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P55302

- AMRP_MOUSE

UniProt

P55302 - AMRP_MOUSE

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Protein
Alpha-2-macroglobulin receptor-associated protein
Gene
Lrpap1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. low-density lipoprotein particle receptor binding Source: MGI

GO - Biological processi

  1. extracellular negative regulation of signal transduction Source: Ensembl
  2. negative regulation of beta-amyloid clearance Source: Ensembl
  3. negative regulation of protein binding Source: Ensembl
  4. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-macroglobulin receptor-associated protein
Short name:
Alpha-2-MRAP
Alternative name(s):
Heparin-binding protein 44
Short name:
HBP-44
Low density lipoprotein receptor-related protein-associated protein 1
Short name:
RAP
Gene namesi
Name:Lrpap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96829. Lrpap1.

Subcellular locationi

Endoplasmic reticulum By similarity. Cytoplasm By similarity. Cell surface By similarity
Note: Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum By similarity.

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. extracellular region Source: Ensembl
  3. plasma membrane Source: MGI
  4. rough endoplasmic reticulum lumen Source: Ensembl
  5. vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 360332Alpha-2-macroglobulin receptor-associated protein
PRO_0000020725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP55302.
PaxDbiP55302.
PRIDEiP55302.

2D gel databases

REPRODUCTION-2DPAGEIPI00469307.
P55302.

PTM databases

PhosphoSiteiP55302.

Expressioni

Tissue specificityi

Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells.1 Publication

Gene expression databases

ArrayExpressiP55302.
BgeeiP55302.
GenevestigatoriP55302.

Interactioni

Subunit structurei

Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation By similarity.

Protein-protein interaction databases

BioGridi201205. 1 interaction.
IntActiP55302. 5 interactions.
MINTiMINT-4087673.
STRINGi10090.ENSMUSP00000030986.

Structurei

3D structure databases

ProteinModelPortaliP55302.
SMRiP55302. Positions 38-360.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 356117LDL receptor binding Reviewed prediction
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili184 – 302119 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi357 – 3604Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the alpha-2-MRAP family.

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG323629.
HOVERGENiHBG000197.
InParanoidiP55302.
OMAiFRMAKLN.
OrthoDBiEOG7P5T15.
PhylomeDBiP55302.
TreeFamiTF320678.

Family and domain databases

Gene3Di1.20.81.10. 1 hit.
InterProiIPR010483. Alpha_2_MRAP_C.
IPR009066. MG_RAP_rcpt_1.
[Graphical view]
PfamiPF06401. Alpha-2-MRAP_C. 1 hit.
PF06400. Alpha-2-MRAP_N. 1 hit.
[Graphical view]
SUPFAMiSSF47045. SSF47045. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55302-1 [UniParc]FASTAAdd to Basket

« Hide

MAPRRERVST LPRLQLLVLL LLPLMLVPQP IAGHGGKYSR EKNEPEMAAK    50
RESGEEFRME KLNQLWEKAK RLHLSPVRLA ELHSDLKIQE RDELNWKKLK 100
VEGLDKDGEK EAKLIHNLNV ILARYGLDGR KDAQMVHSNA LNEDTQDELG 150
DPRLEKLWHK AKTSGKFSSE ELDKLWREFL HYKEKIQEYN VLLDTLSRAE 200
EGYENLLSPS DMAHIKSDTL ISKHSELKDR LRSINQGLDR LRKVSHQGYG 250
STTEFEEPRV IDLWDLAQSA NFTEKELESF REELKHFEAK IEKHNHYQKQ 300
LEISHQKLKH VESIGDPEHI SRNKEKYVLL EEKTKELGYK VKKHLQDLSS 350
RVSRARHNEL 360
Length:360
Mass (Da):42,215
Last modified:October 1, 1996 - v1
Checksum:i72ED46FA0AC05D51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67967 mRNA. Translation: AAC60668.1.
D00622 mRNA. Translation: BAA00500.1.
CCDSiCCDS19225.1.
PIRiJX0281.
RefSeqiNP_038615.2. NM_013587.2.
UniGeneiMm.277661.

Genome annotation databases

EnsembliENSMUST00000030986; ENSMUSP00000030986; ENSMUSG00000029103.
GeneIDi16976.
KEGGimmu:16976.
UCSCiuc008xdo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67967 mRNA. Translation: AAC60668.1 .
D00622 mRNA. Translation: BAA00500.1 .
CCDSi CCDS19225.1.
PIRi JX0281.
RefSeqi NP_038615.2. NM_013587.2.
UniGenei Mm.277661.

3D structure databases

ProteinModelPortali P55302.
SMRi P55302. Positions 38-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201205. 1 interaction.
IntActi P55302. 5 interactions.
MINTi MINT-4087673.
STRINGi 10090.ENSMUSP00000030986.

PTM databases

PhosphoSitei P55302.

2D gel databases

REPRODUCTION-2DPAGE IPI00469307.
P55302.

Proteomic databases

MaxQBi P55302.
PaxDbi P55302.
PRIDEi P55302.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030986 ; ENSMUSP00000030986 ; ENSMUSG00000029103 .
GeneIDi 16976.
KEGGi mmu:16976.
UCSCi uc008xdo.1. mouse.

Organism-specific databases

CTDi 4043.
MGIi MGI:96829. Lrpap1.

Phylogenomic databases

eggNOGi NOG323629.
HOVERGENi HBG000197.
InParanoidi P55302.
OMAi FRMAKLN.
OrthoDBi EOG7P5T15.
PhylomeDBi P55302.
TreeFami TF320678.

Miscellaneous databases

NextBioi 291044.
PROi P55302.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55302.
Bgeei P55302.
Genevestigatori P55302.

Family and domain databases

Gene3Di 1.20.81.10. 1 hit.
InterProi IPR010483. Alpha_2_MRAP_C.
IPR009066. MG_RAP_rcpt_1.
[Graphical view ]
Pfami PF06401. Alpha-2-MRAP_C. 1 hit.
PF06400. Alpha-2-MRAP_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47045. SSF47045. 3 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse heparin binding protein-44 (HBP-44) associates with brushin, a high-molecular-weight glycoprotein antigen common to the kidney and teratocarcinomas."
    Nakamoto M., Ozawa M., Jacinto S.D., Furukawa T., Natori Y., Shirahama H., Yonezawa S., Nakayama T., Muramatsu T.
    J. Biochem. 114:344-349(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis."
    Furukawa T., Ozawa M., Huang R.P., Muramatsu T.
    J. Biochem. 108:297-302(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-360, TISSUE SPECIFICITY.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 310-322, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiAMRP_MOUSE
AccessioniPrimary (citable) accession number: P55302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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