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P55297 (MANB_PIRSP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannan endo-1,4-beta-mannosidase B

EC=3.2.1.78
Alternative name(s):
1,4-beta-D-mannan mannanohydrolase B
Beta-mannanase B
Gene names
Name:MANB
OrganismPiromyces sp.
Taxonomic identifier45796 [NCBI]
Taxonomic lineageEukaryotaFungiNeocallimastigomycotaNeocallimastigomycetesNeocallimastigalesNeocallimastigaceaePiromyces

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sequence similarities

Belongs to the glycosyl hydrolase 26 family.

Contains 2 CBM10 (carbohydrate binding type-10) domains.

Contains 1 CBM6 (carbohydrate binding type-6) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 571552Mannan endo-1,4-beta-mannosidase B
PRO_0000012175

Regions

Domain22 – 141120CBM6
Domain491 – 52636CBM10 1
Domain535 – 57036CBM10 2
Compositional bias475 – 4795Poly-Asn
Compositional bias482 – 4887Poly-Asn

Sequences

Sequence LengthMass (Da)Tools
P55297 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B13E44581FAA9DAA

FASTA57164,397
        10         20         30         40         50         60 
MNSLSLLLFC IFFVFSTFAK KVYYEAENGK LDGVTVYKSD LTGFSGTGYV GRFENPGNSV 

        70         80         90        100        110        120 
TVTVEVPQTG MYDLTIVYCA NMGQKINSLT VNGQSAGDIT FTENTKFEDL NVGAIYLNKG 

       130        140        150        160        170        180 
KNTIGLVSSW GWMWVDAFVI NDAPNAAKDV TSKLNPTLIN PKAIPAAKKL YDFLKTNYGK 

       190        200        210        220        230        240 
RILSGQVGAA GQAGDEGQEI QRIQKATGKL PAVWNMDFIF ESNDCTWRPQ NPDITEMAIN 

       250        260        270        280        290        300 
WWKKYQGKGI MSAQWHWNIA GKTGDFAFYK KDTTFSIDNA VTEGTWEYEK IIKDIDRVAG 

       310        320        330        340        350        360 
HIKKLQAVNM PLIWRPLHEN DGDWFWWGNN PKSCAKLWKI LYERMVNYHG LNNLIWLWNG 

       370        380        390        400        410        420 
KNDANTPVDY IDIIGVDIYA NDHGPQTTAY NTHFDFYGGK KMVVLSENGR IPDIQQCVDQ 

       430        440        450        460        470        480 
NAWWGYFQTW NSEFILQDSY HTDAQLKEYF THKTVMNMDE LPSFNVNSYE YQSGNNNNNS 

       490        500        510        520        530        540 
SNNNNNNNSS ECFSIPLGYP CCKGNTVVYT DNDGDWGVEN NEWCGIGNSS SAVVCWSEAL 

       550        560        570 
GYPCCVSSSD VYYTDNDGEW GVENGDWCGI I 

« Hide

References

[1]"Evidence that the Piromyces gene family encoding endo-1,4-mannanases arose through gene duplication."
Millward-Sadler S.J., Hall J., Black G.W., Hazlewood G.P., Gilbert H.J.
FEMS Microbiol. Lett. 141:183-188(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97408 mRNA. Translation: CAA66061.1.

3D structure databases

ProteinModelPortalP55297.
SMRP55297. Positions 534-571.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM35. Carbohydrate-Binding Module Family 35.
GH26. Glycoside Hydrolase Family 26.
mycoCLAPMAN26B_PIRSP.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
3.90.1220.10. 2 hits.
InterProIPR002883. CBM10/Dockerin_dom.
IPR005084. CMB_fam6.
IPR009034. Dockerin_dom.
IPR022790. EndoGluc_H/Glyco_hydro_26.
IPR008979. Galactose-bd-like.
IPR000805. Glyco_hydro_26.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF02013. CBM_10. 2 hits.
PF02156. Glyco_hydro_26. 1 hit.
[Graphical view]
PRINTSPR00739. GLHYDRLASE26.
SUPFAMSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF64571. SSF64571. 2 hits.
PROSITEPS51175. CBM6. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_PIRSP
AccessionPrimary (citable) accession number: P55297
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries