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P55302

- AMRP_MOUSE

UniProt

P55302 - AMRP_MOUSE

Protein

Alpha-2-macroglobulin receptor-associated protein

Gene

Lrpap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. low-density lipoprotein particle receptor binding Source: MGI

    GO - Biological processi

    1. extracellular negative regulation of signal transduction Source: Ensembl
    2. negative regulation of beta-amyloid clearance Source: Ensembl
    3. negative regulation of protein binding Source: Ensembl
    4. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2-macroglobulin receptor-associated protein
    Short name:
    Alpha-2-MRAP
    Alternative name(s):
    Heparin-binding protein 44
    Short name:
    HBP-44
    Low density lipoprotein receptor-related protein-associated protein 1
    Short name:
    RAP
    Gene namesi
    Name:Lrpap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:96829. Lrpap1.

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation. Cytoplasm By similarity. Cell surface By similarity
    Note: Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum By similarity.By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: Ensembl
    3. plasma membrane Source: MGI
    4. rough endoplasmic reticulum lumen Source: Ensembl
    5. vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 360332Alpha-2-macroglobulin receptor-associated proteinPRO_0000020725Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP55302.
    PaxDbiP55302.
    PRIDEiP55302.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00469307.
    P55302.

    PTM databases

    PhosphoSiteiP55302.

    Expressioni

    Tissue specificityi

    Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells.1 Publication

    Gene expression databases

    ArrayExpressiP55302.
    BgeeiP55302.
    GenevestigatoriP55302.

    Interactioni

    Subunit structurei

    Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201205. 1 interaction.
    IntActiP55302. 5 interactions.
    MINTiMINT-4087673.
    STRINGi10090.ENSMUSP00000030986.

    Structurei

    3D structure databases

    ProteinModelPortaliP55302.
    SMRiP55302. Positions 38-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni240 – 356117LDL receptor bindingSequence AnalysisAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili184 – 302119Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi357 – 3604Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the alpha-2-MRAP family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG323629.
    HOVERGENiHBG000197.
    InParanoidiP55302.
    OMAiFRMAKLN.
    OrthoDBiEOG7P5T15.
    PhylomeDBiP55302.
    TreeFamiTF320678.

    Family and domain databases

    Gene3Di1.20.81.10. 1 hit.
    InterProiIPR010483. Alpha_2_MRAP_C.
    IPR009066. MG_RAP_rcpt_1.
    [Graphical view]
    PfamiPF06401. Alpha-2-MRAP_C. 1 hit.
    PF06400. Alpha-2-MRAP_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47045. SSF47045. 3 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55302-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRRERVST LPRLQLLVLL LLPLMLVPQP IAGHGGKYSR EKNEPEMAAK    50
    RESGEEFRME KLNQLWEKAK RLHLSPVRLA ELHSDLKIQE RDELNWKKLK 100
    VEGLDKDGEK EAKLIHNLNV ILARYGLDGR KDAQMVHSNA LNEDTQDELG 150
    DPRLEKLWHK AKTSGKFSSE ELDKLWREFL HYKEKIQEYN VLLDTLSRAE 200
    EGYENLLSPS DMAHIKSDTL ISKHSELKDR LRSINQGLDR LRKVSHQGYG 250
    STTEFEEPRV IDLWDLAQSA NFTEKELESF REELKHFEAK IEKHNHYQKQ 300
    LEISHQKLKH VESIGDPEHI SRNKEKYVLL EEKTKELGYK VKKHLQDLSS 350
    RVSRARHNEL 360
    Length:360
    Mass (Da):42,215
    Last modified:October 1, 1996 - v1
    Checksum:i72ED46FA0AC05D51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67967 mRNA. Translation: AAC60668.1.
    D00622 mRNA. Translation: BAA00500.1.
    CCDSiCCDS19225.1.
    PIRiJX0281.
    RefSeqiNP_038615.2. NM_013587.2.
    UniGeneiMm.277661.

    Genome annotation databases

    EnsembliENSMUST00000030986; ENSMUSP00000030986; ENSMUSG00000029103.
    GeneIDi16976.
    KEGGimmu:16976.
    UCSCiuc008xdo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67967 mRNA. Translation: AAC60668.1 .
    D00622 mRNA. Translation: BAA00500.1 .
    CCDSi CCDS19225.1.
    PIRi JX0281.
    RefSeqi NP_038615.2. NM_013587.2.
    UniGenei Mm.277661.

    3D structure databases

    ProteinModelPortali P55302.
    SMRi P55302. Positions 38-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201205. 1 interaction.
    IntActi P55302. 5 interactions.
    MINTi MINT-4087673.
    STRINGi 10090.ENSMUSP00000030986.

    PTM databases

    PhosphoSitei P55302.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00469307.
    P55302.

    Proteomic databases

    MaxQBi P55302.
    PaxDbi P55302.
    PRIDEi P55302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030986 ; ENSMUSP00000030986 ; ENSMUSG00000029103 .
    GeneIDi 16976.
    KEGGi mmu:16976.
    UCSCi uc008xdo.1. mouse.

    Organism-specific databases

    CTDi 4043.
    MGIi MGI:96829. Lrpap1.

    Phylogenomic databases

    eggNOGi NOG323629.
    HOVERGENi HBG000197.
    InParanoidi P55302.
    OMAi FRMAKLN.
    OrthoDBi EOG7P5T15.
    PhylomeDBi P55302.
    TreeFami TF320678.

    Miscellaneous databases

    NextBioi 291044.
    PROi P55302.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55302.
    Bgeei P55302.
    Genevestigatori P55302.

    Family and domain databases

    Gene3Di 1.20.81.10. 1 hit.
    InterProi IPR010483. Alpha_2_MRAP_C.
    IPR009066. MG_RAP_rcpt_1.
    [Graphical view ]
    Pfami PF06401. Alpha-2-MRAP_C. 1 hit.
    PF06400. Alpha-2-MRAP_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47045. SSF47045. 3 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high-molecular-weight glycoprotein antigen common to the kidney and teratocarcinomas."
      Nakamoto M., Ozawa M., Jacinto S.D., Furukawa T., Natori Y., Shirahama H., Yonezawa S., Nakayama T., Muramatsu T.
      J. Biochem. 114:344-349(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis."
      Furukawa T., Ozawa M., Huang R.P., Muramatsu T.
      J. Biochem. 108:297-302(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-360, TISSUE SPECIFICITY.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 310-322, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiAMRP_MOUSE
    AccessioniPrimary (citable) accession number: P55302
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3