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P55297

- MANB_PIRSP

UniProt

P55297 - MANB_PIRSP

Protein

Mannan endo-1,4-beta-mannosidase B

Gene

MANB

Organism
Piromyces sp.
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cellulase activity Source: InterPro
    3. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. substituted mannan metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiCBM35. Carbohydrate-Binding Module Family 35.
    GH26. Glycoside Hydrolase Family 26.
    mycoCLAPiMAN26B_PIRSP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannan endo-1,4-beta-mannosidase B (EC:3.2.1.78)
    Alternative name(s):
    1,4-beta-D-mannan mannanohydrolase B
    Beta-mannanase B
    Gene namesi
    Name:MANB
    OrganismiPiromyces sp.
    Taxonomic identifieri45796 [NCBI]
    Taxonomic lineageiEukaryotaFungiNeocallimastigomycotaNeocallimastigomycetesNeocallimastigalesNeocallimastigaceaePiromyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 571552Mannan endo-1,4-beta-mannosidase BPRO_0000012175Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP55297.
    SMRiP55297. Positions 534-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 141120CBM6PROSITE-ProRule annotationAdd
    BLAST
    Domaini491 – 52636CBM10 1Add
    BLAST
    Domaini535 – 57036CBM10 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi475 – 4795Poly-Asn
    Compositional biasi482 – 4887Poly-Asn

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 26 family.Curated
    Contains 1 CBM6 (carbohydrate binding type-6) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    3.90.1220.10. 2 hits.
    InterProiIPR002883. CBM10/Dockerin_dom.
    IPR005084. CMB_fam6.
    IPR009034. Dockerin_dom_fun.
    IPR022790. EndoGluc_H/Glyco_hydro_26.
    IPR008979. Galactose-bd-like.
    IPR000805. Glyco_hydro_26.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02013. CBM_10. 2 hits.
    PF02156. Glyco_hydro_26. 1 hit.
    [Graphical view]
    PRINTSiPR00739. GLHYDRLASE26.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF64571. SSF64571. 2 hits.
    PROSITEiPS51175. CBM6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55297-1 [UniParc]FASTAAdd to Basket

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    MNSLSLLLFC IFFVFSTFAK KVYYEAENGK LDGVTVYKSD LTGFSGTGYV    50
    GRFENPGNSV TVTVEVPQTG MYDLTIVYCA NMGQKINSLT VNGQSAGDIT 100
    FTENTKFEDL NVGAIYLNKG KNTIGLVSSW GWMWVDAFVI NDAPNAAKDV 150
    TSKLNPTLIN PKAIPAAKKL YDFLKTNYGK RILSGQVGAA GQAGDEGQEI 200
    QRIQKATGKL PAVWNMDFIF ESNDCTWRPQ NPDITEMAIN WWKKYQGKGI 250
    MSAQWHWNIA GKTGDFAFYK KDTTFSIDNA VTEGTWEYEK IIKDIDRVAG 300
    HIKKLQAVNM PLIWRPLHEN DGDWFWWGNN PKSCAKLWKI LYERMVNYHG 350
    LNNLIWLWNG KNDANTPVDY IDIIGVDIYA NDHGPQTTAY NTHFDFYGGK 400
    KMVVLSENGR IPDIQQCVDQ NAWWGYFQTW NSEFILQDSY HTDAQLKEYF 450
    THKTVMNMDE LPSFNVNSYE YQSGNNNNNS SNNNNNNNSS ECFSIPLGYP 500
    CCKGNTVVYT DNDGDWGVEN NEWCGIGNSS SAVVCWSEAL GYPCCVSSSD 550
    VYYTDNDGEW GVENGDWCGI I 571
    Length:571
    Mass (Da):64,397
    Last modified:October 1, 1996 - v1
    Checksum:iB13E44581FAA9DAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97408 mRNA. Translation: CAA66061.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97408 mRNA. Translation: CAA66061.1 .

    3D structure databases

    ProteinModelPortali P55297.
    SMRi P55297. Positions 534-571.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM35. Carbohydrate-Binding Module Family 35.
    GH26. Glycoside Hydrolase Family 26.
    mycoCLAPi MAN26B_PIRSP.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    3.90.1220.10. 2 hits.
    InterProi IPR002883. CBM10/Dockerin_dom.
    IPR005084. CMB_fam6.
    IPR009034. Dockerin_dom_fun.
    IPR022790. EndoGluc_H/Glyco_hydro_26.
    IPR008979. Galactose-bd-like.
    IPR000805. Glyco_hydro_26.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02013. CBM_10. 2 hits.
    PF02156. Glyco_hydro_26. 1 hit.
    [Graphical view ]
    PRINTSi PR00739. GLHYDRLASE26.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF64571. SSF64571. 2 hits.
    PROSITEi PS51175. CBM6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence that the Piromyces gene family encoding endo-1,4-mannanases arose through gene duplication."
      Millward-Sadler S.J., Hall J., Black G.W., Hazlewood G.P., Gilbert H.J.
      FEMS Microbiol. Lett. 141:183-188(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMANB_PIRSP
    AccessioniPrimary (citable) accession number: P55297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3