00006410.
    GeneIDi2868532.
    KEGGiani:AN8637.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37803 Genomic DNA. Translation: AAC49254.1 . Frameshift.
    AACD01000158 Genomic DNA. Translation: EAA60671.1 .
    BN001303 Genomic DNA. Translation: CBF78282.1 .
    PIRi S68115.
    RefSeqi XP_681906.1. XM_676814.1.

    3D structure databases

    ProteinModelPortali P55305.
    SMRi P55305. Positions 44-744.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 162425.CADANIAP00006410.

    Protein family/group databases

    PeroxiBasei 5213. AniKat01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00006410 ; CADANIAP00006410 ; CADANIAG00006410 .
    GeneIDi 2868532.
    KEGGi ani:AN8637.2.

    Phylogenomic databases

    eggNOGi COG0753.
    HOGENOMi HOG000087851.
    KOi K03781.
    OMAi SMSEHEK.
    OrthoDBi EOG7K9KBN.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    3.40.50.880. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024712. Catalase_clade2.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    IPR029062. Class_I_gatase-like.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038927. Catalase_clade2. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase."
      Navarro R.E., Stringer M.A., Hansberg W., Timberlake W.E., Aguirre J.
      Curr. Genet. 29:352-359(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FGSC 26.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiCATA_EMENI
    AccessioniPrimary (citable) accession number: P55305
    Secondary accession number(s): C8VAD2, Q5ASU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3