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Protein

Mannan endo-1,4-beta-mannosidase B

Gene

MANB

Organism
Piromyces sp.
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei319Proton donorPROSITE-ProRule annotation1
Active sitei407NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiCBM35 Carbohydrate-Binding Module Family 35
GH26 Glycoside Hydrolase Family 26
mycoCLAPiMAN26B_PIRSP

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan endo-1,4-beta-mannosidase B (EC:3.2.1.78)
Alternative name(s):
1,4-beta-D-mannan mannanohydrolase B
Beta-mannanase B
Gene namesi
Name:MANB
OrganismiPiromyces sp.
Taxonomic identifieri45796 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisChytridiomycotaNeocallimastigomycetesNeocallimastigalesNeocallimastigaceaePiromyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001217520 – 571Mannan endo-1,4-beta-mannosidase BAdd BLAST552

Structurei

3D structure databases

ProteinModelPortaliP55297
SMRiP55297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 141CBM6PROSITE-ProRule annotationAdd BLAST120
Domaini165 – 459GH26PROSITE-ProRule annotationAdd BLAST295
Domaini491 – 527CBM10 1PROSITE-ProRule annotationAdd BLAST37
Domaini534 – 571CBM10 2PROSITE-ProRule annotationAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi475 – 479Poly-Asn5
Compositional biasi482 – 488Poly-Asn7

Sequence similaritiesi

Belongs to the glycosyl hydrolase 26 family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.260, 1 hit
3.90.1220.10, 2 hits
InterProiView protein in InterPro
IPR002883 CBM10/Dockerin_dom
IPR005084 CMB_fam6
IPR009034 Dockerin_dom_fun_sf
IPR008979 Galactose-bd-like_sf
IPR022790 GH26_dom
IPR000805 Glyco_hydro_26
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR40079 PTHR40079, 1 hit
PfamiView protein in Pfam
PF02013 CBM_10, 2 hits
PF16990 CBM_35, 1 hit
PF02156 Glyco_hydro_26, 1 hit
PRINTSiPR00739 GLHYDRLASE26
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF64571 SSF64571, 2 hits
PROSITEiView protein in PROSITE
PS51763 CBM10, 2 hits
PS51175 CBM6, 1 hit
PS51764 GH26, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSLLLFC IFFVFSTFAK KVYYEAENGK LDGVTVYKSD LTGFSGTGYV
60 70 80 90 100
GRFENPGNSV TVTVEVPQTG MYDLTIVYCA NMGQKINSLT VNGQSAGDIT
110 120 130 140 150
FTENTKFEDL NVGAIYLNKG KNTIGLVSSW GWMWVDAFVI NDAPNAAKDV
160 170 180 190 200
TSKLNPTLIN PKAIPAAKKL YDFLKTNYGK RILSGQVGAA GQAGDEGQEI
210 220 230 240 250
QRIQKATGKL PAVWNMDFIF ESNDCTWRPQ NPDITEMAIN WWKKYQGKGI
260 270 280 290 300
MSAQWHWNIA GKTGDFAFYK KDTTFSIDNA VTEGTWEYEK IIKDIDRVAG
310 320 330 340 350
HIKKLQAVNM PLIWRPLHEN DGDWFWWGNN PKSCAKLWKI LYERMVNYHG
360 370 380 390 400
LNNLIWLWNG KNDANTPVDY IDIIGVDIYA NDHGPQTTAY NTHFDFYGGK
410 420 430 440 450
KMVVLSENGR IPDIQQCVDQ NAWWGYFQTW NSEFILQDSY HTDAQLKEYF
460 470 480 490 500
THKTVMNMDE LPSFNVNSYE YQSGNNNNNS SNNNNNNNSS ECFSIPLGYP
510 520 530 540 550
CCKGNTVVYT DNDGDWGVEN NEWCGIGNSS SAVVCWSEAL GYPCCVSSSD
560 570
VYYTDNDGEW GVENGDWCGI I
Length:571
Mass (Da):64,397
Last modified:October 1, 1996 - v1
Checksum:iB13E44581FAA9DAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97408 mRNA Translation: CAA66061.1

Similar proteinsi

Entry informationi

Entry nameiMANB_PIRSP
AccessioniPrimary (citable) accession number: P55297
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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