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Protein

Catalase A

Gene

catA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93PROSITE-ProRule annotation1
Active sitei166PROSITE-ProRule annotation1
Metal bindingi380Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: AspGD
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to heat Source: AspGD
  • cellular response to hydrogen peroxide Source: AspGD
  • cellular response to iron ion starvation Source: AspGD
  • hydrogen peroxide catabolic process Source: GO_Central
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Sporulation
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei5213 AniKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase A (EC:1.11.1.6)
Alternative name(s):
Spore-specific catalase
Gene namesi
Name:catA
ORF Names:AN8637
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849211 – 744Catalase AAdd BLAST744

Proteomic databases

PRIDEiP55305

Expressioni

Developmental stagei

Sporulation-specific.

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006410

Structurei

3D structure databases

ProteinModelPortaliP55305
SMRiP55305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

HOGENOMiHOG000087851
InParanoidiP55305
KOiK03781
OMAiVMWQMSD
OrthoDBiEOG092C0NOX

Family and domain databases

Gene3Di2.40.180.10, 1 hit
3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024712 Catalase_clade2
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
IPR029062 Class_I_gatase-like
PANTHERiPTHR42821 PTHR42821, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038927 Catalase_clade2, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P55305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSITAGLQ KAQQAVQDTA TKNKKIVDIS HDTVNVHTDQ EQRTDFGVAI
60 70 80 90 100
TDPDHWLRVT NETHSGPSLL EDHIARERIH RFDHERIPER VVHARGTGAY
110 120 130 140 150
GNFTLKESIE DLTYAGVLTD TSRNTPVFVR FSTVQGSRGS ADTVRDVRGF
160 170 180 190 200
AVKFYTDEGN WDIVGNNIPV FFIQDAIKFP DFVHAVKPEP HNEVPQAQTA
210 220 230 240 250
HNNFWDFVYL HPEATHMFMW AMSDRAIPRS YRMMQGFGVN TFSLVNKEGK
260 270 280 290 300
RHFVKFHWIP HLGVHSLVWD EALKLAGQDP DFHRKDLMEA IDNKAYPKWD
310 320 330 340 350
FAIQAIPEED QDKFEFDIFD ATKVWPEEQV PLRVVGELEL NRNIDEFFPE
360 370 380 390 400
TEQVAFCTSH IVPGIDFSDD PLLQGRNFSY QDTQISRLGV NWEEIPINRP
410 420 430 440 450
VCPFLNHNRD GAKRHRITKG TVNYWPNRFE ANPPASDKGF KSHPAPITGR
460 470 480 490 500
KRRDLTPKFK EYHNQAQLFY NSLSEVEKVH VKKAFSFELD HCDDPIVYER
510 520 530 540 550
LAGQRLAEID LPLAQAVAEM VGAPIPTKAL RDNHGKTSVR LSQFDFTPKA
560 570 580 590 600
PGIISRRIAI IIGDGYDKIA FNGMKAAILA AQALPFVIGT KRSAIYAQGE
610 620 630 640 650
DKNSSKGVIP DHMYDGMRST MFDATFIPGG SHIETLQKNG QIRYWIAETF
660 670 680 690 700
GHLKALGAMG EAAQLVKEVL GNVMGVQIAG ADSAEPVEWY GVVTARGPES
710 720 730 740
AESLSEGFKV LKDAGDFTSK FFYQISQHRN WQRELDGLAS TVAF
Length:744
Mass (Da):83,990
Last modified:May 26, 2009 - v2
Checksum:i3933E190CCBB0713
GO

Sequence cautioni

The sequence AAC49254 differs from that shown. Reason: Frameshift at positions 583 and 592.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti582Q → A in AAC49254 (PubMed:8598056).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37803 Genomic DNA Translation: AAC49254.1 Frameshift.
AACD01000158 Genomic DNA Translation: EAA60671.1
BN001303 Genomic DNA Translation: CBF78282.1
PIRiS68115
RefSeqiXP_681906.1, XM_676814.1

Genome annotation databases

EnsemblFungiiCADANIAT00006410; CADANIAP00006410; CADANIAG00006410
EAA60671; EAA60671; AN8637.2
GeneIDi2868532
KEGGiani:AN8637.2

Similar proteinsi

Entry informationi

Entry nameiCATA_EMENI
AccessioniPrimary (citable) accession number: P55305
Secondary accession number(s): C8VAD2, Q5ASU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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